Incidental Mutation 'R7574:Dapk1'
| ID |
586268 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
045660-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7574 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 60908987 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 1200
(G1200D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076666
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044083
AA Change: G1200D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: G1200D
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000077453
AA Change: G1200D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: G1200D
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226059
AA Change: G1200D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833420G17Rik |
T |
C |
13: 119,606,478 (GRCm39) |
V240A |
probably damaging |
Het |
| A930009A15Rik |
C |
T |
10: 115,406,019 (GRCm39) |
|
probably benign |
Het |
| Aarsd1 |
A |
G |
11: 101,301,970 (GRCm39) |
I201T |
probably damaging |
Het |
| Acaca |
T |
A |
11: 84,152,414 (GRCm39) |
Y854N |
probably benign |
Het |
| Adra2c |
T |
C |
5: 35,437,759 (GRCm39) |
L177P |
probably damaging |
Het |
| Akr1c12 |
A |
T |
13: 4,329,309 (GRCm39) |
I16N |
probably damaging |
Het |
| Aldh8a1 |
A |
T |
10: 21,256,729 (GRCm39) |
I47F |
possibly damaging |
Het |
| Birc6 |
A |
G |
17: 74,886,879 (GRCm39) |
I736V |
probably benign |
Het |
| Bmp2 |
A |
T |
2: 133,402,817 (GRCm39) |
M123L |
probably benign |
Het |
| C1ql1 |
T |
C |
11: 102,836,812 (GRCm39) |
Y159C |
probably damaging |
Het |
| Ccdc148 |
T |
C |
2: 58,713,645 (GRCm39) |
Y502C |
probably damaging |
Het |
| Ccdc168 |
A |
T |
1: 44,098,593 (GRCm39) |
V835E |
possibly damaging |
Het |
| Cenpf |
A |
T |
1: 189,390,864 (GRCm39) |
N989K |
probably damaging |
Het |
| Ciz1 |
A |
G |
2: 32,257,380 (GRCm39) |
M142V |
probably benign |
Het |
| Cnot4 |
T |
C |
6: 35,029,939 (GRCm39) |
R320G |
possibly damaging |
Het |
| Cyth1 |
G |
T |
11: 118,073,689 (GRCm39) |
H215N |
probably damaging |
Het |
| Dhps |
A |
G |
8: 85,799,181 (GRCm39) |
Y103C |
probably damaging |
Het |
| Dnah1 |
T |
A |
14: 31,041,865 (GRCm39) |
E35D |
probably benign |
Het |
| Dnajb9 |
A |
T |
12: 44,254,169 (GRCm39) |
D79E |
probably damaging |
Het |
| Eif4a2 |
T |
C |
16: 22,928,877 (GRCm39) |
F164S |
probably benign |
Het |
| Enpp2 |
T |
C |
15: 54,714,813 (GRCm39) |
T595A |
probably benign |
Het |
| Exoc6b |
T |
A |
6: 84,768,366 (GRCm39) |
|
probably null |
Het |
| Fam171a1 |
T |
C |
2: 3,221,391 (GRCm39) |
S286P |
probably damaging |
Het |
| Fermt2 |
T |
A |
14: 45,706,782 (GRCm39) |
N338I |
probably damaging |
Het |
| Fhdc1 |
A |
G |
3: 84,353,438 (GRCm39) |
F596L |
probably benign |
Het |
| Fry |
T |
C |
5: 150,304,359 (GRCm39) |
V583A |
probably benign |
Het |
| Gbp10 |
G |
A |
5: 105,384,015 (GRCm39) |
|
probably benign |
Het |
| Gdap1 |
T |
A |
1: 17,231,665 (GRCm39) |
F337I |
possibly damaging |
Het |
| Git2 |
C |
T |
5: 114,904,550 (GRCm39) |
R123H |
probably damaging |
Het |
| Gpr6 |
A |
T |
10: 40,946,652 (GRCm39) |
I310N |
possibly damaging |
Het |
| Gpsm2 |
G |
A |
3: 108,608,061 (GRCm39) |
A239V |
probably damaging |
Het |
| Hexa |
T |
C |
9: 59,471,267 (GRCm39) |
V507A |
probably benign |
Het |
| Hmcn2 |
A |
T |
2: 31,345,531 (GRCm39) |
H4718L |
possibly damaging |
Het |
| Hrh4 |
T |
C |
18: 13,154,970 (GRCm39) |
F170L |
possibly damaging |
Het |
| Ica1 |
T |
C |
6: 8,658,266 (GRCm39) |
T284A |
probably benign |
Het |
| Itga5 |
T |
C |
15: 103,258,876 (GRCm39) |
N774S |
probably damaging |
Het |
| Itgb2 |
T |
C |
10: 77,395,992 (GRCm39) |
S556P |
probably benign |
Het |
| Kash5 |
A |
T |
7: 44,854,035 (GRCm39) |
H31Q |
possibly damaging |
Het |
| Kcnq4 |
A |
G |
4: 120,568,565 (GRCm39) |
F384L |
probably benign |
Het |
| Lama2 |
A |
T |
10: 26,882,726 (GRCm39) |
N2612K |
probably benign |
Het |
| Lnx1 |
T |
C |
5: 74,846,099 (GRCm39) |
E117G |
probably benign |
Het |
| Lrrc14b |
G |
T |
13: 74,508,892 (GRCm39) |
A505E |
probably damaging |
Het |
| Ly6g |
T |
C |
15: 75,030,413 (GRCm39) |
I77T |
probably benign |
Het |
| Mmp1a |
TG |
TGG |
9: 7,465,083 (GRCm38) |
|
probably null |
Het |
| Mrgpre |
C |
T |
7: 143,335,087 (GRCm39) |
V139M |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,753,411 (GRCm38) |
S1096T |
probably benign |
Het |
| Myrfl |
G |
A |
10: 116,667,430 (GRCm39) |
R337* |
probably null |
Het |
| Ndufa4 |
C |
T |
6: 11,906,092 (GRCm39) |
V20I |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,299,595 (GRCm39) |
D241G |
probably null |
Het |
| Nid1 |
A |
G |
13: 13,643,028 (GRCm39) |
D322G |
probably benign |
Het |
| Nova1 |
A |
T |
12: 46,747,544 (GRCm39) |
D244E |
unknown |
Het |
| Or11g27 |
T |
A |
14: 50,771,770 (GRCm39) |
D300E |
probably benign |
Het |
| Or4a68 |
T |
C |
2: 89,269,745 (GRCm39) |
K293E |
possibly damaging |
Het |
| Or5m10b |
A |
G |
2: 85,699,350 (GRCm39) |
K138R |
probably benign |
Het |
| Padi2 |
C |
A |
4: 140,676,648 (GRCm39) |
N595K |
possibly damaging |
Het |
| Pag1 |
A |
G |
3: 9,758,951 (GRCm39) |
I389T |
probably damaging |
Het |
| Pcdh10 |
G |
T |
3: 45,335,810 (GRCm39) |
G708V |
possibly damaging |
Het |
| Pecam1 |
A |
G |
11: 106,590,610 (GRCm39) |
S55P |
probably damaging |
Het |
| Plin3 |
A |
T |
17: 56,591,192 (GRCm39) |
V196E |
possibly damaging |
Het |
| Plxdc1 |
A |
T |
11: 97,847,316 (GRCm39) |
L119Q |
possibly damaging |
Het |
| Pnliprp1 |
A |
T |
19: 58,726,681 (GRCm39) |
N346I |
probably damaging |
Het |
| Ppp1r27 |
A |
T |
11: 120,441,856 (GRCm39) |
Y8* |
probably null |
Het |
| Prg3 |
A |
T |
2: 84,819,746 (GRCm39) |
D80V |
probably damaging |
Het |
| Prmt5 |
T |
C |
14: 54,745,347 (GRCm39) |
N607D |
possibly damaging |
Het |
| Ptprs |
A |
G |
17: 56,730,538 (GRCm39) |
F1144L |
probably benign |
Het |
| Rai14 |
C |
T |
15: 10,593,189 (GRCm39) |
G152R |
probably damaging |
Het |
| Rap1gds1 |
T |
A |
3: 138,661,976 (GRCm39) |
R427* |
probably null |
Het |
| Recql5 |
A |
G |
11: 115,819,248 (GRCm39) |
V106A |
probably benign |
Het |
| Resp18 |
T |
C |
1: 75,250,615 (GRCm39) |
T155A |
probably benign |
Het |
| Rfx6 |
A |
G |
10: 51,557,914 (GRCm39) |
D129G |
probably benign |
Het |
| Rsf1 |
T |
A |
7: 97,310,374 (GRCm39) |
I368K |
|
Het |
| Sema6a |
C |
G |
18: 47,424,231 (GRCm39) |
V226L |
probably damaging |
Het |
| Sf1 |
A |
G |
19: 6,422,234 (GRCm39) |
E220G |
probably damaging |
Het |
| Shld2 |
C |
T |
14: 33,959,423 (GRCm39) |
S853N |
probably damaging |
Het |
| Sidt1 |
T |
A |
16: 44,079,848 (GRCm39) |
Y602F |
probably damaging |
Het |
| Slc17a8 |
A |
G |
10: 89,428,008 (GRCm39) |
I273T |
probably benign |
Het |
| Slc28a2b |
A |
T |
2: 122,353,325 (GRCm39) |
I502F |
not run |
Het |
| Slc41a1 |
A |
T |
1: 131,766,889 (GRCm39) |
I136F |
probably damaging |
Het |
| Snrpb |
T |
C |
2: 130,018,939 (GRCm39) |
I51V |
probably benign |
Het |
| Sprr2f |
T |
A |
3: 92,273,254 (GRCm39) |
C18S |
unknown |
Het |
| Stab1 |
T |
C |
14: 30,876,622 (GRCm39) |
N864S |
probably benign |
Het |
| Svil |
C |
A |
18: 5,095,188 (GRCm39) |
T1457K |
probably benign |
Het |
| Syt1 |
A |
T |
10: 108,340,262 (GRCm39) |
I352N |
probably damaging |
Het |
| Tas2r119 |
A |
G |
15: 32,178,279 (GRCm39) |
K282E |
probably damaging |
Het |
| Timeless |
T |
C |
10: 128,080,538 (GRCm39) |
F473S |
probably damaging |
Het |
| Tmc3 |
A |
G |
7: 83,247,481 (GRCm39) |
D192G |
probably damaging |
Het |
| Trmt1l |
T |
A |
1: 151,316,591 (GRCm39) |
I184N |
possibly damaging |
Het |
| Ttll6 |
G |
A |
11: 96,025,701 (GRCm39) |
V61M |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,632,755 (GRCm39) |
E14100K |
probably damaging |
Het |
| Txndc2 |
T |
A |
17: 65,945,620 (GRCm39) |
I186F |
possibly damaging |
Het |
| Ubr1 |
A |
T |
2: 120,703,672 (GRCm39) |
S1553T |
possibly damaging |
Het |
| Vmn1r208 |
T |
C |
13: 22,956,705 (GRCm39) |
N264S |
probably benign |
Het |
| Vmn1r87 |
T |
A |
7: 12,865,613 (GRCm39) |
M225L |
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,831,899 (GRCm39) |
C632S |
possibly damaging |
Het |
| Wdr97 |
T |
A |
15: 76,241,949 (GRCm39) |
Y747* |
probably null |
Het |
| Zfp474 |
T |
C |
18: 52,772,261 (GRCm39) |
S305P |
probably benign |
Het |
| Zfp59 |
A |
G |
7: 27,552,863 (GRCm39) |
N105S |
probably benign |
Het |
| Zfp804b |
T |
A |
5: 6,822,301 (GRCm39) |
Y254F |
possibly damaging |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATTGTCCCTGTAGAGCACCTC -3'
(R):5'- AACTCTCTTTCAGGGTCTGC -3'
Sequencing Primer
(F):5'- GTAGAGCACCTCACCCCCTTC -3'
(R):5'- TCTGCGCACGGAAGAAGTC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation