Mutagenetix > Incidental Mutation

Incidental Mutation 'R7574:Or11g27'

586275

Institutional Source

Beutler Lab

Gene Symbol

Or11g27

Ensembl Gene

ENSMUSG00000094285

Gene Name

olfactory receptor family 11 subfamily G member 27

Synonyms

GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, Olfr264, Olfr743, Olfr743-ps1, Olfr265, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2N6FY-3870-3385, MOR106-14

MMRRC Submission

045660-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

R7574 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

50770871-50771806 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 50771770 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 300 (D300E)

Ref Sequence

ENSEMBL: ENSMUSP00000150946 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071294] [ENSMUST00000215793]

AlphaFold

L7N1Y2

Predicted Effect

probably benign
Transcript: ENSMUST00000071294
AA Change: D300E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000071263
Gene: ENSMUSG00000094285
AA Change: D300E

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.6e-56	PFAM
Pfam:7tm_1	45	294	1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215793
AA Change: D300E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,606,478 (GRCm39)	V240A	probably damaging	Het
A930009A15Rik	C	T	10: 115,406,019 (GRCm39)		probably benign	Het
Aarsd1	A	G	11: 101,301,970 (GRCm39)	I201T	probably damaging	Het
Acaca	T	A	11: 84,152,414 (GRCm39)	Y854N	probably benign	Het
Adra2c	T	C	5: 35,437,759 (GRCm39)	L177P	probably damaging	Het
Akr1c12	A	T	13: 4,329,309 (GRCm39)	I16N	probably damaging	Het
Aldh8a1	A	T	10: 21,256,729 (GRCm39)	I47F	possibly damaging	Het
Birc6	A	G	17: 74,886,879 (GRCm39)	I736V	probably benign	Het
Bmp2	A	T	2: 133,402,817 (GRCm39)	M123L	probably benign	Het
C1ql1	T	C	11: 102,836,812 (GRCm39)	Y159C	probably damaging	Het
Ccdc148	T	C	2: 58,713,645 (GRCm39)	Y502C	probably damaging	Het
Ccdc168	A	T	1: 44,098,593 (GRCm39)	V835E	possibly damaging	Het
Cenpf	A	T	1: 189,390,864 (GRCm39)	N989K	probably damaging	Het
Ciz1	A	G	2: 32,257,380 (GRCm39)	M142V	probably benign	Het
Cnot4	T	C	6: 35,029,939 (GRCm39)	R320G	possibly damaging	Het
Cyth1	G	T	11: 118,073,689 (GRCm39)	H215N	probably damaging	Het
Dapk1	G	A	13: 60,908,987 (GRCm39)	G1200D	probably damaging	Het
Dhps	A	G	8: 85,799,181 (GRCm39)	Y103C	probably damaging	Het
Dnah1	T	A	14: 31,041,865 (GRCm39)	E35D	probably benign	Het
Dnajb9	A	T	12: 44,254,169 (GRCm39)	D79E	probably damaging	Het
Eif4a2	T	C	16: 22,928,877 (GRCm39)	F164S	probably benign	Het
Enpp2	T	C	15: 54,714,813 (GRCm39)	T595A	probably benign	Het
Exoc6b	T	A	6: 84,768,366 (GRCm39)		probably null	Het
Fam171a1	T	C	2: 3,221,391 (GRCm39)	S286P	probably damaging	Het
Fermt2	T	A	14: 45,706,782 (GRCm39)	N338I	probably damaging	Het
Fhdc1	A	G	3: 84,353,438 (GRCm39)	F596L	probably benign	Het
Fry	T	C	5: 150,304,359 (GRCm39)	V583A	probably benign	Het
Gbp10	G	A	5: 105,384,015 (GRCm39)		probably benign	Het
Gdap1	T	A	1: 17,231,665 (GRCm39)	F337I	possibly damaging	Het
Git2	C	T	5: 114,904,550 (GRCm39)	R123H	probably damaging	Het
Gpr6	A	T	10: 40,946,652 (GRCm39)	I310N	possibly damaging	Het
Gpsm2	G	A	3: 108,608,061 (GRCm39)	A239V	probably damaging	Het
Hexa	T	C	9: 59,471,267 (GRCm39)	V507A	probably benign	Het
Hmcn2	A	T	2: 31,345,531 (GRCm39)	H4718L	possibly damaging	Het
Hrh4	T	C	18: 13,154,970 (GRCm39)	F170L	possibly damaging	Het
Ica1	T	C	6: 8,658,266 (GRCm39)	T284A	probably benign	Het
Itga5	T	C	15: 103,258,876 (GRCm39)	N774S	probably damaging	Het
Itgb2	T	C	10: 77,395,992 (GRCm39)	S556P	probably benign	Het
Kash5	A	T	7: 44,854,035 (GRCm39)	H31Q	possibly damaging	Het
Kcnq4	A	G	4: 120,568,565 (GRCm39)	F384L	probably benign	Het
Lama2	A	T	10: 26,882,726 (GRCm39)	N2612K	probably benign	Het
Lnx1	T	C	5: 74,846,099 (GRCm39)	E117G	probably benign	Het
Lrrc14b	G	T	13: 74,508,892 (GRCm39)	A505E	probably damaging	Het
Ly6g	T	C	15: 75,030,413 (GRCm39)	I77T	probably benign	Het
Mmp1a	TG	TGG	9: 7,465,083 (GRCm38)		probably null	Het
Mrgpre	C	T	7: 143,335,087 (GRCm39)	V139M	probably damaging	Het
Muc4	T	A	16: 32,753,411 (GRCm38)	S1096T	probably benign	Het
Myrfl	G	A	10: 116,667,430 (GRCm39)	R337*	probably null	Het
Ndufa4	C	T	6: 11,906,092 (GRCm39)	V20I	probably benign	Het
Nf1	A	G	11: 79,299,595 (GRCm39)	D241G	probably null	Het
Nid1	A	G	13: 13,643,028 (GRCm39)	D322G	probably benign	Het
Nova1	A	T	12: 46,747,544 (GRCm39)	D244E	unknown	Het
Or4a68	T	C	2: 89,269,745 (GRCm39)	K293E	possibly damaging	Het
Or5m10b	A	G	2: 85,699,350 (GRCm39)	K138R	probably benign	Het
Padi2	C	A	4: 140,676,648 (GRCm39)	N595K	possibly damaging	Het
Pag1	A	G	3: 9,758,951 (GRCm39)	I389T	probably damaging	Het
Pcdh10	G	T	3: 45,335,810 (GRCm39)	G708V	possibly damaging	Het
Pecam1	A	G	11: 106,590,610 (GRCm39)	S55P	probably damaging	Het
Plin3	A	T	17: 56,591,192 (GRCm39)	V196E	possibly damaging	Het
Plxdc1	A	T	11: 97,847,316 (GRCm39)	L119Q	possibly damaging	Het
Pnliprp1	A	T	19: 58,726,681 (GRCm39)	N346I	probably damaging	Het
Ppp1r27	A	T	11: 120,441,856 (GRCm39)	Y8*	probably null	Het
Prg3	A	T	2: 84,819,746 (GRCm39)	D80V	probably damaging	Het
Prmt5	T	C	14: 54,745,347 (GRCm39)	N607D	possibly damaging	Het
Ptprs	A	G	17: 56,730,538 (GRCm39)	F1144L	probably benign	Het
Rai14	C	T	15: 10,593,189 (GRCm39)	G152R	probably damaging	Het
Rap1gds1	T	A	3: 138,661,976 (GRCm39)	R427*	probably null	Het
Recql5	A	G	11: 115,819,248 (GRCm39)	V106A	probably benign	Het
Resp18	T	C	1: 75,250,615 (GRCm39)	T155A	probably benign	Het
Rfx6	A	G	10: 51,557,914 (GRCm39)	D129G	probably benign	Het
Rsf1	T	A	7: 97,310,374 (GRCm39)	I368K		Het
Sema6a	C	G	18: 47,424,231 (GRCm39)	V226L	probably damaging	Het
Sf1	A	G	19: 6,422,234 (GRCm39)	E220G	probably damaging	Het
Shld2	C	T	14: 33,959,423 (GRCm39)	S853N	probably damaging	Het
Sidt1	T	A	16: 44,079,848 (GRCm39)	Y602F	probably damaging	Het
Slc17a8	A	G	10: 89,428,008 (GRCm39)	I273T	probably benign	Het
Slc28a2b	A	T	2: 122,353,325 (GRCm39)	I502F	not run	Het
Slc41a1	A	T	1: 131,766,889 (GRCm39)	I136F	probably damaging	Het
Snrpb	T	C	2: 130,018,939 (GRCm39)	I51V	probably benign	Het
Sprr2f	T	A	3: 92,273,254 (GRCm39)	C18S	unknown	Het
Stab1	T	C	14: 30,876,622 (GRCm39)	N864S	probably benign	Het
Svil	C	A	18: 5,095,188 (GRCm39)	T1457K	probably benign	Het
Syt1	A	T	10: 108,340,262 (GRCm39)	I352N	probably damaging	Het
Tas2r119	A	G	15: 32,178,279 (GRCm39)	K282E	probably damaging	Het
Timeless	T	C	10: 128,080,538 (GRCm39)	F473S	probably damaging	Het
Tmc3	A	G	7: 83,247,481 (GRCm39)	D192G	probably damaging	Het
Trmt1l	T	A	1: 151,316,591 (GRCm39)	I184N	possibly damaging	Het
Ttll6	G	A	11: 96,025,701 (GRCm39)	V61M	probably damaging	Het
Ttn	C	T	2: 76,632,755 (GRCm39)	E14100K	probably damaging	Het
Txndc2	T	A	17: 65,945,620 (GRCm39)	I186F	possibly damaging	Het
Ubr1	A	T	2: 120,703,672 (GRCm39)	S1553T	possibly damaging	Het
Vmn1r208	T	C	13: 22,956,705 (GRCm39)	N264S	probably benign	Het
Vmn1r87	T	A	7: 12,865,613 (GRCm39)	M225L	probably benign	Het
Vmn2r101	T	A	17: 19,831,899 (GRCm39)	C632S	possibly damaging	Het
Wdr97	T	A	15: 76,241,949 (GRCm39)	Y747*	probably null	Het
Zfp474	T	C	18: 52,772,261 (GRCm39)	S305P	probably benign	Het
Zfp59	A	G	7: 27,552,863 (GRCm39)	N105S	probably benign	Het
Zfp804b	T	A	5: 6,822,301 (GRCm39)	Y254F	possibly damaging	Het

Other mutations in Or11g27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01128:Or11g27	APN	14	50,771,406 (GRCm39)	missense	probably damaging	1.00
IGL01551:Or11g27	APN	14	50,771,618 (GRCm39)	missense	probably benign
IGL02024:Or11g27	APN	14	50,771,307 (GRCm39)	missense	probably benign	0.00
IGL02867:Or11g27	APN	14	50,770,970 (GRCm39)	missense	probably benign
IGL02889:Or11g27	APN	14	50,770,970 (GRCm39)	missense	probably benign
IGL03195:Or11g27	APN	14	50,770,877 (GRCm39)	missense	probably benign
IGL03296:Or11g27	APN	14	50,771,402 (GRCm39)	missense	possibly damaging	0.90
R0049:Or11g27	UTSW	14	50,771,151 (GRCm39)	missense	probably damaging	1.00
R0049:Or11g27	UTSW	14	50,771,151 (GRCm39)	missense	probably damaging	1.00
R0102:Or11g27	UTSW	14	50,771,088 (GRCm39)	missense	probably damaging	1.00
R0556:Or11g27	UTSW	14	50,771,381 (GRCm39)	missense	probably benign	0.01
R0626:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R0661:Or11g27	UTSW	14	50,771,552 (GRCm39)	missense	probably benign
R0759:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R0761:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R0894:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1109:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1110:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1312:Or11g27	UTSW	14	50,771,652 (GRCm39)	missense	probably benign
R1446:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1470:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1470:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1502:Or11g27	UTSW	14	50,771,234 (GRCm39)	missense	possibly damaging	0.47
R1518:Or11g27	UTSW	14	50,771,622 (GRCm39)	missense	probably damaging	1.00
R1529:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1624:Or11g27	UTSW	14	50,771,100 (GRCm39)	missense	probably damaging	1.00
R1646:Or11g27	UTSW	14	50,771,040 (GRCm39)	missense	probably benign	0.01
R1687:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R1795:Or11g27	UTSW	14	50,771,159 (GRCm39)	missense	possibly damaging	0.78
R2011:Or11g27	UTSW	14	50,771,141 (GRCm39)	missense	probably damaging	1.00
R2120:Or11g27	UTSW	14	50,771,403 (GRCm39)	missense	probably damaging	1.00
R2697:Or11g27	UTSW	14	50,771,238 (GRCm39)	missense	probably damaging	1.00
R2857:Or11g27	UTSW	14	50,770,897 (GRCm39)	missense	probably benign	0.19
R2858:Or11g27	UTSW	14	50,770,897 (GRCm39)	missense	probably benign	0.19
R3906:Or11g27	UTSW	14	50,771,211 (GRCm39)	missense	probably benign	0.03
R4327:Or11g27	UTSW	14	50,770,971 (GRCm39)	missense	probably benign	0.05
R4355:Or11g27	UTSW	14	50,771,216 (GRCm39)	missense	possibly damaging	0.94
R4663:Or11g27	UTSW	14	50,771,061 (GRCm39)	missense	probably damaging	1.00
R5214:Or11g27	UTSW	14	50,771,804 (GRCm39)	makesense	probably null
R5964:Or11g27	UTSW	14	50,771,655 (GRCm39)	missense	probably damaging	0.99
R6148:Or11g27	UTSW	14	50,771,778 (GRCm39)	missense	probably benign	0.00
R6167:Or11g27	UTSW	14	50,771,612 (GRCm39)	missense	probably damaging	1.00
R6301:Or11g27	UTSW	14	50,771,711 (GRCm39)	missense	probably benign	0.02
R6616:Or11g27	UTSW	14	50,771,364 (GRCm39)	missense	probably benign	0.43
R6910:Or11g27	UTSW	14	50,771,330 (GRCm39)	missense	probably benign	0.31
R7076:Or11g27	UTSW	14	50,771,278 (GRCm39)	nonsense	probably null
R7483:Or11g27	UTSW	14	50,771,472 (GRCm39)	missense	probably benign	0.06
R7731:Or11g27	UTSW	14	50,771,141 (GRCm39)	missense	probably damaging	0.99
R8691:Or11g27	UTSW	14	50,770,910 (GRCm39)	missense	probably benign	0.01
R9072:Or11g27	UTSW	14	50,771,211 (GRCm39)	missense	probably benign	0.03
R9073:Or11g27	UTSW	14	50,771,211 (GRCm39)	missense	probably benign	0.03
R9321:Or11g27	UTSW	14	50,771,471 (GRCm39)	missense	probably benign	0.01
R9478:Or11g27	UTSW	14	50,771,051 (GRCm39)	missense	probably benign	0.01
R9557:Or11g27	UTSW	14	50,771,552 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- AAGGCCTTCTCCACCTGTG -3'
(R):5'- ACCTCCATTTAAATTAGTTTCTGGGA -3'

Sequencing Primer
(F):5'- CCACCTGTGGGTCACATG -3'
(R):5'- GAGAGCATGCATAATTTGTCTTCCC -3'

Posted On

2019-10-24