Incidental Mutation 'R7574:Sema6a'
| ID |
586293 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sema6a
|
| Ensembl Gene |
ENSMUSG00000019647 |
| Gene Name |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms |
VIa, Semaq, Sema6A-1, sema, A730020P05Rik |
| MMRRC Submission |
045660-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7574 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
47378321-47504267 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 47424231 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Leucine
at position 226
(V226L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019791
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019791]
[ENSMUST00000076043]
[ENSMUST00000115449]
[ENSMUST00000126684]
[ENSMUST00000135790]
[ENSMUST00000156422]
|
| AlphaFold |
O35464 |
| PDB Structure |
Mouse Semaphorin 6A extracellular domain [X-RAY DIFFRACTION]
Plexin A2 / Semaphorin 6A complex [X-RAY DIFFRACTION]
Mouse Semaphorin 6A, extracellular domains 1-2 [X-RAY DIFFRACTION]
Plexin A2 in complex with Semaphorin 6A [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000019791
AA Change: V226L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000019791
Gene: ENSMUSG00000019647
AA Change: V226L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076043
AA Change: V226L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000075420
Gene: ENSMUSG00000019647
AA Change: V226L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
593 |
615 |
N/A |
INTRINSIC |
|
low complexity region
|
877 |
896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115449
AA Change: V226L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111109
Gene: ENSMUSG00000019647
AA Change: V226L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
461 |
1.24e-168 |
SMART |
|
PSI
|
488 |
543 |
9.57e-1 |
SMART |
|
transmembrane domain
|
622 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
925 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126684
|
| SMART Domains |
Protein: ENSMUSP00000118655
Gene: ENSMUSG00000019647
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Sema
|
56 |
216 |
2.5e-51 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135790
AA Change: V226L
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000120011
Gene: ENSMUSG00000019647
AA Change: V226L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
665 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
968 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156422
AA Change: V226L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000121442
Gene: ENSMUSG00000019647
AA Change: V226L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit defects in lamina-specific neurite stratification of specific retinal neuron subtypes and disruption of the dendritic plexus organization of On but not Off starburst amacrine cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833420G17Rik |
T |
C |
13: 119,606,478 (GRCm39) |
V240A |
probably damaging |
Het |
| A930009A15Rik |
C |
T |
10: 115,406,019 (GRCm39) |
|
probably benign |
Het |
| Aarsd1 |
A |
G |
11: 101,301,970 (GRCm39) |
I201T |
probably damaging |
Het |
| Acaca |
T |
A |
11: 84,152,414 (GRCm39) |
Y854N |
probably benign |
Het |
| Adra2c |
T |
C |
5: 35,437,759 (GRCm39) |
L177P |
probably damaging |
Het |
| Akr1c12 |
A |
T |
13: 4,329,309 (GRCm39) |
I16N |
probably damaging |
Het |
| Aldh8a1 |
A |
T |
10: 21,256,729 (GRCm39) |
I47F |
possibly damaging |
Het |
| Birc6 |
A |
G |
17: 74,886,879 (GRCm39) |
I736V |
probably benign |
Het |
| Bmp2 |
A |
T |
2: 133,402,817 (GRCm39) |
M123L |
probably benign |
Het |
| C1ql1 |
T |
C |
11: 102,836,812 (GRCm39) |
Y159C |
probably damaging |
Het |
| Ccdc148 |
T |
C |
2: 58,713,645 (GRCm39) |
Y502C |
probably damaging |
Het |
| Ccdc168 |
A |
T |
1: 44,098,593 (GRCm39) |
V835E |
possibly damaging |
Het |
| Cenpf |
A |
T |
1: 189,390,864 (GRCm39) |
N989K |
probably damaging |
Het |
| Ciz1 |
A |
G |
2: 32,257,380 (GRCm39) |
M142V |
probably benign |
Het |
| Cnot4 |
T |
C |
6: 35,029,939 (GRCm39) |
R320G |
possibly damaging |
Het |
| Cyth1 |
G |
T |
11: 118,073,689 (GRCm39) |
H215N |
probably damaging |
Het |
| Dapk1 |
G |
A |
13: 60,908,987 (GRCm39) |
G1200D |
probably damaging |
Het |
| Dhps |
A |
G |
8: 85,799,181 (GRCm39) |
Y103C |
probably damaging |
Het |
| Dnah1 |
T |
A |
14: 31,041,865 (GRCm39) |
E35D |
probably benign |
Het |
| Dnajb9 |
A |
T |
12: 44,254,169 (GRCm39) |
D79E |
probably damaging |
Het |
| Eif4a2 |
T |
C |
16: 22,928,877 (GRCm39) |
F164S |
probably benign |
Het |
| Enpp2 |
T |
C |
15: 54,714,813 (GRCm39) |
T595A |
probably benign |
Het |
| Exoc6b |
T |
A |
6: 84,768,366 (GRCm39) |
|
probably null |
Het |
| Fam171a1 |
T |
C |
2: 3,221,391 (GRCm39) |
S286P |
probably damaging |
Het |
| Fermt2 |
T |
A |
14: 45,706,782 (GRCm39) |
N338I |
probably damaging |
Het |
| Fhdc1 |
A |
G |
3: 84,353,438 (GRCm39) |
F596L |
probably benign |
Het |
| Fry |
T |
C |
5: 150,304,359 (GRCm39) |
V583A |
probably benign |
Het |
| Gbp10 |
G |
A |
5: 105,384,015 (GRCm39) |
|
probably benign |
Het |
| Gdap1 |
T |
A |
1: 17,231,665 (GRCm39) |
F337I |
possibly damaging |
Het |
| Git2 |
C |
T |
5: 114,904,550 (GRCm39) |
R123H |
probably damaging |
Het |
| Gpr6 |
A |
T |
10: 40,946,652 (GRCm39) |
I310N |
possibly damaging |
Het |
| Gpsm2 |
G |
A |
3: 108,608,061 (GRCm39) |
A239V |
probably damaging |
Het |
| Hexa |
T |
C |
9: 59,471,267 (GRCm39) |
V507A |
probably benign |
Het |
| Hmcn2 |
A |
T |
2: 31,345,531 (GRCm39) |
H4718L |
possibly damaging |
Het |
| Hrh4 |
T |
C |
18: 13,154,970 (GRCm39) |
F170L |
possibly damaging |
Het |
| Ica1 |
T |
C |
6: 8,658,266 (GRCm39) |
T284A |
probably benign |
Het |
| Itga5 |
T |
C |
15: 103,258,876 (GRCm39) |
N774S |
probably damaging |
Het |
| Itgb2 |
T |
C |
10: 77,395,992 (GRCm39) |
S556P |
probably benign |
Het |
| Kash5 |
A |
T |
7: 44,854,035 (GRCm39) |
H31Q |
possibly damaging |
Het |
| Kcnq4 |
A |
G |
4: 120,568,565 (GRCm39) |
F384L |
probably benign |
Het |
| Lama2 |
A |
T |
10: 26,882,726 (GRCm39) |
N2612K |
probably benign |
Het |
| Lnx1 |
T |
C |
5: 74,846,099 (GRCm39) |
E117G |
probably benign |
Het |
| Lrrc14b |
G |
T |
13: 74,508,892 (GRCm39) |
A505E |
probably damaging |
Het |
| Ly6g |
T |
C |
15: 75,030,413 (GRCm39) |
I77T |
probably benign |
Het |
| Mmp1a |
TG |
TGG |
9: 7,465,083 (GRCm38) |
|
probably null |
Het |
| Mrgpre |
C |
T |
7: 143,335,087 (GRCm39) |
V139M |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,753,411 (GRCm38) |
S1096T |
probably benign |
Het |
| Myrfl |
G |
A |
10: 116,667,430 (GRCm39) |
R337* |
probably null |
Het |
| Ndufa4 |
C |
T |
6: 11,906,092 (GRCm39) |
V20I |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,299,595 (GRCm39) |
D241G |
probably null |
Het |
| Nid1 |
A |
G |
13: 13,643,028 (GRCm39) |
D322G |
probably benign |
Het |
| Nova1 |
A |
T |
12: 46,747,544 (GRCm39) |
D244E |
unknown |
Het |
| Or11g27 |
T |
A |
14: 50,771,770 (GRCm39) |
D300E |
probably benign |
Het |
| Or4a68 |
T |
C |
2: 89,269,745 (GRCm39) |
K293E |
possibly damaging |
Het |
| Or5m10b |
A |
G |
2: 85,699,350 (GRCm39) |
K138R |
probably benign |
Het |
| Padi2 |
C |
A |
4: 140,676,648 (GRCm39) |
N595K |
possibly damaging |
Het |
| Pag1 |
A |
G |
3: 9,758,951 (GRCm39) |
I389T |
probably damaging |
Het |
| Pcdh10 |
G |
T |
3: 45,335,810 (GRCm39) |
G708V |
possibly damaging |
Het |
| Pecam1 |
A |
G |
11: 106,590,610 (GRCm39) |
S55P |
probably damaging |
Het |
| Plin3 |
A |
T |
17: 56,591,192 (GRCm39) |
V196E |
possibly damaging |
Het |
| Plxdc1 |
A |
T |
11: 97,847,316 (GRCm39) |
L119Q |
possibly damaging |
Het |
| Pnliprp1 |
A |
T |
19: 58,726,681 (GRCm39) |
N346I |
probably damaging |
Het |
| Ppp1r27 |
A |
T |
11: 120,441,856 (GRCm39) |
Y8* |
probably null |
Het |
| Prg3 |
A |
T |
2: 84,819,746 (GRCm39) |
D80V |
probably damaging |
Het |
| Prmt5 |
T |
C |
14: 54,745,347 (GRCm39) |
N607D |
possibly damaging |
Het |
| Ptprs |
A |
G |
17: 56,730,538 (GRCm39) |
F1144L |
probably benign |
Het |
| Rai14 |
C |
T |
15: 10,593,189 (GRCm39) |
G152R |
probably damaging |
Het |
| Rap1gds1 |
T |
A |
3: 138,661,976 (GRCm39) |
R427* |
probably null |
Het |
| Recql5 |
A |
G |
11: 115,819,248 (GRCm39) |
V106A |
probably benign |
Het |
| Resp18 |
T |
C |
1: 75,250,615 (GRCm39) |
T155A |
probably benign |
Het |
| Rfx6 |
A |
G |
10: 51,557,914 (GRCm39) |
D129G |
probably benign |
Het |
| Rsf1 |
T |
A |
7: 97,310,374 (GRCm39) |
I368K |
|
Het |
| Sf1 |
A |
G |
19: 6,422,234 (GRCm39) |
E220G |
probably damaging |
Het |
| Shld2 |
C |
T |
14: 33,959,423 (GRCm39) |
S853N |
probably damaging |
Het |
| Sidt1 |
T |
A |
16: 44,079,848 (GRCm39) |
Y602F |
probably damaging |
Het |
| Slc17a8 |
A |
G |
10: 89,428,008 (GRCm39) |
I273T |
probably benign |
Het |
| Slc28a2b |
A |
T |
2: 122,353,325 (GRCm39) |
I502F |
not run |
Het |
| Slc41a1 |
A |
T |
1: 131,766,889 (GRCm39) |
I136F |
probably damaging |
Het |
| Snrpb |
T |
C |
2: 130,018,939 (GRCm39) |
I51V |
probably benign |
Het |
| Sprr2f |
T |
A |
3: 92,273,254 (GRCm39) |
C18S |
unknown |
Het |
| Stab1 |
T |
C |
14: 30,876,622 (GRCm39) |
N864S |
probably benign |
Het |
| Svil |
C |
A |
18: 5,095,188 (GRCm39) |
T1457K |
probably benign |
Het |
| Syt1 |
A |
T |
10: 108,340,262 (GRCm39) |
I352N |
probably damaging |
Het |
| Tas2r119 |
A |
G |
15: 32,178,279 (GRCm39) |
K282E |
probably damaging |
Het |
| Timeless |
T |
C |
10: 128,080,538 (GRCm39) |
F473S |
probably damaging |
Het |
| Tmc3 |
A |
G |
7: 83,247,481 (GRCm39) |
D192G |
probably damaging |
Het |
| Trmt1l |
T |
A |
1: 151,316,591 (GRCm39) |
I184N |
possibly damaging |
Het |
| Ttll6 |
G |
A |
11: 96,025,701 (GRCm39) |
V61M |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,632,755 (GRCm39) |
E14100K |
probably damaging |
Het |
| Txndc2 |
T |
A |
17: 65,945,620 (GRCm39) |
I186F |
possibly damaging |
Het |
| Ubr1 |
A |
T |
2: 120,703,672 (GRCm39) |
S1553T |
possibly damaging |
Het |
| Vmn1r208 |
T |
C |
13: 22,956,705 (GRCm39) |
N264S |
probably benign |
Het |
| Vmn1r87 |
T |
A |
7: 12,865,613 (GRCm39) |
M225L |
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,831,899 (GRCm39) |
C632S |
possibly damaging |
Het |
| Wdr97 |
T |
A |
15: 76,241,949 (GRCm39) |
Y747* |
probably null |
Het |
| Zfp474 |
T |
C |
18: 52,772,261 (GRCm39) |
S305P |
probably benign |
Het |
| Zfp59 |
A |
G |
7: 27,552,863 (GRCm39) |
N105S |
probably benign |
Het |
| Zfp804b |
T |
A |
5: 6,822,301 (GRCm39) |
Y254F |
possibly damaging |
Het |
|
| Other mutations in Sema6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Sema6a
|
APN |
18 |
47,423,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01351:Sema6a
|
APN |
18 |
47,414,369 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01594:Sema6a
|
APN |
18 |
47,381,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01953:Sema6a
|
APN |
18 |
47,423,187 (GRCm39) |
nonsense |
probably null |
|
|
IGL02077:Sema6a
|
APN |
18 |
47,416,465 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02632:Sema6a
|
APN |
18 |
47,423,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Sema6a
|
APN |
18 |
47,382,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Sema6a
|
APN |
18 |
47,381,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03279:Sema6a
|
APN |
18 |
47,433,157 (GRCm39) |
nonsense |
probably null |
|
|
saphire
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
IGL02988:Sema6a
|
UTSW |
18 |
47,431,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0114:Sema6a
|
UTSW |
18 |
47,423,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0312:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0347:Sema6a
|
UTSW |
18 |
47,424,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0350:Sema6a
|
UTSW |
18 |
47,403,785 (GRCm39) |
missense |
probably benign |
|
|
R0366:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0368:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0391:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0403:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0466:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0515:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0517:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0542:Sema6a
|
UTSW |
18 |
47,381,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0557:Sema6a
|
UTSW |
18 |
47,382,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0569:Sema6a
|
UTSW |
18 |
47,403,872 (GRCm39) |
splice site |
probably null |
|
|
R0650:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0689:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0694:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0726:Sema6a
|
UTSW |
18 |
47,425,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0821:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0824:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0924:Sema6a
|
UTSW |
18 |
47,381,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1108:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1255:Sema6a
|
UTSW |
18 |
47,382,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1531:Sema6a
|
UTSW |
18 |
47,382,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1707:Sema6a
|
UTSW |
18 |
47,416,512 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1746:Sema6a
|
UTSW |
18 |
47,439,416 (GRCm39) |
splice site |
probably benign |
|
|
R1807:Sema6a
|
UTSW |
18 |
47,409,491 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1974:Sema6a
|
UTSW |
18 |
47,403,696 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1987:Sema6a
|
UTSW |
18 |
47,433,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2044:Sema6a
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
R3719:Sema6a
|
UTSW |
18 |
47,382,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4491:Sema6a
|
UTSW |
18 |
47,439,524 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4552:Sema6a
|
UTSW |
18 |
47,424,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Sema6a
|
UTSW |
18 |
47,381,779 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4710:Sema6a
|
UTSW |
18 |
47,403,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4713:Sema6a
|
UTSW |
18 |
47,382,363 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4963:Sema6a
|
UTSW |
18 |
47,431,318 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5088:Sema6a
|
UTSW |
18 |
47,382,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5133:Sema6a
|
UTSW |
18 |
47,433,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Sema6a
|
UTSW |
18 |
47,424,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Sema6a
|
UTSW |
18 |
47,381,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Sema6a
|
UTSW |
18 |
47,409,611 (GRCm39) |
intron |
probably benign |
|
|
R5551:Sema6a
|
UTSW |
18 |
47,381,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5618:Sema6a
|
UTSW |
18 |
47,415,015 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5717:Sema6a
|
UTSW |
18 |
47,382,330 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5729:Sema6a
|
UTSW |
18 |
47,414,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Sema6a
|
UTSW |
18 |
47,381,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Sema6a
|
UTSW |
18 |
47,414,405 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6054:Sema6a
|
UTSW |
18 |
47,416,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6142:Sema6a
|
UTSW |
18 |
47,414,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6209:Sema6a
|
UTSW |
18 |
47,431,369 (GRCm39) |
splice site |
probably null |
|
|
R6307:Sema6a
|
UTSW |
18 |
47,382,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Sema6a
|
UTSW |
18 |
47,412,236 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7014:Sema6a
|
UTSW |
18 |
47,431,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Sema6a
|
UTSW |
18 |
47,381,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8054:Sema6a
|
UTSW |
18 |
47,424,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Sema6a
|
UTSW |
18 |
47,423,182 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8408:Sema6a
|
UTSW |
18 |
47,381,958 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8411:Sema6a
|
UTSW |
18 |
47,382,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8900:Sema6a
|
UTSW |
18 |
47,424,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9140:Sema6a
|
UTSW |
18 |
47,415,009 (GRCm39) |
missense |
probably benign |
|
|
R9158:Sema6a
|
UTSW |
18 |
47,431,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9488:Sema6a
|
UTSW |
18 |
47,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Sema6a
|
UTSW |
18 |
47,382,594 (GRCm39) |
missense |
probably null |
1.00 |
|
R9652:Sema6a
|
UTSW |
18 |
47,382,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9732:Sema6a
|
UTSW |
18 |
47,381,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0065:Sema6a
|
UTSW |
18 |
47,416,386 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGCTTAGTCTGTCACTTCTGG -3'
(R):5'- GCCTTCTGAAATCACTAGCGC -3'
Sequencing Primer
(F):5'- CATCCCTGTTGTCATCGGG -3'
(R):5'- AGCGCTTGCACTTCTGAAG -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation