Incidental Mutation 'R7575:Zc3h7b'
ID 586375
Institutional Source Beutler Lab
Gene Symbol Zc3h7b
Ensembl Gene ENSMUSG00000022390
Gene Name zinc finger CCCH type containing 7B
Synonyms Scrg3
MMRRC Submission 045632-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R7575 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 81629299-81680470 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 81662086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 385 (S385*)
Ref Sequence ENSEMBL: ENSMUSP00000105181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109554]
AlphaFold F8VPP8
Predicted Effect probably null
Transcript: ENSMUST00000109554
AA Change: S385*
SMART Domains Protein: ENSMUSP00000105181
Gene: ENSMUSG00000022390
AA Change: S385*

DomainStartEndE-ValueType
Pfam:TPR_11 34 113 2.3e-12 PFAM
Pfam:TPR_1 82 115 2.4e-6 PFAM
Pfam:TPR_8 82 115 8.2e-4 PFAM
Pfam:TPR_8 116 143 4.8e-3 PFAM
low complexity region 294 309 N/A INTRINSIC
low complexity region 340 354 N/A INTRINSIC
ZnF_C3H1 482 508 2.15e1 SMART
ZnF_C3H1 612 638 2.03e1 SMART
ZnF_C3H1 757 782 8.31e0 SMART
ZnF_C2H2 843 867 2.86e-1 SMART
ZnF_C3H1 889 914 7.81e-1 SMART
low complexity region 959 981 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(9) : Gene trapped(9)

Other mutations in this stock
Total: 91 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik C T 14: 32,384,589 (GRCm39) V459I probably benign Het
4921539E11Rik T C 4: 103,088,192 (GRCm39) D439G probably damaging Het
Adam18 T C 8: 25,115,873 (GRCm39) N607S possibly damaging Het
Adamtsl3 A T 7: 82,223,756 (GRCm39) N1179I possibly damaging Het
Adarb1 A G 10: 77,139,129 (GRCm39) F552S probably damaging Het
Ago1 T C 4: 126,347,701 (GRCm39) E394G probably benign Het
Alb G A 5: 90,613,788 (GRCm39) C224Y probably damaging Het
Alms1 T A 6: 85,599,141 (GRCm39) H1322Q possibly damaging Het
Arhgef18 T G 8: 3,501,635 (GRCm39) V643G probably damaging Het
Asah2 T C 19: 31,994,103 (GRCm39) Q414R probably benign Het
Atpsckmt C T 15: 31,606,186 (GRCm39) A48V probably damaging Het
Bbc3 G A 7: 16,046,292 (GRCm39) R76H possibly damaging Het
Bub1b T A 2: 118,471,639 (GRCm39) S1000T possibly damaging Het
Bud23 A T 5: 135,089,982 (GRCm39) Y70* probably null Het
C1d A G 11: 17,212,694 (GRCm39) E13G probably damaging Het
Camk1 T A 6: 113,315,325 (GRCm39) I158F probably damaging Het
Ccr2 A C 9: 123,905,843 (GRCm39) D41A probably benign Het
Cdh18 G T 15: 23,400,683 (GRCm39) E348* probably null Het
Col6a3 A G 1: 90,738,321 (GRCm39) L1066P possibly damaging Het
Cyp11b1 T A 15: 74,711,162 (GRCm39) D172V probably benign Het
Cyp2j8 A G 4: 96,358,785 (GRCm39) I378T possibly damaging Het
Cys1 T A 12: 24,718,647 (GRCm39) K69* probably null Het
Dip2c A G 13: 9,678,048 (GRCm39) K1165E probably damaging Het
Drd3 A T 16: 43,637,496 (GRCm39) I232F probably benign Het
Dusp7 T C 9: 106,250,876 (GRCm39) C334R probably damaging Het
Eppk1 A G 15: 75,995,442 (GRCm39) S480P not run Het
Erc1 G T 6: 119,801,721 (GRCm39) P99T possibly damaging Het
Fam170b C T 14: 32,558,155 (GRCm39) P330L unknown Het
Fasn G T 11: 120,703,513 (GRCm39) T1573K possibly damaging Het
Fras1 A T 5: 96,691,173 (GRCm39) T130S probably benign Het
Fzd4 A G 7: 89,056,918 (GRCm39) I322V possibly damaging Het
Gbp10 G A 5: 105,384,015 (GRCm39) probably benign Het
Gdpd4 A T 7: 97,647,448 (GRCm39) H365L probably benign Het
Gfy A G 7: 44,827,524 (GRCm39) S191P probably benign Het
Ghr A T 15: 3,349,994 (GRCm39) S395T probably damaging Het
Git2 C T 5: 114,904,550 (GRCm39) R123H probably damaging Het
Htt A G 5: 35,062,987 (GRCm39) D2873G probably damaging Het
Idua A T 5: 108,829,565 (GRCm39) D476V probably damaging Het
Inppl1 G A 7: 101,477,689 (GRCm39) R683W probably damaging Het
Ipp T C 4: 116,389,841 (GRCm39) S466P probably benign Het
Iqgap2 A G 13: 95,798,131 (GRCm39) V1058A probably damaging Het
Jmy A T 13: 93,601,103 (GRCm39) Y434* probably null Het
Kmt2d CTGCTGCTG CTGCTGCTGATGCTGCTG 15: 98,747,492 (GRCm39) probably benign Het
Mogs T G 6: 83,092,816 (GRCm39) S85R probably damaging Het
Mroh2b A T 15: 4,964,087 (GRCm39) D863V probably damaging Het
Mtmr10 A T 7: 63,947,213 (GRCm39) I43F probably damaging Het
Mtr T C 13: 12,213,963 (GRCm39) D903G probably benign Het
Ncor1 A G 11: 62,274,082 (GRCm39) V186A probably benign Het
Notch3 C T 17: 32,373,793 (GRCm39) D472N possibly damaging Het
Or4k44 A T 2: 111,368,597 (GRCm39) F12L probably damaging Het
Or6c68 T C 10: 129,157,728 (GRCm39) F79L probably damaging Het
Or8j3c A G 2: 86,253,582 (GRCm39) F146S probably benign Het
Or9i1 T C 19: 13,839,381 (GRCm39) S75P probably damaging Het
Oxr1 T G 15: 41,686,758 (GRCm39) L547V possibly damaging Het
Pappa2 A T 1: 158,642,100 (GRCm39) C1319S probably damaging Het
Papss1 A C 3: 131,348,857 (GRCm39) K623N probably damaging Het
Parp4 T C 14: 56,875,375 (GRCm39) F1198S probably benign Het
Pcare T A 17: 72,057,850 (GRCm39) Q609L probably damaging Het
Pcnt A T 10: 76,225,086 (GRCm39) V1806D probably benign Het
Pitx2 A T 3: 129,009,375 (GRCm39) H98L probably damaging Het
Polq C A 16: 36,911,496 (GRCm39) D2410E probably benign Het
Prdm9 C T 17: 15,764,890 (GRCm39) C630Y probably damaging Het
Preb A T 5: 31,115,839 (GRCm39) D201E probably damaging Het
Rasa3 A T 8: 13,645,887 (GRCm39) I151N possibly damaging Het
Rasgrp2 T A 19: 6,454,397 (GRCm39) S147T probably damaging Het
Rev3l A G 10: 39,697,441 (GRCm39) D646G possibly damaging Het
Sdc1 A G 12: 8,840,619 (GRCm39) E128G probably damaging Het
Slamf7 A C 1: 171,466,762 (GRCm39) C148G probably damaging Het
Slc19a2 T C 1: 164,084,691 (GRCm39) S194P probably damaging Het
Spata31 C T 13: 65,070,726 (GRCm39) P958L unknown Het
Sprr2b CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC 3: 92,224,826 (GRCm39) probably benign Het
Stradb A G 1: 59,027,739 (GRCm39) I90V probably benign Het
Tas2r134 A G 2: 51,518,166 (GRCm39) D215G probably damaging Het
Tbc1d4 T C 14: 101,685,025 (GRCm39) K1209E probably damaging Het
Thbs1 A G 2: 117,953,409 (GRCm39) D942G probably damaging Het
Tmem107 C T 11: 68,963,633 (GRCm39) P139S probably benign Het
Tmem216 A T 19: 10,529,266 (GRCm39) M40K probably benign Het
Tpte A G 8: 22,845,498 (GRCm39) Y516C probably damaging Het
Trim54 G A 5: 31,291,431 (GRCm39) G184D possibly damaging Het
Try5 A T 6: 41,288,748 (GRCm39) L157Q probably benign Het
Ubqlnl G A 7: 103,797,697 (GRCm39) A600V probably damaging Het
Uhrf2 C A 19: 30,048,768 (GRCm39) P258Q probably damaging Het
Ush2a A T 1: 188,554,885 (GRCm39) E3554D possibly damaging Het
Usp40 A C 1: 87,877,682 (GRCm39) L1158W probably damaging Het
Vmn1r121 T A 7: 20,832,198 (GRCm39) R81* probably null Het
Vmn1r203 C A 13: 22,708,588 (GRCm39) T123K probably benign Het
Vmn2r101 T C 17: 19,831,654 (GRCm39) V550A probably benign Het
Wdr49 A T 3: 75,358,193 (GRCm39) M184K probably damaging Het
Wipi2 A G 5: 142,643,987 (GRCm39) N123S probably damaging Het
Zbtb14 T C 17: 69,694,442 (GRCm39) F47L probably damaging Het
Zhx2 T A 15: 57,686,658 (GRCm39) F676I probably damaging Het
Other mutations in Zc3h7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Zc3h7b APN 15 81,656,000 (GRCm39) missense possibly damaging 0.95
IGL01955:Zc3h7b APN 15 81,676,205 (GRCm39) missense probably benign 0.10
IGL02526:Zc3h7b APN 15 81,677,338 (GRCm39) missense probably benign 0.10
IGL02582:Zc3h7b APN 15 81,653,341 (GRCm39) missense probably benign 0.05
IGL02736:Zc3h7b APN 15 81,676,175 (GRCm39) missense probably benign 0.02
F6893:Zc3h7b UTSW 15 81,662,872 (GRCm39) missense possibly damaging 0.94
R0212:Zc3h7b UTSW 15 81,660,529 (GRCm39) missense probably benign 0.00
R0242:Zc3h7b UTSW 15 81,653,031 (GRCm39) splice site probably benign
R0471:Zc3h7b UTSW 15 81,666,169 (GRCm39) missense probably damaging 1.00
R0590:Zc3h7b UTSW 15 81,661,199 (GRCm39) missense possibly damaging 0.74
R1530:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1563:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1565:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1566:Zc3h7b UTSW 15 81,653,035 (GRCm39) missense possibly damaging 0.91
R1670:Zc3h7b UTSW 15 81,661,268 (GRCm39) missense probably benign
R1712:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1727:Zc3h7b UTSW 15 81,652,230 (GRCm39) missense probably damaging 1.00
R2069:Zc3h7b UTSW 15 81,676,529 (GRCm39) missense probably damaging 0.98
R2375:Zc3h7b UTSW 15 81,676,703 (GRCm39) missense probably benign 0.17
R2656:Zc3h7b UTSW 15 81,664,631 (GRCm39) missense probably damaging 1.00
R4660:Zc3h7b UTSW 15 81,676,451 (GRCm39) missense probably benign 0.07
R4764:Zc3h7b UTSW 15 81,653,384 (GRCm39) critical splice donor site probably null
R4815:Zc3h7b UTSW 15 81,677,864 (GRCm39) missense probably damaging 1.00
R4999:Zc3h7b UTSW 15 81,663,334 (GRCm39) missense probably damaging 1.00
R5086:Zc3h7b UTSW 15 81,677,375 (GRCm39) missense probably damaging 0.96
R5169:Zc3h7b UTSW 15 81,657,515 (GRCm39) missense probably benign 0.01
R5395:Zc3h7b UTSW 15 81,656,702 (GRCm39) missense possibly damaging 0.50
R5407:Zc3h7b UTSW 15 81,670,092 (GRCm39) missense probably damaging 0.99
R5587:Zc3h7b UTSW 15 81,656,059 (GRCm39) missense possibly damaging 0.80
R5721:Zc3h7b UTSW 15 81,657,499 (GRCm39) missense probably benign 0.02
R6001:Zc3h7b UTSW 15 81,676,236 (GRCm39) missense possibly damaging 0.89
R6151:Zc3h7b UTSW 15 81,662,911 (GRCm39) critical splice donor site probably null
R6248:Zc3h7b UTSW 15 81,667,386 (GRCm39) missense probably damaging 1.00
R6397:Zc3h7b UTSW 15 81,677,055 (GRCm39) missense probably benign 0.03
R6502:Zc3h7b UTSW 15 81,653,252 (GRCm39) missense probably benign 0.01
R7248:Zc3h7b UTSW 15 81,655,988 (GRCm39) missense possibly damaging 0.46
R7397:Zc3h7b UTSW 15 81,653,354 (GRCm39) missense possibly damaging 0.50
R7450:Zc3h7b UTSW 15 81,667,281 (GRCm39) missense probably benign
R7471:Zc3h7b UTSW 15 81,664,682 (GRCm39) missense probably damaging 1.00
R7645:Zc3h7b UTSW 15 81,664,803 (GRCm39) missense probably damaging 1.00
R7650:Zc3h7b UTSW 15 81,677,851 (GRCm39) missense possibly damaging 0.81
R7881:Zc3h7b UTSW 15 81,664,679 (GRCm39) missense probably damaging 1.00
R7918:Zc3h7b UTSW 15 81,653,189 (GRCm39) missense probably damaging 0.98
R8001:Zc3h7b UTSW 15 81,663,461 (GRCm39) nonsense probably null
R8504:Zc3h7b UTSW 15 81,664,719 (GRCm39) missense probably damaging 1.00
R8855:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8856:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8857:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8865:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8866:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8867:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8868:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R9071:Zc3h7b UTSW 15 81,677,964 (GRCm39) makesense probably null
R9136:Zc3h7b UTSW 15 81,653,312 (GRCm39) missense probably damaging 1.00
R9169:Zc3h7b UTSW 15 81,661,184 (GRCm39) missense probably benign 0.19
R9701:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
R9802:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAGTGAGCTACGGTCTCACTG -3'
(R):5'- GCCCCTCTTGAAGAATGTAGC -3'

Sequencing Primer
(F):5'- TTCCTCCCATAGACAACAGGAAG -3'
(R):5'- CCTCTTGAAGAATGTAGCATCTCAC -3'
Posted On 2019-10-24