Mutagenetix > Incidental Mutation

Incidental Mutation 'R7575:Olfr1502'

586386

Institutional Source

Beutler Lab

Gene Symbol

Olfr1502

Ensembl Gene

ENSMUSG00000056858

Gene Name

olfactory receptor 1502

Synonyms

GA_x6K02T2RE5P-4193992-4194942, MOR211-1

MMRRC Submission

045632-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.150) question?

Stock #

R7575 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

13861795-13862745 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13862017 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 75 (S75P)

Ref Sequence

ENSEMBL: ENSMUSP00000073843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074221]

AlphaFold

Q8VG66

Predicted Effect

probably damaging
Transcript: ENSMUST00000074221
AA Change: S75P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: S75P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	7.1e-43	PFAM
Pfam:7tm_1	41	290	1.6e-17	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	C	T	14: 32,662,632	V459I	probably benign	Het
4921539E11Rik	T	C	4: 103,230,995	D439G	probably damaging	Het
Adam18	T	C	8: 24,625,857	N607S	possibly damaging	Het
Adamtsl3	A	T	7: 82,574,548	N1179I	possibly damaging	Het
Adarb1	A	G	10: 77,303,295	F552S	probably damaging	Het
Ago1	T	C	4: 126,453,908	E394G	probably benign	Het
Alb	G	A	5: 90,465,929	C224Y	probably damaging	Het
Alms1	T	A	6: 85,622,159	H1322Q	possibly damaging	Het
Arhgef18	T	G	8: 3,451,635	V643G	probably damaging	Het
Asah2	T	C	19: 32,016,703	Q414R	probably benign	Het
Bbc3	G	A	7: 16,312,367	R76H	possibly damaging	Het
BC027072	T	A	17: 71,750,855	Q609L	probably damaging	Het
Bub1b	T	A	2: 118,641,158	S1000T	possibly damaging	Het
Bud23	A	T	5: 135,061,128	Y70*	probably null	Het
C1d	A	G	11: 17,262,694	E13G	probably damaging	Het
Camk1	T	A	6: 113,338,364	I158F	probably damaging	Het
Ccr2	A	C	9: 124,105,806	D41A	probably benign	Het
Cdh18	G	T	15: 23,400,597	E348*	probably null	Het
Col6a3	A	G	1: 90,810,599	L1066P	possibly damaging	Het
Cyp11b1	T	A	15: 74,839,313	D172V	probably benign	Het
Cyp2j8	A	G	4: 96,470,548	I378T	possibly damaging	Het
Cys1	T	A	12: 24,668,648	K69*	probably null	Het
Dip2c	A	G	13: 9,628,012	K1165E	probably damaging	Het
Drd3	A	T	16: 43,817,133	I232F	probably benign	Het
Dusp7	T	C	9: 106,373,677	C334R	probably damaging	Het
Eppk1	A	G	15: 76,111,242	S480P	not run	Het
Erc1	G	T	6: 119,824,760	P99T	possibly damaging	Het
Fam170b	C	T	14: 32,836,198	P330L	unknown	Het
Fam173b	C	T	15: 31,606,040	A48V	probably damaging	Het
Fasn	G	T	11: 120,812,687	T1573K	possibly damaging	Het
Fras1	A	T	5: 96,543,314	T130S	probably benign	Het
Fzd4	A	G	7: 89,407,710	I322V	possibly damaging	Het
Gbp10	G	A	5: 105,236,149		probably benign	Het
Gdpd4	A	T	7: 97,998,241	H365L	probably benign	Het
Gfy	A	G	7: 45,178,100	S191P	probably benign	Het
Ghr	A	T	15: 3,320,512	S395T	probably damaging	Het
Git2	C	T	5: 114,766,489	R123H	probably damaging	Het
Htt	A	G	5: 34,905,643	D2873G	probably damaging	Het
Idua	A	T	5: 108,681,699	D476V	probably damaging	Het
Inppl1	G	A	7: 101,828,482	R683W	probably damaging	Het
Ipp	T	C	4: 116,532,644	S466P	probably benign	Het
Iqgap2	A	G	13: 95,661,623	V1058A	probably damaging	Het
Jmy	A	T	13: 93,464,595	Y434*	probably null	Het
Kmt2d	CTGCTGCTG	CTGCTGCTGATGCTGCTG	15: 98,849,611		probably benign	Het
Mogs	T	G	6: 83,115,835	S85R	probably damaging	Het
Mroh2b	A	T	15: 4,934,605	D863V	probably damaging	Het
Mtmr10	A	T	7: 64,297,465	I43F	probably damaging	Het
Mtr	T	C	13: 12,199,077	D903G	probably benign	Het
Ncor1	A	G	11: 62,383,256	V186A	probably benign	Het
Notch3	C	T	17: 32,154,819	D472N	possibly damaging	Het
Olfr1062	A	G	2: 86,423,238	F146S	probably benign	Het
Olfr1294	A	T	2: 111,538,252	F12L	probably damaging	Het
Olfr780	T	C	10: 129,321,859	F79L	probably damaging	Het
Oxr1	T	G	15: 41,823,362	L547V	possibly damaging	Het
Pappa2	A	T	1: 158,814,530	C1319S	probably damaging	Het
Papss1	A	C	3: 131,643,096	K623N	probably damaging	Het
Parp4	T	C	14: 56,637,918	F1198S	probably benign	Het
Pcnt	A	T	10: 76,389,252	V1806D	probably benign	Het
Pitx2	A	T	3: 129,215,726	H98L	probably damaging	Het
Polq	C	A	16: 37,091,134	D2410E	probably benign	Het
Prdm9	C	T	17: 15,544,628	C630Y	probably damaging	Het
Preb	A	T	5: 30,958,495	D201E	probably damaging	Het
Rasa3	A	T	8: 13,595,887	I151N	possibly damaging	Het
Rasgrp2	T	A	19: 6,404,367	S147T	probably damaging	Het
Rev3l	A	G	10: 39,821,445	D646G	possibly damaging	Het
Sdc1	A	G	12: 8,790,619	E128G	probably damaging	Het
Slamf7	A	C	1: 171,639,194	C148G	probably damaging	Het
Slc19a2	T	C	1: 164,257,122	S194P	probably damaging	Het
Spata31	C	T	13: 64,922,912	P958L	unknown	Het
Sprr2b	CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC	CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC	3: 92,317,519		probably benign	Het
Stradb	A	G	1: 58,988,580	I90V	probably benign	Het
Tas2r134	A	G	2: 51,628,154	D215G	probably damaging	Het
Tbc1d4	T	C	14: 101,447,589	K1209E	probably damaging	Het
Thbs1	A	G	2: 118,122,928	D942G	probably damaging	Het
Tmem107	C	T	11: 69,072,807	P139S	probably benign	Het
Tmem216	A	T	19: 10,551,902	M40K	probably benign	Het
Tpte	A	G	8: 22,355,482	Y516C	probably damaging	Het
Trim54	G	A	5: 31,134,087	G184D	possibly damaging	Het
Try5	A	T	6: 41,311,814	L157Q	probably benign	Het
Ubqlnl	G	A	7: 104,148,490	A600V	probably damaging	Het
Uhrf2	C	A	19: 30,071,368	P258Q	probably damaging	Het
Ush2a	A	T	1: 188,822,688	E3554D	possibly damaging	Het
Usp40	A	C	1: 87,949,960	L1158W	probably damaging	Het
Vmn1r121	T	A	7: 21,098,273	R81*	probably null	Het
Vmn1r203	C	A	13: 22,524,418	T123K	probably benign	Het
Vmn2r101	T	C	17: 19,611,392	V550A	probably benign	Het
Wdr49	A	T	3: 75,450,886	M184K	probably damaging	Het
Wipi2	A	G	5: 142,658,232	N123S	probably damaging	Het
Zbtb14	T	C	17: 69,387,447	F47L	probably damaging	Het
Zc3h7b	C	A	15: 81,777,885	S385*	probably null	Het
Zhx2	T	A	15: 57,823,262	F676I	probably damaging	Het

Other mutations in Olfr1502

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Olfr1502	APN	19	13861786	unclassified	probably benign
IGL01061:Olfr1502	APN	19	13862705	missense	possibly damaging	0.94
IGL01534:Olfr1502	APN	19	13861919	missense	probably damaging	1.00
IGL02017:Olfr1502	APN	19	13862231	missense	possibly damaging	0.58
IGL02039:Olfr1502	APN	19	13862719	nonsense	probably null
IGL02173:Olfr1502	APN	19	13862014	missense	probably benign	0.00
IGL02219:Olfr1502	APN	19	13861823	missense	probably damaging	1.00
IGL02475:Olfr1502	APN	19	13862299	missense	probably damaging	1.00
IGL02604:Olfr1502	APN	19	13861806	missense	probably benign	0.01
R0012:Olfr1502	UTSW	19	13861823	missense	probably damaging	0.98
R0594:Olfr1502	UTSW	19	13862279	missense	probably benign	0.04
R2184:Olfr1502	UTSW	19	13862035	missense	probably benign	0.02
R2518:Olfr1502	UTSW	19	13862309	missense	probably damaging	1.00
R5541:Olfr1502	UTSW	19	13861964	missense	probably benign
R5587:Olfr1502	UTSW	19	13862576	missense	probably damaging	1.00
R6211:Olfr1502	UTSW	19	13862574	missense	probably benign	0.01
R6351:Olfr1502	UTSW	19	13861822	missense	probably benign	0.04
R8425:Olfr1502	UTSW	19	13862485	missense	probably benign	0.00
R9545:Olfr1502	UTSW	19	13861853	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- CAGTAACGGAATTCATCCTAATAGGC -3'
(R):5'- CAACATTTTCTAGGGCCCATGG -3'

Sequencing Primer
(F):5'- TAGGCTTTAATGACCACCCCAAGTG -3'
(R):5'- CATGGCCACAGTGTAGAGC -3'

Posted On

2019-10-24