Incidental Mutation 'R7577:Trp53bp1'
| ID |
586478 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trp53bp1
|
| Ensembl Gene |
ENSMUSG00000043909 |
| Gene Name |
transformation related protein 53 binding protein 1 |
| Synonyms |
53BP1, p53BP1 |
| MMRRC Submission |
045662-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7577 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
121023762-121101888 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 121067119 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Proline
at position 536
(T536P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110647]
[ENSMUST00000110648]
[ENSMUST00000129752]
[ENSMUST00000131245]
|
| AlphaFold |
P70399 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110647
AA Change: T536P
PolyPhen 2
Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000106277
Gene: ENSMUSG00000043909
AA Change: T536P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1430 |
1551 |
2.5e-80 |
PFAM |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
BRCT
|
1673 |
1785 |
7.13e-1 |
SMART |
|
BRCT
|
1813 |
1901 |
1.03e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110648
AA Change: T536P
PolyPhen 2
Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000106278
Gene: ENSMUSG00000043909
AA Change: T536P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
low complexity region
|
1389 |
1409 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1480 |
1601 |
1.5e-80 |
PFAM |
|
low complexity region
|
1631 |
1651 |
N/A |
INTRINSIC |
|
BRCT
|
1723 |
1835 |
7.13e-1 |
SMART |
|
BRCT
|
1863 |
1951 |
1.03e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129752
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131245
AA Change: T536P
PolyPhen 2
Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000114457
Gene: ENSMUSG00000043909
AA Change: T536P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142400
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147540
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous mutations in this gene result in growth retardation, immunodeficiency, thymic hypoplasia, and increased incidence of thymic lymphomas. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610008E11Rik |
C |
T |
10: 78,902,325 (GRCm39) |
V664M |
possibly damaging |
Het |
| Abca4 |
A |
G |
3: 121,967,663 (GRCm39) |
T2238A |
probably damaging |
Het |
| Adss2 |
G |
A |
1: 177,595,263 (GRCm39) |
Q426* |
probably null |
Het |
| Afap1l2 |
T |
C |
19: 56,933,199 (GRCm39) |
E71G |
probably damaging |
Het |
| Afg1l |
T |
C |
10: 42,194,607 (GRCm39) |
D395G |
probably damaging |
Het |
| Akap9 |
C |
G |
5: 4,018,745 (GRCm39) |
H1109D |
probably benign |
Het |
| Alms1 |
A |
G |
6: 85,592,302 (GRCm39) |
T385A |
probably benign |
Het |
| Ank3 |
C |
T |
10: 69,828,402 (GRCm39) |
T2357I |
|
Het |
| Ankfn1 |
T |
A |
11: 89,394,797 (GRCm39) |
S263C |
probably benign |
Het |
| Atpsckmt |
C |
T |
15: 31,606,186 (GRCm39) |
A48V |
probably damaging |
Het |
| Azin1 |
C |
T |
15: 38,501,665 (GRCm39) |
V29I |
probably benign |
Het |
| B3galt2 |
T |
C |
1: 143,523,042 (GRCm39) |
Y393H |
probably damaging |
Het |
| Cnbd2 |
G |
T |
2: 156,170,296 (GRCm39) |
R127L |
possibly damaging |
Het |
| Col6a5 |
A |
T |
9: 105,741,887 (GRCm39) |
L2344* |
probably null |
Het |
| Csn3 |
T |
C |
5: 88,077,821 (GRCm39) |
V109A |
not run |
Het |
| Cxcr2 |
C |
G |
1: 74,198,074 (GRCm39) |
N189K |
probably benign |
Het |
| Dclre1a |
A |
G |
19: 56,517,965 (GRCm39) |
F1038S |
probably damaging |
Het |
| Ddx21 |
T |
C |
10: 62,426,449 (GRCm39) |
Q468R |
probably benign |
Het |
| Dlx6 |
A |
G |
6: 6,863,423 (GRCm39) |
D15G |
probably damaging |
Het |
| Dnajb14 |
T |
C |
3: 137,610,558 (GRCm39) |
V262A |
possibly damaging |
Het |
| Dpp7 |
A |
G |
2: 25,245,603 (GRCm39) |
V161A |
probably benign |
Het |
| Enkur |
C |
T |
2: 21,209,913 (GRCm39) |
S16N |
probably benign |
Het |
| Ensa |
C |
A |
3: 95,535,956 (GRCm39) |
H96Q |
probably damaging |
Het |
| Ero1b |
T |
G |
13: 12,617,254 (GRCm39) |
C393G |
probably damaging |
Het |
| Fbxo3 |
T |
C |
2: 103,881,543 (GRCm39) |
F292L |
possibly damaging |
Het |
| Fcgbpl1 |
A |
G |
7: 27,853,848 (GRCm39) |
D1604G |
possibly damaging |
Het |
| Fos |
T |
C |
12: 85,521,871 (GRCm39) |
S102P |
probably benign |
Het |
| Foxs1 |
C |
T |
2: 152,774,361 (GRCm39) |
G231S |
probably benign |
Het |
| Furin |
T |
C |
7: 80,046,734 (GRCm39) |
D174G |
probably damaging |
Het |
| Gbp10 |
G |
A |
5: 105,384,015 (GRCm39) |
|
probably benign |
Het |
| Git2 |
C |
T |
5: 114,904,550 (GRCm39) |
R123H |
probably damaging |
Het |
| Gm32687 |
T |
A |
10: 81,716,023 (GRCm39) |
C472S |
probably damaging |
Het |
| Gmip |
A |
G |
8: 70,267,085 (GRCm39) |
E327G |
probably benign |
Het |
| Gpld1 |
A |
G |
13: 25,146,388 (GRCm39) |
T211A |
probably benign |
Het |
| Grin2d |
T |
C |
7: 45,511,803 (GRCm39) |
H214R |
probably benign |
Het |
| Hfm1 |
T |
C |
5: 107,043,909 (GRCm39) |
T576A |
probably benign |
Het |
| Hnrnpd |
A |
T |
5: 100,115,113 (GRCm39) |
F142I |
probably damaging |
Het |
| Krt32 |
T |
A |
11: 99,972,047 (GRCm39) |
T434S |
probably benign |
Het |
| Lct |
T |
G |
1: 128,228,469 (GRCm39) |
D1008A |
probably damaging |
Het |
| Man1c1 |
A |
G |
4: 134,291,814 (GRCm39) |
|
probably null |
Het |
| Marchf7 |
T |
A |
2: 60,060,048 (GRCm39) |
C58* |
probably null |
Het |
| Mccc1 |
C |
T |
3: 36,029,943 (GRCm39) |
|
probably null |
Het |
| Mybpc1 |
T |
A |
10: 88,385,187 (GRCm39) |
D484V |
probably damaging |
Het |
| Myh10 |
T |
A |
11: 68,636,806 (GRCm39) |
C227S |
unknown |
Het |
| Niban1 |
T |
A |
1: 151,594,063 (GRCm39) |
V916E |
probably benign |
Het |
| Nin |
T |
C |
12: 70,109,480 (GRCm39) |
E153G |
|
Het |
| Nr1h2 |
G |
A |
7: 44,200,216 (GRCm39) |
T313M |
probably damaging |
Het |
| Or4g7 |
T |
A |
2: 111,309,477 (GRCm39) |
I116K |
probably damaging |
Het |
| Or5k15 |
G |
T |
16: 58,709,629 (GRCm39) |
A318D |
probably benign |
Het |
| Otog |
C |
A |
7: 45,937,279 (GRCm39) |
H1663N |
possibly damaging |
Het |
| Piezo2 |
G |
T |
18: 63,186,081 (GRCm39) |
T1696K |
probably benign |
Het |
| Plcd1 |
A |
T |
9: 118,901,322 (GRCm39) |
N703K |
possibly damaging |
Het |
| Plekhg4 |
T |
A |
8: 106,102,031 (GRCm39) |
C7S |
probably benign |
Het |
| Pnma2 |
A |
G |
14: 67,153,428 (GRCm39) |
|
probably benign |
Het |
| Potegl |
A |
G |
2: 23,097,837 (GRCm39) |
Y5C |
probably benign |
Het |
| Prag1 |
A |
G |
8: 36,614,096 (GRCm39) |
Y1216C |
probably damaging |
Het |
| Prima1 |
T |
C |
12: 103,163,566 (GRCm39) |
Y135C |
probably damaging |
Het |
| Prkce |
C |
A |
17: 86,800,721 (GRCm39) |
S379* |
probably null |
Het |
| Prmt7 |
A |
G |
8: 106,968,835 (GRCm39) |
N383S |
probably damaging |
Het |
| Ptafr |
A |
G |
4: 132,307,063 (GRCm39) |
Y151C |
probably damaging |
Het |
| Ptprn2 |
T |
C |
12: 116,449,486 (GRCm39) |
M1T |
probably null |
Het |
| Rad23a |
A |
T |
8: 85,565,108 (GRCm39) |
S136T |
probably benign |
Het |
| Rnf123 |
A |
T |
9: 107,947,818 (GRCm39) |
Y137N |
probably damaging |
Het |
| Sfxn4 |
A |
C |
19: 60,842,324 (GRCm39) |
I126S |
probably benign |
Het |
| Slc4a4 |
A |
G |
5: 89,373,726 (GRCm39) |
H935R |
probably damaging |
Het |
| Slitrk3 |
T |
G |
3: 72,958,448 (GRCm39) |
N108T |
probably damaging |
Het |
| Spred1 |
T |
A |
2: 117,007,806 (GRCm39) |
H237Q |
probably benign |
Het |
| Syne1 |
T |
A |
10: 5,074,820 (GRCm39) |
K1168N |
probably damaging |
Het |
| Syt14 |
T |
C |
1: 192,665,885 (GRCm39) |
K340E |
unknown |
Het |
| Tespa1 |
T |
C |
10: 130,190,624 (GRCm39) |
S84P |
probably damaging |
Het |
| Tmem268 |
G |
T |
4: 63,480,681 (GRCm39) |
|
probably benign |
Het |
| Tmem52b |
T |
A |
6: 129,493,040 (GRCm39) |
Y48* |
probably null |
Het |
| Tox2 |
C |
A |
2: 163,157,822 (GRCm39) |
Y295* |
probably null |
Het |
| Tysnd1 |
T |
C |
10: 61,531,665 (GRCm39) |
C106R |
probably benign |
Het |
| Unc5d |
T |
C |
8: 29,381,449 (GRCm39) |
I63V |
probably damaging |
Het |
| Vmn1r235 |
A |
G |
17: 21,481,881 (GRCm39) |
N69D |
possibly damaging |
Het |
| Vps11 |
A |
T |
9: 44,260,258 (GRCm39) |
M868K |
probably benign |
Het |
| Wipf3 |
A |
G |
6: 54,462,509 (GRCm39) |
T240A |
possibly damaging |
Het |
| Xirp2 |
G |
A |
2: 67,345,309 (GRCm39) |
E2517K |
possibly damaging |
Het |
| Ylpm1 |
T |
A |
12: 85,043,994 (GRCm39) |
L244Q |
unknown |
Het |
| Zdhhc18 |
G |
T |
4: 133,342,520 (GRCm39) |
S198* |
probably null |
Het |
| Zfp760 |
T |
A |
17: 21,941,242 (GRCm39) |
L139* |
probably null |
Het |
|
| Other mutations in Trp53bp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Trp53bp1
|
APN |
2 |
121,087,060 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL00690:Trp53bp1
|
APN |
2 |
121,066,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00922:Trp53bp1
|
APN |
2 |
121,038,963 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01475:Trp53bp1
|
APN |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
IGL01639:Trp53bp1
|
APN |
2 |
121,033,173 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01662:Trp53bp1
|
APN |
2 |
121,066,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01757:Trp53bp1
|
APN |
2 |
121,041,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01829:Trp53bp1
|
APN |
2 |
121,046,377 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02247:Trp53bp1
|
APN |
2 |
121,067,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Trp53bp1
|
APN |
2 |
121,029,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02391:Trp53bp1
|
APN |
2 |
121,033,191 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
chives
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
concur
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
confirmation
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Infra
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
Legume
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
lentil
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
lentil2
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Profundus
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
split_pea
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
verily
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Trp53bp1
|
UTSW |
2 |
121,101,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0045:Trp53bp1
|
UTSW |
2 |
121,034,978 (GRCm39) |
missense |
probably benign |
|
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0281:Trp53bp1
|
UTSW |
2 |
121,100,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0386:Trp53bp1
|
UTSW |
2 |
121,035,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Trp53bp1
|
UTSW |
2 |
121,066,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trp53bp1
|
UTSW |
2 |
121,100,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0522:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0523:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0525:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0543:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0559:Trp53bp1
|
UTSW |
2 |
121,058,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Trp53bp1
|
UTSW |
2 |
121,058,653 (GRCm39) |
splice site |
probably benign |
|
|
R0593:Trp53bp1
|
UTSW |
2 |
121,101,009 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0648:Trp53bp1
|
UTSW |
2 |
121,066,188 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0680:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0732:Trp53bp1
|
UTSW |
2 |
121,078,745 (GRCm39) |
missense |
probably null |
0.96 |
|
R0905:Trp53bp1
|
UTSW |
2 |
121,034,799 (GRCm39) |
splice site |
probably benign |
|
|
R1377:Trp53bp1
|
UTSW |
2 |
121,101,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1415:Trp53bp1
|
UTSW |
2 |
121,066,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Trp53bp1
|
UTSW |
2 |
121,082,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1971:Trp53bp1
|
UTSW |
2 |
121,035,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Trp53bp1
|
UTSW |
2 |
121,034,964 (GRCm39) |
missense |
probably benign |
|
|
R2143:Trp53bp1
|
UTSW |
2 |
121,046,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2282:Trp53bp1
|
UTSW |
2 |
121,100,754 (GRCm39) |
nonsense |
probably null |
|
|
R2296:Trp53bp1
|
UTSW |
2 |
121,039,728 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3106:Trp53bp1
|
UTSW |
2 |
121,067,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3793:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Trp53bp1
|
UTSW |
2 |
121,059,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4001:Trp53bp1
|
UTSW |
2 |
121,035,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4327:Trp53bp1
|
UTSW |
2 |
121,087,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Trp53bp1
|
UTSW |
2 |
121,038,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Trp53bp1
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4744:Trp53bp1
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4751:Trp53bp1
|
UTSW |
2 |
121,058,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Trp53bp1
|
UTSW |
2 |
121,038,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Trp53bp1
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
R4850:Trp53bp1
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4870:Trp53bp1
|
UTSW |
2 |
121,087,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4879:Trp53bp1
|
UTSW |
2 |
121,033,084 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4924:Trp53bp1
|
UTSW |
2 |
121,051,701 (GRCm39) |
nonsense |
probably null |
|
|
R4962:Trp53bp1
|
UTSW |
2 |
121,101,027 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5019:Trp53bp1
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
R5111:Trp53bp1
|
UTSW |
2 |
121,041,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5149:Trp53bp1
|
UTSW |
2 |
121,046,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5252:Trp53bp1
|
UTSW |
2 |
121,074,464 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5533:Trp53bp1
|
UTSW |
2 |
121,038,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Trp53bp1
|
UTSW |
2 |
121,067,143 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5773:Trp53bp1
|
UTSW |
2 |
121,074,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5819:Trp53bp1
|
UTSW |
2 |
121,038,873 (GRCm39) |
nonsense |
probably null |
|
|
R5886:Trp53bp1
|
UTSW |
2 |
121,035,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5908:Trp53bp1
|
UTSW |
2 |
121,067,304 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Trp53bp1
|
UTSW |
2 |
121,087,083 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6351:Trp53bp1
|
UTSW |
2 |
121,100,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Trp53bp1
|
UTSW |
2 |
121,101,093 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6575:Trp53bp1
|
UTSW |
2 |
121,059,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6619:Trp53bp1
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6626:Trp53bp1
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6754:Trp53bp1
|
UTSW |
2 |
121,101,057 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6765:Trp53bp1
|
UTSW |
2 |
121,039,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6806:Trp53bp1
|
UTSW |
2 |
121,059,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6860:Trp53bp1
|
UTSW |
2 |
121,029,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6991:Trp53bp1
|
UTSW |
2 |
121,038,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7278:Trp53bp1
|
UTSW |
2 |
121,029,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Trp53bp1
|
UTSW |
2 |
121,066,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7357:Trp53bp1
|
UTSW |
2 |
121,041,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7477:Trp53bp1
|
UTSW |
2 |
121,066,827 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7643:Trp53bp1
|
UTSW |
2 |
121,078,295 (GRCm39) |
splice site |
probably null |
|
|
R7728:Trp53bp1
|
UTSW |
2 |
121,038,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Trp53bp1
|
UTSW |
2 |
121,035,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7955:Trp53bp1
|
UTSW |
2 |
121,066,225 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8099:Trp53bp1
|
UTSW |
2 |
121,030,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8200:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8282:Trp53bp1
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9136:Trp53bp1
|
UTSW |
2 |
121,067,092 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9152:Trp53bp1
|
UTSW |
2 |
121,029,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9292:Trp53bp1
|
UTSW |
2 |
121,046,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9340:Trp53bp1
|
UTSW |
2 |
121,100,460 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9475:Trp53bp1
|
UTSW |
2 |
121,039,761 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9616:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9675:Trp53bp1
|
UTSW |
2 |
121,087,089 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9779:Trp53bp1
|
UTSW |
2 |
121,066,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF046:Trp53bp1
|
UTSW |
2 |
121,046,482 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Trp53bp1
|
UTSW |
2 |
121,084,126 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1177:Trp53bp1
|
UTSW |
2 |
121,074,541 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGTGAGGTCGATGCAAAC -3'
(R):5'- AGGTGGAGGTTTACATAGCTCATC -3'
Sequencing Primer
(F):5'- ATCTTCAGCAACCGCGTC -3'
(R):5'- GGAGGTTTACATAGCTCATCTCTTAC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation