Incidental Mutation 'R7579:Zranb2'
ID 586626
Institutional Source Beutler Lab
Gene Symbol Zranb2
Ensembl Gene ENSMUSG00000028180
Gene Name zinc finger, RAN-binding domain containing 2
Synonyms Zfp265, Zis, Znf265
MMRRC Submission 045633-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7579 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 157239797-157254047 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 157246309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 114 (Y114C)
Ref Sequence ENSEMBL: ENSMUSP00000101673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029831] [ENSMUST00000106057] [ENSMUST00000106058] [ENSMUST00000184802] [ENSMUST00000198915]
AlphaFold Q9R020
Predicted Effect probably damaging
Transcript: ENSMUST00000029831
AA Change: Y77C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029831
Gene: ENSMUSG00000028180
AA Change: Y77C

DomainStartEndE-ValueType
ZnF_RBZ 11 35 1.02e-2 SMART
ZnF_RBZ 36 54 2.09e-1 SMART
low complexity region 70 82 N/A INTRINSIC
low complexity region 108 145 N/A INTRINSIC
low complexity region 156 293 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106057
AA Change: Y114C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101672
Gene: ENSMUSG00000028180
AA Change: Y114C

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 312 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106058
AA Change: Y114C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101673
Gene: ENSMUSG00000028180
AA Change: Y114C

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 340 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000101678
Gene: ENSMUSG00000028180
AA Change: Y7C

DomainStartEndE-ValueType
ZnF_RBZ 11 37 8.79e-7 SMART
ZnF_RBZ 67 91 3.11e-7 SMART
low complexity region 107 119 N/A INTRINSIC
low complexity region 145 182 N/A INTRINSIC
low complexity region 193 330 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184802
Predicted Effect probably benign
Transcript: ENSMUST00000198915
Meta Mutation Damage Score 0.6316 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 96% (51/53)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 G T 7: 119,292,933 (GRCm39) R21L probably benign Het
Adgb T A 10: 10,286,562 (GRCm39) R120* probably null Het
Adgra3 C A 5: 50,144,977 (GRCm39) A539S probably benign Het
Ank2 A G 3: 126,740,047 (GRCm39) S1946P unknown Het
Card6 TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG 15: 5,128,173 (GRCm39) probably benign Het
Cdc20b A T 13: 113,173,582 (GRCm39) probably null Het
Cfh T G 1: 140,036,328 (GRCm39) D730A possibly damaging Het
Dennd1a T C 2: 37,748,444 (GRCm39) H345R probably damaging Het
Dhx36 T C 3: 62,388,294 (GRCm39) S614G possibly damaging Het
Dio1 C T 4: 107,149,583 (GRCm39) V240I possibly damaging Het
Dnah12 A G 14: 26,492,460 (GRCm39) D1200G probably benign Het
Dpy19l4 A T 4: 11,265,909 (GRCm39) S680T probably benign Het
Eef2 CCC CCCC 10: 81,014,602 (GRCm39) probably null Het
Fcrlb T C 1: 170,735,416 (GRCm39) probably null Het
Gad1 T A 2: 70,417,476 (GRCm39) I253K possibly damaging Het
Gars1 A G 6: 55,054,688 (GRCm39) D665G probably damaging Het
Gldn A G 9: 54,245,648 (GRCm39) T400A probably benign Het
Gm1110 C A 9: 26,795,122 (GRCm39) V455L possibly damaging Het
Gm11444 A G 11: 85,741,069 (GRCm39) V30A unknown Het
Gm5134 T C 10: 75,800,271 (GRCm39) S51P probably damaging Het
Gprc6a C T 10: 51,502,883 (GRCm39) A327T probably benign Het
Gstt2 A T 10: 75,670,019 (GRCm39) D34E probably benign Het
Icam2 A G 11: 106,271,589 (GRCm39) F78L probably damaging Het
Jakmip1 T G 5: 37,284,802 (GRCm39) C630G possibly damaging Het
Kcnu1 A T 8: 26,386,686 (GRCm39) N523I probably damaging Het
Klf10 A G 15: 38,297,282 (GRCm39) S253P probably benign Het
Mmd2 A T 5: 142,594,361 (GRCm39) M1K probably null Het
Mroh2b G T 15: 4,960,543 (GRCm39) G759C probably benign Het
Or10w3 T C 19: 13,704,465 (GRCm39) L280P probably damaging Het
Or2b7 A T 13: 21,740,176 (GRCm39) N5K probably benign Het
Or8k32 C T 2: 86,368,872 (GRCm39) C127Y probably damaging Het
Orc5 A G 5: 22,755,197 (GRCm39) F22S possibly damaging Het
Prlr A G 15: 10,329,021 (GRCm39) I499V probably benign Het
Ptbp1 A G 10: 79,694,954 (GRCm39) N94S probably benign Het
Rassf3 C A 10: 121,312,103 (GRCm39) probably benign Het
Rbm33 C T 5: 28,573,264 (GRCm39) P455S probably damaging Het
Sgcd C G 11: 47,016,481 (GRCm39) G127A possibly damaging Het
Slc22a13 A G 9: 119,024,226 (GRCm39) I336T possibly damaging Het
Slc25a31 A T 3: 40,679,471 (GRCm39) D312V possibly damaging Het
Slc37a4 G A 9: 44,312,818 (GRCm39) S324N probably benign Het
Slco1a5 A G 6: 142,221,207 (GRCm39) V13A probably benign Het
Srgap2 T C 1: 131,220,371 (GRCm39) H907R probably damaging Het
Supv3l1 A C 10: 62,271,487 (GRCm39) V381G probably damaging Het
Supv3l1 C A 10: 62,271,488 (GRCm39) V381L possibly damaging Het
Syne1 T C 10: 5,299,324 (GRCm39) D977G probably damaging Het
Syt3 T A 7: 44,040,272 (GRCm39) Y168* probably null Het
Tshz1 A T 18: 84,032,790 (GRCm39) Y539* probably null Het
Ttll13 A G 7: 79,907,981 (GRCm39) K501R probably benign Het
Ttn G A 2: 76,612,732 (GRCm39) Q17116* probably null Het
Vcan T C 13: 89,840,577 (GRCm39) T1656A probably damaging Het
Vmn1r73 G T 7: 11,491,082 (GRCm39) C300F probably benign Het
Vmn2r9 T C 5: 108,992,948 (GRCm39) K521E probably damaging Het
Zdhhc11 T A 13: 74,130,885 (GRCm39) probably benign Het
Zfp760 T C 17: 21,941,907 (GRCm39) S361P possibly damaging Het
Other mutations in Zranb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Zranb2 APN 3 157,252,328 (GRCm39) unclassified probably benign
IGL01528:Zranb2 APN 3 157,250,602 (GRCm39) unclassified probably benign
IGL03008:Zranb2 APN 3 157,252,302 (GRCm39) splice site probably null
R0528:Zranb2 UTSW 3 157,240,096 (GRCm39) missense probably benign 0.26
R0659:Zranb2 UTSW 3 157,247,400 (GRCm39) missense probably benign 0.23
R1170:Zranb2 UTSW 3 157,247,502 (GRCm39) utr 3 prime probably benign
R1673:Zranb2 UTSW 3 157,243,277 (GRCm39) missense probably damaging 1.00
R1885:Zranb2 UTSW 3 157,248,793 (GRCm39) critical splice acceptor site probably null
R4127:Zranb2 UTSW 3 157,243,227 (GRCm39) nonsense probably null
R4610:Zranb2 UTSW 3 157,247,521 (GRCm39) splice site probably benign
R4981:Zranb2 UTSW 3 157,252,378 (GRCm39) unclassified probably benign
R5053:Zranb2 UTSW 3 157,246,796 (GRCm39) missense probably damaging 0.96
R5742:Zranb2 UTSW 3 157,246,340 (GRCm39) nonsense probably null
R5873:Zranb2 UTSW 3 157,242,020 (GRCm39) nonsense probably null
R6086:Zranb2 UTSW 3 157,248,883 (GRCm39) critical splice donor site probably null
R7015:Zranb2 UTSW 3 157,242,370 (GRCm39) critical splice acceptor site probably null
R7547:Zranb2 UTSW 3 157,246,806 (GRCm39) missense possibly damaging 0.93
R8119:Zranb2 UTSW 3 157,241,969 (GRCm39) critical splice acceptor site probably null
R8237:Zranb2 UTSW 3 157,250,677 (GRCm39) missense probably null
R8296:Zranb2 UTSW 3 157,247,412 (GRCm39) missense unknown
R8345:Zranb2 UTSW 3 157,251,731 (GRCm39) missense unknown
R8414:Zranb2 UTSW 3 157,252,312 (GRCm39) missense unknown
R8478:Zranb2 UTSW 3 157,251,745 (GRCm39) makesense probably null
R8768:Zranb2 UTSW 3 157,247,327 (GRCm39) splice site probably benign
R9021:Zranb2 UTSW 3 157,250,720 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AGCAGATCCTACTTGTTTTCTATCG -3'
(R):5'- AGGCTCAATGAGAACTATCATCC -3'

Sequencing Primer
(F):5'- GTTACGTGAATGACCACC -3'
(R):5'- TGAGAACTATCATCCAACATCCTC -3'
Posted On 2019-10-24