Incidental Mutation 'R7579:Vmn2r9'
| ID |
586633 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r9
|
| Ensembl Gene |
ENSMUSG00000091624 |
| Gene Name |
vomeronasal 2, receptor 9 |
| Synonyms |
EG435864 |
| MMRRC Submission |
045633-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R7579 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
108990813-109000376 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 108992948 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 521
(K521E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170419]
|
| AlphaFold |
K7N6Z8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170419
AA Change: K521E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: K521E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
412 |
8.1e-29 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
2.3e-16 |
PFAM |
|
Pfam:7tm_3
|
592 |
829 |
3.4e-54 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
96% (51/53) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm4 |
G |
T |
7: 119,292,933 (GRCm39) |
R21L |
probably benign |
Het |
| Adgb |
T |
A |
10: 10,286,562 (GRCm39) |
R120* |
probably null |
Het |
| Adgra3 |
C |
A |
5: 50,144,977 (GRCm39) |
A539S |
probably benign |
Het |
| Ank2 |
A |
G |
3: 126,740,047 (GRCm39) |
S1946P |
unknown |
Het |
| Card6 |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
15: 5,128,173 (GRCm39) |
|
probably benign |
Het |
| Cdc20b |
A |
T |
13: 113,173,582 (GRCm39) |
|
probably null |
Het |
| Cfh |
T |
G |
1: 140,036,328 (GRCm39) |
D730A |
possibly damaging |
Het |
| Dennd1a |
T |
C |
2: 37,748,444 (GRCm39) |
H345R |
probably damaging |
Het |
| Dhx36 |
T |
C |
3: 62,388,294 (GRCm39) |
S614G |
possibly damaging |
Het |
| Dio1 |
C |
T |
4: 107,149,583 (GRCm39) |
V240I |
possibly damaging |
Het |
| Dnah12 |
A |
G |
14: 26,492,460 (GRCm39) |
D1200G |
probably benign |
Het |
| Dpy19l4 |
A |
T |
4: 11,265,909 (GRCm39) |
S680T |
probably benign |
Het |
| Eef2 |
CCC |
CCCC |
10: 81,014,602 (GRCm39) |
|
probably null |
Het |
| Fcrlb |
T |
C |
1: 170,735,416 (GRCm39) |
|
probably null |
Het |
| Gad1 |
T |
A |
2: 70,417,476 (GRCm39) |
I253K |
possibly damaging |
Het |
| Gars1 |
A |
G |
6: 55,054,688 (GRCm39) |
D665G |
probably damaging |
Het |
| Gldn |
A |
G |
9: 54,245,648 (GRCm39) |
T400A |
probably benign |
Het |
| Gm1110 |
C |
A |
9: 26,795,122 (GRCm39) |
V455L |
possibly damaging |
Het |
| Gm11444 |
A |
G |
11: 85,741,069 (GRCm39) |
V30A |
unknown |
Het |
| Gm5134 |
T |
C |
10: 75,800,271 (GRCm39) |
S51P |
probably damaging |
Het |
| Gprc6a |
C |
T |
10: 51,502,883 (GRCm39) |
A327T |
probably benign |
Het |
| Gstt2 |
A |
T |
10: 75,670,019 (GRCm39) |
D34E |
probably benign |
Het |
| Icam2 |
A |
G |
11: 106,271,589 (GRCm39) |
F78L |
probably damaging |
Het |
| Jakmip1 |
T |
G |
5: 37,284,802 (GRCm39) |
C630G |
possibly damaging |
Het |
| Kcnu1 |
A |
T |
8: 26,386,686 (GRCm39) |
N523I |
probably damaging |
Het |
| Klf10 |
A |
G |
15: 38,297,282 (GRCm39) |
S253P |
probably benign |
Het |
| Mmd2 |
A |
T |
5: 142,594,361 (GRCm39) |
M1K |
probably null |
Het |
| Mroh2b |
G |
T |
15: 4,960,543 (GRCm39) |
G759C |
probably benign |
Het |
| Or10w3 |
T |
C |
19: 13,704,465 (GRCm39) |
L280P |
probably damaging |
Het |
| Or2b7 |
A |
T |
13: 21,740,176 (GRCm39) |
N5K |
probably benign |
Het |
| Or8k32 |
C |
T |
2: 86,368,872 (GRCm39) |
C127Y |
probably damaging |
Het |
| Orc5 |
A |
G |
5: 22,755,197 (GRCm39) |
F22S |
possibly damaging |
Het |
| Prlr |
A |
G |
15: 10,329,021 (GRCm39) |
I499V |
probably benign |
Het |
| Ptbp1 |
A |
G |
10: 79,694,954 (GRCm39) |
N94S |
probably benign |
Het |
| Rassf3 |
C |
A |
10: 121,312,103 (GRCm39) |
|
probably benign |
Het |
| Rbm33 |
C |
T |
5: 28,573,264 (GRCm39) |
P455S |
probably damaging |
Het |
| Sgcd |
C |
G |
11: 47,016,481 (GRCm39) |
G127A |
possibly damaging |
Het |
| Slc22a13 |
A |
G |
9: 119,024,226 (GRCm39) |
I336T |
possibly damaging |
Het |
| Slc25a31 |
A |
T |
3: 40,679,471 (GRCm39) |
D312V |
possibly damaging |
Het |
| Slc37a4 |
G |
A |
9: 44,312,818 (GRCm39) |
S324N |
probably benign |
Het |
| Slco1a5 |
A |
G |
6: 142,221,207 (GRCm39) |
V13A |
probably benign |
Het |
| Srgap2 |
T |
C |
1: 131,220,371 (GRCm39) |
H907R |
probably damaging |
Het |
| Supv3l1 |
A |
C |
10: 62,271,487 (GRCm39) |
V381G |
probably damaging |
Het |
| Supv3l1 |
C |
A |
10: 62,271,488 (GRCm39) |
V381L |
possibly damaging |
Het |
| Syne1 |
T |
C |
10: 5,299,324 (GRCm39) |
D977G |
probably damaging |
Het |
| Syt3 |
T |
A |
7: 44,040,272 (GRCm39) |
Y168* |
probably null |
Het |
| Tshz1 |
A |
T |
18: 84,032,790 (GRCm39) |
Y539* |
probably null |
Het |
| Ttll13 |
A |
G |
7: 79,907,981 (GRCm39) |
K501R |
probably benign |
Het |
| Ttn |
G |
A |
2: 76,612,732 (GRCm39) |
Q17116* |
probably null |
Het |
| Vcan |
T |
C |
13: 89,840,577 (GRCm39) |
T1656A |
probably damaging |
Het |
| Vmn1r73 |
G |
T |
7: 11,491,082 (GRCm39) |
C300F |
probably benign |
Het |
| Zdhhc11 |
T |
A |
13: 74,130,885 (GRCm39) |
|
probably benign |
Het |
| Zfp760 |
T |
C |
17: 21,941,907 (GRCm39) |
S361P |
possibly damaging |
Het |
| Zranb2 |
A |
G |
3: 157,246,309 (GRCm39) |
Y114C |
probably damaging |
Het |
|
| Other mutations in Vmn2r9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00920:Vmn2r9
|
APN |
5 |
108,995,890 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00972:Vmn2r9
|
APN |
5 |
108,996,903 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01102:Vmn2r9
|
APN |
5 |
108,990,811 (GRCm39) |
splice site |
probably null |
|
|
IGL01892:Vmn2r9
|
APN |
5 |
108,995,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02086:Vmn2r9
|
APN |
5 |
108,995,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02119:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02120:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02123:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02131:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02132:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02171:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02186:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02346:Vmn2r9
|
APN |
5 |
108,990,850 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02508:Vmn2r9
|
APN |
5 |
108,996,067 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02815:Vmn2r9
|
APN |
5 |
108,990,856 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL03077:Vmn2r9
|
APN |
5 |
108,996,173 (GRCm39) |
splice site |
probably benign |
|
|
IGL03269:Vmn2r9
|
APN |
5 |
108,995,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Vmn2r9
|
APN |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r9
|
UTSW |
5 |
108,990,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0328:Vmn2r9
|
UTSW |
5 |
108,995,405 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0382:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Vmn2r9
|
UTSW |
5 |
108,996,154 (GRCm39) |
nonsense |
probably null |
|
|
R0975:Vmn2r9
|
UTSW |
5 |
108,991,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Vmn2r9
|
UTSW |
5 |
108,995,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Vmn2r9
|
UTSW |
5 |
108,996,850 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1704:Vmn2r9
|
UTSW |
5 |
108,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Vmn2r9
|
UTSW |
5 |
108,995,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1991:Vmn2r9
|
UTSW |
5 |
108,994,305 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2410:Vmn2r9
|
UTSW |
5 |
108,996,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3419:Vmn2r9
|
UTSW |
5 |
108,994,299 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3852:Vmn2r9
|
UTSW |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3873:Vmn2r9
|
UTSW |
5 |
108,995,701 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3905:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3908:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3921:Vmn2r9
|
UTSW |
5 |
108,996,921 (GRCm39) |
missense |
probably benign |
|
|
R4156:Vmn2r9
|
UTSW |
5 |
108,995,743 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4477:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4478:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4544:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4546:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4627:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Vmn2r9
|
UTSW |
5 |
108,994,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5361:Vmn2r9
|
UTSW |
5 |
108,995,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Vmn2r9
|
UTSW |
5 |
108,995,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6054:Vmn2r9
|
UTSW |
5 |
108,996,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6106:Vmn2r9
|
UTSW |
5 |
108,992,902 (GRCm39) |
missense |
probably benign |
|
|
R6125:Vmn2r9
|
UTSW |
5 |
108,990,836 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6137:Vmn2r9
|
UTSW |
5 |
108,996,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r9
|
UTSW |
5 |
108,996,912 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8683:Vmn2r9
|
UTSW |
5 |
108,996,873 (GRCm39) |
missense |
probably benign |
|
|
R8964:Vmn2r9
|
UTSW |
5 |
108,996,031 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9022:Vmn2r9
|
UTSW |
5 |
108,992,923 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9118:Vmn2r9
|
UTSW |
5 |
108,990,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9125:Vmn2r9
|
UTSW |
5 |
108,996,047 (GRCm39) |
missense |
|
|
|
R9240:Vmn2r9
|
UTSW |
5 |
108,996,099 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9327:Vmn2r9
|
UTSW |
5 |
108,996,841 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9412:Vmn2r9
|
UTSW |
5 |
108,991,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9499:Vmn2r9
|
UTSW |
5 |
108,995,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Vmn2r9
|
UTSW |
5 |
108,995,908 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9790:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9791:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTACAGTTTTCATCTAGGCCAAATC -3'
(R):5'- TGACATTCAGTACATTGCAGGG -3'
Sequencing Primer
(F):5'- AGTTTTCATCTAGGCCAAATCATATC -3'
(R):5'- CATTCAGTACATTGCAGGGTAATAC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation