Mutagenetix > Incidental Mutation

Incidental Mutation 'R7581:Zfp1007'

586736

Institutional Source

Beutler Lab

Gene Symbol

Zfp1007

Ensembl Gene

ENSMUSG00000072763

Gene Name

zinc finger protein 1007

Synonyms

5430403G16Rik, ENSMUSG00000072763

MMRRC Submission

045634-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R7581 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

109822409-109838700 bp(-) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

G to A at 109838654 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000090395 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092720]

AlphaFold

D3Z5L4

Predicted Effect

probably benign
Transcript: ENSMUST00000092720

SMART Domains

Protein: ENSMUSP00000090395
Gene: ENSMUSG00000072763

Domain	Start	End	E-Value	Type
KRAB	4	60	2.47e-14	SMART
ZnF_C2H2	131	153	3.39e-3	SMART
ZnF_C2H2	159	181	3.95e-4	SMART
ZnF_C2H2	187	209	3.95e-4	SMART
ZnF_C2H2	215	237	1.12e-3	SMART
ZnF_C2H2	243	265	4.01e-5	SMART
ZnF_C2H2	271	293	7.78e-3	SMART
ZnF_C2H2	299	321	2.61e-4	SMART
ZnF_C2H2	327	349	1.36e-2	SMART
ZnF_C2H2	355	377	7.37e-4	SMART
ZnF_C2H2	383	405	1.3e-4	SMART
ZnF_C2H2	411	433	3.69e-4	SMART
ZnF_C2H2	439	461	4.3e-5	SMART
ZnF_C2H2	467	489	2.57e-3	SMART
ZnF_C2H2	495	517	2.61e-4	SMART
ZnF_C2H2	523	545	2.05e-2	SMART
ZnF_C2H2	551	573	5.59e-4	SMART
ZnF_C2H2	579	601	1.58e-3	SMART
ZnF_C2H2	607	629	9.08e-4	SMART
ZnF_C2H2	635	657	3.44e-4	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

98% (47/48)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	A	C	6: 92,914,319 (GRCm39)	D196E	probably benign	Het
Adnp	A	T	2: 168,025,386 (GRCm39)	D636E	probably damaging	Het
Afdn	T	C	17: 14,069,500 (GRCm39)	V723A	probably damaging	Het
Arid1a	A	T	4: 133,407,662 (GRCm39)	F1897I	unknown	Het
Atp6v0b	T	C	4: 117,742,483 (GRCm39)	M137V	probably benign	Het
Bicd1	T	A	6: 149,420,502 (GRCm39)	I784N	probably damaging	Het
Cckbr	A	G	7: 105,082,993 (GRCm39)	T119A	probably benign	Het
Creb5	T	C	6: 53,658,222 (GRCm39)	L184P	probably damaging	Het
Cyp2a22	T	G	7: 26,637,573 (GRCm39)	K141Q	possibly damaging	Het
D16Ertd472e	T	C	16: 78,343,445 (GRCm39)	T219A	possibly damaging	Het
Ep400	A	T	5: 110,903,891 (GRCm39)	L236Q	unknown	Het
Exph5	A	G	9: 53,283,857 (GRCm39)	S313G	possibly damaging	Het
Gm10024	T	C	10: 77,547,397 (GRCm39)	V36A	unknown	Het
Gm5493	A	G	17: 22,966,247 (GRCm39)	E44G	probably damaging	Het
Gtdc1	A	T	2: 44,680,017 (GRCm39)		probably null	Het
Invs	T	C	4: 48,421,909 (GRCm39)	V847A	probably benign	Het
Kif18b	C	A	11: 102,805,548 (GRCm39)	Q236H	probably damaging	Het
Kntc1	A	G	5: 123,954,818 (GRCm39)	T2079A	probably benign	Het
Large2	A	G	2: 92,200,538 (GRCm39)	S89P	probably damaging	Het
Maml3	A	C	3: 51,764,189 (GRCm39)	D258E	probably benign	Het
Mdga2	A	T	12: 66,553,029 (GRCm39)	M868K	probably damaging	Het
Mtss2	A	G	8: 111,452,845 (GRCm39)	E30G	possibly damaging	Het
Muc16	T	C	9: 18,556,910 (GRCm39)	I3128V	unknown	Het
Mug2	C	T	6: 122,040,670 (GRCm39)	T740I	probably damaging	Het
Noc2l	T	C	4: 156,329,906 (GRCm39)	V612A	probably benign	Het
Or10g9	A	T	9: 39,911,718 (GRCm39)	D268E	probably damaging	Het
Or6k2	G	A	1: 173,986,337 (GRCm39)		probably null	Het
Padi6	T	C	4: 140,456,240 (GRCm39)	T585A	probably benign	Het
Pcdhga1	A	T	18: 37,795,230 (GRCm39)	N78I	probably damaging	Het
Pdgfd	A	G	9: 6,293,894 (GRCm39)	Y156C	probably damaging	Het
Peg10	GCACATCAGGATCC	GCACATCAGGATCCCCATCAGGATCCTCCACATCAGGATCC	6: 4,756,452 (GRCm39)		probably benign	Het
Pi4ka	C	T	16: 17,118,924 (GRCm39)	V1307I		Het
Pip5k1c	A	G	10: 81,144,794 (GRCm39)	N212D	probably damaging	Het
Plekha1	A	G	7: 130,512,595 (GRCm39)	T264A	probably benign	Het
Polr2b	A	G	5: 77,474,551 (GRCm39)	R463G	probably damaging	Het
Psd2	T	G	18: 36,113,050 (GRCm39)	D248E	probably benign	Het
Rag1	G	T	2: 101,473,649 (GRCm39)	Q498K	possibly damaging	Het
Ryr3	A	G	2: 112,583,372 (GRCm39)	I2853T	probably damaging	Het
Selenow	G	T	7: 15,656,307 (GRCm39)		probably null	Het
Sned1	C	T	1: 93,184,267 (GRCm39)	S165F	probably benign	Het
Spata31d1a	A	G	13: 59,851,953 (GRCm39)		probably null	Het
Taar4	C	A	10: 23,837,052 (GRCm39)	H221N	probably damaging	Het
Tgm6	A	T	2: 129,983,205 (GRCm39)	R265W	probably damaging	Het
Trpm1	A	T	7: 63,854,303 (GRCm39)	Q275L	probably benign	Het
Ulk3	T	C	9: 57,499,325 (GRCm39)	L173P	probably damaging	Het
Urah	A	T	7: 140,415,540 (GRCm39)	T3S	probably benign	Het
Vmn1r149	A	T	7: 22,137,329 (GRCm39)	V109D	probably damaging	Het
Xpc	A	T	6: 91,474,999 (GRCm39)		probably benign	Het
Zglp1	T	A	9: 20,974,004 (GRCm39)	K227N	probably damaging	Het

Other mutations in Zfp1007

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01653:Zfp1007	APN	5	109,825,182 (GRCm39)	nonsense	probably null
IGL02547:Zfp1007	APN	5	109,826,628 (GRCm39)	critical splice donor site	probably null
IGL02589:Zfp1007	APN	5	109,826,386 (GRCm39)	missense	possibly damaging	0.95
BB007:Zfp1007	UTSW	5	109,823,622 (GRCm39)	nonsense	probably null
BB017:Zfp1007	UTSW	5	109,823,622 (GRCm39)	nonsense	probably null
R0363:Zfp1007	UTSW	5	109,824,754 (GRCm39)	missense	probably benign	0.03
R0628:Zfp1007	UTSW	5	109,826,442 (GRCm39)	critical splice acceptor site	probably null
R2858:Zfp1007	UTSW	5	109,823,819 (GRCm39)	missense	probably benign	0.02
R4914:Zfp1007	UTSW	5	109,826,396 (GRCm39)	missense	probably damaging	1.00
R4945:Zfp1007	UTSW	5	109,824,941 (GRCm39)	missense	possibly damaging	0.60
R5444:Zfp1007	UTSW	5	109,823,502 (GRCm39)	nonsense	probably null
R6000:Zfp1007	UTSW	5	109,824,730 (GRCm39)	missense	probably benign	0.19
R6258:Zfp1007	UTSW	5	109,824,433 (GRCm39)	missense	probably benign	0.01
R6389:Zfp1007	UTSW	5	109,823,885 (GRCm39)	missense	possibly damaging	0.84
R6945:Zfp1007	UTSW	5	109,824,711 (GRCm39)	missense	probably benign	0.25
R7225:Zfp1007	UTSW	5	109,825,015 (GRCm39)	missense	possibly damaging	0.69
R7810:Zfp1007	UTSW	5	109,825,170 (GRCm39)	nonsense	probably null
R7930:Zfp1007	UTSW	5	109,823,622 (GRCm39)	nonsense	probably null
R8821:Zfp1007	UTSW	5	109,824,174 (GRCm39)	missense	probably benign	0.00
R8825:Zfp1007	UTSW	5	109,826,746 (GRCm39)	missense	probably damaging	1.00
R8831:Zfp1007	UTSW	5	109,824,174 (GRCm39)	missense	probably benign	0.00
R9179:Zfp1007	UTSW	5	109,823,708 (GRCm39)	missense	probably damaging	1.00
R9429:Zfp1007	UTSW	5	109,824,334 (GRCm39)	nonsense	probably null
R9486:Zfp1007	UTSW	5	109,824,062 (GRCm39)	nonsense	probably null
R9496:Zfp1007	UTSW	5	109,823,924 (GRCm39)	missense	probably damaging	0.98
R9525:Zfp1007	UTSW	5	109,824,846 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- CGGGGAAGTTATTCAGACGC -3'
(R):5'- TCTACACCGCGTACCTTCAG -3'

Sequencing Primer
(F):5'- TATTCAGACGCTACAGCTGG -3'
(R):5'- GCGTACCTTCAGCACACTC -3'

Posted On

2019-10-24