Mutagenetix > Incidental Mutation

Incidental Mutation 'R7582:Psg21'

586796

Institutional Source

Beutler Lab

Gene Symbol

Psg21

Ensembl Gene

ENSMUSG00000070796

Gene Name

pregnancy-specific glycoprotein 21

Synonyms

1600026N13Rik, 1600019C01Rik, 1600025N01Rik, cea8

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

R7582 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

18646736-18656725 bp(-) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 18647203 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Arginine at position 472 (*472R)

Ref Sequence

ENSEMBL: ENSMUSP00000092387 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094793] [ENSMUST00000182128]

AlphaFold

Q9DAV5

Predicted Effect

probably null
Transcript: ENSMUST00000094793
AA Change: *472R

SMART Domains

Protein: ENSMUSP00000092387
Gene: ENSMUSG00000070796
AA Change: *472R

Domain	Start	End	E-Value	Type
IG	39	138	3.04e-3	SMART
IG	159	260	7.25e-1	SMART
IG	276	375	1.25e-4	SMART
IGc2	393	457	1.47e-10	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182128

SMART Domains

Protein: ENSMUSP00000138173
Gene: ENSMUSG00000070796

Domain	Start	End	E-Value	Type
IG	39	138	3.04e-3	SMART
IG	159	260	7.25e-1	SMART
IG	276	375	1.25e-4	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgb	A	G	10: 10,390,821	V1007A	probably damaging	Het
Adgrl3	T	C	5: 81,693,676	V800A	probably damaging	Het
Ankfn1	T	A	11: 89,526,619	M56L	probably benign	Het
Arfgap3	A	C	15: 83,303,101	V72G	possibly damaging	Het
B3galnt2	C	T	13: 13,991,401	R294W	probably damaging	Het
Cadm1	G	T	9: 47,797,442	D157Y	probably damaging	Het
Ccdc81	A	T	7: 89,876,145	Y474N	probably damaging	Het
Cdkl4	T	A	17: 80,533,835	K297I	probably benign	Het
Cep128	G	A	12: 91,347,566	T146M	probably damaging	Het
Cfap161	T	C	7: 83,777,082	N236S	possibly damaging	Het
Chil3	A	T	3: 106,164,256	W31R	probably damaging	Het
Cmtm2b	C	T	8: 104,322,721	S86F	probably damaging	Het
Cntnap5a	G	A	1: 116,446,632	G958D	probably damaging	Het
Col6a5	A	G	9: 105,945,426	L244P	unknown	Het
Crat	C	T	2: 30,404,565	R497Q	probably benign	Het
Cul9	A	G	17: 46,510,979	Y1857H	probably damaging	Het
Dst	A	G	1: 34,169,883	Q1154R	probably damaging	Het
Fgg	G	A	3: 83,014,138	G376D	probably damaging	Het
Fmn2	T	C	1: 174,698,790	S1392P	probably damaging	Het
Focad	T	C	4: 88,229,378	V418A	probably benign	Het
Foxf1	A	T	8: 121,084,691	H98L	possibly damaging	Het
Frmd4a	C	CA	2: 4,594,597		probably null	Het
Fry	C	A	5: 150,496,382	T639K		Het
Fryl	A	G	5: 73,022,500		probably null	Het
Gatsl3	T	C	11: 4,220,457	V151A	probably benign	Het
Gdpd4	A	G	7: 97,957,805		probably null	Het
Gpt2	A	G	8: 85,519,516	K368R	probably damaging	Het
Hc	A	T	2: 34,991,266	V1447E	possibly damaging	Het
Kmt5a	A	G	5: 124,459,919	T280A	probably benign	Het
Lrrc4b	G	T	7: 44,461,810	V369L	probably benign	Het
Ly6g5c	A	G	17: 35,111,807	M102V	probably benign	Het
Malrd1	A	G	2: 15,695,270	S643G	unknown	Het
Mib2	T	C	4: 155,654,810	N904S	probably benign	Het
Mug2	G	A	6: 122,079,644	V1183I	probably damaging	Het
Nckap1l	C	T	15: 103,482,160	T786I	probably damaging	Het
Neb	T	C	2: 52,334,492		probably benign	Het
Neu3	A	G	7: 99,813,967	V183A	probably benign	Het
Nod1	A	G	6: 54,944,307	L342P	probably damaging	Het
Nop58	T	C	1: 59,700,938	V163A	probably damaging	Het
Npr3	C	T	15: 11,895,682	G293R	probably null	Het
Obscn	T	A	11: 59,061,427	K3939*	probably null	Het
Olfr1279	T	A	2: 111,306,448	M81K	probably damaging	Het
Olfr1426	G	A	19: 12,088,006	A262V	probably benign	Het
Olfr180	A	T	16: 58,916,047	M198K	possibly damaging	Het
Olfr502	A	G	7: 108,523,851	I33T	probably benign	Het
Olfr875	T	C	9: 37,772,821	L54P	probably damaging	Het
P2ry6	A	G	7: 100,938,577	Y192H	probably damaging	Het
Paxbp1	A	G	16: 91,022,667		probably null	Het
Pign	G	A	1: 105,649,367	T197I	probably benign	Het
Pirb	A	T	7: 3,713,818		probably null	Het
Pkdrej	C	A	15: 85,818,921	R938L	possibly damaging	Het
Rabgap1l	A	T	1: 160,682,084	S474R	probably benign	Het
Rrn3	C	T	16: 13,810,511	Q519*	probably null	Het
Seh1l	A	T	18: 67,775,118	K37*	probably null	Het
Shprh	A	G	10: 11,164,705	S641G	probably benign	Het
Slc4a1	T	G	11: 102,352,577	S743R	probably damaging	Het
Snx13	C	T	12: 35,124,535	R688*	probably null	Het
Tlr11	C	T	14: 50,361,729	Q391*	probably null	Het
Tmbim4	A	G	10: 120,217,566	H90R	probably benign	Het
Trav8d-1	T	C	14: 52,778,869	S71P	possibly damaging	Het
Trbv5	G	A	6: 41,062,683	R74Q	probably benign	Het
Tril	A	G	6: 53,818,936	S434P	probably benign	Het
Uhmk1	A	G	1: 170,200,001	Y376H	probably damaging	Het
Uty	A	G	Y: 1,170,914	C317R	probably damaging	Het
Vmp1	C	T	11: 86,585,399	C377Y	probably benign	Het
Vwa8	A	C	14: 78,982,234		probably null	Het
Wdr41	T	C	13: 95,005,767	S150P	probably damaging	Het
Zfp617	T	A	8: 71,932,020	Y65N	probably benign	Het
Zfp800	A	C	6: 28,244,090	V292G	probably damaging	Het

Other mutations in Psg21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01571:Psg21	APN	7	18654825	missense	probably damaging	1.00
IGL02390:Psg21	APN	7	18652631	missense	probably benign	0.11
IGL02548:Psg21	APN	7	18655036	missense	possibly damaging	0.89
IGL03001:Psg21	APN	7	18652485	missense	probably benign	0.03
IGL03135:Psg21	APN	7	18654918	missense	probably benign	0.00
R0131:Psg21	UTSW	7	18654868	missense	probably benign	0.39
R0551:Psg21	UTSW	7	18652640	critical splice acceptor site	probably null
R1512:Psg21	UTSW	7	18656500	missense	probably benign	0.00
R1874:Psg21	UTSW	7	18650816	missense	probably benign	0.15
R1993:Psg21	UTSW	7	18654770	missense	probably benign	0.04
R2327:Psg21	UTSW	7	18652453	missense	possibly damaging	0.61
R3414:Psg21	UTSW	7	18652380	missense	probably damaging	1.00
R4422:Psg21	UTSW	7	18647332	missense	probably damaging	1.00
R5138:Psg21	UTSW	7	18656528	start codon destroyed	probably null	0.94
R5623:Psg21	UTSW	7	18655014	missense	probably damaging	1.00
R5686:Psg21	UTSW	7	18652258	intron	probably benign
R6166:Psg21	UTSW	7	18656739	unclassified	probably benign
R6177:Psg21	UTSW	7	18652354	missense	possibly damaging	0.64
R6190:Psg21	UTSW	7	18655001	missense	possibly damaging	0.61
R6210:Psg21	UTSW	7	18652345	missense	probably damaging	1.00
R6482:Psg21	UTSW	7	18654739	splice site	probably null
R6729:Psg21	UTSW	7	18652591	missense	probably damaging	1.00
R6866:Psg21	UTSW	7	18652284	missense	probably damaging	1.00
R6992:Psg21	UTSW	7	18654743	critical splice donor site	probably null
R7075:Psg21	UTSW	7	18654861	missense	probably damaging	1.00
R7081:Psg21	UTSW	7	18654849	nonsense	probably null
R7098:Psg21	UTSW	7	18652545	missense	probably damaging	1.00
R7588:Psg21	UTSW	7	18647209	missense	probably benign	0.00
R7607:Psg21	UTSW	7	18654783	missense	probably benign	0.02
R7830:Psg21	UTSW	7	18647298	missense	probably damaging	1.00
R7964:Psg21	UTSW	7	18647211	missense	probably benign	0.01
R8758:Psg21	UTSW	7	18650753	missense	probably damaging	1.00
R8972:Psg21	UTSW	7	18647368	missense	probably benign	0.03
R8988:Psg21	UTSW	7	18652464	missense	probably benign	0.00
R9119:Psg21	UTSW	7	18647484	missense	probably benign	0.14
R9446:Psg21	UTSW	7	18654940	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- ACTGTGCAACAATAGTGAGCAG -3'
(R):5'- TCAACAATCAGAGTCTGCAGC -3'

Sequencing Primer
(F):5'- ACAGACATTGTGGTACCATATGCTCC -3'
(R):5'- TCAGAGTCTGCAGCTCACAGAG -3'

Posted On

2019-10-24