Incidental Mutation 'R7582:Shprh'
| ID |
586812 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| MMRRC Submission |
045665-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7582 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
11149427-11217595 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11164705 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 641
(S641G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000039422
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
[ENSMUST00000160461]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044053
AA Change: S641G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: S641G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054814
AA Change: S641G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: S641G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159541
AA Change: S641G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: S641G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159810
AA Change: S641G
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
AA Change: S641G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160461
AA Change: S121G
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000125127
Gene: ENSMUSG00000090112
AA Change: S121G
| Domain | Start | End | E-Value | Type |
|---|
|
PHD
|
131 |
178 |
2.33e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgb |
A |
G |
10: 10,390,821 (GRCm38) |
V1007A |
probably damaging |
Het |
| Adgrl3 |
T |
C |
5: 81,693,676 (GRCm38) |
V800A |
probably damaging |
Het |
| Ankfn1 |
T |
A |
11: 89,526,619 (GRCm38) |
M56L |
probably benign |
Het |
| Arfgap3 |
A |
C |
15: 83,303,101 (GRCm38) |
V72G |
possibly damaging |
Het |
| B3galnt2 |
C |
T |
13: 13,991,401 (GRCm38) |
R294W |
probably damaging |
Het |
| Cadm1 |
G |
T |
9: 47,797,442 (GRCm38) |
D157Y |
probably damaging |
Het |
| Ccdc81 |
A |
T |
7: 89,876,145 (GRCm38) |
Y474N |
probably damaging |
Het |
| Cdkl4 |
T |
A |
17: 80,533,835 (GRCm38) |
K297I |
probably benign |
Het |
| Cep128 |
G |
A |
12: 91,347,566 (GRCm38) |
T146M |
probably damaging |
Het |
| Cfap161 |
T |
C |
7: 83,777,082 (GRCm38) |
N236S |
possibly damaging |
Het |
| Chil3 |
A |
T |
3: 106,164,256 (GRCm38) |
W31R |
probably damaging |
Het |
| Cmtm2b |
C |
T |
8: 104,322,721 (GRCm38) |
S86F |
probably damaging |
Het |
| Cntnap5a |
G |
A |
1: 116,446,632 (GRCm38) |
G958D |
probably damaging |
Het |
| Col6a5 |
A |
G |
9: 105,945,426 (GRCm38) |
L244P |
unknown |
Het |
| Crat |
C |
T |
2: 30,404,565 (GRCm38) |
R497Q |
probably benign |
Het |
| Cul9 |
A |
G |
17: 46,510,979 (GRCm38) |
Y1857H |
probably damaging |
Het |
| Dst |
A |
G |
1: 34,169,883 (GRCm38) |
Q1154R |
probably damaging |
Het |
| Fgg |
G |
A |
3: 83,014,138 (GRCm38) |
G376D |
probably damaging |
Het |
| Fmn2 |
T |
C |
1: 174,698,790 (GRCm38) |
S1392P |
probably damaging |
Het |
| Focad |
T |
C |
4: 88,229,378 (GRCm38) |
V418A |
probably benign |
Het |
| Foxf1 |
A |
T |
8: 121,084,691 (GRCm38) |
H98L |
possibly damaging |
Het |
| Frmd4a |
C |
CA |
2: 4,594,597 (GRCm38) |
|
probably null |
Het |
| Fry |
C |
A |
5: 150,496,382 (GRCm38) |
T639K |
|
Het |
| Fryl |
A |
G |
5: 73,022,500 (GRCm38) |
|
probably null |
Het |
| Gatsl3 |
T |
C |
11: 4,220,457 (GRCm38) |
V151A |
probably benign |
Het |
| Gdpd4 |
A |
G |
7: 97,957,805 (GRCm38) |
|
probably null |
Het |
| Gpt2 |
A |
G |
8: 85,519,516 (GRCm38) |
K368R |
probably damaging |
Het |
| Hc |
A |
T |
2: 34,991,266 (GRCm38) |
V1447E |
possibly damaging |
Het |
| Kmt5a |
A |
G |
5: 124,459,919 (GRCm38) |
T280A |
probably benign |
Het |
| Lrrc4b |
G |
T |
7: 44,461,810 (GRCm38) |
V369L |
probably benign |
Het |
| Ly6g5c |
A |
G |
17: 35,111,807 (GRCm38) |
M102V |
probably benign |
Het |
| Malrd1 |
A |
G |
2: 15,695,270 (GRCm38) |
S643G |
unknown |
Het |
| Mib2 |
T |
C |
4: 155,654,810 (GRCm38) |
N904S |
probably benign |
Het |
| Mug2 |
G |
A |
6: 122,079,644 (GRCm38) |
V1183I |
probably damaging |
Het |
| Nckap1l |
C |
T |
15: 103,482,160 (GRCm38) |
T786I |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,334,492 (GRCm38) |
|
probably benign |
Het |
| Neu3 |
A |
G |
7: 99,813,967 (GRCm38) |
V183A |
probably benign |
Het |
| Nod1 |
A |
G |
6: 54,944,307 (GRCm38) |
L342P |
probably damaging |
Het |
| Nop58 |
T |
C |
1: 59,700,938 (GRCm38) |
V163A |
probably damaging |
Het |
| Npr3 |
C |
T |
15: 11,895,682 (GRCm38) |
G293R |
probably null |
Het |
| Obscn |
T |
A |
11: 59,061,427 (GRCm38) |
K3939* |
probably null |
Het |
| Olfr1279 |
T |
A |
2: 111,306,448 (GRCm38) |
M81K |
probably damaging |
Het |
| Olfr1426 |
G |
A |
19: 12,088,006 (GRCm38) |
A262V |
probably benign |
Het |
| Olfr180 |
A |
T |
16: 58,916,047 (GRCm38) |
M198K |
possibly damaging |
Het |
| Olfr502 |
A |
G |
7: 108,523,851 (GRCm38) |
I33T |
probably benign |
Het |
| Olfr875 |
T |
C |
9: 37,772,821 (GRCm38) |
L54P |
probably damaging |
Het |
| P2ry6 |
A |
G |
7: 100,938,577 (GRCm38) |
Y192H |
probably damaging |
Het |
| Paxbp1 |
A |
G |
16: 91,022,667 (GRCm38) |
|
probably null |
Het |
| Pign |
G |
A |
1: 105,649,367 (GRCm38) |
T197I |
probably benign |
Het |
| Pirb |
A |
T |
7: 3,713,818 (GRCm38) |
|
probably null |
Het |
| Pkdrej |
C |
A |
15: 85,818,921 (GRCm38) |
R938L |
possibly damaging |
Het |
| Psg21 |
A |
G |
7: 18,647,203 (GRCm38) |
*472R |
probably null |
Het |
| Rabgap1l |
A |
T |
1: 160,682,084 (GRCm38) |
S474R |
probably benign |
Het |
| Rrn3 |
C |
T |
16: 13,810,511 (GRCm38) |
Q519* |
probably null |
Het |
| Seh1l |
A |
T |
18: 67,775,118 (GRCm38) |
K37* |
probably null |
Het |
| Slc4a1 |
T |
G |
11: 102,352,577 (GRCm38) |
S743R |
probably damaging |
Het |
| Snx13 |
C |
T |
12: 35,124,535 (GRCm38) |
R688* |
probably null |
Het |
| Tlr11 |
C |
T |
14: 50,361,729 (GRCm38) |
Q391* |
probably null |
Het |
| Tmbim4 |
A |
G |
10: 120,217,566 (GRCm38) |
H90R |
probably benign |
Het |
| Trav8d-1 |
T |
C |
14: 52,778,869 (GRCm38) |
S71P |
possibly damaging |
Het |
| Trbv5 |
G |
A |
6: 41,062,683 (GRCm38) |
R74Q |
probably benign |
Het |
| Tril |
A |
G |
6: 53,818,936 (GRCm38) |
S434P |
probably benign |
Het |
| Uhmk1 |
A |
G |
1: 170,200,001 (GRCm38) |
Y376H |
probably damaging |
Het |
| Uty |
A |
G |
Y: 1,170,914 (GRCm38) |
C317R |
probably damaging |
Het |
| Vmp1 |
C |
T |
11: 86,585,399 (GRCm38) |
C377Y |
probably benign |
Het |
| Vwa8 |
A |
C |
14: 78,982,234 (GRCm38) |
|
probably null |
Het |
| Wdr41 |
T |
C |
13: 95,005,767 (GRCm38) |
S150P |
probably damaging |
Het |
| Zfp617 |
T |
A |
8: 71,932,020 (GRCm38) |
Y65N |
probably benign |
Het |
| Zfp800 |
A |
C |
6: 28,244,090 (GRCm38) |
V292G |
probably damaging |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,188,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,188,020 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,163,037 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,183,868 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,170,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,170,019 (GRCm38) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,191,062 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,181,502 (GRCm38) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,194,357 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,154,765 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,192,494 (GRCm38) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,186,391 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,170,109 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,194,170 (GRCm38) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,157,191 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,162,812 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,183,887 (GRCm38) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,163,077 (GRCm38) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,207,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,186,847 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,159,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,164,744 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,157,078 (GRCm38) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,186,911 (GRCm38) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,186,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,183,797 (GRCm38) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,152,120 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,162,235 (GRCm38) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,171,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,166,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,164,356 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,170,413 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,170,030 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,178,757 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,207,860 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,186,518 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,160,471 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,170,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,181,540 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,164,557 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4937:Shprh
|
UTSW |
10 |
11,157,119 (GRCm38) |
missense |
probably benign |
|
|
R5140:Shprh
|
UTSW |
10 |
11,154,705 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,166,557 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,170,297 (GRCm38) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,212,330 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,188,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,178,741 (GRCm38) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,167,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,171,937 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,186,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,194,267 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,166,545 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,181,508 (GRCm38) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,166,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,166,730 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7757:Shprh
|
UTSW |
10 |
11,162,180 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,185,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,212,333 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,151,811 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,213,461 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,187,983 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,181,569 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,151,934 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,157,164 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,185,437 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,164,830 (GRCm38) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,154,702 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,162,845 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,160,576 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,162,889 (GRCm38) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,205,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,166,491 (GRCm38) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,206,332 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,162,830 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,213,504 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,164,460 (GRCm38) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,164,841 (GRCm38) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,186,862 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,186,447 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,164,553 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,151,762 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTGAAGAAGCCTGCTTTACTAAC -3'
(R):5'- CATCGCAACAAGACAGTGGG -3'
Sequencing Primer
(F):5'- GCCTGCTTTACTAACTAAAAAGGG -3'
(R):5'- GGGCAGTAAAAAGGCTTAACC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation