Incidental Mutation 'R7582:Ly6g5c'
ID 586833
Institutional Source Beutler Lab
Gene Symbol Ly6g5c
Ensembl Gene ENSMUSG00000034482
Gene Name lymphocyte antigen 6 family member G5C
Synonyms NG33, G5c
MMRRC Submission 045665-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R7582 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 35327255-35330967 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 35330783 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 102 (M102V)
Ref Sequence ENSEMBL: ENSMUSP00000039151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025246] [ENSMUST00000037849] [ENSMUST00000062657] [ENSMUST00000172854] [ENSMUST00000173114] [ENSMUST00000174024] [ENSMUST00000174779]
AlphaFold Q8K1T5
Predicted Effect probably benign
Transcript: ENSMUST00000025246
SMART Domains Protein: ENSMUSP00000025246
Gene: ENSMUSG00000024387

DomainStartEndE-ValueType
CK_II_beta 8 191 9.99e-143 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000037849
AA Change: M102V

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000039151
Gene: ENSMUSG00000034482
AA Change: M102V

DomainStartEndE-ValueType
low complexity region 28 40 N/A INTRINSIC
Blast:LU 59 145 2e-31 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000062657
SMART Domains Protein: ENSMUSP00000052133
Gene: ENSMUSG00000043807

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Blast:CK_II_beta 21 115 1e-40 BLAST
Blast:CK_II_beta 125 170 3e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000172854
SMART Domains Protein: ENSMUSP00000138033
Gene: ENSMUSG00000043807

DomainStartEndE-ValueType
Blast:CK_II_beta 1 60 2e-18 BLAST
Blast:CK_II_beta 70 115 1e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000173114
SMART Domains Protein: ENSMUSP00000134218
Gene: ENSMUSG00000024387

DomainStartEndE-ValueType
CK_II_beta 8 191 9.99e-143 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173633
SMART Domains Protein: ENSMUSP00000133826
Gene: ENSMUSG00000024387

DomainStartEndE-ValueType
CK_II_beta 2 91 1.28e-26 SMART
Blast:CK_II_beta 121 154 4e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000174024
SMART Domains Protein: ENSMUSP00000134673
Gene: ENSMUSG00000024387

DomainStartEndE-ValueType
CK_II_beta 8 169 5.07e-71 SMART
Blast:CK_II_beta 189 220 6e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000174779
SMART Domains Protein: ENSMUSP00000133684
Gene: ENSMUSG00000024387

DomainStartEndE-ValueType
CK_II_beta 1 140 2.47e-83 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A G 10: 10,266,565 (GRCm39) V1007A probably damaging Het
Adgrl3 T C 5: 81,841,523 (GRCm39) V800A probably damaging Het
Ankfn1 T A 11: 89,417,445 (GRCm39) M56L probably benign Het
Arfgap3 A C 15: 83,187,302 (GRCm39) V72G possibly damaging Het
B3galnt2 C T 13: 14,165,986 (GRCm39) R294W probably damaging Het
Cadm1 G T 9: 47,708,740 (GRCm39) D157Y probably damaging Het
Castor1 T C 11: 4,170,457 (GRCm39) V151A probably benign Het
Ccdc81 A T 7: 89,525,353 (GRCm39) Y474N probably damaging Het
Cdkl4 T A 17: 80,841,264 (GRCm39) K297I probably benign Het
Cep128 G A 12: 91,314,340 (GRCm39) T146M probably damaging Het
Cfap161 T C 7: 83,426,290 (GRCm39) N236S possibly damaging Het
Chil3 A T 3: 106,071,572 (GRCm39) W31R probably damaging Het
Cmtm2b C T 8: 105,049,353 (GRCm39) S86F probably damaging Het
Cntnap5a G A 1: 116,374,362 (GRCm39) G958D probably damaging Het
Col6a5 A G 9: 105,822,625 (GRCm39) L244P unknown Het
Crat C T 2: 30,294,577 (GRCm39) R497Q probably benign Het
Cul9 A G 17: 46,821,905 (GRCm39) Y1857H probably damaging Het
Dst A G 1: 34,208,964 (GRCm39) Q1154R probably damaging Het
Fgg G A 3: 82,921,445 (GRCm39) G376D probably damaging Het
Fmn2 T C 1: 174,526,356 (GRCm39) S1392P probably damaging Het
Focad T C 4: 88,147,615 (GRCm39) V418A probably benign Het
Foxf1 A T 8: 121,811,430 (GRCm39) H98L possibly damaging Het
Frmd4a C CA 2: 4,599,408 (GRCm39) probably null Het
Fry C A 5: 150,419,847 (GRCm39) T639K Het
Fryl A G 5: 73,179,843 (GRCm39) probably null Het
Gdpd4 A G 7: 97,607,012 (GRCm39) probably null Het
Gpt2 A G 8: 86,246,145 (GRCm39) K368R probably damaging Het
Hc A T 2: 34,881,278 (GRCm39) V1447E possibly damaging Het
Kmt5a A G 5: 124,597,982 (GRCm39) T280A probably benign Het
Lrrc4b G T 7: 44,111,234 (GRCm39) V369L probably benign Het
Malrd1 A G 2: 15,700,081 (GRCm39) S643G unknown Het
Mib2 T C 4: 155,739,267 (GRCm39) N904S probably benign Het
Mug2 G A 6: 122,056,603 (GRCm39) V1183I probably damaging Het
Nckap1l C T 15: 103,390,587 (GRCm39) T786I probably damaging Het
Neb T C 2: 52,224,504 (GRCm39) probably benign Het
Neu3 A G 7: 99,463,174 (GRCm39) V183A probably benign Het
Nod1 A G 6: 54,921,292 (GRCm39) L342P probably damaging Het
Nop58 T C 1: 59,740,097 (GRCm39) V163A probably damaging Het
Npr3 C T 15: 11,895,768 (GRCm39) G293R probably null Het
Obscn T A 11: 58,952,253 (GRCm39) K3939* probably null Het
Or4d10c G A 19: 12,065,370 (GRCm39) A262V probably benign Het
Or4g16 T A 2: 111,136,793 (GRCm39) M81K probably damaging Het
Or5k16 A T 16: 58,736,410 (GRCm39) M198K possibly damaging Het
Or5p76 A G 7: 108,123,058 (GRCm39) I33T probably benign Het
Or8b12b T C 9: 37,684,117 (GRCm39) L54P probably damaging Het
P2ry6 A G 7: 100,587,784 (GRCm39) Y192H probably damaging Het
Paxbp1 A G 16: 90,819,555 (GRCm39) probably null Het
Pign G A 1: 105,577,092 (GRCm39) T197I probably benign Het
Pirb A T 7: 3,716,817 (GRCm39) probably null Het
Pkdrej C A 15: 85,703,122 (GRCm39) R938L possibly damaging Het
Psg21 A G 7: 18,381,128 (GRCm39) *472R probably null Het
Rabgap1l A T 1: 160,509,654 (GRCm39) S474R probably benign Het
Rrn3 C T 16: 13,628,375 (GRCm39) Q519* probably null Het
Seh1l A T 18: 67,908,188 (GRCm39) K37* probably null Het
Shprh A G 10: 11,040,449 (GRCm39) S641G probably benign Het
Slc4a1 T G 11: 102,243,403 (GRCm39) S743R probably damaging Het
Snx13 C T 12: 35,174,534 (GRCm39) R688* probably null Het
Tlr11 C T 14: 50,599,186 (GRCm39) Q391* probably null Het
Tmbim4 A G 10: 120,053,471 (GRCm39) H90R probably benign Het
Trav8d-1 T C 14: 53,016,326 (GRCm39) S71P possibly damaging Het
Trbv5 G A 6: 41,039,617 (GRCm39) R74Q probably benign Het
Tril A G 6: 53,795,921 (GRCm39) S434P probably benign Het
Uhmk1 A G 1: 170,027,570 (GRCm39) Y376H probably damaging Het
Uty A G Y: 1,170,914 (GRCm39) C317R probably damaging Het
Vmp1 C T 11: 86,476,225 (GRCm39) C377Y probably benign Het
Vwa8 A C 14: 79,219,674 (GRCm39) probably null Het
Wdr41 T C 13: 95,142,275 (GRCm39) S150P probably damaging Het
Zfp617 T A 8: 72,685,864 (GRCm39) Y65N probably benign Het
Zfp800 A C 6: 28,244,089 (GRCm39) V292G probably damaging Het
Other mutations in Ly6g5c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02344:Ly6g5c APN 17 35,329,723 (GRCm39) missense possibly damaging 0.94
R1923:Ly6g5c UTSW 17 35,330,863 (GRCm39) missense possibly damaging 0.92
R8041:Ly6g5c UTSW 17 35,330,808 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ACGCTTGGTCTCCTTGCATG -3'
(R):5'- TCCAGTCTGGAGGTTAGCTG -3'

Sequencing Primer
(F):5'- TTGCATGGTCACAACTTCAAATCC -3'
(R):5'- CTGGAGGTTAGCTGGCAGGAC -3'
Posted On 2019-10-24