Mutagenetix > Incidental Mutations

Incidental Mutation 'R7584:Olfr1211'

586946

Institutional Source

Beutler Lab

Gene Symbol

Olfr1211

Ensembl Gene

ENSMUSG00000075112

Gene Name

olfactory receptor 1211

Synonyms

MOR233-21, MOR233-16P, GA_x6K02T2Q125-50409367-50408432

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R7584 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

88926876-88938111 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 88929805 bp

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 170 (P170L)

Ref Sequence

ENSEMBL: ENSMUSP00000150571 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]

Predicted Effect

probably damaging
Transcript: ENSMUST00000099808
AA Change: P170L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: P170L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	9.5e-49	PFAM
Pfam:7tm_1	39	286	2.5e-14	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213412
AA Change: P170L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000215205
AA Change: P170L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

99% (74/75)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017D01Rik	A	G	19: 11,110,361	F69L	possibly damaging	Het
1700123L14Rik	A	C	6: 96,165,392	L224V	probably benign	Het
Abcc10	A	G	17: 46,315,378		probably null	Het
Actrt3	T	C	3: 30,598,207	K246R	probably benign	Het
Adam23	T	A	1: 63,545,462	V343D	probably damaging	Het
Ak2	T	C	4: 128,999,212	S55P	probably damaging	Het
Ank2	G	A	3: 126,946,128	Q2036*	probably null	Het
Ano10	A	G	9: 122,275,531	I40T	probably benign	Het
Aoc2	T	A	11: 101,326,179	C363S	possibly damaging	Het
Aplp2	A	T	9: 31,157,781	V584E	possibly damaging	Het
Arhgap32	A	T	9: 32,256,967	T749S	probably benign	Het
Atm	A	T	9: 53,513,127	F625I	probably damaging	Het
Atr	T	C	9: 95,942,713	L2387P	probably damaging	Het
Barhl1	C	T	2: 28,909,791	G274D	probably damaging	Het
Bcl2a1a	A	T	9: 88,957,292	D81V	probably damaging	Het
Ccdc63	T	G	5: 122,113,204	D381A	possibly damaging	Het
Col12a1	A	G	9: 79,703,296		probably null	Het
Crat	C	T	2: 30,404,565	R497Q	probably benign	Het
Cyp4b1	T	A	4: 115,628,687	D351V	probably damaging	Het
D130043K22Rik	A	G	13: 24,872,370	S562G	probably damaging	Het
D430042O09Rik	G	T	7: 125,870,666	V1436L	probably damaging	Het
Dgkb	T	A	12: 38,139,392		probably null	Het
Dmbt1	C	T	7: 131,088,751	Q905*	probably null	Het
Dnajc21	A	C	15: 10,462,295	Y81*	probably null	Het
Dnali1	T	C	4: 125,065,538	T21A	probably benign	Het
Dpp8	A	T	9: 65,078,782	L851F	probably damaging	Het
Dpt	T	C	1: 164,818,908	Y149H	probably benign	Het
Ep300	T	C	15: 81,628,426	V983A	unknown	Het
Faf1	C	T	4: 109,925,957	R549C	probably damaging	Het
Gcm1	A	G	9: 78,064,467	N230S	possibly damaging	Het
Gm10803	T	A	2: 93,564,168	I95N	probably damaging	Het
Hectd4	T	A	5: 121,318,735	I721N	possibly damaging	Het
Hsp90ab1	T	C	17: 45,570,271	H315R	probably damaging	Het
Igkv10-95	T	A	6: 68,680,756	S85R	possibly damaging	Het
Kcnq5	T	C	1: 21,402,321	T901A	probably benign	Het
Kremen1	C	T	11: 5,194,964	V471M	possibly damaging	Het
Lama2	C	A	10: 27,104,261	D1853Y	possibly damaging	Het
Lrif1	A	G	3: 106,731,901	T76A	probably benign	Het
Lrrtm2	T	A	18: 35,212,765	I495F	possibly damaging	Het
Ltbr	G	T	6: 125,307,241	Q413K	probably benign	Het
Myrfl	T	A	10: 116,828,997	Y376F	probably damaging	Het
Nup98	G	T	7: 102,176,389	N414K	probably benign	Het
Nynrin	A	G	14: 55,871,584	T1383A	probably damaging	Het
Olfr1106	A	T	2: 87,049,134	I34N	probably benign	Het
Olfr784	T	A	10: 129,388,032	I133N	probably damaging	Het
Olfr845	C	A	9: 19,339,273	T271K	possibly damaging	Het
Olfr915	G	T	9: 38,646,895	P210T	possibly damaging	Het
Pcdhb5	T	A	18: 37,322,372	S602T	possibly damaging	Het
Sall3	A	G	18: 80,974,530	F61S	probably benign	Het
Scube1	G	T	15: 83,721,887	C61*	probably null	Het
Sec31b	T	C	19: 44,531,556		probably null	Het
Sec31b	T	C	19: 44,543,323	D49G	probably damaging	Het
Skiv2l	A	G	17: 34,841,675	I822T	possibly damaging	Het
Slc19a3	C	T	1: 83,022,748	V183M	possibly damaging	Het
Slc41a2	T	C	10: 83,316,789		probably benign	Het
Sphk2	C	A	7: 45,712,507	V169L	probably damaging	Het
Synpo	C	A	18: 60,596,277	R951L	probably damaging	Het
Tbc1d9b	G	A	11: 50,170,716	C1017Y	probably damaging	Het
Tmtc4	C	A	14: 122,978,151	V28F	probably benign	Het
Tprkb	A	G	6: 85,928,827	I165V	probably benign	Het
Ttc23l	T	A	15: 10,533,708	I250F	probably damaging	Het
Ubr3	G	A	2: 69,991,503	V1370I	probably damaging	Het
Ush2a	A	G	1: 188,728,109		probably null	Het
Usp9y	T	C	Y: 1,384,451	Y689C	probably damaging	Het
Vmn1r56	A	T	7: 5,195,896	Y241N	probably damaging	Het
Vmn2r6	T	C	3: 64,565,262	T13A	probably benign	Het
Vmn2r92	T	A	17: 18,166,766	N122K	probably benign	Het
Vps9d1	A	G	8: 123,250,717	F131S	probably damaging	Het
Vwa8	A	C	14: 78,982,234		probably null	Het
Wfdc16	A	T	2: 164,638,627		probably null	Het
Zbtb41	T	A	1: 139,424,057	Y303N	probably benign	Het
Zbtb5	T	C	4: 44,993,678	T569A	probably benign	Het
Zcchc11	T	C	4: 108,479,346	V89A	probably benign	Het
Zfp111	A	G	7: 24,198,600	S530P	possibly damaging	Het

Other mutations in Olfr1211

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02724:Olfr1211	APN	2	88929448	missense	probably damaging	1.00
IGL02936:Olfr1211	APN	2	88929784	missense	probably benign	0.01
IGL02960:Olfr1211	APN	2	88929784	missense	possibly damaging	0.80
IGL02989:Olfr1211	APN	2	88929704	missense	possibly damaging	0.72
R0193:Olfr1211	UTSW	2	88930283	missense	probably benign	0.01
R0413:Olfr1211	UTSW	2	88929562	missense	probably benign	0.16
R1644:Olfr1211	UTSW	2	88929387	missense	probably benign	0.01
R3715:Olfr1211	UTSW	2	88929413	missense	probably benign	0.07
R4019:Olfr1211	UTSW	2	88929736	missense	probably benign	0.02
R4722:Olfr1211	UTSW	2	88929980	missense	possibly damaging	0.91
R4751:Olfr1211	UTSW	2	88929914	missense	probably damaging	1.00
R4859:Olfr1211	UTSW	2	88930283	missense	probably benign	0.01
R5053:Olfr1211	UTSW	2	88930253	missense	probably benign	0.02
R6148:Olfr1211	UTSW	2	88930253	missense	probably benign	0.00
R7064:Olfr1211	UTSW	2	88929509	missense	probably benign	0.00
R7527:Olfr1211	UTSW	2	88930090	missense	probably benign	0.00
R7989:Olfr1211	UTSW	2	88929514	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TCGCCCTTCAGAACTGTGAG -3'
(R):5'- AGTTATTTGCTGAGCACTTCCTTG -3'

Sequencing Primer
(F):5'- CCTTCAGAACTGTGAGCTTTCAGAG -3'
(R):5'- CACTTCCTTGCAGCAGTAGAAGTG -3'

Posted On

2019-10-24