Mutagenetix > Incidental Mutation

Incidental Mutation 'R7584:Ank2'

586951

Institutional Source

Beutler Lab

Gene Symbol

Ank2

Ensembl Gene

ENSMUSG00000032826

Gene Name

ankyrin 2, brain

Synonyms

Gm4392, Ank-2, ankyrin B, Ankyrin-B, Ankyrin-2

MMRRC Submission

045667-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7584 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

126715261-127292999 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 126739777 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 2036 (Q2036*)

Ref Sequence

ENSEMBL: ENSMUSP00000138620 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044443] [ENSMUST00000182064] [ENSMUST00000182078]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000044443

SMART Domains

Protein: ENSMUSP00000043765
Gene: ENSMUSG00000032826

Domain	Start	End	E-Value	Type
low complexity region	9	22	N/A	INTRINSIC
low complexity region	57	69	N/A	INTRINSIC
ZU5	128	232	4.13e-61	SMART
Pfam:ZU5	289	374	2.8e-8	PFAM
low complexity region	587	597	N/A	INTRINSIC
DEATH	603	697	1.52e-27	SMART
low complexity region	732	748	N/A	INTRINSIC
low complexity region	860	873	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182025

Predicted Effect

probably benign
Transcript: ENSMUST00000182062

Predicted Effect

probably null
Transcript: ENSMUST00000182064
AA Change: Q2036*

SMART Domains

Protein: ENSMUSP00000138620
Gene: ENSMUSG00000032826
AA Change: Q2036*

Domain	Start	End	E-Value	Type
ANK	9	38	1e1	SMART
ANK	42	71	8.9e-7	SMART
ANK	75	104	4.4e-9	SMART
ANK	108	137	2.8e-9	SMART
ANK	141	169	5.3e-1	SMART
ANK	170	199	7.3e-1	SMART
ANK	211	240	1.1e-7	SMART
ANK	244	273	4.4e-9	SMART
ANK	277	306	9.3e-8	SMART
ANK	310	339	2.1e-8	SMART
ANK	343	372	1.3e-7	SMART
ANK	376	405	6.2e-9	SMART
ANK	409	438	1.1e-7	SMART
ANK	442	471	2.9e-8	SMART
ANK	475	504	1.1e-5	SMART
ANK	508	537	6.5e-6	SMART
ANK	541	570	2.3e-7	SMART
ANK	574	603	2.4e-7	SMART
ANK	607	636	3.2e-9	SMART
ANK	640	669	5.5e-5	SMART
ANK	673	702	1.9e-8	SMART
ANK	706	735	3.3e-9	SMART
low complexity region	755	775	N/A	INTRINSIC
low complexity region	793	806	N/A	INTRINSIC
low complexity region	841	853	N/A	INTRINSIC
ZU5	912	1016	2e-63	SMART
low complexity region	1371	1381	N/A	INTRINSIC
low complexity region	1448	1463	N/A	INTRINSIC
low complexity region	1490	1503	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000182078
AA Change: Q1949*

SMART Domains

Protein: ENSMUSP00000138753
Gene: ENSMUSG00000032826
AA Change: Q1949*

Domain	Start	End	E-Value	Type
low complexity region	7	18	N/A	INTRINSIC
low complexity region	114	125	N/A	INTRINSIC
low complexity region	191	209	N/A	INTRINSIC
low complexity region	304	312	N/A	INTRINSIC
low complexity region	478	493	N/A	INTRINSIC
low complexity region	527	544	N/A	INTRINSIC
DEATH	591	685	1e-29	SMART
low complexity region	720	736	N/A	INTRINSIC
low complexity region	848	861	N/A	INTRINSIC

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

99% (74/75)

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	A	G	17: 46,626,304 (GRCm39)		probably null	Het
Actrt3	T	C	3: 30,652,356 (GRCm39)	K246R	probably benign	Het
Adam23	T	A	1: 63,584,621 (GRCm39)	V343D	probably damaging	Het
Ak2	T	C	4: 128,893,005 (GRCm39)	S55P	probably damaging	Het
Ano10	A	G	9: 122,104,597 (GRCm39)	I40T	probably benign	Het
Aoc2	T	A	11: 101,217,005 (GRCm39)	C363S	possibly damaging	Het
Aplp2	A	T	9: 31,069,077 (GRCm39)	V584E	possibly damaging	Het
Arhgap32	A	T	9: 32,168,263 (GRCm39)	T749S	probably benign	Het
Atm	A	T	9: 53,424,427 (GRCm39)	F625I	probably damaging	Het
Atr	T	C	9: 95,824,766 (GRCm39)	L2387P	probably damaging	Het
Barhl1	C	T	2: 28,799,803 (GRCm39)	G274D	probably damaging	Het
Bcl2a1a	A	T	9: 88,839,345 (GRCm39)	D81V	probably damaging	Het
Ccdc63	T	G	5: 122,251,267 (GRCm39)	D381A	possibly damaging	Het
Col12a1	A	G	9: 79,610,578 (GRCm39)		probably null	Het
Crat	C	T	2: 30,294,577 (GRCm39)	R497Q	probably benign	Het
Cyp4b1	T	A	4: 115,485,884 (GRCm39)	D351V	probably damaging	Het
D130043K22Rik	A	G	13: 25,056,353 (GRCm39)	S562G	probably damaging	Het
Dgkb	T	A	12: 38,189,391 (GRCm39)		probably null	Het
Dmbt1	C	T	7: 130,690,481 (GRCm39)	Q905*	probably null	Het
Dnajc21	A	C	15: 10,462,381 (GRCm39)	Y81*	probably null	Het
Dnali1	T	C	4: 124,959,331 (GRCm39)	T21A	probably benign	Het
Dpp8	A	T	9: 64,986,064 (GRCm39)	L851F	probably damaging	Het
Dpt	T	C	1: 164,646,477 (GRCm39)	Y149H	probably benign	Het
Ep300	T	C	15: 81,512,627 (GRCm39)	V983A	unknown	Het
Faf1	C	T	4: 109,783,154 (GRCm39)	R549C	probably damaging	Het
Gcm1	A	G	9: 77,971,749 (GRCm39)	N230S	possibly damaging	Het
Gm10803	T	A	2: 93,394,513 (GRCm39)	I95N	probably damaging	Het
Hectd4	T	A	5: 121,456,798 (GRCm39)	I721N	possibly damaging	Het
Hsp90ab1	T	C	17: 45,881,197 (GRCm39)	H315R	probably damaging	Het
Igkv10-95	T	A	6: 68,657,740 (GRCm39)	S85R	possibly damaging	Het
Katnip	G	T	7: 125,469,838 (GRCm39)	V1436L	probably damaging	Het
Kcnq5	T	C	1: 21,472,545 (GRCm39)	T901A	probably benign	Het
Kremen1	C	T	11: 5,144,964 (GRCm39)	V471M	possibly damaging	Het
Lama2	C	A	10: 26,980,257 (GRCm39)	D1853Y	possibly damaging	Het
Lrif1	A	G	3: 106,639,217 (GRCm39)	T76A	probably benign	Het
Lrrtm2	T	A	18: 35,345,818 (GRCm39)	I495F	possibly damaging	Het
Ltbr	G	T	6: 125,284,204 (GRCm39)	Q413K	probably benign	Het
Ms4a20	A	G	19: 11,087,725 (GRCm39)	F69L	possibly damaging	Het
Myrfl	T	A	10: 116,664,902 (GRCm39)	Y376F	probably damaging	Het
Nup50l	A	C	6: 96,142,373 (GRCm39)	L224V	probably benign	Het
Nup98	G	T	7: 101,825,596 (GRCm39)	N414K	probably benign	Het
Nynrin	A	G	14: 56,109,041 (GRCm39)	T1383A	probably damaging	Het
Or4c15	G	A	2: 88,760,149 (GRCm39)	P170L	probably damaging	Het
Or5j1	A	T	2: 86,879,478 (GRCm39)	I34N	probably benign	Het
Or6c208	T	A	10: 129,223,901 (GRCm39)	I133N	probably damaging	Het
Or7g27	C	A	9: 19,250,569 (GRCm39)	T271K	possibly damaging	Het
Or8b1d	G	T	9: 38,558,191 (GRCm39)	P210T	possibly damaging	Het
Pcdhb5	T	A	18: 37,455,425 (GRCm39)	S602T	possibly damaging	Het
Sall3	A	G	18: 81,017,745 (GRCm39)	F61S	probably benign	Het
Scube1	G	T	15: 83,606,088 (GRCm39)	C61*	probably null	Het
Sec31b	T	C	19: 44,519,995 (GRCm39)		probably null	Het
Sec31b	T	C	19: 44,531,762 (GRCm39)	D49G	probably damaging	Het
Skic2	A	G	17: 35,060,651 (GRCm39)	I822T	possibly damaging	Het
Slc19a3	C	T	1: 83,000,469 (GRCm39)	V183M	possibly damaging	Het
Slc41a2	T	C	10: 83,152,653 (GRCm39)		probably benign	Het
Sphk2	C	A	7: 45,361,931 (GRCm39)	V169L	probably damaging	Het
Synpo	C	A	18: 60,729,349 (GRCm39)	R951L	probably damaging	Het
Tbc1d9b	G	A	11: 50,061,543 (GRCm39)	C1017Y	probably damaging	Het
Tmtc4	C	A	14: 123,215,563 (GRCm39)	V28F	probably benign	Het
Tprkb	A	G	6: 85,905,809 (GRCm39)	I165V	probably benign	Het
Ttc23l	T	A	15: 10,533,794 (GRCm39)	I250F	probably damaging	Het
Tut4	T	C	4: 108,336,543 (GRCm39)	V89A	probably benign	Het
Ubr3	G	A	2: 69,821,847 (GRCm39)	V1370I	probably damaging	Het
Ush2a	A	G	1: 188,460,306 (GRCm39)		probably null	Het
Usp9y	T	C	Y: 1,384,451 (GRCm39)	Y689C	probably damaging	Het
Vmn1r56	A	T	7: 5,198,895 (GRCm39)	Y241N	probably damaging	Het
Vmn2r6	T	C	3: 64,472,683 (GRCm39)	T13A	probably benign	Het
Vmn2r92	T	A	17: 18,387,028 (GRCm39)	N122K	probably benign	Het
Vps9d1	A	G	8: 123,977,456 (GRCm39)	F131S	probably damaging	Het
Vwa8	A	C	14: 79,219,674 (GRCm39)		probably null	Het
Wfdc16	A	T	2: 164,480,547 (GRCm39)		probably null	Het
Zbtb41	T	A	1: 139,351,795 (GRCm39)	Y303N	probably benign	Het
Zbtb5	T	C	4: 44,993,678 (GRCm39)	T569A	probably benign	Het
Zfp111	A	G	7: 23,898,025 (GRCm39)	S530P	possibly damaging	Het

Other mutations in Ank2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01298:Ank2	APN	3	126,753,369 (GRCm39)	missense	possibly damaging	0.80
IGL01652:Ank2	APN	3	126,726,690 (GRCm39)	missense	probably benign	0.00
IGL01969:Ank2	APN	3	126,746,872 (GRCm39)	missense	possibly damaging	0.47
IGL02122:Ank2	APN	3	126,731,523 (GRCm39)	splice site	probably benign
IGL02537:Ank2	APN	3	126,749,565 (GRCm39)	missense	probably damaging	1.00
IGL02858:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL02981:Ank2	APN	3	126,728,211 (GRCm39)	missense	possibly damaging	0.58
IGL02981:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03024:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03074:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03111:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03129:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03174:Ank2	APN	3	126,733,744 (GRCm39)	missense	probably damaging	0.98
IGL03177:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03185:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03188:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03242:Ank2	APN	3	126,722,454 (GRCm39)	missense	possibly damaging	0.90
IGL03244:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03248:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03285:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03304:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03358:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03380:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03389:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03400:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03409:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
ballast	UTSW	3	126,736,782 (GRCm39)	missense	unknown
Chain	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
Deadman	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
drag	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
mooring	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
Treasure	UTSW	3	126,740,398 (GRCm39)	missense	unknown
Windlass	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R0033:Ank2	UTSW	3	126,898,397 (GRCm39)	splice site	probably benign
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0079:Ank2	UTSW	3	126,728,264 (GRCm39)	missense	probably benign	0.01
R0423:Ank2	UTSW	3	126,723,509 (GRCm39)	nonsense	probably null
R0699:Ank2	UTSW	3	126,723,478 (GRCm39)	missense	probably benign	0.00
R0724:Ank2	UTSW	3	126,755,986 (GRCm39)	missense	probably damaging	1.00
R0990:Ank2	UTSW	3	126,728,315 (GRCm39)	missense	possibly damaging	0.64
R1450:Ank2	UTSW	3	126,750,951 (GRCm39)	missense	possibly damaging	0.94
R1500:Ank2	UTSW	3	126,726,631 (GRCm39)	missense	probably benign
R1702:Ank2	UTSW	3	126,749,548 (GRCm39)	missense	probably benign	0.00
R1703:Ank2	UTSW	3	126,723,415 (GRCm39)	missense	probably damaging	1.00
R1710:Ank2	UTSW	3	126,726,709 (GRCm39)	nonsense	probably null
R1743:Ank2	UTSW	3	126,722,324 (GRCm39)	missense	probably damaging	0.99
R1775:Ank2	UTSW	3	126,728,196 (GRCm39)	missense	probably benign	0.00
R1852:Ank2	UTSW	3	126,791,500 (GRCm39)	critical splice donor site	probably null
R2198:Ank2	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
R2892:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2893:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2894:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R3148:Ank2	UTSW	3	126,726,724 (GRCm39)	missense	probably benign	0.00
R3776:Ank2	UTSW	3	126,735,911 (GRCm39)	intron	probably benign
R3784:Ank2	UTSW	3	126,746,842 (GRCm39)	missense	probably damaging	1.00
R3856:Ank2	UTSW	3	126,723,493 (GRCm39)	missense	probably benign	0.00
R3906:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3907:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3953:Ank2	UTSW	3	126,781,809 (GRCm39)	missense	probably damaging	1.00
R3963:Ank2	UTSW	3	126,728,245 (GRCm39)	missense	probably benign
R4367:Ank2	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R4414:Ank2	UTSW	3	127,019,411 (GRCm39)	critical splice donor site	probably null
R4432:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4433:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4579:Ank2	UTSW	3	126,752,612 (GRCm39)	missense	probably damaging	1.00
R4597:Ank2	UTSW	3	126,781,800 (GRCm39)	missense	probably damaging	1.00
R4603:Ank2	UTSW	3	126,825,665 (GRCm39)	missense	probably benign	0.00
R4729:Ank2	UTSW	3	126,770,545 (GRCm39)	nonsense	probably null
R4815:Ank2	UTSW	3	126,730,410 (GRCm39)	missense	probably benign
R4826:Ank2	UTSW	3	126,749,650 (GRCm39)	missense	probably benign	0.35
R4871:Ank2	UTSW	3	126,753,444 (GRCm39)	missense	probably damaging	1.00
R4880:Ank2	UTSW	3	126,840,475 (GRCm39)	splice site	probably null
R4915:Ank2	UTSW	3	126,736,320 (GRCm39)	intron	probably benign
R4935:Ank2	UTSW	3	126,749,713 (GRCm39)	missense	probably damaging	1.00
R4936:Ank2	UTSW	3	126,748,688 (GRCm39)	missense	possibly damaging	0.94
R4937:Ank2	UTSW	3	126,756,050 (GRCm39)	missense	probably damaging	1.00
R4946:Ank2	UTSW	3	126,735,589 (GRCm39)	intron	probably benign
R4963:Ank2	UTSW	3	126,825,745 (GRCm39)	missense	probably benign	0.01
R4989:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5023:Ank2	UTSW	3	126,735,520 (GRCm39)	intron	probably benign
R5060:Ank2	UTSW	3	126,739,570 (GRCm39)	intron	probably benign
R5078:Ank2	UTSW	3	126,736,002 (GRCm39)	intron	probably benign
R5086:Ank2	UTSW	3	126,740,997 (GRCm39)	intron	probably benign
R5134:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5148:Ank2	UTSW	3	126,819,285 (GRCm39)	splice site	probably null
R5175:Ank2	UTSW	3	126,797,673 (GRCm39)	missense	probably damaging	1.00
R5275:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5295:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5303:Ank2	UTSW	3	126,739,453 (GRCm39)	intron	probably benign
R5309:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5312:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5352:Ank2	UTSW	3	127,292,640 (GRCm39)	utr 5 prime	probably benign
R5355:Ank2	UTSW	3	126,737,698 (GRCm39)	intron	probably benign
R5386:Ank2	UTSW	3	126,775,582 (GRCm39)	missense	probably benign	0.01
R5396:Ank2	UTSW	3	126,746,875 (GRCm39)	missense	probably damaging	1.00
R5518:Ank2	UTSW	3	126,753,348 (GRCm39)	missense	probably damaging	0.98
R5534:Ank2	UTSW	3	126,740,947 (GRCm39)	intron	probably benign
R5554:Ank2	UTSW	3	126,792,622 (GRCm39)	missense	possibly damaging	0.78
R5582:Ank2	UTSW	3	126,739,954 (GRCm39)	intron	probably benign
R5747:Ank2	UTSW	3	126,735,400 (GRCm39)	intron	probably benign
R5794:Ank2	UTSW	3	126,723,669 (GRCm39)	missense	probably benign	0.00
R5831:Ank2	UTSW	3	127,132,808 (GRCm39)	start gained	probably benign
R5925:Ank2	UTSW	3	126,726,612 (GRCm39)	missense	probably benign	0.18
R5954:Ank2	UTSW	3	126,791,510 (GRCm39)	missense	probably benign	0.34
R5956:Ank2	UTSW	3	126,736,337 (GRCm39)	intron	probably benign
R5986:Ank2	UTSW	3	126,806,335 (GRCm39)	missense	possibly damaging	0.94
R5992:Ank2	UTSW	3	126,753,300 (GRCm39)	critical splice donor site	probably null
R6020:Ank2	UTSW	3	126,740,470 (GRCm39)	intron	probably benign
R6027:Ank2	UTSW	3	126,791,528 (GRCm39)	missense	possibly damaging	0.92
R6049:Ank2	UTSW	3	126,736,669 (GRCm39)	missense	possibly damaging	0.95
R6060:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
R6114:Ank2	UTSW	3	126,804,700 (GRCm39)	missense	probably damaging	1.00
R6124:Ank2	UTSW	3	127,041,800 (GRCm39)	missense	probably benign	0.31
R6156:Ank2	UTSW	3	126,737,886 (GRCm39)	missense	probably damaging	1.00
R6173:Ank2	UTSW	3	126,846,395 (GRCm39)	missense	probably damaging	1.00
R6176:Ank2	UTSW	3	126,739,120 (GRCm39)	missense	probably benign	0.05
R6184:Ank2	UTSW	3	126,756,047 (GRCm39)	missense	probably damaging	1.00
R6199:Ank2	UTSW	3	126,797,655 (GRCm39)	missense	probably damaging	1.00
R6241:Ank2	UTSW	3	126,846,397 (GRCm39)	missense	probably damaging	1.00
R6254:Ank2	UTSW	3	126,735,453 (GRCm39)	intron	probably benign
R6259:Ank2	UTSW	3	126,810,635 (GRCm39)	missense	probably benign	0.28
R6260:Ank2	UTSW	3	126,737,206 (GRCm39)	missense	probably benign
R6321:Ank2	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
R6393:Ank2	UTSW	3	126,723,406 (GRCm39)	missense	probably damaging	1.00
R6406:Ank2	UTSW	3	126,825,874 (GRCm39)	missense	probably damaging	1.00
R6544:Ank2	UTSW	3	126,726,871 (GRCm39)	missense	probably damaging	0.99
R6583:Ank2	UTSW	3	126,810,613 (GRCm39)	missense	probably damaging	1.00
R6739:Ank2	UTSW	3	126,873,643 (GRCm39)	missense	probably damaging	1.00
R6754:Ank2	UTSW	3	126,890,488 (GRCm39)	intron	probably benign
R6786:Ank2	UTSW	3	126,752,581 (GRCm39)	missense	probably damaging	0.99
R6798:Ank2	UTSW	3	126,737,913 (GRCm39)	intron	probably benign
R6882:Ank2	UTSW	3	126,739,406 (GRCm39)	intron	probably benign
R6940:Ank2	UTSW	3	126,735,621 (GRCm39)	intron	probably benign
R6949:Ank2	UTSW	3	126,804,533 (GRCm39)	missense	probably benign	0.00
R7001:Ank2	UTSW	3	126,871,230 (GRCm39)	missense	probably damaging	1.00
R7033:Ank2	UTSW	3	126,738,499 (GRCm39)	nonsense	probably null
R7036:Ank2	UTSW	3	126,740,041 (GRCm39)	intron	probably benign
R7045:Ank2	UTSW	3	126,806,393 (GRCm39)	missense	probably damaging	1.00
R7048:Ank2	UTSW	3	126,819,267 (GRCm39)	missense	probably benign	0.03
R7054:Ank2	UTSW	3	126,736,952 (GRCm39)	intron	probably benign
R7069:Ank2	UTSW	3	126,739,947 (GRCm39)	intron	probably benign
R7091:Ank2	UTSW	3	126,817,000 (GRCm39)	missense	probably damaging	0.98
R7107:Ank2	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
R7175:Ank2	UTSW	3	126,740,590 (GRCm39)	missense	unknown
R7191:Ank2	UTSW	3	126,740,041 (GRCm39)	missense	unknown
R7272:Ank2	UTSW	3	126,736,782 (GRCm39)	missense	unknown
R7381:Ank2	UTSW	3	126,730,277 (GRCm39)	missense	possibly damaging	0.46
R7394:Ank2	UTSW	3	126,730,302 (GRCm39)	missense	possibly damaging	0.77
R7462:Ank2	UTSW	3	126,736,683 (GRCm39)	missense	unknown
R7490:Ank2	UTSW	3	126,752,538 (GRCm39)	missense	probably damaging	0.99
R7514:Ank2	UTSW	3	126,819,252 (GRCm39)	missense	probably benign	0.06
R7534:Ank2	UTSW	3	126,727,982 (GRCm39)	splice site	probably null
R7540:Ank2	UTSW	3	126,781,808 (GRCm39)	missense	possibly damaging	0.94
R7547:Ank2	UTSW	3	126,738,852 (GRCm39)	missense	unknown
R7579:Ank2	UTSW	3	126,740,047 (GRCm39)	missense	unknown
R7625:Ank2	UTSW	3	126,846,449 (GRCm39)	missense	probably damaging	1.00
R7698:Ank2	UTSW	3	126,825,860 (GRCm39)	missense	probably benign	0.35
R7716:Ank2	UTSW	3	126,736,815 (GRCm39)	missense	unknown
R7718:Ank2	UTSW	3	126,758,662 (GRCm39)	missense	possibly damaging	0.88
R7722:Ank2	UTSW	3	126,822,951 (GRCm39)	missense	probably benign	0.01
R7738:Ank2	UTSW	3	126,741,271 (GRCm39)	missense
R7977:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R7987:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R8007:Ank2	UTSW	3	126,730,096 (GRCm39)	intron	probably benign
R8150:Ank2	UTSW	3	126,741,162 (GRCm39)	missense
R8161:Ank2	UTSW	3	126,825,778 (GRCm39)	missense
R8196:Ank2	UTSW	3	126,723,532 (GRCm39)	missense	probably damaging	0.99
R8248:Ank2	UTSW	3	126,731,434 (GRCm39)	missense	possibly damaging	0.78
R8255:Ank2	UTSW	3	126,740,398 (GRCm39)	missense	unknown
R8279:Ank2	UTSW	3	126,726,820 (GRCm39)	missense	probably benign	0.04
R8300:Ank2	UTSW	3	126,804,555 (GRCm39)	missense
R8716:Ank2	UTSW	3	126,736,488 (GRCm39)	nonsense	probably null
R8724:Ank2	UTSW	3	126,737,405 (GRCm39)	missense	unknown
R8765:Ank2	UTSW	3	126,850,731 (GRCm39)	missense	possibly damaging	0.94
R8779:Ank2	UTSW	3	126,758,751 (GRCm39)	missense	probably damaging	0.99
R8783:Ank2	UTSW	3	126,846,455 (GRCm39)	missense	probably damaging	1.00
R8785:Ank2	UTSW	3	126,791,570 (GRCm39)	missense	probably damaging	1.00
R8826:Ank2	UTSW	3	126,740,951 (GRCm39)	missense	unknown
R8872:Ank2	UTSW	3	126,791,525 (GRCm39)	missense	possibly damaging	0.88
R8903:Ank2	UTSW	3	126,840,431 (GRCm39)	missense	probably damaging	1.00
R8906:Ank2	UTSW	3	126,726,720 (GRCm39)	missense	probably benign	0.00
R8918:Ank2	UTSW	3	126,737,380 (GRCm39)	missense	unknown
R8947:Ank2	UTSW	3	126,736,396 (GRCm39)	intron	probably benign
R8977:Ank2	UTSW	3	126,738,575 (GRCm39)	missense	unknown
R8990:Ank2	UTSW	3	126,841,829 (GRCm39)	critical splice donor site	probably null
R8994:Ank2	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
R9009:Ank2	UTSW	3	126,728,025 (GRCm39)	unclassified	probably benign
R9123:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9125:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9130:Ank2	UTSW	3	126,810,565 (GRCm39)	missense
R9175:Ank2	UTSW	3	126,722,402 (GRCm39)	missense	possibly damaging	0.52
R9220:Ank2	UTSW	3	126,737,086 (GRCm39)	missense	unknown
R9225:Ank2	UTSW	3	126,736,111 (GRCm39)	missense	unknown
R9286:Ank2	UTSW	3	126,846,381 (GRCm39)	missense	probably damaging	0.99
R9325:Ank2	UTSW	3	126,775,504 (GRCm39)	missense	probably damaging	0.98
R9367:Ank2	UTSW	3	126,738,678 (GRCm39)	missense	unknown
R9385:Ank2	UTSW	3	126,753,366 (GRCm39)	missense	probably benign	0.00
R9391:Ank2	UTSW	3	126,731,394 (GRCm39)	missense	probably damaging	0.99
R9422:Ank2	UTSW	3	126,890,505 (GRCm39)	missense	unknown
R9536:Ank2	UTSW	3	126,736,031 (GRCm39)	missense	unknown
R9647:Ank2	UTSW	3	126,792,623 (GRCm39)	missense	possibly damaging	0.93
R9650:Ank2	UTSW	3	126,735,829 (GRCm39)	missense	unknown
R9666:Ank2	UTSW	3	126,726,838 (GRCm39)	nonsense	probably null
R9686:Ank2	UTSW	3	126,740,550 (GRCm39)	missense	unknown
R9730:Ank2	UTSW	3	127,019,493 (GRCm39)	missense
R9738:Ank2	UTSW	3	126,737,121 (GRCm39)	missense	unknown
R9743:Ank2	UTSW	3	126,733,794 (GRCm39)	missense	possibly damaging	0.81
R9747:Ank2	UTSW	3	126,752,667 (GRCm39)	missense	probably damaging	1.00
R9800:Ank2	UTSW	3	126,740,149 (GRCm39)	missense	unknown
R9803:Ank2	UTSW	3	126,752,726 (GRCm39)	missense	possibly damaging	0.64
RF020:Ank2	UTSW	3	126,739,125 (GRCm39)	missense	unknown
Z1088:Ank2	UTSW	3	126,823,158 (GRCm39)	missense	possibly damaging	0.45
Z1177:Ank2	UTSW	3	126,738,006 (GRCm39)	missense	unknown
Z1187:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1190:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1192:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTGATGGAACTACCTCGGG -3'
(R):5'- TCTCCTGGGAAGACAGAAAAGC -3'

Sequencing Primer
(F):5'- ACTACCTCGGGTGTTTTAATAATGG -3'
(R):5'- TCCAAAACCGAACGAATTGAGG -3'

Posted On

2019-10-24