Incidental Mutation 'R7585:Lrp4'
| ID |
587020 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
045635-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.781)
|
| Stock # |
R7585 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 91322933 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 1139
(Y1139C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028689
AA Change: Y1139C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: Y1139C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700034J05Rik |
T |
C |
6: 146,854,851 (GRCm39) |
T64A |
probably benign |
Het |
| A930009A15Rik |
T |
A |
10: 115,414,230 (GRCm39) |
V52D |
unknown |
Het |
| Aadacl2fm2 |
C |
A |
3: 59,651,143 (GRCm39) |
D88E |
possibly damaging |
Het |
| Acacb |
A |
G |
5: 114,384,073 (GRCm39) |
I2201V |
probably damaging |
Het |
| Aco2 |
A |
C |
15: 81,756,685 (GRCm39) |
|
probably benign |
Het |
| Acod1 |
C |
T |
14: 103,292,177 (GRCm39) |
Q234* |
probably null |
Het |
| Actr6 |
T |
C |
10: 89,561,658 (GRCm39) |
S163G |
probably benign |
Het |
| Agmat |
T |
C |
4: 141,477,056 (GRCm39) |
V154A |
probably benign |
Het |
| Agrn |
T |
C |
4: 156,255,131 (GRCm39) |
N1584S |
probably benign |
Het |
| Alg6 |
A |
T |
4: 99,626,371 (GRCm39) |
S60C |
probably damaging |
Het |
| Ap5s1 |
T |
C |
2: 131,054,482 (GRCm39) |
F98L |
probably damaging |
Het |
| Atp6v1f |
G |
A |
6: 29,467,927 (GRCm39) |
V38I |
possibly damaging |
Het |
| B3gnt3 |
T |
C |
8: 72,145,972 (GRCm39) |
T186A |
probably damaging |
Het |
| Brpf1 |
T |
C |
6: 113,292,007 (GRCm39) |
V351A |
possibly damaging |
Het |
| Cacna1g |
A |
G |
11: 94,364,368 (GRCm39) |
S26P |
probably benign |
Het |
| Camta1 |
G |
A |
4: 151,229,287 (GRCm39) |
S515L |
probably damaging |
Het |
| Ccdc122 |
C |
A |
14: 77,329,139 (GRCm39) |
A64E |
probably damaging |
Het |
| Ccdc89 |
C |
A |
7: 90,076,510 (GRCm39) |
T240K |
possibly damaging |
Het |
| Cercam |
T |
C |
2: 29,771,743 (GRCm39) |
L521P |
probably damaging |
Het |
| Cfb |
T |
C |
17: 35,076,737 (GRCm39) |
N561S |
probably benign |
Het |
| Clk3 |
T |
C |
9: 57,669,119 (GRCm39) |
E159G |
probably damaging |
Het |
| Cntf |
A |
T |
19: 12,741,587 (GRCm39) |
L91* |
probably null |
Het |
| Cntn4 |
T |
A |
6: 106,466,572 (GRCm39) |
I158N |
probably damaging |
Het |
| Cog5 |
T |
A |
12: 31,810,888 (GRCm39) |
I194K |
probably damaging |
Het |
| Col22a1 |
T |
A |
15: 71,764,054 (GRCm39) |
D66V |
probably damaging |
Het |
| Crat |
C |
T |
2: 30,294,577 (GRCm39) |
R497Q |
probably benign |
Het |
| Csmd3 |
T |
C |
15: 48,485,471 (GRCm39) |
T145A |
possibly damaging |
Het |
| D130043K22Rik |
A |
G |
13: 25,069,568 (GRCm39) |
I876V |
probably benign |
Het |
| Dlec1 |
T |
C |
9: 118,971,819 (GRCm39) |
S1335P |
probably benign |
Het |
| Dnah5 |
A |
T |
15: 28,402,014 (GRCm39) |
T3392S |
probably benign |
Het |
| Dnal1 |
A |
G |
12: 84,171,267 (GRCm39) |
K21E |
probably benign |
Het |
| Dspp |
T |
C |
5: 104,323,391 (GRCm39) |
V178A |
possibly damaging |
Het |
| Dst |
A |
G |
1: 34,153,096 (GRCm39) |
D119G |
possibly damaging |
Het |
| Dyrk4 |
T |
A |
6: 126,867,007 (GRCm39) |
I342F |
probably damaging |
Het |
| Eif3b |
A |
G |
5: 140,425,757 (GRCm39) |
D649G |
probably damaging |
Het |
| Exoc7 |
T |
C |
11: 116,191,124 (GRCm39) |
D259G |
probably benign |
Het |
| Fancm |
T |
C |
12: 65,153,021 (GRCm39) |
V1159A |
possibly damaging |
Het |
| Fat3 |
T |
C |
9: 15,909,558 (GRCm39) |
D2148G |
probably benign |
Het |
| Fdps |
C |
A |
3: 89,001,113 (GRCm39) |
R300L |
probably benign |
Het |
| Gfm2 |
T |
C |
13: 97,315,540 (GRCm39) |
L736P |
probably benign |
Het |
| Grin2b |
T |
A |
6: 135,756,301 (GRCm39) |
T475S |
probably damaging |
Het |
| H2-M3 |
T |
G |
17: 37,581,599 (GRCm39) |
L87R |
probably damaging |
Het |
| Hao1 |
T |
A |
2: 134,343,076 (GRCm39) |
I272F |
probably damaging |
Het |
| Hapln2 |
C |
T |
3: 87,929,980 (GRCm39) |
G299S |
probably damaging |
Het |
| Hdac3 |
A |
T |
18: 38,078,408 (GRCm39) |
I154N |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,352,829 (GRCm39) |
D2105G |
probably damaging |
Het |
| Kcna2 |
T |
C |
3: 107,012,658 (GRCm39) |
F413S |
probably damaging |
Het |
| Kctd13 |
A |
G |
7: 126,528,458 (GRCm39) |
T78A |
possibly damaging |
Het |
| Kif20a |
A |
G |
18: 34,758,591 (GRCm39) |
D20G |
probably benign |
Het |
| Kif26b |
A |
T |
1: 178,744,061 (GRCm39) |
I1386F |
probably benign |
Het |
| Klc4 |
T |
A |
17: 46,942,810 (GRCm39) |
M585L |
probably benign |
Het |
| Lrp5 |
A |
T |
19: 3,654,094 (GRCm39) |
I1111N |
possibly damaging |
Het |
| Lrriq1 |
A |
T |
10: 103,050,807 (GRCm39) |
D648E |
possibly damaging |
Het |
| Mmp2 |
G |
A |
8: 93,563,564 (GRCm39) |
G346D |
probably damaging |
Het |
| Mrgpra4 |
T |
A |
7: 47,631,377 (GRCm39) |
I75L |
probably benign |
Het |
| Muc4 |
T |
A |
16: 32,586,076 (GRCm39) |
V537D |
|
Het |
| Myh2 |
T |
A |
11: 67,070,237 (GRCm39) |
|
probably null |
Het |
| Myrf |
T |
C |
19: 10,194,091 (GRCm39) |
T487A |
probably damaging |
Het |
| Nalcn |
A |
T |
14: 123,753,050 (GRCm39) |
L312H |
probably damaging |
Het |
| Nop14 |
G |
A |
5: 34,802,124 (GRCm39) |
P560L |
probably damaging |
Het |
| Nufip1 |
C |
G |
14: 76,348,427 (GRCm39) |
P19A |
probably benign |
Het |
| Oosp3 |
G |
T |
19: 11,678,322 (GRCm39) |
M99I |
probably benign |
Het |
| Or14c40 |
T |
C |
7: 86,313,880 (GRCm39) |
*337Q |
probably null |
Het |
| Or4c52 |
A |
T |
2: 89,845,393 (GRCm39) |
I40F |
probably damaging |
Het |
| Or4x13 |
T |
A |
2: 90,231,367 (GRCm39) |
Y121N |
probably damaging |
Het |
| Or51aa5 |
C |
A |
7: 103,167,166 (GRCm39) |
V142L |
possibly damaging |
Het |
| Or51k2 |
A |
G |
7: 103,596,607 (GRCm39) |
N278S |
probably benign |
Het |
| Or52n4b |
C |
A |
7: 108,144,598 (GRCm39) |
P289T |
probably damaging |
Het |
| Or6b2b |
A |
G |
1: 92,419,042 (GRCm39) |
V145A |
probably benign |
Het |
| Or7e175 |
T |
C |
9: 20,040,307 (GRCm39) |
|
|
Het |
| Panx2 |
A |
G |
15: 88,952,169 (GRCm39) |
K212R |
probably damaging |
Het |
| Paxip1 |
A |
C |
5: 27,977,002 (GRCm39) |
H353Q |
unknown |
Het |
| Pbx4 |
C |
A |
8: 70,285,475 (GRCm39) |
D39E |
probably damaging |
Het |
| Phc2 |
G |
A |
4: 128,604,932 (GRCm39) |
A223T |
probably benign |
Het |
| Plcl1 |
A |
G |
1: 55,445,608 (GRCm39) |
D21G |
probably benign |
Het |
| Plec |
G |
A |
15: 76,057,632 (GRCm39) |
R4102W |
probably damaging |
Het |
| Plekhh2 |
A |
G |
17: 84,884,608 (GRCm39) |
Y774C |
probably benign |
Het |
| Polr2a |
A |
T |
11: 69,630,828 (GRCm39) |
Y1197N |
probably damaging |
Het |
| Psmg4 |
A |
T |
13: 34,347,195 (GRCm39) |
H46L |
probably benign |
Het |
| Ptprk |
A |
G |
10: 28,436,084 (GRCm39) |
Y815C |
probably damaging |
Het |
| Qrich2 |
T |
C |
11: 116,346,547 (GRCm39) |
I1426V |
probably benign |
Het |
| Rbm43 |
T |
C |
2: 51,816,763 (GRCm39) |
D68G |
probably benign |
Het |
| Rgs6 |
T |
C |
12: 83,153,644 (GRCm39) |
S360P |
probably damaging |
Het |
| Rp1l1 |
T |
G |
14: 64,267,588 (GRCm39) |
L1058R |
probably damaging |
Het |
| Rreb1 |
A |
G |
13: 38,077,874 (GRCm39) |
S29G |
probably benign |
Het |
| Scube1 |
C |
A |
15: 83,522,988 (GRCm39) |
R284L |
possibly damaging |
Het |
| Serpinb9h |
G |
T |
13: 33,588,299 (GRCm39) |
D295Y |
probably benign |
Het |
| Slc13a3 |
T |
C |
2: 165,272,242 (GRCm39) |
Q267R |
probably benign |
Het |
| Slc49a3 |
T |
C |
5: 108,596,685 (GRCm39) |
T16A |
probably benign |
Het |
| Slc5a1 |
A |
T |
5: 33,318,288 (GRCm39) |
N647I |
probably damaging |
Het |
| Sphk2 |
A |
T |
7: 45,361,006 (GRCm39) |
S333T |
probably benign |
Het |
| Sptan1 |
A |
G |
2: 29,890,068 (GRCm39) |
D1050G |
probably benign |
Het |
| Tdo2 |
G |
T |
3: 81,870,065 (GRCm39) |
A269E |
probably damaging |
Het |
| Tnc |
A |
T |
4: 63,938,648 (GRCm39) |
C64S |
probably damaging |
Het |
| Trim47 |
T |
A |
11: 115,998,383 (GRCm39) |
E360D |
probably damaging |
Het |
| Trp53i13 |
T |
A |
11: 77,399,129 (GRCm39) |
T374S |
possibly damaging |
Het |
| Try5 |
A |
G |
6: 41,288,748 (GRCm39) |
L157P |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,578,176 (GRCm39) |
V24239D |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,773,667 (GRCm39) |
Y2318C |
unknown |
Het |
| Txn1 |
T |
C |
4: 57,945,199 (GRCm39) |
D68G |
possibly damaging |
Het |
| Upf3a |
A |
G |
8: 13,837,418 (GRCm39) |
D121G |
probably damaging |
Het |
| Vmn2r114 |
T |
C |
17: 23,510,239 (GRCm39) |
Y747C |
probably damaging |
Het |
| Vmn2r68 |
A |
G |
7: 84,881,587 (GRCm39) |
W498R |
probably damaging |
Het |
| Vwa8 |
A |
C |
14: 79,219,674 (GRCm39) |
|
probably null |
Het |
| Zp2 |
A |
T |
7: 119,733,167 (GRCm39) |
F591L |
probably damaging |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATGAGGACATCATCACTACAG -3'
(R):5'- CAGTGCTCCTATGCTTCATGG -3'
Sequencing Primer
(F):5'- ACTACAGGTGAGCCTTCCTC -3'
(R):5'- TTCACCTATCCATAGTCTCGGCTAAG -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation