Incidental Mutation 'R7589:Olfr1411'
ID587292
Institutional Source Beutler Lab
Gene Symbol Olfr1411
Ensembl Gene ENSMUSG00000062497
Gene Nameolfactory receptor 1411
SynonymsGA_x6K02T2R7CC-81157497-81156526, MOR208-3
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #R7589 (G1)
Quality Score225.009
Status Not validated
Chromosome1
Chromosomal Location92594411-92597753 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 92597059 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Histidine at position 180 (R180H)
Ref Sequence ENSEMBL: ENSMUSP00000140373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073748] [ENSMUST00000190844] [ENSMUST00000216444]
Predicted Effect probably benign
Transcript: ENSMUST00000073748
AA Change: R180H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: R180H

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.4e-53 PFAM
Pfam:7tm_1 48 297 1.2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190844
AA Change: R180H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000140373
Gene: ENSMUSG00000062497
AA Change: R180H

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
low complexity region 32 44 N/A INTRINSIC
Pfam:7tm_1 48 297 6.7e-25 PFAM
Pfam:7tm_4 146 290 2.9e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216444
AA Change: R180H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T G 7: 41,626,972 C700G probably damaging Het
4930486L24Rik T C 13: 60,842,933 K316E probably damaging Het
Akap6 A T 12: 53,142,063 K2087* probably null Het
Alpk2 A T 18: 65,300,073 H1320Q probably damaging Het
Aox1 A T 1: 58,041,484 R31W probably damaging Het
Asnsd1 G T 1: 53,347,967 A167E probably benign Het
Atg14 T C 14: 47,543,090 D409G probably benign Het
Atp13a3 T A 16: 30,344,615 E574D probably benign Het
Bicd1 A T 6: 149,513,667 Y626F possibly damaging Het
Cdc5l C T 17: 45,410,781 R521Q probably benign Het
Dglucy T C 12: 100,841,401 F160L probably damaging Het
Enpp5 G A 17: 44,085,264 G356S probably damaging Het
Fmo9 T A 1: 166,674,428 K209N possibly damaging Het
Gsdmc2 C A 15: 63,825,043 L426F probably damaging Het
Hip1 T C 5: 135,414,311 D956G probably benign Het
Kif28 C T 1: 179,731,400 V248I probably benign Het
Klk10 T C 7: 43,783,627 V149A probably benign Het
Krt40 G T 11: 99,540,157 N255K probably damaging Het
Map4k4 T A 1: 40,021,091 Y1013* probably null Het
Mcur1 T C 13: 43,551,625 Y185C probably damaging Het
Mzt1 T C 14: 99,036,512 probably null Het
Naip5 G T 13: 100,219,697 Q1137K not run Het
Naip5 T C 13: 100,219,696 Q1137R probably benign Het
Nkx1-2 T C 7: 132,599,475 I18V probably damaging Het
Ofcc1 T A 13: 40,255,484 Q155L probably benign Het
Olfr1239 A G 2: 89,418,380 V11A possibly damaging Het
Olfr1282 T C 2: 111,335,374 K235E probably damaging Het
Olfr1377 A T 11: 50,985,030 M110L probably damaging Het
Olfr635 T C 7: 103,979,791 Y200H probably damaging Het
Prnp A G 2: 131,936,866 D146G probably benign Het
Rhbdf1 C T 11: 32,212,903 V455I probably benign Het
Rnf6 G A 5: 146,211,429 R260W possibly damaging Het
Rtl1 T C 12: 109,593,845 N520S possibly damaging Het
Setbp1 A T 18: 78,856,492 M1320K probably benign Het
Slc39a8 A G 3: 135,884,362 T338A probably damaging Het
Tcf4 A G 18: 69,682,819 *693W probably null Het
Ttc8 A T 12: 98,976,437 D412V probably damaging Het
Ush2a G T 1: 188,542,849 A1840S probably benign Het
Vmn1r60 A T 7: 5,544,689 S137R Het
Vmn1r91 T A 7: 20,101,877 H240Q probably benign Het
Vmn2r107 A T 17: 20,375,372 H729L probably benign Het
Yme1l1 C T 2: 23,160,262 T35I probably benign Het
Zfp292 A G 4: 34,806,777 V2094A probably damaging Het
Zfp934 A T 13: 62,518,316 N202K Het
Other mutations in Olfr1411
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01382:Olfr1411 APN 1 92597200 missense possibly damaging 0.46
IGL02011:Olfr1411 APN 1 92596899 missense probably damaging 1.00
PIT4810001:Olfr1411 UTSW 1 92597154 missense probably benign 0.04
R2036:Olfr1411 UTSW 1 92596606 missense probably benign 0.19
R2044:Olfr1411 UTSW 1 92596969 missense probably benign 0.00
R4133:Olfr1411 UTSW 1 92596743 missense probably benign 0.09
R4406:Olfr1411 UTSW 1 92597314 missense possibly damaging 0.90
R4568:Olfr1411 UTSW 1 92597391 missense probably benign 0.09
R4701:Olfr1411 UTSW 1 92597438 missense probably benign 0.00
R4801:Olfr1411 UTSW 1 92596998 missense probably benign 0.01
R4802:Olfr1411 UTSW 1 92596998 missense probably benign 0.01
R6564:Olfr1411 UTSW 1 92596563 missense probably benign
R7082:Olfr1411 UTSW 1 92596418 start gained probably benign
R7349:Olfr1411 UTSW 1 92597182 missense possibly damaging 0.95
Z1177:Olfr1411 UTSW 1 92597266 missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTAGCTGTGATGGCCTATGACC -3'
(R):5'- ACAGCCATCATATGAGAGCC -3'

Sequencing Primer
(F):5'- ATGGCCTATGACCGTTTCATG -3'
(R):5'- TGGAGAAGACCTTGTGCCTC -3'
Posted On2019-10-24