Incidental Mutation 'R7589:Klk10'
ID 587308
Institutional Source Beutler Lab
Gene Symbol Klk10
Ensembl Gene ENSMUSG00000030693
Gene Name kallikrein related-peptidase 10
Synonyms 2300002A13Rik, PRSSL1, NES1
MMRRC Submission 045637-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R7589 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 43430478-43434834 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 43433051 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 149 (V149A)
Ref Sequence ENSEMBL: ENSMUSP00000014058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014058] [ENSMUST00000080211] [ENSMUST00000171458]
AlphaFold Q99M20
Predicted Effect probably benign
Transcript: ENSMUST00000014058
AA Change: V149A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000014058
Gene: ENSMUSG00000030693
AA Change: V149A

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Tryp_SPc 46 271 1.35e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080211
SMART Domains Protein: ENSMUSP00000079101
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
low complexity region 22 37 N/A INTRINSIC
Tryp_SPc 47 269 5.14e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171458
SMART Domains Protein: ENSMUSP00000132721
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Tryp_SPc 20 242 5.14e-95 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T G 7: 41,276,396 (GRCm39) C700G probably damaging Het
4930486L24Rik T C 13: 60,990,747 (GRCm39) K316E probably damaging Het
Akap6 A T 12: 53,188,846 (GRCm39) K2087* probably null Het
Alpk2 A T 18: 65,433,144 (GRCm39) H1320Q probably damaging Het
Aox1 A T 1: 58,080,643 (GRCm39) R31W probably damaging Het
Asnsd1 G T 1: 53,387,126 (GRCm39) A167E probably benign Het
Atg14 T C 14: 47,780,547 (GRCm39) D409G probably benign Het
Atp13a3 T A 16: 30,163,433 (GRCm39) E574D probably benign Het
Bicd1 A T 6: 149,415,165 (GRCm39) Y626F possibly damaging Het
Cdc5l C T 17: 45,721,707 (GRCm39) R521Q probably benign Het
Dglucy T C 12: 100,807,660 (GRCm39) F160L probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Fmo9 T A 1: 166,501,997 (GRCm39) K209N possibly damaging Het
Gsdmc2 C A 15: 63,696,892 (GRCm39) L426F probably damaging Het
Hip1 T C 5: 135,443,165 (GRCm39) D956G probably benign Het
Kif28 C T 1: 179,558,965 (GRCm39) V248I probably benign Het
Krt40 G T 11: 99,430,983 (GRCm39) N255K probably damaging Het
Map4k4 T A 1: 40,060,251 (GRCm39) Y1013* probably null Het
Mcur1 T C 13: 43,705,101 (GRCm39) Y185C probably damaging Het
Mzt1 T C 14: 99,273,948 (GRCm39) probably null Het
Naip5 T C 13: 100,356,204 (GRCm39) Q1137R probably benign Het
Naip5 G T 13: 100,356,205 (GRCm39) Q1137K not run Het
Nkx1-2 T C 7: 132,201,204 (GRCm39) I18V probably damaging Het
Ofcc1 T A 13: 40,408,960 (GRCm39) Q155L probably benign Het
Or1ad1 A T 11: 50,875,857 (GRCm39) M110L probably damaging Het
Or4a2 A G 2: 89,248,724 (GRCm39) V11A possibly damaging Het
Or4k38 T C 2: 111,165,719 (GRCm39) K235E probably damaging Het
Or51q1 T C 7: 103,628,998 (GRCm39) Y200H probably damaging Het
Or9s15 G A 1: 92,524,781 (GRCm39) R180H probably benign Het
Prnp A G 2: 131,778,786 (GRCm39) D146G probably benign Het
Rhbdf1 C T 11: 32,162,903 (GRCm39) V455I probably benign Het
Rnf6 G A 5: 146,148,239 (GRCm39) R260W possibly damaging Het
Rtl1 T C 12: 109,560,279 (GRCm39) N520S possibly damaging Het
Setbp1 A T 18: 78,899,707 (GRCm39) M1320K probably benign Het
Slc39a8 A G 3: 135,590,123 (GRCm39) T338A probably damaging Het
Tcf4 A G 18: 69,815,890 (GRCm39) *693W probably null Het
Ttc8 A T 12: 98,942,696 (GRCm39) D412V probably damaging Het
Ush2a G T 1: 188,275,046 (GRCm39) A1840S probably benign Het
Vmn1r60 A T 7: 5,547,688 (GRCm39) S137R Het
Vmn1r91 T A 7: 19,835,802 (GRCm39) H240Q probably benign Het
Vmn2r107 A T 17: 20,595,634 (GRCm39) H729L probably benign Het
Yme1l1 C T 2: 23,050,274 (GRCm39) T35I probably benign Het
Zfp292 A G 4: 34,806,777 (GRCm39) V2094A probably damaging Het
Zfp934 A T 13: 62,666,130 (GRCm39) N202K Het
Other mutations in Klk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01488:Klk10 APN 7 43,434,400 (GRCm39) missense probably damaging 1.00
IGL01657:Klk10 APN 7 43,431,013 (GRCm39) missense possibly damaging 0.49
IGL02049:Klk10 APN 7 43,433,882 (GRCm39) splice site probably benign
IGL02725:Klk10 APN 7 43,431,044 (GRCm39) missense probably damaging 1.00
IGL03382:Klk10 APN 7 43,433,883 (GRCm39) splice site probably benign
R0433:Klk10 UTSW 7 43,430,989 (GRCm39) missense possibly damaging 0.51
R1521:Klk10 UTSW 7 43,432,304 (GRCm39) missense probably benign 0.00
R1580:Klk10 UTSW 7 43,432,286 (GRCm39) missense probably damaging 1.00
R4825:Klk10 UTSW 7 43,433,022 (GRCm39) missense probably damaging 1.00
R5969:Klk10 UTSW 7 43,434,409 (GRCm39) missense probably damaging 1.00
R6437:Klk10 UTSW 7 43,432,241 (GRCm39) missense probably benign 0.04
R6641:Klk10 UTSW 7 43,434,324 (GRCm39) missense possibly damaging 0.94
R7599:Klk10 UTSW 7 43,433,851 (GRCm39) missense probably benign 0.03
R7902:Klk10 UTSW 7 43,432,942 (GRCm39) missense probably benign 0.34
R8519:Klk10 UTSW 7 43,432,239 (GRCm39) nonsense probably null
R9560:Klk10 UTSW 7 43,433,746 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGGGTTAGGCTCTGTCTCC -3'
(R):5'- TCCCTCAGATCTAGGGTCTAGC -3'

Sequencing Primer
(F):5'- AGGCTCTGTCTCCATGAAGG -3'
(R):5'- AGATCTAGGGTCTAGCTCTCACTCAG -3'
Posted On 2019-10-24