Incidental Mutation 'R7589:Zfp934'
| ID |
587321 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp934
|
| Ensembl Gene |
ENSMUSG00000074865 |
| Gene Name |
zinc finger protein 934 |
| Synonyms |
6720457D02Rik |
| MMRRC Submission |
045637-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.125)
|
| Stock # |
R7589 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
62664609-62727170 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 62666130 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 202
(N202K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099083
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076195]
[ENSMUST00000082203]
[ENSMUST00000101547]
[ENSMUST00000220648]
[ENSMUST00000221250]
[ENSMUST00000222429]
[ENSMUST00000222746]
[ENSMUST00000222852]
|
| AlphaFold |
K7N6H3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076195
|
| SMART Domains |
Protein: ENSMUSP00000075552
Gene: ENSMUSG00000055228
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
8.26e-16 |
SMART |
|
ZnF_C2H2
|
133 |
155 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
161 |
183 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
189 |
211 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
245 |
267 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
273 |
295 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
1.2e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082203
AA Change: N170K
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000080837
Gene: ENSMUSG00000074865
AA Change: N170K
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
3e-16 |
BLAST |
|
ZnF_C2H2
|
101 |
123 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
129 |
149 |
1.68e1 |
SMART |
|
ZnF_C2H2
|
157 |
179 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
185 |
207 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
269 |
292 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
298 |
320 |
4.87e-4 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000099083
Gene: ENSMUSG00000074865
AA Change: N202K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
65 |
5.01e-15 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
160 |
180 |
1.68e1 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
9.22e-5 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
2.43e-4 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
4.87e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220648
AA Change: N170K
PolyPhen 2
Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221250
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222429
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222746
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222852
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610021A01Rik |
T |
G |
7: 41,276,396 (GRCm39) |
C700G |
probably damaging |
Het |
| 4930486L24Rik |
T |
C |
13: 60,990,747 (GRCm39) |
K316E |
probably damaging |
Het |
| Akap6 |
A |
T |
12: 53,188,846 (GRCm39) |
K2087* |
probably null |
Het |
| Alpk2 |
A |
T |
18: 65,433,144 (GRCm39) |
H1320Q |
probably damaging |
Het |
| Aox1 |
A |
T |
1: 58,080,643 (GRCm39) |
R31W |
probably damaging |
Het |
| Asnsd1 |
G |
T |
1: 53,387,126 (GRCm39) |
A167E |
probably benign |
Het |
| Atg14 |
T |
C |
14: 47,780,547 (GRCm39) |
D409G |
probably benign |
Het |
| Atp13a3 |
T |
A |
16: 30,163,433 (GRCm39) |
E574D |
probably benign |
Het |
| Bicd1 |
A |
T |
6: 149,415,165 (GRCm39) |
Y626F |
possibly damaging |
Het |
| Cdc5l |
C |
T |
17: 45,721,707 (GRCm39) |
R521Q |
probably benign |
Het |
| Dglucy |
T |
C |
12: 100,807,660 (GRCm39) |
F160L |
probably damaging |
Het |
| Enpp5 |
G |
A |
17: 44,396,155 (GRCm39) |
G356S |
probably damaging |
Het |
| Fmo9 |
T |
A |
1: 166,501,997 (GRCm39) |
K209N |
possibly damaging |
Het |
| Gsdmc2 |
C |
A |
15: 63,696,892 (GRCm39) |
L426F |
probably damaging |
Het |
| Hip1 |
T |
C |
5: 135,443,165 (GRCm39) |
D956G |
probably benign |
Het |
| Kif28 |
C |
T |
1: 179,558,965 (GRCm39) |
V248I |
probably benign |
Het |
| Klk10 |
T |
C |
7: 43,433,051 (GRCm39) |
V149A |
probably benign |
Het |
| Krt40 |
G |
T |
11: 99,430,983 (GRCm39) |
N255K |
probably damaging |
Het |
| Map4k4 |
T |
A |
1: 40,060,251 (GRCm39) |
Y1013* |
probably null |
Het |
| Mcur1 |
T |
C |
13: 43,705,101 (GRCm39) |
Y185C |
probably damaging |
Het |
| Mzt1 |
T |
C |
14: 99,273,948 (GRCm39) |
|
probably null |
Het |
| Naip5 |
G |
T |
13: 100,356,205 (GRCm39) |
Q1137K |
not run |
Het |
| Naip5 |
T |
C |
13: 100,356,204 (GRCm39) |
Q1137R |
probably benign |
Het |
| Nkx1-2 |
T |
C |
7: 132,201,204 (GRCm39) |
I18V |
probably damaging |
Het |
| Ofcc1 |
T |
A |
13: 40,408,960 (GRCm39) |
Q155L |
probably benign |
Het |
| Or1ad1 |
A |
T |
11: 50,875,857 (GRCm39) |
M110L |
probably damaging |
Het |
| Or4a2 |
A |
G |
2: 89,248,724 (GRCm39) |
V11A |
possibly damaging |
Het |
| Or4k38 |
T |
C |
2: 111,165,719 (GRCm39) |
K235E |
probably damaging |
Het |
| Or51q1 |
T |
C |
7: 103,628,998 (GRCm39) |
Y200H |
probably damaging |
Het |
| Or9s15 |
G |
A |
1: 92,524,781 (GRCm39) |
R180H |
probably benign |
Het |
| Prnp |
A |
G |
2: 131,778,786 (GRCm39) |
D146G |
probably benign |
Het |
| Rhbdf1 |
C |
T |
11: 32,162,903 (GRCm39) |
V455I |
probably benign |
Het |
| Rnf6 |
G |
A |
5: 146,148,239 (GRCm39) |
R260W |
possibly damaging |
Het |
| Rtl1 |
T |
C |
12: 109,560,279 (GRCm39) |
N520S |
possibly damaging |
Het |
| Setbp1 |
A |
T |
18: 78,899,707 (GRCm39) |
M1320K |
probably benign |
Het |
| Slc39a8 |
A |
G |
3: 135,590,123 (GRCm39) |
T338A |
probably damaging |
Het |
| Tcf4 |
A |
G |
18: 69,815,890 (GRCm39) |
*693W |
probably null |
Het |
| Ttc8 |
A |
T |
12: 98,942,696 (GRCm39) |
D412V |
probably damaging |
Het |
| Ush2a |
G |
T |
1: 188,275,046 (GRCm39) |
A1840S |
probably benign |
Het |
| Vmn1r60 |
A |
T |
7: 5,547,688 (GRCm39) |
S137R |
|
Het |
| Vmn1r91 |
T |
A |
7: 19,835,802 (GRCm39) |
H240Q |
probably benign |
Het |
| Vmn2r107 |
A |
T |
17: 20,595,634 (GRCm39) |
H729L |
probably benign |
Het |
| Yme1l1 |
C |
T |
2: 23,050,274 (GRCm39) |
T35I |
probably benign |
Het |
| Zfp292 |
A |
G |
4: 34,806,777 (GRCm39) |
V2094A |
probably damaging |
Het |
|
| Other mutations in Zfp934 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R1915:Zfp934
|
UTSW |
13 |
62,665,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Zfp934
|
UTSW |
13 |
62,666,108 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2113:Zfp934
|
UTSW |
13 |
62,666,507 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2145:Zfp934
|
UTSW |
13 |
62,665,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3732:Zfp934
|
UTSW |
13 |
62,665,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3797:Zfp934
|
UTSW |
13 |
62,665,702 (GRCm39) |
missense |
probably benign |
|
|
R4326:Zfp934
|
UTSW |
13 |
62,665,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4327:Zfp934
|
UTSW |
13 |
62,665,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4909:Zfp934
|
UTSW |
13 |
62,665,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5236:Zfp934
|
UTSW |
13 |
62,665,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Zfp934
|
UTSW |
13 |
62,665,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6305:Zfp934
|
UTSW |
13 |
62,666,370 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6729:Zfp934
|
UTSW |
13 |
62,640,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Zfp934
|
UTSW |
13 |
62,668,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7186:Zfp934
|
UTSW |
13 |
62,640,204 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7235:Zfp934
|
UTSW |
13 |
62,665,964 (GRCm39) |
missense |
|
|
|
R7453:Zfp934
|
UTSW |
13 |
62,666,517 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7552:Zfp934
|
UTSW |
13 |
62,640,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7624:Zfp934
|
UTSW |
13 |
62,666,338 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7651:Zfp934
|
UTSW |
13 |
62,666,327 (GRCm39) |
missense |
probably benign |
|
|
R7780:Zfp934
|
UTSW |
13 |
62,666,358 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7857:Zfp934
|
UTSW |
13 |
62,665,361 (GRCm39) |
missense |
|
|
|
R7891:Zfp934
|
UTSW |
13 |
62,668,003 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8130:Zfp934
|
UTSW |
13 |
62,667,985 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8298:Zfp934
|
UTSW |
13 |
62,666,295 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAGATGACATTTCTCAGAAAAGGT -3'
(R):5'- GGTAAAGCTTTCACATGTGCCA -3'
Sequencing Primer
(F):5'- tgtagggtttctctccaga -3'
(R):5'- GGATTTGCAAAGCCCAGTC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation