Mutagenetix > Incidental Mutations

Incidental Mutation 'R0622:Olfr898'

58735

Institutional Source

Beutler Lab

Gene Symbol

Olfr898

Ensembl Gene

ENSMUSG00000094588

Gene Name

olfactory receptor 898

Synonyms

GA_x6K02T2PVTD-32037624-32038565, MOR170-3

MMRRC Submission

038811-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.212) question?

Stock #

R0622 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

38348411-38352919 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 38349371 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 96 (N96S)

Ref Sequence

ENSEMBL: ENSMUSP00000075824 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076504] [ENSMUST00000216304] [ENSMUST00000217063]

AlphaFold

L7N1Z5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000076504
AA Change: N96S

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000075824
Gene: ENSMUSG00000094588
AA Change: N96S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	313	2.2e-47	PFAM
Pfam:7tm_1	47	313	1.7e-21	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216304
AA Change: N90S

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217063
AA Change: N90S

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.7%
20x: 95.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agtr1a	T	A	13: 30,381,681	M243K	probably benign	Het
Ap1b1	A	G	11: 5,037,707	M744V	probably damaging	Het
C87977	T	C	4: 144,213,013		probably benign	Het
Ccdc152	T	C	15: 3,298,178	N39S	probably damaging	Het
Cd163	G	A	6: 124,317,352	V490M	probably damaging	Het
Col6a5	G	T	9: 105,925,852	H1305N	unknown	Het
Cpb1	C	A	3: 20,249,818	D361Y	probably damaging	Het
Dchs1	T	A	7: 105,763,449	Y1248F	probably damaging	Het
Dhdds	G	C	4: 133,994,236	F83L	probably damaging	Het
Dsg4	T	A	18: 20,449,788	V161E	possibly damaging	Het
Exosc4	A	G	15: 76,327,536	D15G	probably damaging	Het
F3	A	T	3: 121,725,019	D44V	probably damaging	Het
Fat2	A	T	11: 55,283,128	F2253Y	probably damaging	Het
Fbn1	T	C	2: 125,379,024	D650G	possibly damaging	Het
Gramd4	T	A	15: 86,091,389	F36I	probably damaging	Het
Grm7	G	A	6: 111,358,496	A623T	probably damaging	Het
Gys1	A	T	7: 45,439,995	T193S	probably damaging	Het
Hectd4	A	G	5: 121,348,625	T3228A	possibly damaging	Het
Itpk1	G	T	12: 102,573,980	D281E	probably damaging	Het
Kcnh7	A	C	2: 62,837,289		probably null	Het
Klhl29	A	G	12: 5,081,224	L852P	probably damaging	Het
Lrch1	T	C	14: 74,796,051	Y509C	probably benign	Het
Lrp1b	A	G	2: 41,728,551		probably null	Het
Mcpt4	C	A	14: 56,060,662	R144L	probably benign	Het
Mia2	C	T	12: 59,131,578	R12W	probably damaging	Het
Mrps5	A	G	2: 127,594,531	K116R	probably benign	Het
Myrf	G	A	19: 10,223,452	P286S	probably damaging	Het
Nanp	A	G	2: 151,039,244	M28T	probably benign	Het
Neb	T	C	2: 52,212,951	I4472V	probably benign	Het
Nfix	A	C	8: 84,726,482	N314K	probably damaging	Het
Nlrc3	C	T	16: 3,953,968	R849Q	probably benign	Het
Nup210l	G	A	3: 90,167,740	V786M	probably damaging	Het
Olfr1346	T	C	7: 6,474,599	I163T	possibly damaging	Het
Olfr314	T	C	11: 58,786,341	S36P	probably damaging	Het
Olfr600	A	G	7: 103,346,857	S24P	probably damaging	Het
Pdia4	A	T	6: 47,806,518	F197Y	probably damaging	Het
Phldb1	T	C	9: 44,715,852	D432G	probably damaging	Het
Pik3ca	A	G	3: 32,436,552	E116G	probably damaging	Het
Polq	T	C	16: 37,060,993	V1173A	probably benign	Het
Pou2f3	C	T	9: 43,125,119	R423H	probably damaging	Het
Prkag2	T	C	5: 24,869,249	N246S	probably damaging	Het
Proser1	A	G	3: 53,477,860	S388G	probably benign	Het
Ralgps1	G	A	2: 33,174,447	R238*	probably null	Het
Rfx2	T	C	17: 56,777,071	D657G	probably damaging	Het
Ryr3	A	G	2: 112,662,555	F3724S	probably damaging	Het
Sh2d5	T	C	4: 138,259,228	S421P	probably damaging	Het
Slc17a2	C	A	13: 23,812,611	T33K	probably damaging	Het
St8sia5	A	G	18: 77,246,113	T156A	probably damaging	Het
Stk32c	T	C	7: 139,188,110	D85G	probably benign	Het
Tnks	A	G	8: 34,940,822	S251P	probably damaging	Het
Tnxb	T	A	17: 34,718,729	L3864Q	probably damaging	Het
Trim9	A	G	12: 70,346,604	Y189H	probably damaging	Het
Vmn1r77	T	G	7: 12,041,388	F30L	probably benign	Het
Wasf3	A	G	5: 146,466,792		probably null	Het
Wdr90	C	T	17: 25,855,658	C603Y	probably damaging	Het
Zdhhc25	T	C	15: 88,601,107	L215P	probably damaging	Het
Zeb1	C	T	18: 5,759,123	Q140*	probably null	Het
Zfp677	C	T	17: 21,397,700	L340F	probably benign	Het

Other mutations in Olfr898

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01394:Olfr898	APN	9	38349805	missense	possibly damaging	0.95
IGL02477:Olfr898	APN	9	38349125	missense	probably benign	0.16
IGL02858:Olfr898	APN	9	38349173	missense	probably benign	0.04
PIT4362001:Olfr898	UTSW	9	38349198	missense	probably benign	0.34
R0060:Olfr898	UTSW	9	38349512	missense	probably benign	0.23
R0518:Olfr898	UTSW	9	38349203	missense	probably damaging	0.99
R0521:Olfr898	UTSW	9	38349203	missense	probably damaging	0.99
R0898:Olfr898	UTSW	9	38349442	missense	probably damaging	0.97
R1562:Olfr898	UTSW	9	38349362	nonsense	probably null
R3903:Olfr898	UTSW	9	38349658	nonsense	probably null
R4375:Olfr898	UTSW	9	38349169	missense	probably benign
R4459:Olfr898	UTSW	9	38349992	missense	probably damaging	1.00
R4762:Olfr898	UTSW	9	38349281	missense	probably damaging	1.00
R4943:Olfr898	UTSW	9	38349628	missense	probably damaging	1.00
R5033:Olfr898	UTSW	9	38349628	missense	probably damaging	1.00
R5442:Olfr898	UTSW	9	38349862	missense	probably benign	0.06
R5863:Olfr898	UTSW	9	38349787	missense	probably benign	0.09
R5988:Olfr898	UTSW	9	38349749	missense	probably benign	0.30
R7077:Olfr898	UTSW	9	38349970	missense	probably damaging	1.00
R7509:Olfr898	UTSW	9	38349572	missense	probably benign	0.26
R7709:Olfr898	UTSW	9	38349277	missense	probably benign	0.02
R9305:Olfr898	UTSW	9	38349085	start codon destroyed	probably benign	0.33

Predicted Primers

PCR Primer
(F):5'- TTCAACGAGAGTTCCAGTTGCCC -3'
(R):5'- ATGGCTTGACATAAGCAAGGAGACC -3'

Sequencing Primer
(F):5'- CTCTTCTTGTTAAACTACACAGCCAC -3'
(R):5'- CCTGATCATAAACCCTGTGTGAG -3'

Posted On

2013-07-11