Incidental Mutation 'R7592:Or7g32'
ID 587458
Institutional Source Beutler Lab
Gene Symbol Or7g32
Ensembl Gene ENSMUSG00000052625
Gene Name olfactory receptor family 7 subfamily G member 32
Synonyms MOR155-1, GA_x6K02T2PVTD-13234278-13235216, Olfr851
MMRRC Submission 045639-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.342) question?
Stock # R7592 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 19404591-19414111 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 19389128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 139 (M139I)
Ref Sequence ENSEMBL: ENSMUSP00000076569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077347] [ENSMUST00000211832]
AlphaFold Q7TRG0
Predicted Effect possibly damaging
Transcript: ENSMUST00000077347
AA Change: M139I

PolyPhen 2 Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000076569
Gene: ENSMUSG00000094535
AA Change: M139I

DomainStartEndE-ValueType
low complexity region 10 21 N/A INTRINSIC
Pfam:7tm_4 34 311 1.8e-51 PFAM
Pfam:7TM_GPCR_Srsx 38 304 1e-6 PFAM
Pfam:7tm_1 44 293 5.1e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000211832
AA Change: M136I

PolyPhen 2 Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A G 16: 4,667,138 (GRCm39) T204A unknown Het
Abca12 T C 1: 71,327,836 (GRCm39) T1415A probably benign Het
Adamtsl3 A G 7: 81,986,459 (GRCm39) T24A probably benign Het
Ankrd13b A C 11: 77,367,327 (GRCm39) V194G probably benign Het
Aurkc C T 7: 7,003,006 (GRCm39) T167I probably benign Het
Capn1 T C 19: 6,064,469 (GRCm39) Y10C probably benign Het
Ccnk T C 12: 108,152,724 (GRCm39) S14P possibly damaging Het
Cebpe T A 14: 54,949,298 (GRCm39) I40F probably damaging Het
Cers3 G A 7: 66,439,377 (GRCm39) C296Y probably damaging Het
Cog8 A T 8: 107,776,861 (GRCm39) C505S possibly damaging Het
Col4a3 A G 1: 82,626,338 (GRCm39) I92V unknown Het
Col5a3 T A 9: 20,708,689 (GRCm39) H645L unknown Het
Crispld1 A T 1: 17,798,990 (GRCm39) E37V possibly damaging Het
Csmd2 A G 4: 128,357,591 (GRCm39) Y1684C Het
Cstdc5 A T 16: 36,187,862 (GRCm39) M1K probably null Het
Dcst1 C A 3: 89,260,599 (GRCm39) S555I probably benign Het
Drc1 A G 5: 30,499,060 (GRCm39) S70G possibly damaging Het
Elavl2 A T 4: 91,199,808 (GRCm39) probably null Het
Emc1 A G 4: 139,087,877 (GRCm39) H300R probably benign Het
Gcnt4 G A 13: 97,083,669 (GRCm39) V322I probably benign Het
Gsg1l2 A G 11: 67,665,584 (GRCm39) N51D probably benign Het
Gucy2e A T 11: 69,114,150 (GRCm39) probably null Het
Hip1r A G 5: 124,136,036 (GRCm39) E579G probably benign Het
Hoxa4 T C 6: 52,168,520 (GRCm39) H50R unknown Het
Htr7 T C 19: 36,034,292 (GRCm39) Y121C probably damaging Het
Ift43 G A 12: 86,207,964 (GRCm39) D111N probably damaging Het
Itih3 A G 14: 30,630,722 (GRCm39) V863A probably damaging Het
Macf1 T C 4: 123,304,686 (GRCm39) probably benign Het
Mgat3 A G 15: 80,095,193 (GRCm39) K7E probably damaging Het
Ndst4 T A 3: 125,364,436 (GRCm39) V371E probably damaging Het
Npr1 T G 3: 90,372,323 (GRCm39) D163A possibly damaging Het
Nudt12 T C 17: 59,313,589 (GRCm39) I330V probably benign Het
Or2a20 T G 6: 43,194,179 (GRCm39) C111G probably damaging Het
Or4k2 T A 14: 50,424,020 (GRCm39) Y219F probably damaging Het
Or51l4 C A 7: 103,404,279 (GRCm39) C171F probably damaging Het
Poc1a A T 9: 106,226,967 (GRCm39) R402S probably benign Het
Prex2 G T 1: 11,193,437 (GRCm39) V470L probably damaging Het
Prom1 T C 5: 44,220,469 (GRCm39) E93G probably damaging Het
Psma1 A T 7: 113,868,961 (GRCm39) M180K probably benign Het
Pudp A T 18: 50,701,053 (GRCm39) F227I probably damaging Het
Rab15 T A 12: 76,851,223 (GRCm39) Q60L probably damaging Het
Scaf8 T C 17: 3,221,497 (GRCm39) probably null Het
Septin9 T A 11: 117,181,488 (GRCm39) I96N probably damaging Het
Sez6 T C 11: 77,868,876 (GRCm39) S976P probably damaging Het
Slc2a12 A G 10: 22,540,802 (GRCm39) Y219C probably damaging Het
Slc38a9 T A 13: 112,831,889 (GRCm39) I213K probably damaging Het
Stil T A 4: 114,881,005 (GRCm39) D516E probably benign Het
Supt20 A G 3: 54,614,543 (GRCm39) D184G probably damaging Het
Tars3 G A 7: 65,308,619 (GRCm39) S263N probably benign Het
Tmem181a C A 17: 6,339,295 (GRCm39) T68K probably benign Het
Trav21-dv12 G T 14: 54,113,997 (GRCm39) C39F probably damaging Het
Tshz1 T C 18: 84,032,173 (GRCm39) E745G probably damaging Het
Ugt1a8 T A 1: 88,015,904 (GRCm39) F106I probably benign Het
Vmn1r39 C A 6: 66,781,428 (GRCm39) V297L probably benign Het
Vmn2r101 G A 17: 19,811,443 (GRCm39) probably null Het
Vmn2r69 GAAAA GAAAAA 7: 85,060,768 (GRCm39) probably null Het
Other mutations in Or7g32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or7g32 APN 9 19,408,155 (GRCm39) missense probably damaging 1.00
IGL01992:Or7g32 APN 9 19,408,070 (GRCm39) missense probably benign 0.00
IGL02455:Or7g32 APN 9 19,408,559 (GRCm39) nonsense probably null
IGL02468:Or7g32 APN 9 19,408,473 (GRCm39) missense probably benign
IGL02685:Or7g32 APN 9 19,408,098 (GRCm39) missense probably benign
IGL02723:Or7g32 APN 9 19,388,805 (GRCm39) missense probably damaging 1.00
IGL03294:Or7g32 APN 9 19,389,285 (GRCm39) missense possibly damaging 0.95
PIT4305001:Or7g32 UTSW 9 19,389,357 (GRCm39) missense probably damaging 1.00
R0153:Or7g32 UTSW 9 19,408,233 (GRCm39) missense probably damaging 1.00
R0364:Or7g32 UTSW 9 19,389,268 (GRCm39) nonsense probably null
R0379:Or7g32 UTSW 9 19,388,776 (GRCm39) missense possibly damaging 0.75
R0449:Or7g32 UTSW 9 19,389,388 (GRCm39) missense possibly damaging 0.89
R0682:Or7g32 UTSW 9 19,388,645 (GRCm39) missense probably benign 0.03
R0693:Or7g32 UTSW 9 19,389,268 (GRCm39) nonsense probably null
R0789:Or7g32 UTSW 9 19,408,458 (GRCm39) missense possibly damaging 0.68
R1484:Or7g32 UTSW 9 19,389,423 (GRCm39) missense probably damaging 1.00
R1599:Or7g32 UTSW 9 19,389,517 (GRCm39) missense probably damaging 0.97
R1626:Or7g32 UTSW 9 19,389,495 (GRCm39) missense probably damaging 1.00
R1742:Or7g32 UTSW 9 19,389,337 (GRCm39) missense probably damaging 1.00
R2041:Or7g32 UTSW 9 19,408,131 (GRCm39) missense probably benign
R2060:Or7g32 UTSW 9 19,408,533 (GRCm39) missense possibly damaging 0.88
R4232:Or7g32 UTSW 9 19,389,022 (GRCm39) missense probably damaging 0.98
R4237:Or7g32 UTSW 9 19,388,893 (GRCm39) missense probably benign 0.00
R4474:Or7g32 UTSW 9 19,408,173 (GRCm39) missense probably damaging 1.00
R5081:Or7g32 UTSW 9 19,408,557 (GRCm39) missense probably benign 0.05
R5116:Or7g32 UTSW 9 19,389,094 (GRCm39) missense possibly damaging 0.67
R5643:Or7g32 UTSW 9 19,388,853 (GRCm39) missense probably benign 0.22
R6271:Or7g32 UTSW 9 19,389,337 (GRCm39) missense probably damaging 1.00
R6815:Or7g32 UTSW 9 19,389,061 (GRCm39) missense probably benign 0.20
R6853:Or7g32 UTSW 9 19,408,102 (GRCm39) nonsense probably null
R7150:Or7g32 UTSW 9 19,408,145 (GRCm39) missense probably benign 0.44
R7222:Or7g32 UTSW 9 19,388,763 (GRCm39) missense probably damaging 1.00
R7378:Or7g32 UTSW 9 19,408,398 (GRCm39) missense probably damaging 1.00
R7456:Or7g32 UTSW 9 19,408,844 (GRCm39) missense probably damaging 1.00
R7527:Or7g32 UTSW 9 19,408,685 (GRCm39) missense probably damaging 0.98
R7587:Or7g32 UTSW 9 19,408,818 (GRCm39) missense probably damaging 1.00
R8155:Or7g32 UTSW 9 19,389,453 (GRCm39) missense probably benign 0.17
R8215:Or7g32 UTSW 9 19,408,796 (GRCm39) missense probably damaging 1.00
R8220:Or7g32 UTSW 9 19,408,317 (GRCm39) missense probably damaging 0.97
R8296:Or7g32 UTSW 9 19,408,377 (GRCm39) missense probably damaging 1.00
R8732:Or7g32 UTSW 9 19,408,098 (GRCm39) missense probably benign
R8813:Or7g32 UTSW 9 19,389,477 (GRCm39) missense possibly damaging 0.75
R9152:Or7g32 UTSW 9 19,408,448 (GRCm39) missense probably damaging 1.00
R9187:Or7g32 UTSW 9 19,389,166 (GRCm39) missense probably benign
R9528:Or7g32 UTSW 9 19,389,444 (GRCm39) missense probably damaging 1.00
R9789:Or7g32 UTSW 9 19,389,382 (GRCm39) missense probably benign 0.35
R9795:Or7g32 UTSW 9 19,408,412 (GRCm39) missense probably damaging 1.00
RF034:Or7g32 UTSW 9 19,388,928 (GRCm39) missense possibly damaging 0.46
X0058:Or7g32 UTSW 9 19,389,519 (GRCm39) missense probably benign 0.10
Z1177:Or7g32 UTSW 9 19,388,633 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GGAATACCAGTAAATATGCATGCAG -3'
(R):5'- AGCACGATCCCAAAGATGCTG -3'

Sequencing Primer
(F):5'- TGCATGCAGAAAGATAGATCAATATG -3'
(R):5'- TCCCAAAGATGCTGGTGAAC -3'
Posted On 2019-10-24