Incidental Mutation 'R7593:Erbb4'
| ID |
587488 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7593 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 68293758 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 711
(R711L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119142
AA Change: R711L
PolyPhen 2
Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: R711L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121473
AA Change: R711L
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: R711L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153432
AA Change: R701L
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: R701L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
C |
T |
5: 64,055,774 (GRCm39) |
A170V |
probably damaging |
Het |
| Acp6 |
A |
T |
3: 97,073,266 (GRCm39) |
E102D |
probably benign |
Het |
| Acss1 |
T |
A |
2: 150,461,688 (GRCm39) |
R632* |
probably null |
Het |
| Adamtsl1 |
G |
T |
4: 86,259,450 (GRCm39) |
C832F |
probably damaging |
Het |
| Adgrg6 |
T |
G |
10: 14,344,573 (GRCm39) |
M127L |
probably damaging |
Het |
| Alkbh1 |
A |
T |
12: 87,487,095 (GRCm39) |
Y91* |
probably null |
Het |
| Arhgap35 |
A |
T |
7: 16,298,786 (GRCm39) |
I93N |
probably damaging |
Het |
| Asic2 |
A |
T |
11: 81,858,657 (GRCm39) |
D118E |
probably benign |
Het |
| Asprv1 |
G |
T |
6: 86,605,762 (GRCm39) |
V203L |
probably damaging |
Het |
| Atad2b |
G |
A |
12: 5,081,726 (GRCm39) |
D1212N |
probably benign |
Het |
| Atp4a |
A |
G |
7: 30,424,105 (GRCm39) |
I960V |
probably benign |
Het |
| Bin1 |
G |
T |
18: 32,552,932 (GRCm39) |
E186* |
probably null |
Het |
| Bmp10 |
A |
G |
6: 87,410,651 (GRCm39) |
Y148C |
probably damaging |
Het |
| Ccdc152 |
T |
A |
15: 3,310,137 (GRCm39) |
D246V |
probably damaging |
Het |
| Cdc16 |
A |
G |
8: 13,827,605 (GRCm39) |
T504A |
probably benign |
Het |
| Cdh9 |
A |
T |
15: 16,823,261 (GRCm39) |
D81V |
probably damaging |
Het |
| Cep162 |
A |
T |
9: 87,086,250 (GRCm39) |
S1025T |
probably benign |
Het |
| Cidea |
A |
G |
18: 67,493,283 (GRCm39) |
I101V |
probably benign |
Het |
| Clock |
G |
A |
5: 76,384,145 (GRCm39) |
S478L |
possibly damaging |
Het |
| Cp |
T |
A |
3: 20,020,494 (GRCm39) |
N162K |
probably benign |
Het |
| Crb1 |
C |
T |
1: 139,164,978 (GRCm39) |
E1110K |
probably damaging |
Het |
| Cyp2b13 |
A |
T |
7: 25,780,416 (GRCm39) |
I146L |
possibly damaging |
Het |
| D630045J12Rik |
A |
G |
6: 38,172,429 (GRCm39) |
S580P |
possibly damaging |
Het |
| Dars2 |
T |
C |
1: 160,885,113 (GRCm39) |
E224G |
probably damaging |
Het |
| Dcbld2 |
A |
G |
16: 58,244,941 (GRCm39) |
T72A |
possibly damaging |
Het |
| Ddx11 |
A |
T |
17: 66,433,193 (GRCm39) |
I8F |
possibly damaging |
Het |
| Dennd2d |
T |
C |
3: 106,407,244 (GRCm39) |
F432L |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,823,608 (GRCm39) |
V543A |
probably benign |
Het |
| Eef2k |
G |
A |
7: 120,488,491 (GRCm39) |
|
probably null |
Het |
| Elmo1 |
A |
G |
13: 20,474,610 (GRCm39) |
M345V |
probably benign |
Het |
| Ephb4 |
A |
G |
5: 137,359,560 (GRCm39) |
M377V |
probably benign |
Het |
| Fads1 |
A |
G |
19: 10,162,361 (GRCm39) |
E95G |
probably damaging |
Het |
| Farsa |
G |
A |
8: 85,594,278 (GRCm39) |
|
probably null |
Het |
| Galntl6 |
A |
G |
8: 58,230,293 (GRCm39) |
S42P |
probably damaging |
Het |
| Gga2 |
G |
A |
7: 121,589,672 (GRCm39) |
T559M |
probably benign |
Het |
| Glipr1l2 |
G |
A |
10: 111,928,465 (GRCm39) |
G120D |
probably damaging |
Het |
| Gm14226 |
A |
T |
2: 154,866,114 (GRCm39) |
I24L |
unknown |
Het |
| Gprc5b |
G |
T |
7: 118,583,492 (GRCm39) |
R126S |
probably damaging |
Het |
| Gys1 |
A |
G |
7: 45,092,360 (GRCm39) |
D321G |
probably damaging |
Het |
| Hdlbp |
C |
T |
1: 93,358,005 (GRCm39) |
A299T |
probably benign |
Het |
| Hic2 |
A |
G |
16: 17,076,979 (GRCm39) |
T603A |
probably damaging |
Het |
| Hoxa11 |
A |
T |
6: 52,220,524 (GRCm39) |
I253N |
probably damaging |
Het |
| Iglon5 |
A |
T |
7: 43,126,064 (GRCm39) |
D222E |
probably benign |
Het |
| Inpp5d |
T |
A |
1: 87,645,500 (GRCm39) |
S1023T |
possibly damaging |
Het |
| Kif21a |
C |
T |
15: 90,828,064 (GRCm39) |
A1233T |
probably benign |
Het |
| Kif9 |
A |
T |
9: 110,350,421 (GRCm39) |
T771S |
possibly damaging |
Het |
| Klre1 |
T |
A |
6: 129,560,150 (GRCm39) |
C141S |
probably damaging |
Het |
| Lats1 |
A |
G |
10: 7,577,476 (GRCm39) |
Y200C |
probably damaging |
Het |
| Lgr4 |
T |
A |
2: 109,829,801 (GRCm39) |
L247H |
probably damaging |
Het |
| Lrrc37a |
T |
C |
11: 103,391,778 (GRCm39) |
K1216E |
probably benign |
Het |
| Lrrc41 |
G |
A |
4: 115,950,141 (GRCm39) |
R518H |
possibly damaging |
Het |
| Lrrk1 |
A |
G |
7: 65,958,439 (GRCm39) |
V320A |
probably benign |
Het |
| Mcm9 |
C |
T |
10: 53,506,088 (GRCm39) |
R62H |
probably benign |
Het |
| Mmp10 |
T |
G |
9: 7,503,154 (GRCm39) |
L38R |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,071,867 (GRCm39) |
L546P |
probably damaging |
Het |
| Mtcl2 |
A |
T |
2: 156,882,776 (GRCm39) |
D425E |
probably benign |
Het |
| Myt1 |
T |
A |
2: 181,439,532 (GRCm39) |
D393E |
possibly damaging |
Het |
| Mzb1 |
A |
T |
18: 35,780,901 (GRCm39) |
I129N |
probably damaging |
Het |
| Nek10 |
A |
G |
14: 14,826,955 (GRCm38) |
D51G |
probably benign |
Het |
| Nme5 |
A |
G |
18: 34,700,201 (GRCm39) |
I148T |
probably benign |
Het |
| Nr2e1 |
G |
A |
10: 42,439,475 (GRCm39) |
P348L |
probably damaging |
Het |
| Nrp2 |
A |
G |
1: 62,758,203 (GRCm39) |
E63G |
probably damaging |
Het |
| Or2d2 |
A |
T |
7: 106,727,782 (GRCm39) |
S273T |
probably damaging |
Het |
| Or51ab3 |
A |
T |
7: 103,200,956 (GRCm39) |
|
probably benign |
Het |
| Or52e3 |
A |
G |
7: 102,869,471 (GRCm39) |
E182G |
probably damaging |
Het |
| Or52e5 |
A |
G |
7: 104,718,704 (GRCm39) |
H10R |
probably benign |
Het |
| Or56a3 |
A |
G |
7: 104,735,372 (GRCm39) |
T150A |
probably benign |
Het |
| Pak5 |
A |
G |
2: 135,942,884 (GRCm39) |
S419P |
probably benign |
Het |
| Pfas |
C |
A |
11: 68,881,921 (GRCm39) |
M25I |
|
Het |
| Prdm9 |
A |
G |
17: 15,764,867 (GRCm39) |
S638P |
possibly damaging |
Het |
| Psd |
G |
A |
19: 46,301,352 (GRCm39) |
T954I |
possibly damaging |
Het |
| Psph |
T |
C |
5: 129,864,337 (GRCm39) |
|
probably benign |
Het |
| Ptprf |
A |
G |
4: 118,069,593 (GRCm39) |
I1517T |
probably benign |
Het |
| Rassf8 |
A |
G |
6: 145,761,129 (GRCm39) |
R152G |
probably benign |
Het |
| Rfx3 |
G |
A |
19: 27,827,139 (GRCm39) |
T149I |
probably benign |
Het |
| Rfx8 |
A |
T |
1: 39,722,838 (GRCm39) |
F260I |
probably damaging |
Het |
| Rnft1 |
C |
T |
11: 86,384,023 (GRCm39) |
Q308* |
probably null |
Het |
| Rock2 |
A |
G |
12: 17,008,241 (GRCm39) |
N528S |
probably benign |
Het |
| Rpp25l |
T |
C |
4: 41,712,305 (GRCm39) |
R157G |
unknown |
Het |
| Ryr1 |
A |
T |
7: 28,735,528 (GRCm39) |
N4083K |
probably damaging |
Het |
| Scd1 |
G |
T |
19: 44,388,739 (GRCm39) |
T237N |
probably benign |
Het |
| Sema3d |
T |
C |
5: 12,558,112 (GRCm39) |
F215L |
probably benign |
Het |
| Sema7a |
C |
T |
9: 57,867,858 (GRCm39) |
T478I |
probably benign |
Het |
| Sftpc |
T |
C |
14: 70,759,623 (GRCm39) |
T99A |
possibly damaging |
Het |
| Slc25a4 |
G |
A |
8: 46,662,241 (GRCm39) |
T139I |
probably damaging |
Het |
| Snx27 |
T |
C |
3: 94,410,272 (GRCm39) |
E468G |
possibly damaging |
Het |
| Snx33 |
T |
C |
9: 56,834,058 (GRCm39) |
K4E |
possibly damaging |
Het |
| Soat1 |
A |
T |
1: 156,268,148 (GRCm39) |
L253* |
probably null |
Het |
| Sycp2l |
A |
T |
13: 41,326,192 (GRCm39) |
N749I |
probably damaging |
Het |
| Synj2bp |
A |
T |
12: 81,557,664 (GRCm39) |
I47N |
probably damaging |
Het |
| Tmem82 |
T |
A |
4: 141,343,605 (GRCm39) |
I222F |
probably damaging |
Het |
| Ube2o |
A |
T |
11: 116,471,905 (GRCm39) |
L112Q |
possibly damaging |
Het |
| Vmn1r204 |
G |
A |
13: 22,740,754 (GRCm39) |
W128* |
probably null |
Het |
| Vmn2r114 |
A |
T |
17: 23,510,817 (GRCm39) |
Y554* |
probably null |
Het |
| Vmn2r62 |
A |
T |
7: 42,437,213 (GRCm39) |
Y424N |
possibly damaging |
Het |
| Vmn2r70 |
A |
T |
7: 85,215,312 (GRCm39) |
L74* |
probably null |
Het |
| Vmp1 |
T |
A |
11: 86,477,377 (GRCm39) |
Y341F |
probably benign |
Het |
| Vps13a |
A |
T |
19: 16,703,027 (GRCm39) |
V642D |
probably damaging |
Het |
| Vps33a |
T |
C |
5: 123,674,619 (GRCm39) |
M383V |
probably benign |
Het |
| Vwf |
G |
A |
6: 125,624,731 (GRCm39) |
V1827I |
|
Het |
| Zc3hav1 |
A |
G |
6: 38,306,121 (GRCm39) |
Y644H |
probably benign |
Het |
| Zfp429 |
A |
C |
13: 67,538,410 (GRCm39) |
C345G |
probably damaging |
Het |
| Zfp595 |
T |
C |
13: 67,464,823 (GRCm39) |
H483R |
probably benign |
Het |
| Zfp748 |
G |
T |
13: 67,690,638 (GRCm39) |
H207Q |
probably benign |
Het |
| Zfp758 |
T |
C |
17: 22,593,939 (GRCm39) |
S142P |
probably damaging |
Het |
| Znfx1 |
A |
C |
2: 166,898,145 (GRCm39) |
S260A |
probably benign |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAACTTCTCAGCACTACTAAGGATTG -3'
(R):5'- TGGGGCTGTGGCAAATATTC -3'
Sequencing Primer
(F):5'- TTATGGAGCAGAGAACTACCTCGTC -3'
(R):5'- GCTGTGGCAAATATTCAGTGG -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation