Incidental Mutation 'R7593:Lrrk1'
| ID |
587533 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7593 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 65958439 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 320
(V320A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000015277
AA Change: V320A
PolyPhen 2
Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: V320A
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207140
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
C |
T |
5: 64,055,774 (GRCm39) |
A170V |
probably damaging |
Het |
| Acp6 |
A |
T |
3: 97,073,266 (GRCm39) |
E102D |
probably benign |
Het |
| Acss1 |
T |
A |
2: 150,461,688 (GRCm39) |
R632* |
probably null |
Het |
| Adamtsl1 |
G |
T |
4: 86,259,450 (GRCm39) |
C832F |
probably damaging |
Het |
| Adgrg6 |
T |
G |
10: 14,344,573 (GRCm39) |
M127L |
probably damaging |
Het |
| Alkbh1 |
A |
T |
12: 87,487,095 (GRCm39) |
Y91* |
probably null |
Het |
| Arhgap35 |
A |
T |
7: 16,298,786 (GRCm39) |
I93N |
probably damaging |
Het |
| Asic2 |
A |
T |
11: 81,858,657 (GRCm39) |
D118E |
probably benign |
Het |
| Asprv1 |
G |
T |
6: 86,605,762 (GRCm39) |
V203L |
probably damaging |
Het |
| Atad2b |
G |
A |
12: 5,081,726 (GRCm39) |
D1212N |
probably benign |
Het |
| Atp4a |
A |
G |
7: 30,424,105 (GRCm39) |
I960V |
probably benign |
Het |
| Bin1 |
G |
T |
18: 32,552,932 (GRCm39) |
E186* |
probably null |
Het |
| Bmp10 |
A |
G |
6: 87,410,651 (GRCm39) |
Y148C |
probably damaging |
Het |
| Ccdc152 |
T |
A |
15: 3,310,137 (GRCm39) |
D246V |
probably damaging |
Het |
| Cdc16 |
A |
G |
8: 13,827,605 (GRCm39) |
T504A |
probably benign |
Het |
| Cdh9 |
A |
T |
15: 16,823,261 (GRCm39) |
D81V |
probably damaging |
Het |
| Cep162 |
A |
T |
9: 87,086,250 (GRCm39) |
S1025T |
probably benign |
Het |
| Cidea |
A |
G |
18: 67,493,283 (GRCm39) |
I101V |
probably benign |
Het |
| Clock |
G |
A |
5: 76,384,145 (GRCm39) |
S478L |
possibly damaging |
Het |
| Cp |
T |
A |
3: 20,020,494 (GRCm39) |
N162K |
probably benign |
Het |
| Crb1 |
C |
T |
1: 139,164,978 (GRCm39) |
E1110K |
probably damaging |
Het |
| Cyp2b13 |
A |
T |
7: 25,780,416 (GRCm39) |
I146L |
possibly damaging |
Het |
| D630045J12Rik |
A |
G |
6: 38,172,429 (GRCm39) |
S580P |
possibly damaging |
Het |
| Dars2 |
T |
C |
1: 160,885,113 (GRCm39) |
E224G |
probably damaging |
Het |
| Dcbld2 |
A |
G |
16: 58,244,941 (GRCm39) |
T72A |
possibly damaging |
Het |
| Ddx11 |
A |
T |
17: 66,433,193 (GRCm39) |
I8F |
possibly damaging |
Het |
| Dennd2d |
T |
C |
3: 106,407,244 (GRCm39) |
F432L |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,823,608 (GRCm39) |
V543A |
probably benign |
Het |
| Eef2k |
G |
A |
7: 120,488,491 (GRCm39) |
|
probably null |
Het |
| Elmo1 |
A |
G |
13: 20,474,610 (GRCm39) |
M345V |
probably benign |
Het |
| Ephb4 |
A |
G |
5: 137,359,560 (GRCm39) |
M377V |
probably benign |
Het |
| Erbb4 |
C |
A |
1: 68,293,758 (GRCm39) |
R711L |
probably damaging |
Het |
| Fads1 |
A |
G |
19: 10,162,361 (GRCm39) |
E95G |
probably damaging |
Het |
| Farsa |
G |
A |
8: 85,594,278 (GRCm39) |
|
probably null |
Het |
| Galntl6 |
A |
G |
8: 58,230,293 (GRCm39) |
S42P |
probably damaging |
Het |
| Gga2 |
G |
A |
7: 121,589,672 (GRCm39) |
T559M |
probably benign |
Het |
| Glipr1l2 |
G |
A |
10: 111,928,465 (GRCm39) |
G120D |
probably damaging |
Het |
| Gm14226 |
A |
T |
2: 154,866,114 (GRCm39) |
I24L |
unknown |
Het |
| Gprc5b |
G |
T |
7: 118,583,492 (GRCm39) |
R126S |
probably damaging |
Het |
| Gys1 |
A |
G |
7: 45,092,360 (GRCm39) |
D321G |
probably damaging |
Het |
| Hdlbp |
C |
T |
1: 93,358,005 (GRCm39) |
A299T |
probably benign |
Het |
| Hic2 |
A |
G |
16: 17,076,979 (GRCm39) |
T603A |
probably damaging |
Het |
| Hoxa11 |
A |
T |
6: 52,220,524 (GRCm39) |
I253N |
probably damaging |
Het |
| Iglon5 |
A |
T |
7: 43,126,064 (GRCm39) |
D222E |
probably benign |
Het |
| Inpp5d |
T |
A |
1: 87,645,500 (GRCm39) |
S1023T |
possibly damaging |
Het |
| Kif21a |
C |
T |
15: 90,828,064 (GRCm39) |
A1233T |
probably benign |
Het |
| Kif9 |
A |
T |
9: 110,350,421 (GRCm39) |
T771S |
possibly damaging |
Het |
| Klre1 |
T |
A |
6: 129,560,150 (GRCm39) |
C141S |
probably damaging |
Het |
| Lats1 |
A |
G |
10: 7,577,476 (GRCm39) |
Y200C |
probably damaging |
Het |
| Lgr4 |
T |
A |
2: 109,829,801 (GRCm39) |
L247H |
probably damaging |
Het |
| Lrrc37a |
T |
C |
11: 103,391,778 (GRCm39) |
K1216E |
probably benign |
Het |
| Lrrc41 |
G |
A |
4: 115,950,141 (GRCm39) |
R518H |
possibly damaging |
Het |
| Mcm9 |
C |
T |
10: 53,506,088 (GRCm39) |
R62H |
probably benign |
Het |
| Mmp10 |
T |
G |
9: 7,503,154 (GRCm39) |
L38R |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,071,867 (GRCm39) |
L546P |
probably damaging |
Het |
| Mtcl2 |
A |
T |
2: 156,882,776 (GRCm39) |
D425E |
probably benign |
Het |
| Myt1 |
T |
A |
2: 181,439,532 (GRCm39) |
D393E |
possibly damaging |
Het |
| Mzb1 |
A |
T |
18: 35,780,901 (GRCm39) |
I129N |
probably damaging |
Het |
| Nek10 |
A |
G |
14: 14,826,955 (GRCm38) |
D51G |
probably benign |
Het |
| Nme5 |
A |
G |
18: 34,700,201 (GRCm39) |
I148T |
probably benign |
Het |
| Nr2e1 |
G |
A |
10: 42,439,475 (GRCm39) |
P348L |
probably damaging |
Het |
| Nrp2 |
A |
G |
1: 62,758,203 (GRCm39) |
E63G |
probably damaging |
Het |
| Or2d2 |
A |
T |
7: 106,727,782 (GRCm39) |
S273T |
probably damaging |
Het |
| Or51ab3 |
A |
T |
7: 103,200,956 (GRCm39) |
|
probably benign |
Het |
| Or52e3 |
A |
G |
7: 102,869,471 (GRCm39) |
E182G |
probably damaging |
Het |
| Or52e5 |
A |
G |
7: 104,718,704 (GRCm39) |
H10R |
probably benign |
Het |
| Or56a3 |
A |
G |
7: 104,735,372 (GRCm39) |
T150A |
probably benign |
Het |
| Pak5 |
A |
G |
2: 135,942,884 (GRCm39) |
S419P |
probably benign |
Het |
| Pfas |
C |
A |
11: 68,881,921 (GRCm39) |
M25I |
|
Het |
| Prdm9 |
A |
G |
17: 15,764,867 (GRCm39) |
S638P |
possibly damaging |
Het |
| Psd |
G |
A |
19: 46,301,352 (GRCm39) |
T954I |
possibly damaging |
Het |
| Psph |
T |
C |
5: 129,864,337 (GRCm39) |
|
probably benign |
Het |
| Ptprf |
A |
G |
4: 118,069,593 (GRCm39) |
I1517T |
probably benign |
Het |
| Rassf8 |
A |
G |
6: 145,761,129 (GRCm39) |
R152G |
probably benign |
Het |
| Rfx3 |
G |
A |
19: 27,827,139 (GRCm39) |
T149I |
probably benign |
Het |
| Rfx8 |
A |
T |
1: 39,722,838 (GRCm39) |
F260I |
probably damaging |
Het |
| Rnft1 |
C |
T |
11: 86,384,023 (GRCm39) |
Q308* |
probably null |
Het |
| Rock2 |
A |
G |
12: 17,008,241 (GRCm39) |
N528S |
probably benign |
Het |
| Rpp25l |
T |
C |
4: 41,712,305 (GRCm39) |
R157G |
unknown |
Het |
| Ryr1 |
A |
T |
7: 28,735,528 (GRCm39) |
N4083K |
probably damaging |
Het |
| Scd1 |
G |
T |
19: 44,388,739 (GRCm39) |
T237N |
probably benign |
Het |
| Sema3d |
T |
C |
5: 12,558,112 (GRCm39) |
F215L |
probably benign |
Het |
| Sema7a |
C |
T |
9: 57,867,858 (GRCm39) |
T478I |
probably benign |
Het |
| Sftpc |
T |
C |
14: 70,759,623 (GRCm39) |
T99A |
possibly damaging |
Het |
| Slc25a4 |
G |
A |
8: 46,662,241 (GRCm39) |
T139I |
probably damaging |
Het |
| Snx27 |
T |
C |
3: 94,410,272 (GRCm39) |
E468G |
possibly damaging |
Het |
| Snx33 |
T |
C |
9: 56,834,058 (GRCm39) |
K4E |
possibly damaging |
Het |
| Soat1 |
A |
T |
1: 156,268,148 (GRCm39) |
L253* |
probably null |
Het |
| Sycp2l |
A |
T |
13: 41,326,192 (GRCm39) |
N749I |
probably damaging |
Het |
| Synj2bp |
A |
T |
12: 81,557,664 (GRCm39) |
I47N |
probably damaging |
Het |
| Tmem82 |
T |
A |
4: 141,343,605 (GRCm39) |
I222F |
probably damaging |
Het |
| Ube2o |
A |
T |
11: 116,471,905 (GRCm39) |
L112Q |
possibly damaging |
Het |
| Vmn1r204 |
G |
A |
13: 22,740,754 (GRCm39) |
W128* |
probably null |
Het |
| Vmn2r114 |
A |
T |
17: 23,510,817 (GRCm39) |
Y554* |
probably null |
Het |
| Vmn2r62 |
A |
T |
7: 42,437,213 (GRCm39) |
Y424N |
possibly damaging |
Het |
| Vmn2r70 |
A |
T |
7: 85,215,312 (GRCm39) |
L74* |
probably null |
Het |
| Vmp1 |
T |
A |
11: 86,477,377 (GRCm39) |
Y341F |
probably benign |
Het |
| Vps13a |
A |
T |
19: 16,703,027 (GRCm39) |
V642D |
probably damaging |
Het |
| Vps33a |
T |
C |
5: 123,674,619 (GRCm39) |
M383V |
probably benign |
Het |
| Vwf |
G |
A |
6: 125,624,731 (GRCm39) |
V1827I |
|
Het |
| Zc3hav1 |
A |
G |
6: 38,306,121 (GRCm39) |
Y644H |
probably benign |
Het |
| Zfp429 |
A |
C |
13: 67,538,410 (GRCm39) |
C345G |
probably damaging |
Het |
| Zfp595 |
T |
C |
13: 67,464,823 (GRCm39) |
H483R |
probably benign |
Het |
| Zfp748 |
G |
T |
13: 67,690,638 (GRCm39) |
H207Q |
probably benign |
Het |
| Zfp758 |
T |
C |
17: 22,593,939 (GRCm39) |
S142P |
probably damaging |
Het |
| Znfx1 |
A |
C |
2: 166,898,145 (GRCm39) |
S260A |
probably benign |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTTCTCTGGCTCCTAAGGG -3'
(R):5'- CGTGTGAAATGGTCCCATCTG -3'
Sequencing Primer
(F):5'- TGGCTCCTAAGGGGTCAGAGATC -3'
(R):5'- GAAATGGTCCCATCTGAAGTTGCC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation