Incidental Mutation 'R7594:Mtus2'
ID 587619
Institutional Source Beutler Lab
Gene Symbol Mtus2
Ensembl Gene ENSMUSG00000029651
Gene Name microtubule associated tumor suppressor candidate 2
Synonyms C130038G02Rik, A730013O20Rik, 5730592G18Rik
MMRRC Submission 045670-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R7594 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 147894130-148252875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 148014216 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 336 (R336S)
Ref Sequence ENSEMBL: ENSMUSP00000082694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085558] [ENSMUST00000129092]
AlphaFold Q3UHD3
Predicted Effect probably benign
Transcript: ENSMUST00000085558
AA Change: R336S

PolyPhen 2 Score 0.439 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000082694
Gene: ENSMUSG00000029651
AA Change: R336S

DomainStartEndE-ValueType
internal_repeat_1 57 290 2.46e-5 PROSPERO
internal_repeat_1 312 525 2.46e-5 PROSPERO
low complexity region 530 541 N/A INTRINSIC
low complexity region 802 818 N/A INTRINSIC
low complexity region 841 852 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
coiled coil region 1029 1080 N/A INTRINSIC
SCOP:d1fxkc_ 1167 1294 3e-4 SMART
low complexity region 1332 1349 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000129092
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930516K23Rik T C 7: 103,708,470 (GRCm39) E113G probably damaging Het
Acsm3 A G 7: 119,384,213 (GRCm39) probably null Het
Acvr2a T A 2: 48,784,749 (GRCm39) L345* probably null Het
App T C 16: 84,876,890 (GRCm39) D167G unknown Het
Arhgef33 A G 17: 80,677,734 (GRCm39) D427G probably damaging Het
Arid2 T C 15: 96,288,875 (GRCm39) S1675P probably damaging Het
Atp8a1 T C 5: 67,808,935 (GRCm39) Y985C Het
AW209491 A G 13: 14,811,831 (GRCm39) D228G probably benign Het
Casc3 G A 11: 98,712,311 (GRCm39) A117T probably benign Het
Cass4 C T 2: 172,271,568 (GRCm39) P645S probably benign Het
Ccar2 A T 14: 70,379,243 (GRCm39) Y553* probably null Het
Cox16 A T 12: 81,521,352 (GRCm39) probably null Het
Cpeb3 A T 19: 37,151,551 (GRCm39) V275E possibly damaging Het
Dido1 A G 2: 180,316,905 (GRCm39) V634A probably benign Het
Dnajb1 G A 8: 84,336,473 (GRCm39) S81N probably benign Het
Dst A G 1: 34,252,094 (GRCm39) K2262E probably damaging Het
Eya3 T C 4: 132,422,136 (GRCm39) V237A probably benign Het
Fbxo31 T A 8: 122,279,107 (GRCm39) D460V probably damaging Het
Fcgbpl1 T C 7: 27,830,885 (GRCm39) C33R probably damaging Het
Gabrg3 A T 7: 56,632,443 (GRCm39) N168K possibly damaging Het
Ggh C G 4: 20,049,833 (GRCm39) S88C probably damaging Het
Gm10134 T C 2: 28,396,372 (GRCm39) M89T unknown Het
Kif17 T C 4: 138,005,236 (GRCm39) L267P probably damaging Het
Ksr2 C A 5: 117,693,131 (GRCm39) T193N possibly damaging Het
Lmtk2 T C 5: 144,110,564 (GRCm39) L428P probably damaging Het
Mdn1 G T 4: 32,696,359 (GRCm39) L1247F probably benign Het
Med24 T C 11: 98,605,923 (GRCm39) Y323C probably damaging Het
Mthfd2 A G 6: 83,283,665 (GRCm39) V339A probably benign Het
Muc16 T C 9: 18,556,358 (GRCm39) T3312A unknown Het
Nacad A G 11: 6,552,457 (GRCm39) S245P probably damaging Het
Nacc1 T C 8: 85,401,631 (GRCm39) D394G probably damaging Het
Nfatc2 A G 2: 168,365,268 (GRCm39) V582A probably damaging Het
Nid2 T A 14: 19,818,791 (GRCm39) D428E probably benign Het
Or10ag57 A G 2: 87,218,613 (GRCm39) H188R probably damaging Het
Or4a80 T A 2: 89,582,906 (GRCm39) T89S probably benign Het
Or56a4 A G 7: 104,806,880 (GRCm39) L3S probably benign Het
Osbpl5 A T 7: 143,247,534 (GRCm39) L768Q probably benign Het
Plch2 C T 4: 155,091,484 (GRCm39) V210I probably damaging Het
Plekhh1 C T 12: 79,123,277 (GRCm39) T1153I possibly damaging Het
Ppp1r14c T C 10: 3,316,670 (GRCm39) S2P possibly damaging Het
Pramel26 A T 4: 143,539,286 (GRCm39) I69N probably damaging Het
Psmd5 G T 2: 34,750,741 (GRCm39) H239Q probably benign Het
Ptcd2 C A 13: 99,456,790 (GRCm39) A345S possibly damaging Het
Sap30l G A 11: 57,700,947 (GRCm39) probably null Het
Sec14l2 A G 11: 4,061,213 (GRCm39) Y83H probably damaging Het
Slc2a9 A G 5: 38,508,634 (GRCm39) I470T probably benign Het
Sp110 G A 1: 85,506,813 (GRCm39) R417C probably benign Het
Syne1 A G 10: 5,165,190 (GRCm39) probably null Het
Tg T A 15: 66,601,432 (GRCm39) D1766E probably benign Het
Tlr12 T C 4: 128,511,473 (GRCm39) E259G probably benign Het
Tlr6 T C 5: 65,110,594 (GRCm39) Y771C probably damaging Het
Tnrc6b T A 15: 80,764,508 (GRCm39) V670E possibly damaging Het
Top2b A G 14: 16,428,587 (GRCm38) T1522A probably benign Het
Tpcn1 A G 5: 120,694,595 (GRCm39) M158T possibly damaging Het
Ttn T C 2: 76,557,186 (GRCm39) I29940V probably benign Het
Ttn G A 2: 76,581,698 (GRCm39) T23065I probably damaging Het
Umodl1 A G 17: 31,173,779 (GRCm39) S20G probably benign Het
Uts2r G T 11: 121,052,191 (GRCm39) V352F possibly damaging Het
Vmn1r67 T A 7: 10,181,342 (GRCm39) M202K possibly damaging Het
Vmn2r107 T C 17: 20,580,635 (GRCm39) V524A probably benign Het
Zc3h12d C A 10: 7,738,382 (GRCm39) D229E probably damaging Het
Zfp541 A G 7: 15,810,311 (GRCm39) D116G probably damaging Het
Zfp971 A G 2: 177,675,793 (GRCm39) E464G possibly damaging Het
Other mutations in Mtus2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Mtus2 APN 5 148,013,819 (GRCm39) splice site probably null
IGL01911:Mtus2 APN 5 148,015,030 (GRCm39) missense probably benign 0.00
IGL01973:Mtus2 APN 5 148,240,286 (GRCm39) splice site probably benign
IGL02452:Mtus2 APN 5 148,014,473 (GRCm39) missense probably benign 0.01
IGL02476:Mtus2 APN 5 148,014,748 (GRCm39) missense probably benign 0.01
IGL02716:Mtus2 APN 5 148,173,120 (GRCm39) missense probably benign 0.05
IGL03194:Mtus2 APN 5 148,043,913 (GRCm39) missense probably damaging 1.00
rumblado UTSW 5 148,243,518 (GRCm39) nonsense probably null
IGL02991:Mtus2 UTSW 5 148,250,310 (GRCm39) missense probably damaging 1.00
PIT4431001:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0310:Mtus2 UTSW 5 148,043,829 (GRCm39) missense probably benign 0.17
R0729:Mtus2 UTSW 5 148,014,097 (GRCm39) missense probably benign 0.08
R0968:Mtus2 UTSW 5 148,014,994 (GRCm39) missense probably benign 0.09
R1231:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1253:Mtus2 UTSW 5 148,240,380 (GRCm39) nonsense probably null
R1556:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1561:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1574:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1750:Mtus2 UTSW 5 148,214,443 (GRCm39) missense probably damaging 0.97
R2318:Mtus2 UTSW 5 148,043,892 (GRCm39) nonsense probably null
R2327:Mtus2 UTSW 5 148,014,725 (GRCm39) missense probably benign 0.00
R3153:Mtus2 UTSW 5 148,019,870 (GRCm39) missense probably damaging 1.00
R3154:Mtus2 UTSW 5 148,240,083 (GRCm39) intron probably benign
R3158:Mtus2 UTSW 5 148,168,637 (GRCm39) missense probably damaging 1.00
R3548:Mtus2 UTSW 5 148,232,316 (GRCm39) missense probably damaging 1.00
R3861:Mtus2 UTSW 5 148,250,223 (GRCm39) missense probably damaging 1.00
R4395:Mtus2 UTSW 5 148,013,432 (GRCm39) missense probably benign 0.17
R4396:Mtus2 UTSW 5 148,140,748 (GRCm39) missense possibly damaging 0.81
R4667:Mtus2 UTSW 5 148,235,070 (GRCm39) missense possibly damaging 0.64
R4887:Mtus2 UTSW 5 148,013,913 (GRCm39) nonsense probably null
R4931:Mtus2 UTSW 5 148,014,226 (GRCm39) missense probably benign 0.09
R5097:Mtus2 UTSW 5 148,232,392 (GRCm39) missense probably damaging 0.99
R5318:Mtus2 UTSW 5 148,013,382 (GRCm39) missense probably benign 0.05
R5372:Mtus2 UTSW 5 148,250,222 (GRCm39) missense probably damaging 1.00
R5388:Mtus2 UTSW 5 148,243,518 (GRCm39) nonsense probably null
R5622:Mtus2 UTSW 5 148,015,244 (GRCm39) missense probably benign 0.09
R6009:Mtus2 UTSW 5 148,243,462 (GRCm39) missense probably damaging 1.00
R6379:Mtus2 UTSW 5 148,014,008 (GRCm39) missense probably benign 0.00
R6409:Mtus2 UTSW 5 148,014,425 (GRCm39) missense probably benign
R6527:Mtus2 UTSW 5 148,214,408 (GRCm39) critical splice acceptor site probably null
R6853:Mtus2 UTSW 5 148,043,821 (GRCm39) missense probably damaging 1.00
R7001:Mtus2 UTSW 5 148,214,438 (GRCm39) missense probably damaging 1.00
R7187:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R7276:Mtus2 UTSW 5 148,013,368 (GRCm39) missense probably benign
R7790:Mtus2 UTSW 5 148,014,998 (GRCm39) missense probably benign 0.09
R7967:Mtus2 UTSW 5 148,014,656 (GRCm39) missense probably benign 0.32
R7987:Mtus2 UTSW 5 148,168,836 (GRCm39) splice site probably null
R8112:Mtus2 UTSW 5 148,013,713 (GRCm39) nonsense probably null
R8273:Mtus2 UTSW 5 148,043,815 (GRCm39) missense probably damaging 1.00
R8527:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8542:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8783:Mtus2 UTSW 5 148,019,861 (GRCm39) missense probably damaging 1.00
R8805:Mtus2 UTSW 5 148,015,303 (GRCm39) missense possibly damaging 0.58
R9204:Mtus2 UTSW 5 148,238,293 (GRCm39) missense probably damaging 1.00
R9210:Mtus2 UTSW 5 148,014,124 (GRCm39) missense probably benign 0.00
R9261:Mtus2 UTSW 5 148,243,453 (GRCm39) nonsense probably null
R9419:Mtus2 UTSW 5 148,243,451 (GRCm39) missense probably damaging 1.00
R9477:Mtus2 UTSW 5 148,014,740 (GRCm39) missense probably benign
R9483:Mtus2 UTSW 5 148,232,300 (GRCm39) missense possibly damaging 0.80
R9563:Mtus2 UTSW 5 148,250,217 (GRCm39) missense
R9643:Mtus2 UTSW 5 148,014,025 (GRCm39) missense probably benign 0.04
R9716:Mtus2 UTSW 5 148,013,464 (GRCm39) missense possibly damaging 0.82
R9745:Mtus2 UTSW 5 148,013,311 (GRCm39) missense possibly damaging 0.81
X0017:Mtus2 UTSW 5 148,214,410 (GRCm39) missense possibly damaging 0.83
X0028:Mtus2 UTSW 5 148,014,128 (GRCm39) missense probably benign 0.03
Z1088:Mtus2 UTSW 5 148,240,073 (GRCm39) intron probably benign
Z1176:Mtus2 UTSW 5 148,014,068 (GRCm39) missense probably benign 0.05
Z1176:Mtus2 UTSW 5 148,013,552 (GRCm39) missense probably benign 0.31
Z1177:Mtus2 UTSW 5 148,140,887 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACTCCCAGTTCAGCTTCAG -3'
(R):5'- ACCGGCTGACATTTTACCGG -3'

Sequencing Primer
(F):5'- GCTTCAGCGTCGAAGGAAAACC -3'
(R):5'- GACATTTTACCGGTGAGTCTAGTACC -3'
Posted On 2019-10-24