Incidental Mutation 'R7599:Dennd4c'
| ID |
587890 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
045673-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7599 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
86666792-86768840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86729849 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 817
(L817P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045512
AA Change: L817P
PolyPhen 2
Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: L817P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082026
AA Change: L817P
PolyPhen 2
Score 0.182 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: L817P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142837
AA Change: L817P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: L817P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts3 |
T |
C |
5: 90,009,256 (GRCm39) |
S136G |
probably benign |
Het |
| Apba3 |
T |
A |
10: 81,108,180 (GRCm39) |
N445K |
probably damaging |
Het |
| Aqp6 |
A |
G |
15: 99,501,652 (GRCm39) |
K237E |
possibly damaging |
Het |
| Arhgap23 |
A |
G |
11: 97,391,169 (GRCm39) |
T1229A |
probably benign |
Het |
| Bpifb1 |
T |
C |
2: 154,056,071 (GRCm39) |
I379T |
probably damaging |
Het |
| Bpnt2 |
G |
A |
4: 4,778,207 (GRCm39) |
T177I |
probably damaging |
Het |
| Ccdc169 |
A |
G |
3: 55,047,530 (GRCm39) |
D7G |
probably damaging |
Het |
| Cyp2f2 |
T |
A |
7: 26,830,784 (GRCm39) |
|
probably null |
Het |
| Daam2 |
T |
A |
17: 49,787,755 (GRCm39) |
K453* |
probably null |
Het |
| Efcab6 |
T |
A |
15: 83,755,189 (GRCm39) |
R1376W |
probably damaging |
Het |
| Esrra |
G |
T |
19: 6,891,214 (GRCm39) |
A182E |
possibly damaging |
Het |
| Fam234b |
T |
A |
6: 135,203,874 (GRCm39) |
V392E |
probably damaging |
Het |
| Fanca |
A |
G |
8: 123,997,999 (GRCm39) |
V1229A |
probably benign |
Het |
| Fdps |
G |
T |
3: 89,006,693 (GRCm39) |
Q66K |
probably benign |
Het |
| Fer1l6 |
T |
A |
15: 58,499,438 (GRCm39) |
D1269E |
probably benign |
Het |
| Foxred1 |
G |
A |
9: 35,116,932 (GRCm39) |
R353W |
probably damaging |
Het |
| Gabrg2 |
C |
T |
11: 41,858,451 (GRCm39) |
V226I |
possibly damaging |
Het |
| Gcnt2 |
C |
A |
13: 41,014,343 (GRCm39) |
C171* |
probably null |
Het |
| Glyat |
C |
A |
19: 12,617,172 (GRCm39) |
A8E |
probably damaging |
Het |
| Golgb1 |
C |
A |
16: 36,695,758 (GRCm39) |
R86S |
unknown |
Het |
| Hc |
T |
A |
2: 34,940,431 (GRCm39) |
T136S |
probably damaging |
Het |
| Hdac1 |
G |
T |
4: 129,411,259 (GRCm39) |
S421* |
probably null |
Het |
| Hmcn2 |
G |
T |
2: 31,246,298 (GRCm39) |
A756S |
possibly damaging |
Het |
| Igkv8-26 |
A |
G |
6: 70,170,571 (GRCm39) |
N54S |
probably benign |
Het |
| Itgae |
T |
A |
11: 73,012,786 (GRCm39) |
V706E |
possibly damaging |
Het |
| Itgax |
G |
A |
7: 127,747,262 (GRCm39) |
V992M |
probably damaging |
Het |
| Klk10 |
A |
G |
7: 43,433,851 (GRCm39) |
D221G |
probably benign |
Het |
| Klkb1 |
T |
C |
8: 45,731,150 (GRCm39) |
I205V |
probably benign |
Het |
| Kpna2 |
T |
C |
11: 106,889,583 (GRCm39) |
N8S |
probably null |
Het |
| L3mbtl1 |
A |
C |
2: 162,806,434 (GRCm39) |
T442P |
possibly damaging |
Het |
| Lrp1b |
C |
T |
2: 40,551,561 (GRCm39) |
C4181Y |
|
Het |
| Mcat |
T |
C |
15: 83,431,872 (GRCm39) |
Y332C |
probably damaging |
Het |
| Mecom |
T |
C |
3: 30,010,534 (GRCm39) |
D648G |
probably damaging |
Het |
| Mesp2 |
A |
T |
7: 79,460,717 (GRCm39) |
D14V |
probably damaging |
Het |
| Mlh3 |
A |
T |
12: 85,314,973 (GRCm39) |
Y404* |
probably null |
Het |
| Mterf3 |
A |
T |
13: 67,065,212 (GRCm39) |
F230I |
probably damaging |
Het |
| Nrxn3 |
T |
C |
12: 89,478,832 (GRCm39) |
V602A |
probably benign |
Het |
| Or4a74 |
T |
A |
2: 89,439,571 (GRCm39) |
I292F |
possibly damaging |
Het |
| Plekhg6 |
A |
G |
6: 125,351,623 (GRCm39) |
F209L |
probably damaging |
Het |
| Pmp22 |
C |
A |
11: 63,049,174 (GRCm39) |
A139D |
probably damaging |
Het |
| Polr2e |
T |
C |
10: 79,874,404 (GRCm39) |
D34G |
possibly damaging |
Het |
| Ppard |
T |
A |
17: 28,516,091 (GRCm39) |
L105H |
probably damaging |
Het |
| Ptpn14 |
T |
A |
1: 189,582,942 (GRCm39) |
D596E |
probably benign |
Het |
| Ptprz1 |
C |
T |
6: 23,002,518 (GRCm39) |
A1536V |
not run |
Het |
| Qng1 |
T |
A |
13: 58,529,649 (GRCm39) |
H321L |
probably damaging |
Het |
| Rabgap1 |
TGGGG |
TGGG |
2: 37,392,908 (GRCm39) |
|
probably null |
Het |
| Retreg1 |
T |
A |
15: 25,971,727 (GRCm39) |
D222E |
probably benign |
Het |
| Rmnd1 |
T |
C |
10: 4,363,404 (GRCm39) |
K282R |
probably benign |
Het |
| Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Het |
| Sall3 |
C |
T |
18: 81,015,267 (GRCm39) |
R887H |
possibly damaging |
Het |
| Samd3 |
A |
G |
10: 26,139,711 (GRCm39) |
D281G |
probably benign |
Het |
| Scube1 |
T |
A |
15: 83,497,653 (GRCm39) |
D766V |
probably damaging |
Het |
| Sec24b |
TGC |
TGCAGC |
3: 129,834,460 (GRCm39) |
|
probably benign |
Het |
| Slc2a2 |
A |
G |
3: 28,752,166 (GRCm39) |
M1V |
probably null |
Het |
| Slc39a2 |
A |
T |
14: 52,132,488 (GRCm39) |
T144S |
probably benign |
Het |
| Slc5a9 |
T |
C |
4: 111,734,937 (GRCm39) |
H619R |
probably benign |
Het |
| Slco4a1 |
T |
C |
2: 180,113,048 (GRCm39) |
F427L |
probably benign |
Het |
| Snapc3 |
C |
A |
4: 83,336,073 (GRCm39) |
Y28* |
probably null |
Het |
| St3gal6 |
C |
T |
16: 58,293,800 (GRCm39) |
R243H |
probably benign |
Het |
| Stat2 |
T |
A |
10: 128,113,066 (GRCm39) |
N119K |
possibly damaging |
Het |
| Syne2 |
G |
C |
12: 76,013,145 (GRCm39) |
V2779L |
probably benign |
Het |
| Tacc1 |
T |
A |
8: 25,691,301 (GRCm39) |
M1L |
probably damaging |
Het |
| Tbc1d32 |
A |
T |
10: 56,027,929 (GRCm39) |
F724L |
possibly damaging |
Het |
| Ttc23l |
A |
G |
15: 10,533,766 (GRCm39) |
I259T |
possibly damaging |
Het |
| Ucn2 |
T |
C |
9: 108,815,292 (GRCm39) |
I18T |
probably benign |
Het |
| Wdr35 |
G |
C |
12: 9,074,886 (GRCm39) |
A1000P |
probably benign |
Het |
| Wnk1 |
C |
A |
6: 119,906,789 (GRCm39) |
C244F |
possibly damaging |
Het |
| Zeb2 |
T |
G |
2: 44,884,625 (GRCm39) |
D1022A |
probably damaging |
Het |
| Zfp26 |
A |
T |
9: 20,349,129 (GRCm39) |
H478Q |
probably damaging |
Het |
| Zfp410 |
A |
G |
12: 84,378,630 (GRCm39) |
K265R |
probably benign |
Het |
| Zfp575 |
T |
C |
7: 24,286,093 (GRCm39) |
D21G |
probably benign |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,723,724 (GRCm39) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,717,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,721,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,732,036 (GRCm39) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,725,672 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,717,778 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,743,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,692,490 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,739,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,692,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,707,057 (GRCm39) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,696,140 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,696,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,696,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,725,663 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,717,701 (GRCm39) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,699,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,699,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,744,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,731,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,730,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,707,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,763,145 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,725,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,729,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,692,769 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,704,331 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,725,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Dennd4c
|
UTSW |
4 |
86,721,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,743,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,755,634 (GRCm39) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,729,764 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,699,881 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,743,557 (GRCm39) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,698,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,692,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,725,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,716,312 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,738,200 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,743,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4923:Dennd4c
|
UTSW |
4 |
86,725,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,699,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,713,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,729,693 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,713,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,729,690 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,744,223 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,709,589 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,743,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,723,828 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,743,686 (GRCm39) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,717,626 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,754,694 (GRCm39) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,717,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,730,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,725,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,721,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,747,975 (GRCm39) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,759,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7329:Dennd4c
|
UTSW |
4 |
86,698,111 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7466:Dennd4c
|
UTSW |
4 |
86,692,568 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,717,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,692,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,713,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,704,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,747,179 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7790:Dennd4c
|
UTSW |
4 |
86,717,754 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,763,213 (GRCm39) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,744,109 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,759,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,744,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,754,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,739,702 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,743,349 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,755,637 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,738,170 (GRCm39) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,747,208 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,713,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,743,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,754,625 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGAGATGTTATACGAATCCACCAC -3'
(R):5'- GGATACTTGGCAGACTAAGAGC -3'
Sequencing Primer
(F):5'- CAATGGGCCAAGTATCTATTCAGC -3'
(R):5'- TGAAACTTGGGGCAATCTCC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation