|Institutional Source||Beutler Lab|
|Gene Name||histone deacetylase 1|
|Synonyms||HD1, MommeD5, RPD3|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R7599 (G1)|
|Chromosomal Location||129516104-129542713 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||G to T at 129517466 bp|
|Amino Acid Change||Serine to Stop codon at position 421 (S421*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000099657 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000062356] [ENSMUST00000102597]|
|Predicted Effect||probably benign
|Predicted Effect||probably null
AA Change: S421*
AA Change: S421*
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hdac1||
(F):5'- ACCTCCAGTTTAAGCTCCAAAGG -3'
(R):5'- CCAGCTGTGTGCAAACATTTG -3'
(F):5'- TCCAAAGGAGCTGGCTGG -3'
(R):5'- GTGCAAACATTTGTTTTGAGACCCC -3'