|Institutional Source||Beutler Lab|
|Gene Name||cytochrome P450, family 2, subfamily f, polypeptide 2|
|Essential gene?||Probably non essential (E-score: 0.120)|
|Stock #||R7599 (G1)|
|Chromosomal Location||27119909-27133660 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to A at 27131359 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000003100 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000003100] [ENSMUST00000003100] [ENSMUST00000206552]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cyp2f2||
(F):5'- CGTGCAGGAAGAGATTGACC -3'
(R):5'- GGAGTTCCGATCTCTTCTGATATG -3'
(F):5'- TGCAGGAAGAGATTGACCGTGTG -3'
(R):5'- TTCGGGAGTTCAAGTCCAAC -3'