Mutagenetix > Incidental Mutations

Incidental Mutation 'R7603:Vmn1r202'

588130

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r202

Ensembl Gene

ENSMUSG00000094379

Gene Name

vomeronasal 1 receptor 202

Synonyms

V1ri7

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.104) question?

Stock #

R7603 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

22497750-22505381 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22501620 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 209 (L209Q)

Ref Sequence

ENSEMBL: ENSMUSP00000077711 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078642] [ENSMUST00000228020]

Predicted Effect

probably damaging
Transcript: ENSMUST00000078642
AA Change: L209Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077711
Gene: ENSMUSG00000094379
AA Change: L209Q

Domain	Start	End	E-Value	Type
Pfam:TAS2R	5	301	2.2e-11	PFAM
Pfam:V1R	35	300	5.6e-44	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000228020
AA Change: L209Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

98% (47/48)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	T	C	11: 23,566,191	T709A	probably benign	Het
Abca6	T	C	11: 110,180,258	K1536E	possibly damaging	Het
Abhd16a	T	A	17: 35,101,960		probably null	Het
Actrt3	C	T	3: 30,598,547	A133T	probably benign	Het
Adcy10	C	T	1: 165,564,237	R1329W	probably damaging	Het
Apol7b	T	C	15: 77,423,456	M280V	possibly damaging	Het
Canx	A	T	11: 50,311,628	D50E	probably benign	Het
Csmd1	A	T	8: 16,288,682	D470E	probably damaging	Het
Cyp2c23	C	T	19: 44,014,930	D269N	probably damaging	Het
Ddah1	T	C	3: 145,759,019	V53A	probably benign	Het
Epha7	C	T	4: 28,871,937	S422L	probably benign	Het
Fastkd5	A	G	2: 130,615,041	V543A	possibly damaging	Het
Fggy	G	A	4: 95,769,506	G295R	probably damaging	Het
Frs2	T	C	10: 117,074,063	T465A	probably benign	Het
Glipr1	A	T	10: 111,988,832	N156K	probably benign	Het
Gnpnat1	C	T	14: 45,384,617	V40I	probably benign	Het
H2-Q7	T	C	17: 35,439,963	L130P	probably damaging	Het
Herc1	T	A	9: 66,451,383	L86*	probably null	Het
Hspg2	T	C	4: 137,548,368	L2778P	probably damaging	Het
Hspg2	T	A	4: 137,557,192	I3487N	possibly damaging	Het
Htra4	T	G	8: 25,025,700	I441L	probably benign	Het
Ints7	A	T	1: 191,596,224	H203L	probably damaging	Het
Lama2	T	C	10: 27,266,680	T601A	possibly damaging	Het
Lin7b	T	C	7: 45,368,432		probably benign	Het
Lmbr1l	G	A	15: 98,908,691	Q280*	probably null	Het
Lpin3	G	T	2: 160,903,754		probably null	Het
Map1lc3b	A	T	8: 121,593,529	H27L	possibly damaging	Het
Mfsd14a	C	A	3: 116,633,883	V369F	probably damaging	Het
Ndufa12	C	T	10: 94,220,779	A123V	probably benign	Het
Nek9	A	G	12: 85,303,514	F929L	probably benign	Het
Nup210	A	T	6: 91,076,697	D279E	probably benign	Het
Olfr553	A	G	7: 102,614,938	V17A	probably benign	Het
Parp1	T	C	1: 180,600,212		probably null	Het
Phc3	T	C	3: 30,907,452	I944V	probably damaging	Het
Phf20	C	T	2: 156,302,851	A793V	probably benign	Het
Phf21a	A	C	2: 92,357,007	R540S	probably benign	Het
Pogk	A	G	1: 166,401,911	C124R	probably benign	Het
Rif1	C	T	2: 52,076,175	S93L	probably damaging	Het
Sele	A	G	1: 164,049,515	E120G	probably damaging	Het
Slc4a1ap	T	C	5: 31,546,195	L49P		Het
Snap47	T	C	11: 59,428,547	D255G	probably damaging	Het
Tcstv3	T	C	13: 120,317,610	V15A	probably damaging	Het
Tmcc1	A	T	6: 116,043,131	Y453*	probably null	Het
Tpsg1	G	T	17: 25,373,210	G86V	probably damaging	Het
Urb1	CACTTAC	CAC	16: 90,772,573		probably benign	Het
Usp20	T	A	2: 31,011,474	V459E	probably damaging	Het
Vps13b	T	C	15: 35,576,439	S998P	probably damaging	Het

Other mutations in Vmn1r202

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01472:Vmn1r202	APN	13	22501989	missense	possibly damaging	0.95
IGL01516:Vmn1r202	APN	13	22501462	missense	possibly damaging	0.57
IGL01722:Vmn1r202	APN	13	22501720	missense	probably benign	0.00
IGL02641:Vmn1r202	APN	13	22502104	missense	probably benign	0.34
IGL02863:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL02876:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL02891:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL02943:Vmn1r202	APN	13	22502194	missense	probably benign	0.01
IGL03057:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL03114:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL03114:Vmn1r202	APN	13	22501330	utr 3 prime	probably benign
IGL03143:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL03159:Vmn1r202	APN	13	22501470	missense	probably benign	0.00
IGL03097:Vmn1r202	UTSW	13	22501470	missense	probably benign	0.00
R0611:Vmn1r202	UTSW	13	22501654	missense	probably damaging	1.00
R1350:Vmn1r202	UTSW	13	22501716	missense	probably benign	0.04
R1666:Vmn1r202	UTSW	13	22501370	missense	possibly damaging	0.94
R1668:Vmn1r202	UTSW	13	22501370	missense	possibly damaging	0.94
R1803:Vmn1r202	UTSW	13	22502143	missense	probably benign	0.00
R2035:Vmn1r202	UTSW	13	22501602	missense	probably damaging	0.98
R2112:Vmn1r202	UTSW	13	22501734	missense	possibly damaging	0.76
R2145:Vmn1r202	UTSW	13	22501783	missense	possibly damaging	0.79
R3026:Vmn1r202	UTSW	13	22501762	missense	probably benign	0.03
R3808:Vmn1r202	UTSW	13	22501900	missense	possibly damaging	0.83
R4714:Vmn1r202	UTSW	13	22501807	missense	probably damaging	1.00
R5016:Vmn1r202	UTSW	13	22502205	missense	probably damaging	1.00
R5124:Vmn1r202	UTSW	13	22501750	missense	probably benign	0.01
R6136:Vmn1r202	UTSW	13	22501462	missense	possibly damaging	0.90
R6365:Vmn1r202	UTSW	13	22502204	missense	probably benign	0.12
R6982:Vmn1r202	UTSW	13	22501747	missense	probably benign	0.02
R7293:Vmn1r202	UTSW	13	22501702	missense	probably benign	0.00
R7502:Vmn1r202	UTSW	13	22502018	missense	probably damaging	1.00
R7672:Vmn1r202	UTSW	13	22501680	missense	probably benign	0.45
R7822:Vmn1r202	UTSW	13	22502071	missense	probably damaging	1.00
R7954:Vmn1r202	UTSW	13	22501701	missense	probably benign	0.01
R8026:Vmn1r202	UTSW	13	22502144	missense	possibly damaging	0.65
R8419:Vmn1r202	UTSW	13	22501815	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTGCCACTGTGGAACCTGTG -3'
(R):5'- CACCATGGCATGTTCTTGC -3'

Sequencing Primer
(F):5'- CCACTGTGGAACCTGTGTATAAG -3'
(R):5'- TTGCTGCACTATATCACAGCAGG -3'

Posted On

2019-10-24