Incidental Mutation 'R7605:Vmn2r68'
| ID |
588240 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r68
|
| Ensembl Gene |
ENSMUSG00000096861 |
| Gene Name |
vomeronasal 2, receptor 68 |
| Synonyms |
EG620697, Vmn2r68-ps |
| MMRRC Submission |
045675-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
R7605 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
84870726-84886912 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84883116 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 212
(D212G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129411
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061074]
|
| AlphaFold |
L7N2B3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061074
AA Change: D212G
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000129411
Gene: ENSMUSG00000096861
AA Change: D212G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
463 |
4.5e-28 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
1.1e-18 |
PFAM |
|
Pfam:7tm_3
|
589 |
827 |
3.7e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb5 |
A |
G |
12: 118,881,899 (GRCm39) |
L610P |
probably damaging |
Het |
| Acta2 |
G |
A |
19: 34,229,931 (GRCm39) |
T8I |
probably benign |
Het |
| Asphd2 |
A |
G |
5: 112,539,807 (GRCm39) |
W9R |
probably damaging |
Het |
| Blvrb |
T |
A |
7: 27,165,218 (GRCm39) |
H179Q |
probably damaging |
Het |
| Capn13 |
A |
T |
17: 73,652,132 (GRCm39) |
|
probably null |
Het |
| Casp6 |
A |
T |
3: 129,705,812 (GRCm39) |
M160L |
probably benign |
Het |
| Chordc1 |
A |
G |
9: 18,215,668 (GRCm39) |
E140G |
probably benign |
Het |
| Col24a1 |
A |
T |
3: 145,244,442 (GRCm39) |
Y1572F |
possibly damaging |
Het |
| Cul9 |
A |
G |
17: 46,852,658 (GRCm39) |
S235P |
probably damaging |
Het |
| Cyp2u1 |
A |
T |
3: 131,091,602 (GRCm39) |
M306K |
probably damaging |
Het |
| Dhx33 |
A |
G |
11: 70,890,299 (GRCm39) |
L240P |
probably damaging |
Het |
| Dna2 |
T |
A |
10: 62,796,054 (GRCm39) |
D494E |
probably benign |
Het |
| Dnah7c |
C |
T |
1: 46,671,470 (GRCm39) |
R1620C |
probably damaging |
Het |
| Dpp8 |
G |
A |
9: 64,962,240 (GRCm39) |
V427M |
probably benign |
Het |
| Dpt |
G |
A |
1: 164,624,400 (GRCm39) |
G34S |
unknown |
Het |
| Emb |
T |
A |
13: 117,401,046 (GRCm39) |
N198K |
probably damaging |
Het |
| Entpd5 |
T |
G |
12: 84,443,482 (GRCm39) |
H62P |
probably damaging |
Het |
| Ep300 |
A |
C |
15: 81,505,353 (GRCm39) |
M658L |
unknown |
Het |
| Epb41l4a |
T |
A |
18: 33,930,504 (GRCm39) |
D651V |
probably damaging |
Het |
| Epha7 |
C |
T |
4: 28,871,937 (GRCm39) |
S422L |
probably benign |
Het |
| Ephb2 |
A |
T |
4: 136,498,419 (GRCm39) |
V220E |
probably damaging |
Het |
| Fam187a |
T |
A |
11: 102,776,874 (GRCm39) |
L226H |
possibly damaging |
Het |
| Fbxo42 |
G |
A |
4: 140,927,129 (GRCm39) |
A470T |
probably benign |
Het |
| Fcgrt |
C |
T |
7: 44,744,675 (GRCm39) |
W264* |
probably null |
Het |
| Flt3 |
A |
C |
5: 147,286,386 (GRCm39) |
H733Q |
probably benign |
Het |
| Gabrr2 |
A |
G |
4: 33,082,560 (GRCm39) |
D228G |
probably damaging |
Het |
| Gars1 |
T |
C |
6: 55,054,735 (GRCm39) |
S681P |
probably damaging |
Het |
| Gata2 |
T |
C |
6: 88,177,390 (GRCm39) |
V140A |
possibly damaging |
Het |
| Gm8232 |
A |
T |
14: 44,672,384 (GRCm39) |
N100I |
|
Het |
| Grik4 |
A |
G |
9: 42,599,367 (GRCm39) |
C37R |
probably damaging |
Het |
| Grm8 |
T |
C |
6: 27,618,678 (GRCm39) |
E388G |
probably damaging |
Het |
| Hivep3 |
CGG |
CG |
4: 119,955,108 (GRCm39) |
1141 |
probably null |
Het |
| Igsf9b |
C |
T |
9: 27,234,608 (GRCm39) |
T491I |
probably damaging |
Het |
| Impa1 |
C |
T |
3: 10,389,147 (GRCm39) |
V105I |
probably damaging |
Het |
| Inf2 |
A |
G |
12: 112,567,771 (GRCm39) |
T134A |
probably damaging |
Het |
| Itgb4 |
T |
A |
11: 115,897,302 (GRCm39) |
V1521E |
probably benign |
Het |
| Iws1 |
T |
A |
18: 32,222,540 (GRCm39) |
D623E |
probably benign |
Het |
| Lhfpl5 |
T |
C |
17: 28,795,305 (GRCm39) |
S111P |
possibly damaging |
Het |
| Lyzl1 |
T |
C |
18: 4,169,244 (GRCm39) |
C83R |
probably damaging |
Het |
| Madd |
G |
A |
2: 91,000,055 (GRCm39) |
T617M |
possibly damaging |
Het |
| Magi2 |
A |
G |
5: 20,433,383 (GRCm39) |
T163A |
probably damaging |
Het |
| Mdn1 |
C |
A |
4: 32,694,599 (GRCm39) |
H1107Q |
probably damaging |
Het |
| Mfsd14b |
A |
T |
13: 65,214,591 (GRCm39) |
Y454N |
probably benign |
Het |
| Mrgprb3 |
T |
A |
7: 48,292,862 (GRCm39) |
I230F |
probably benign |
Het |
| Mroh2b |
C |
T |
15: 4,974,505 (GRCm39) |
L1162F |
probably damaging |
Het |
| Or11i1 |
G |
T |
3: 106,729,337 (GRCm39) |
H179Q |
probably damaging |
Het |
| Or2aj5 |
T |
C |
16: 19,425,022 (GRCm39) |
Y131C |
probably damaging |
Het |
| Or51f23b |
C |
T |
7: 102,402,952 (GRCm39) |
M61I |
probably benign |
Het |
| Or51m1 |
T |
C |
7: 103,578,075 (GRCm39) |
L15P |
probably damaging |
Het |
| Or5ar1 |
A |
G |
2: 85,671,383 (GRCm39) |
F251L |
probably benign |
Het |
| Or9e1 |
A |
G |
11: 58,732,326 (GRCm39) |
I129V |
probably benign |
Het |
| Pclo |
T |
C |
5: 14,729,050 (GRCm39) |
L2636P |
unknown |
Het |
| Pfkm |
G |
A |
15: 98,019,191 (GRCm39) |
A181T |
probably damaging |
Het |
| Pik3r1 |
C |
T |
13: 101,839,346 (GRCm39) |
A169T |
probably benign |
Het |
| R3hdml |
T |
A |
2: 163,337,688 (GRCm39) |
M114K |
probably damaging |
Het |
| Robo1 |
C |
A |
16: 72,821,189 (GRCm39) |
R1310S |
probably benign |
Het |
| Scnm1 |
A |
T |
3: 95,040,186 (GRCm39) |
N115K |
probably benign |
Het |
| Sfn |
A |
G |
4: 133,328,548 (GRCm39) |
V178A |
probably damaging |
Het |
| Shank2 |
C |
T |
7: 143,645,516 (GRCm39) |
T366I |
possibly damaging |
Het |
| Siah1a |
T |
C |
8: 87,451,953 (GRCm39) |
D177G |
probably damaging |
Het |
| Slc37a2 |
A |
C |
9: 37,148,624 (GRCm39) |
I286S |
possibly damaging |
Het |
| Smarce1 |
T |
C |
11: 99,119,118 (GRCm39) |
T12A |
probably benign |
Het |
| Spata31d1c |
T |
A |
13: 65,183,654 (GRCm39) |
S399T |
probably benign |
Het |
| Specc1 |
A |
G |
11: 62,102,506 (GRCm39) |
S942G |
possibly damaging |
Het |
| Syt13 |
T |
C |
2: 92,773,478 (GRCm39) |
F164S |
probably benign |
Het |
| Topbp1 |
A |
T |
9: 103,209,905 (GRCm39) |
T851S |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,800,015 (GRCm39) |
S398T |
unknown |
Het |
| Vmn1r12 |
T |
C |
6: 57,136,521 (GRCm39) |
V206A |
probably damaging |
Het |
| Vmn1r224 |
G |
A |
17: 20,640,221 (GRCm39) |
W266* |
probably null |
Het |
| Vps13b |
G |
T |
15: 35,770,792 (GRCm39) |
K2078N |
probably damaging |
Het |
| Zfp251 |
A |
C |
15: 76,738,557 (GRCm39) |
F179V |
possibly damaging |
Het |
|
| Other mutations in Vmn2r68 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01391:Vmn2r68
|
APN |
7 |
84,886,819 (GRCm39) |
missense |
probably benign |
|
|
IGL01477:Vmn2r68
|
APN |
7 |
84,882,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01600:Vmn2r68
|
APN |
7 |
84,871,468 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01979:Vmn2r68
|
APN |
7 |
84,871,325 (GRCm39) |
missense |
probably benign |
|
|
IGL01999:Vmn2r68
|
APN |
7 |
84,871,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02269:Vmn2r68
|
APN |
7 |
84,870,947 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02517:Vmn2r68
|
APN |
7 |
84,871,153 (GRCm39) |
nonsense |
probably null |
|
|
IGL02827:Vmn2r68
|
APN |
7 |
84,886,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Vmn2r68
|
APN |
7 |
84,882,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02982:Vmn2r68
|
APN |
7 |
84,883,649 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03099:Vmn2r68
|
APN |
7 |
84,871,448 (GRCm39) |
nonsense |
probably null |
|
|
IGL03166:Vmn2r68
|
APN |
7 |
84,871,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03168:Vmn2r68
|
APN |
7 |
84,870,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03243:Vmn2r68
|
APN |
7 |
84,882,963 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
F5770:Vmn2r68
|
UTSW |
7 |
84,871,088 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0280:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0280:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
|
R0281:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0281:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
|
R0348:Vmn2r68
|
UTSW |
7 |
84,870,884 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0390:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0390:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
|
R0722:Vmn2r68
|
UTSW |
7 |
84,870,794 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1129:Vmn2r68
|
UTSW |
7 |
84,886,712 (GRCm39) |
splice site |
probably null |
|
|
R1136:Vmn2r68
|
UTSW |
7 |
84,871,549 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1319:Vmn2r68
|
UTSW |
7 |
84,881,700 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1614:Vmn2r68
|
UTSW |
7 |
84,870,946 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1682:Vmn2r68
|
UTSW |
7 |
84,882,574 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1837:Vmn2r68
|
UTSW |
7 |
84,882,886 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1893:Vmn2r68
|
UTSW |
7 |
84,883,867 (GRCm39) |
nonsense |
probably null |
|
|
R1908:Vmn2r68
|
UTSW |
7 |
84,883,260 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1909:Vmn2r68
|
UTSW |
7 |
84,883,260 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1951:Vmn2r68
|
UTSW |
7 |
84,883,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Vmn2r68
|
UTSW |
7 |
84,871,123 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2178:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R2185:Vmn2r68
|
UTSW |
7 |
84,882,901 (GRCm39) |
nonsense |
probably null |
|
|
R2188:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R2282:Vmn2r68
|
UTSW |
7 |
84,870,859 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2567:Vmn2r68
|
UTSW |
7 |
84,883,803 (GRCm39) |
missense |
probably benign |
|
|
R2869:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2869:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2870:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2870:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2871:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2871:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2873:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2874:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
|
R3149:Vmn2r68
|
UTSW |
7 |
84,886,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3401:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R3978:Vmn2r68
|
UTSW |
7 |
84,881,670 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4399:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R4401:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R4421:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R4478:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R4479:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R4495:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
|
R4628:Vmn2r68
|
UTSW |
7 |
84,883,673 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4649:Vmn2r68
|
UTSW |
7 |
84,870,743 (GRCm39) |
missense |
probably benign |
|
|
R4654:Vmn2r68
|
UTSW |
7 |
84,882,769 (GRCm39) |
nonsense |
probably null |
|
|
R4793:Vmn2r68
|
UTSW |
7 |
84,883,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5007:Vmn2r68
|
UTSW |
7 |
84,881,622 (GRCm39) |
missense |
probably benign |
|
|
R5021:Vmn2r68
|
UTSW |
7 |
84,882,942 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5082:Vmn2r68
|
UTSW |
7 |
84,883,076 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5177:Vmn2r68
|
UTSW |
7 |
84,871,199 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5221:Vmn2r68
|
UTSW |
7 |
84,871,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5514:Vmn2r68
|
UTSW |
7 |
84,886,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5521:Vmn2r68
|
UTSW |
7 |
84,882,926 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5563:Vmn2r68
|
UTSW |
7 |
84,871,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5664:Vmn2r68
|
UTSW |
7 |
84,882,978 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5829:Vmn2r68
|
UTSW |
7 |
84,886,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6016:Vmn2r68
|
UTSW |
7 |
84,871,453 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6356:Vmn2r68
|
UTSW |
7 |
84,883,048 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6413:Vmn2r68
|
UTSW |
7 |
84,870,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6418:Vmn2r68
|
UTSW |
7 |
84,882,915 (GRCm39) |
missense |
probably benign |
|
|
R6699:Vmn2r68
|
UTSW |
7 |
84,881,583 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7287:Vmn2r68
|
UTSW |
7 |
84,871,460 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7319:Vmn2r68
|
UTSW |
7 |
84,883,042 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r68
|
UTSW |
7 |
84,881,607 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7585:Vmn2r68
|
UTSW |
7 |
84,881,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7892:Vmn2r68
|
UTSW |
7 |
84,883,722 (GRCm39) |
missense |
probably benign |
|
|
R7979:Vmn2r68
|
UTSW |
7 |
84,883,625 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8177:Vmn2r68
|
UTSW |
7 |
84,871,422 (GRCm39) |
nonsense |
probably null |
|
|
R8349:Vmn2r68
|
UTSW |
7 |
84,882,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8378:Vmn2r68
|
UTSW |
7 |
84,871,108 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8397:Vmn2r68
|
UTSW |
7 |
84,886,722 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8449:Vmn2r68
|
UTSW |
7 |
84,882,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8543:Vmn2r68
|
UTSW |
7 |
84,883,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8680:Vmn2r68
|
UTSW |
7 |
84,871,321 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9056:Vmn2r68
|
UTSW |
7 |
84,871,420 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9342:Vmn2r68
|
UTSW |
7 |
84,882,993 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9734:Vmn2r68
|
UTSW |
7 |
84,882,757 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
V7581:Vmn2r68
|
UTSW |
7 |
84,871,088 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Vmn2r68
|
UTSW |
7 |
84,871,289 (GRCm39) |
missense |
probably benign |
0.27 |
|
Z1176:Vmn2r68
|
UTSW |
7 |
84,870,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r68
|
UTSW |
7 |
84,871,307 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGAGGTGTAGTCTCCATACAC -3'
(R):5'- TTCTAGAATGAATACCCTCAGGTC -3'
Sequencing Primer
(F):5'- GAGGTGTAGTCTCCATACACTATCAC -3'
(R):5'- ACACACTCTACATCATTGCCTATG -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation