Mutagenetix > Incidental Mutations

Incidental Mutation 'R7606:Vmn2r72'

588301

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R7606 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85751154 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 229 (E229V)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000063425
AA Change: E229V

PolyPhen 2 Score 0.909 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: E229V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (59/59)

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadac	T	A	3: 60,036,035		probably null	Het
Adat1	T	C	8: 111,982,604	K196E	possibly damaging	Het
Aire	T	C	10: 78,037,933	D314G	probably damaging	Het
Atp11a	C	T	8: 12,844,427	T674I	probably damaging	Het
Atp8b1	T	C	18: 64,555,115	D644G	probably damaging	Het
Bag4	A	G	8: 25,769,305	S289P	probably damaging	Het
Bcat1	G	T	6: 145,048,632	H46Q	probably benign	Het
Btg4	A	G	9: 51,118,007	N164S	probably damaging	Het
Ccz1	G	A	5: 144,014,808	A2V	probably benign	Het
Cd209g	T	C	8: 4,136,839	L128P	probably damaging	Het
Col4a2	T	A	8: 11,443,571	M1380K	probably benign	Het
Cpox	T	C	16: 58,674,449	V283A	probably benign	Het
Dnah10	A	T	5: 124,817,712	D3504V	probably benign	Het
Eml1	A	T	12: 108,537,366	I741F	probably benign	Het
Fam171a2	A	G	11: 102,444,176	V45A	possibly damaging	Het
Fem1a	A	G	17: 56,256,946	D13G	probably damaging	Het
Fkbp14	A	G	6: 54,593,018	I9T	probably benign	Het
Golt1b	G	A	6: 142,392,342	G13D	probably damaging	Het
Heatr5b	T	C	17: 78,763,026	N1653D	probably benign	Het
Hrg	A	G	16: 22,951,123	M1V	probably null	Het
Itgb2	T	A	10: 77,556,161	I356N	probably damaging	Het
Kcnb2	A	G	1: 15,312,840	E130G	probably damaging	Het
Kpna2	A	T	11: 106,992,058	F124Y	probably damaging	Het
Lyst	T	C	13: 13,637,475	I824T	probably damaging	Het
Meis2	T	C	2: 116,063,320	H38R	possibly damaging	Het
Mknk1	T	G	4: 115,877,994	I353S	probably damaging	Het
Mrc1	T	A	2: 14,238,144	I27N	probably damaging	Het
Mup4	T	C	4: 59,958,568	T111A	probably damaging	Het
Myo1f	T	C	17: 33,576,450	V53A	probably damaging	Het
Neb	T	G	2: 52,226,444	E994A		Het
Nlrc5	T	C	8: 94,477,117	M615T	possibly damaging	Het
Nup88	T	C	11: 70,961,615	E218G	possibly damaging	Het
Olfr1219	A	G	2: 89,075,297		probably benign	Het
Olfr1513	A	T	14: 52,349,963	F28I	probably benign	Het
Parp11	A	G	6: 127,470,760	D19G	probably benign	Het
Parp2	A	T	14: 50,820,030	T429S	probably damaging	Het
Pcdhb6	G	A	18: 37,335,606	E527K	probably damaging	Het
Pde8a	A	G	7: 81,332,967	Y778C	probably damaging	Het
Pea15a	T	C	1: 172,200,583		probably null	Het
Plcd3	A	G	11: 103,076,857	Y420H	probably damaging	Het
Ppp1ca	C	A	19: 4,193,089	S85R	possibly damaging	Het
Pth	A	C	7: 113,386,243	I13S	probably benign	Het
Rbm27	A	G	18: 42,327,513	T842A	probably damaging	Het
Rcbtb2	T	A	14: 73,182,366		probably null	Het
Rubcnl	C	T	14: 75,038,874	L323F	probably benign	Het
Ryr3	A	T	2: 112,645,245	Y4539*	probably null	Het
Scamp3	T	A	3: 89,181,218	F244I	probably damaging	Het
Sema4d	T	C	13: 51,723,622	D58G	probably benign	Het
Skor1	G	T	9: 63,145,382	A435E	probably damaging	Het
Slc35a4	A	G	18: 36,682,585	Y156C	probably benign	Het
Spryd7	T	C	14: 61,540,158	T158A	possibly damaging	Het
Srgap3	A	C	6: 112,739,376	I621S	probably benign	Het
Tbc1d31	A	G	15: 57,951,670	E581G	probably damaging	Het
Tcf4	C	T	18: 69,642,983	T318I	probably damaging	Het
Usf3	C	T	16: 44,218,943	T1262M	probably damaging	Het
Vcam1	T	C	3: 116,121,055	D316G	possibly damaging	Het
Zfhx2	T	C	14: 55,066,663	E1288G	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCCTTTTGATTTAAACCAATGGAGG -3'
(R):5'- GCTAAAGCACACTCTACATCATGTTC -3'

Sequencing Primer
(F):5'- TTTAAACCAATGGAGGACAAGATC -3'
(R):5'- AGCTTTACTGCGGTCATTTTC -3'

Posted On

2019-10-24