Incidental Mutation 'R7607:Vmn2r98'
| ID |
588405 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r98
|
| Ensembl Gene |
ENSMUSG00000096717 |
| Gene Name |
vomeronasal 2, receptor 98 |
| Synonyms |
EG224552 |
| MMRRC Submission |
045677-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
R7607 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19053460-19082411 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19067308 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 468
(N468D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
| AlphaFold |
E9PZ56 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170424
AA Change: N468D
PolyPhen 2
Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: N468D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
99% (69/70) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610010K14Rik |
A |
T |
11: 70,237,557 (GRCm38) |
H30Q |
probably damaging |
Het |
| 1700012P22Rik |
T |
A |
4: 144,419,762 (GRCm38) |
H107L |
probably damaging |
Het |
| A930009A15Rik |
G |
A |
10: 115,581,989 (GRCm38) |
|
probably null |
Het |
| Abca7 |
T |
C |
10: 80,011,833 (GRCm38) |
L1779P |
probably damaging |
Het |
| Aff1 |
G |
A |
5: 103,849,459 (GRCm38) |
V1140I |
possibly damaging |
Het |
| Ano2 |
C |
T |
6: 125,712,419 (GRCm38) |
A169V |
probably damaging |
Het |
| Atat1 |
T |
C |
17: 35,909,107 (GRCm38) |
Y101C |
possibly damaging |
Het |
| Atp6v1c1 |
T |
C |
15: 38,683,011 (GRCm38) |
|
probably null |
Het |
| Atp7b |
T |
G |
8: 22,011,506 (GRCm38) |
K912T |
probably damaging |
Het |
| Ceacam14 |
T |
C |
7: 17,814,321 (GRCm38) |
V112A |
possibly damaging |
Het |
| Cobll1 |
T |
C |
2: 65,095,857 (GRCm38) |
N1119S |
probably benign |
Het |
| Csmd1 |
G |
T |
8: 15,918,331 (GRCm38) |
Q3099K |
possibly damaging |
Het |
| Cyp3a25 |
A |
G |
5: 145,984,981 (GRCm38) |
V381A |
possibly damaging |
Het |
| Dctn1 |
C |
T |
6: 83,195,069 (GRCm38) |
R948* |
probably null |
Het |
| Dhrs3 |
A |
G |
4: 144,923,940 (GRCm38) |
T219A |
probably benign |
Het |
| Epha7 |
C |
T |
4: 28,871,937 (GRCm38) |
S422L |
probably benign |
Het |
| Esrp1 |
A |
G |
4: 11,384,449 (GRCm38) |
V78A |
probably damaging |
Het |
| Evc2 |
A |
G |
5: 37,386,856 (GRCm38) |
T650A |
possibly damaging |
Het |
| Exoc6b |
T |
A |
6: 84,989,409 (GRCm38) |
K194N |
possibly damaging |
Het |
| Fer1l6 |
G |
A |
15: 58,662,732 (GRCm38) |
W1809* |
probably null |
Het |
| Frmd4a |
T |
A |
2: 4,591,936 (GRCm38) |
L156* |
probably null |
Het |
| Gk5 |
A |
T |
9: 96,153,210 (GRCm38) |
|
probably null |
Het |
| Gm3573 |
A |
G |
14: 42,189,750 (GRCm38) |
F8L |
probably benign |
Het |
| Gm906 |
T |
C |
13: 50,250,260 (GRCm38) |
E2G |
possibly damaging |
Het |
| Gm9767 |
G |
A |
10: 26,078,940 (GRCm38) |
C130Y |
unknown |
Het |
| Grip2 |
T |
C |
6: 91,788,412 (GRCm38) |
T30A |
probably benign |
Het |
| Gskip |
C |
A |
12: 105,698,897 (GRCm38) |
A65E |
possibly damaging |
Het |
| Gtf2e2 |
A |
G |
8: 33,776,465 (GRCm38) |
R259G |
probably benign |
Het |
| Gucy1b2 |
T |
A |
14: 62,419,177 (GRCm38) |
I244F |
probably damaging |
Het |
| Gxylt2 |
G |
T |
6: 100,798,190 (GRCm38) |
V357L |
possibly damaging |
Het |
| Hivep3 |
CGG |
CG |
4: 120,097,911 (GRCm38) |
1141 |
probably null |
Het |
| Igdcc4 |
C |
T |
9: 65,133,758 (GRCm38) |
P1024S |
possibly damaging |
Het |
| Ino80 |
A |
T |
2: 119,382,269 (GRCm38) |
|
probably null |
Het |
| Knl1 |
T |
C |
2: 119,095,133 (GRCm38) |
F1881S |
possibly damaging |
Het |
| Mbd6 |
T |
C |
10: 127,285,230 (GRCm38) |
E518G |
unknown |
Het |
| Mlh1 |
A |
G |
9: 111,229,890 (GRCm38) |
S689P |
probably damaging |
Het |
| Mmrn2 |
T |
C |
14: 34,398,940 (GRCm38) |
I589T |
possibly damaging |
Het |
| Mtmr12 |
C |
T |
15: 12,257,708 (GRCm38) |
Q291* |
probably null |
Het |
| Mup8 |
T |
A |
4: 60,222,035 (GRCm38) |
I33F |
probably benign |
Het |
| Mylk |
C |
T |
16: 34,894,814 (GRCm38) |
P504L |
probably benign |
Het |
| Ntrk3 |
C |
T |
7: 78,250,873 (GRCm38) |
A573T |
probably benign |
Het |
| Obscn |
G |
T |
11: 58,998,265 (GRCm38) |
S7560R |
unknown |
Het |
| Olfr24 |
A |
G |
9: 18,754,882 (GRCm38) |
F251S |
possibly damaging |
Het |
| Olfr617 |
A |
C |
7: 103,584,930 (GRCm38) |
T303P |
probably damaging |
Het |
| Pde1c |
T |
C |
6: 56,150,628 (GRCm38) |
T391A |
probably damaging |
Het |
| Pla2g4d |
T |
A |
2: 120,288,976 (GRCm38) |
H19L |
probably benign |
Het |
| Plce1 |
C |
A |
19: 38,524,752 (GRCm38) |
A165E |
probably benign |
Het |
| Polr1a |
T |
C |
6: 71,913,021 (GRCm38) |
S75P |
probably benign |
Het |
| Psg21 |
T |
C |
7: 18,654,783 (GRCm38) |
E128G |
probably benign |
Het |
| Radil |
A |
T |
5: 142,494,795 (GRCm38) |
M635K |
probably damaging |
Het |
| Radil |
A |
G |
5: 142,506,613 (GRCm38) |
I420T |
probably damaging |
Het |
| Rnase11 |
G |
A |
14: 51,049,572 (GRCm38) |
T175I |
probably damaging |
Het |
| Robo1 |
C |
T |
16: 72,563,738 (GRCm38) |
P13S |
|
Het |
| Slc18a2 |
C |
A |
19: 59,284,358 (GRCm38) |
A364D |
probably benign |
Het |
| Snph |
C |
T |
2: 151,594,586 (GRCm38) |
D141N |
probably damaging |
Het |
| Snrnp70 |
T |
C |
7: 45,392,264 (GRCm38) |
K70R |
possibly damaging |
Het |
| Snx33 |
T |
C |
9: 56,926,713 (GRCm38) |
D24G |
probably benign |
Het |
| Spag6 |
T |
A |
2: 18,731,962 (GRCm38) |
D165E |
possibly damaging |
Het |
| Spata31 |
T |
G |
13: 64,921,592 (GRCm38) |
L518R |
probably damaging |
Het |
| Sspo |
G |
A |
6: 48,489,727 (GRCm38) |
V4059M |
probably damaging |
Het |
| St6galnac2 |
T |
C |
11: 116,679,979 (GRCm38) |
Y261C |
probably damaging |
Het |
| Stoml1 |
A |
G |
9: 58,256,658 (GRCm38) |
R87G |
probably damaging |
Het |
| Suv39h2 |
T |
C |
2: 3,474,829 (GRCm38) |
T40A |
unknown |
Het |
| Terb2 |
G |
T |
2: 122,186,475 (GRCm38) |
G26W |
probably damaging |
Het |
| Tmem62 |
T |
C |
2: 120,996,440 (GRCm38) |
I406T |
probably benign |
Het |
| Tnfrsf11a |
G |
A |
1: 105,844,732 (GRCm38) |
V582I |
probably benign |
Het |
| Tpsg1 |
G |
T |
17: 25,373,210 (GRCm38) |
G86V |
probably damaging |
Het |
| Unc13c |
T |
C |
9: 73,669,535 (GRCm38) |
D1480G |
probably damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,772,573 (GRCm38) |
|
probably benign |
Het |
| Vmn1r48 |
C |
A |
6: 90,035,980 (GRCm38) |
V288L |
probably benign |
Het |
| Vmn2r13 |
A |
G |
5: 109,173,640 (GRCm38) |
V397A |
probably damaging |
Het |
| Zfhx2 |
G |
T |
14: 55,066,231 (GRCm38) |
T1432K |
possibly damaging |
Het |
| Zswim5 |
T |
A |
4: 116,986,742 (GRCm38) |
D992E |
possibly damaging |
Het |
|
| Other mutations in Vmn2r98 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r98
|
APN |
17 |
19,065,745 (GRCm38) |
splice site |
probably benign |
|
|
IGL01296:Vmn2r98
|
APN |
17 |
19,065,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01363:Vmn2r98
|
APN |
17 |
19,065,758 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01618:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01746:Vmn2r98
|
APN |
17 |
19,066,451 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01747:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01770:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01868:Vmn2r98
|
APN |
17 |
19,066,286 (GRCm38) |
missense |
probably benign |
|
|
IGL02123:Vmn2r98
|
APN |
17 |
19,080,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r98
|
APN |
17 |
19,065,851 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02543:Vmn2r98
|
APN |
17 |
19,065,821 (GRCm38) |
missense |
probably benign |
|
|
IGL02650:Vmn2r98
|
APN |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02676:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02803:Vmn2r98
|
APN |
17 |
19,066,013 (GRCm38) |
missense |
probably benign |
|
|
IGL02807:Vmn2r98
|
APN |
17 |
19,081,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03307:Vmn2r98
|
APN |
17 |
19,065,980 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
IGL03396:Vmn2r98
|
APN |
17 |
19,069,845 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0122:Vmn2r98
|
UTSW |
17 |
19,066,400 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0329:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0330:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0368:Vmn2r98
|
UTSW |
17 |
19,065,827 (GRCm38) |
nonsense |
probably null |
|
|
R0545:Vmn2r98
|
UTSW |
17 |
19,053,613 (GRCm38) |
missense |
probably benign |
0.15 |
|
R0635:Vmn2r98
|
UTSW |
17 |
19,080,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0689:Vmn2r98
|
UTSW |
17 |
19,080,520 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1035:Vmn2r98
|
UTSW |
17 |
19,080,749 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1243:Vmn2r98
|
UTSW |
17 |
19,065,948 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R1421:Vmn2r98
|
UTSW |
17 |
19,065,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1629:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1643:Vmn2r98
|
UTSW |
17 |
19,080,908 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1795:Vmn2r98
|
UTSW |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1958:Vmn2r98
|
UTSW |
17 |
19,066,418 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R1962:Vmn2r98
|
UTSW |
17 |
19,065,333 (GRCm38) |
nonsense |
probably null |
|
|
R2165:Vmn2r98
|
UTSW |
17 |
19,081,291 (GRCm38) |
missense |
unknown |
|
|
R2238:Vmn2r98
|
UTSW |
17 |
19,065,951 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2252:Vmn2r98
|
UTSW |
17 |
19,080,436 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2323:Vmn2r98
|
UTSW |
17 |
19,065,819 (GRCm38) |
missense |
probably benign |
0.18 |
|
R2887:Vmn2r98
|
UTSW |
17 |
19,081,177 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R2909:Vmn2r98
|
UTSW |
17 |
19,067,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3001:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3002:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3003:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3788:Vmn2r98
|
UTSW |
17 |
19,080,625 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4570:Vmn2r98
|
UTSW |
17 |
19,066,092 (GRCm38) |
missense |
probably benign |
0.11 |
|
R4706:Vmn2r98
|
UTSW |
17 |
19,069,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4723:Vmn2r98
|
UTSW |
17 |
19,066,340 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5036:Vmn2r98
|
UTSW |
17 |
19,066,157 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5072:Vmn2r98
|
UTSW |
17 |
19,066,044 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5121:Vmn2r98
|
UTSW |
17 |
19,053,553 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5283:Vmn2r98
|
UTSW |
17 |
19,080,719 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5294:Vmn2r98
|
UTSW |
17 |
19,069,754 (GRCm38) |
nonsense |
probably null |
|
|
R5371:Vmn2r98
|
UTSW |
17 |
19,069,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5598:Vmn2r98
|
UTSW |
17 |
19,080,899 (GRCm38) |
missense |
probably benign |
0.37 |
|
R5800:Vmn2r98
|
UTSW |
17 |
19,065,998 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6089:Vmn2r98
|
UTSW |
17 |
19,066,074 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6155:Vmn2r98
|
UTSW |
17 |
19,065,881 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6853:Vmn2r98
|
UTSW |
17 |
19,065,801 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r98
|
UTSW |
17 |
19,065,248 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7012:Vmn2r98
|
UTSW |
17 |
19,066,268 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7042:Vmn2r98
|
UTSW |
17 |
19,080,922 (GRCm38) |
missense |
probably benign |
|
|
R7068:Vmn2r98
|
UTSW |
17 |
19,065,313 (GRCm38) |
missense |
probably benign |
|
|
R7763:Vmn2r98
|
UTSW |
17 |
19,080,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7771:Vmn2r98
|
UTSW |
17 |
19,067,198 (GRCm38) |
splice site |
probably null |
|
|
R7915:Vmn2r98
|
UTSW |
17 |
19,067,231 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8028:Vmn2r98
|
UTSW |
17 |
19,053,650 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8205:Vmn2r98
|
UTSW |
17 |
19,081,163 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8241:Vmn2r98
|
UTSW |
17 |
19,080,769 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8906:Vmn2r98
|
UTSW |
17 |
19,066,270 (GRCm38) |
missense |
probably benign |
|
|
R8952:Vmn2r98
|
UTSW |
17 |
19,065,269 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R9147:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9148:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9187:Vmn2r98
|
UTSW |
17 |
19,081,219 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9344:Vmn2r98
|
UTSW |
17 |
19,066,515 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9467:Vmn2r98
|
UTSW |
17 |
19,067,255 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9487:Vmn2r98
|
UTSW |
17 |
19,081,234 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9753:Vmn2r98
|
UTSW |
17 |
19,065,403 (GRCm38) |
missense |
probably benign |
0.27 |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,067,423 (GRCm38) |
nonsense |
probably null |
|
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,065,136 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGTCAGGTTTTCACTAAGTCATC -3'
(R):5'- ATGGGACTTGAGCCAATCATC -3'
Sequencing Primer
(F):5'- TAAGCTTAACTCGTTCCTG -3'
(R):5'- GGACTTGAGCCAATCATCATTATATC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation