Incidental Mutation 'R7607:Vmn2r98'
ID |
588405 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r98
|
Ensembl Gene |
ENSMUSG00000096717 |
Gene Name |
vomeronasal 2, receptor 98 |
Synonyms |
EG224552 |
MMRRC Submission |
045677-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R7607 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 19287570 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Aspartic acid
at position 468
(N468D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
AlphaFold |
E9PZ56 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170424
AA Change: N468D
PolyPhen 2
Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000131261 Gene: ENSMUSG00000096717 AA Change: N468D
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
Validation Efficiency |
99% (69/70) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 73 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
0610010K14Rik |
A |
T |
11: 70,128,383 (GRCm39) |
H30Q |
probably damaging |
Het |
A930009A15Rik |
G |
A |
10: 115,417,894 (GRCm39) |
|
probably null |
Het |
Abca7 |
T |
C |
10: 79,847,667 (GRCm39) |
L1779P |
probably damaging |
Het |
Aff1 |
G |
A |
5: 103,997,325 (GRCm39) |
V1140I |
possibly damaging |
Het |
Ano2 |
C |
T |
6: 125,689,382 (GRCm39) |
A169V |
probably damaging |
Het |
Atat1 |
T |
C |
17: 36,219,999 (GRCm39) |
Y101C |
possibly damaging |
Het |
Atp6v1c1 |
T |
C |
15: 38,683,255 (GRCm39) |
|
probably null |
Het |
Atp7b |
T |
G |
8: 22,501,522 (GRCm39) |
K912T |
probably damaging |
Het |
Ceacam14 |
T |
C |
7: 17,548,246 (GRCm39) |
V112A |
possibly damaging |
Het |
Cfap107 |
T |
A |
4: 144,146,332 (GRCm39) |
H107L |
probably damaging |
Het |
Cobll1 |
T |
C |
2: 64,926,201 (GRCm39) |
N1119S |
probably benign |
Het |
Csmd1 |
G |
T |
8: 15,968,331 (GRCm39) |
Q3099K |
possibly damaging |
Het |
Cyp3a25 |
A |
G |
5: 145,921,791 (GRCm39) |
V381A |
possibly damaging |
Het |
Dctn1 |
C |
T |
6: 83,172,051 (GRCm39) |
R948* |
probably null |
Het |
Dhrs3 |
A |
G |
4: 144,650,510 (GRCm39) |
T219A |
probably benign |
Het |
Epha7 |
C |
T |
4: 28,871,937 (GRCm39) |
S422L |
probably benign |
Het |
Esrp1 |
A |
G |
4: 11,384,449 (GRCm39) |
V78A |
probably damaging |
Het |
Evc2 |
A |
G |
5: 37,544,200 (GRCm39) |
T650A |
possibly damaging |
Het |
Exoc6b |
T |
A |
6: 84,966,391 (GRCm39) |
K194N |
possibly damaging |
Het |
Fer1l6 |
G |
A |
15: 58,534,581 (GRCm39) |
W1809* |
probably null |
Het |
Frmd4a |
T |
A |
2: 4,596,747 (GRCm39) |
L156* |
probably null |
Het |
Gk5 |
A |
T |
9: 96,035,263 (GRCm39) |
|
probably null |
Het |
Gm3573 |
A |
G |
14: 42,011,707 (GRCm39) |
F8L |
probably benign |
Het |
Gm9767 |
G |
A |
10: 25,954,838 (GRCm39) |
C130Y |
unknown |
Het |
Grip2 |
T |
C |
6: 91,765,393 (GRCm39) |
T30A |
probably benign |
Het |
Gskip |
C |
A |
12: 105,665,156 (GRCm39) |
A65E |
possibly damaging |
Het |
Gtf2e2 |
A |
G |
8: 34,266,493 (GRCm39) |
R259G |
probably benign |
Het |
Gucy1b2 |
T |
A |
14: 62,656,626 (GRCm39) |
I244F |
probably damaging |
Het |
Gxylt2 |
G |
T |
6: 100,775,151 (GRCm39) |
V357L |
possibly damaging |
Het |
Hivep3 |
CGG |
CG |
4: 119,955,108 (GRCm39) |
1141 |
probably null |
Het |
Igdcc4 |
C |
T |
9: 65,041,040 (GRCm39) |
P1024S |
possibly damaging |
Het |
Ino80 |
A |
T |
2: 119,212,750 (GRCm39) |
|
probably null |
Het |
Knl1 |
T |
C |
2: 118,925,614 (GRCm39) |
F1881S |
possibly damaging |
Het |
Mbd6 |
T |
C |
10: 127,121,099 (GRCm39) |
E518G |
unknown |
Het |
Mlh1 |
A |
G |
9: 111,058,958 (GRCm39) |
S689P |
probably damaging |
Het |
Mmrn2 |
T |
C |
14: 34,120,897 (GRCm39) |
I589T |
possibly damaging |
Het |
Mtmr12 |
C |
T |
15: 12,257,794 (GRCm39) |
Q291* |
probably null |
Het |
Mup8 |
T |
A |
4: 60,222,035 (GRCm39) |
I33F |
probably benign |
Het |
Mylk |
C |
T |
16: 34,715,184 (GRCm39) |
P504L |
probably benign |
Het |
Ntrk3 |
C |
T |
7: 77,900,621 (GRCm39) |
A573T |
probably benign |
Het |
Obscn |
G |
T |
11: 58,889,091 (GRCm39) |
S7560R |
unknown |
Het |
Or1m1 |
A |
G |
9: 18,666,178 (GRCm39) |
F251S |
possibly damaging |
Het |
Or52z12 |
A |
C |
7: 103,234,137 (GRCm39) |
T303P |
probably damaging |
Het |
Pde1c |
T |
C |
6: 56,127,613 (GRCm39) |
T391A |
probably damaging |
Het |
Pla2g4d |
T |
A |
2: 120,119,457 (GRCm39) |
H19L |
probably benign |
Het |
Plce1 |
C |
A |
19: 38,513,196 (GRCm39) |
A165E |
probably benign |
Het |
Polr1a |
T |
C |
6: 71,890,005 (GRCm39) |
S75P |
probably benign |
Het |
Psg21 |
T |
C |
7: 18,388,708 (GRCm39) |
E128G |
probably benign |
Het |
Radil |
A |
G |
5: 142,492,368 (GRCm39) |
I420T |
probably damaging |
Het |
Radil |
A |
T |
5: 142,480,550 (GRCm39) |
M635K |
probably damaging |
Het |
Rnase11 |
G |
A |
14: 51,287,029 (GRCm39) |
T175I |
probably damaging |
Het |
Robo1 |
C |
T |
16: 72,360,626 (GRCm39) |
P13S |
|
Het |
Slc18a2 |
C |
A |
19: 59,272,790 (GRCm39) |
A364D |
probably benign |
Het |
Snph |
C |
T |
2: 151,436,506 (GRCm39) |
D141N |
probably damaging |
Het |
Snrnp70 |
T |
C |
7: 45,041,688 (GRCm39) |
K70R |
possibly damaging |
Het |
Snx33 |
T |
C |
9: 56,833,997 (GRCm39) |
D24G |
probably benign |
Het |
Spag6 |
T |
A |
2: 18,736,773 (GRCm39) |
D165E |
possibly damaging |
Het |
Spata31 |
T |
G |
13: 65,069,406 (GRCm39) |
L518R |
probably damaging |
Het |
Spata31e3 |
T |
C |
13: 50,404,296 (GRCm39) |
E2G |
possibly damaging |
Het |
Sspo |
G |
A |
6: 48,466,661 (GRCm39) |
V4059M |
probably damaging |
Het |
St6galnac2 |
T |
C |
11: 116,570,805 (GRCm39) |
Y261C |
probably damaging |
Het |
Stoml1 |
A |
G |
9: 58,163,941 (GRCm39) |
R87G |
probably damaging |
Het |
Suv39h2 |
T |
C |
2: 3,475,866 (GRCm39) |
T40A |
unknown |
Het |
Terb2 |
G |
T |
2: 122,016,956 (GRCm39) |
G26W |
probably damaging |
Het |
Tmem62 |
T |
C |
2: 120,826,921 (GRCm39) |
I406T |
probably benign |
Het |
Tnfrsf11a |
G |
A |
1: 105,772,458 (GRCm39) |
V582I |
probably benign |
Het |
Tpsg1 |
G |
T |
17: 25,592,184 (GRCm39) |
G86V |
probably damaging |
Het |
Unc13c |
T |
C |
9: 73,576,817 (GRCm39) |
D1480G |
probably damaging |
Het |
Urb1 |
CACTTAC |
CAC |
16: 90,569,461 (GRCm39) |
|
probably benign |
Het |
Vmn1r48 |
C |
A |
6: 90,012,962 (GRCm39) |
V288L |
probably benign |
Het |
Vmn2r13 |
A |
G |
5: 109,321,506 (GRCm39) |
V397A |
probably damaging |
Het |
Zfhx2 |
G |
T |
14: 55,303,688 (GRCm39) |
T1432K |
possibly damaging |
Het |
Zswim5 |
T |
A |
4: 116,843,939 (GRCm39) |
D992E |
possibly damaging |
Het |
|
Other mutations in Vmn2r98 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- ACAGTCAGGTTTTCACTAAGTCATC -3'
(R):5'- ATGGGACTTGAGCCAATCATC -3'
Sequencing Primer
(F):5'- TAAGCTTAACTCGTTCCTG -3'
(R):5'- GGACTTGAGCCAATCATCATTATATC -3'
|
Posted On |
2019-10-24 |