|Institutional Source||Beutler Lab|
|Gene Name||Kruppel-like factor 14|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7610 (G1)|
|Chromosomal Location||30956023-30959078 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 30958070 bp|
|Amino Acid Change||Serine to Proline at position 210 (S210P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000099122 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000101589]|
|Predicted Effect||probably damaging
AA Change: S210P
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: S210P
|Coding Region Coverage||
|Validation Efficiency||100% (51/51)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for a null allele display genome instability and increased tumor incidence with age. Mice homozygous for a conditional allele knocked out in the liver exhibit decreased circulating HDL cholesterol levels. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Klf14||
(F):5'- GAGAGAACTGCTTGGGACAC -3'
(R):5'- CTTCTTCGAGGATGAGCTCTC -3'
(F):5'- ACTGCTTGGGACACAGCGG -3'
(R):5'- GAGAGCTCCTGCAGTGATTC -3'