Incidental Mutation 'R0233:Kdm5b'
| ID |
58858 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
038474-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R0233 (G1)
|
| Quality Score |
206 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to G
at 134604634 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107817
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| PDB Structure |
Solution structure of the ARID domain of Jarid1b protein [SOLUTION NMR]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047714
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000112197
|
| SMART Domains |
Protein: ENSMUSP00000107816
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
225 |
236 |
N/A |
INTRINSIC |
|
PHD
|
308 |
354 |
6.15e-14 |
SMART |
|
JmjC
|
450 |
595 |
2.6e-24 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112198
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.4%
|
| Validation Efficiency |
99% (93/94) |
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,663,373 |
S212P |
probably benign |
Het |
| 4932438A13Rik |
T |
A |
3: 36,948,563 |
C1552* |
probably null |
Het |
| A730018C14Rik |
A |
C |
12: 112,415,430 |
|
noncoding transcript |
Het |
| Acsf3 |
A |
G |
8: 122,780,292 |
Y108C |
probably damaging |
Het |
| Acsl1 |
A |
G |
8: 46,513,569 |
|
probably benign |
Het |
| Adad1 |
T |
A |
3: 37,084,948 |
I389N |
possibly damaging |
Het |
| Ankrd27 |
T |
C |
7: 35,601,560 |
L95P |
probably damaging |
Het |
| Ano5 |
T |
C |
7: 51,535,470 |
F46S |
possibly damaging |
Het |
| Ap2a1 |
T |
C |
7: 44,915,973 |
N114S |
probably damaging |
Het |
| Arap1 |
C |
T |
7: 101,400,241 |
S970L |
possibly damaging |
Het |
| Atad3a |
A |
T |
4: 155,746,067 |
S525T |
probably damaging |
Het |
| B4galnt1 |
T |
C |
10: 127,170,911 |
|
probably benign |
Het |
| Cacna2d2 |
A |
T |
9: 107,514,670 |
I463F |
probably damaging |
Het |
| Casp6 |
T |
A |
3: 129,905,975 |
N34K |
probably damaging |
Het |
| Ccdc175 |
A |
T |
12: 72,105,876 |
F752I |
probably benign |
Het |
| Cdhr4 |
A |
G |
9: 107,996,934 |
I76V |
probably benign |
Het |
| Copa |
T |
C |
1: 172,087,667 |
|
probably null |
Het |
| Cox11 |
C |
T |
11: 90,644,500 |
T259I |
probably damaging |
Het |
| Cuzd1 |
C |
A |
7: 131,311,816 |
K357N |
possibly damaging |
Het |
| Dnah5 |
T |
A |
15: 28,333,070 |
F2206I |
probably damaging |
Het |
| Dnase2b |
T |
A |
3: 146,582,550 |
K263N |
probably benign |
Het |
| Dync1h1 |
T |
A |
12: 110,640,980 |
D2668E |
probably benign |
Het |
| Eno1b |
T |
C |
18: 48,047,739 |
I328T |
probably benign |
Het |
| Fam124b |
T |
C |
1: 80,212,986 |
S227G |
probably damaging |
Het |
| Fam13b |
T |
A |
18: 34,448,084 |
Y675F |
probably damaging |
Het |
| Fgf21 |
T |
A |
7: 45,615,297 |
M4L |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,201,797 |
C377* |
probably null |
Het |
| Foxp2 |
T |
C |
6: 15,409,753 |
S451P |
probably damaging |
Het |
| Gli2 |
A |
T |
1: 118,835,925 |
S1499T |
probably damaging |
Het |
| Gm13078 |
A |
T |
4: 143,726,063 |
E21D |
possibly damaging |
Het |
| Gm8909 |
A |
G |
17: 36,167,469 |
Y224H |
probably benign |
Het |
| Gm9920 |
A |
T |
15: 55,112,461 |
|
probably benign |
Het |
| Gpx5 |
T |
A |
13: 21,287,403 |
D210V |
probably damaging |
Het |
| Hoxb5 |
T |
A |
11: 96,305,027 |
S234T |
probably benign |
Het |
| Irf9 |
C |
A |
14: 55,606,094 |
N140K |
probably benign |
Het |
| Isg20 |
C |
T |
7: 78,914,495 |
T50M |
probably damaging |
Het |
| Isg20 |
C |
A |
7: 78,916,586 |
D94E |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,624,168 |
L115P |
probably damaging |
Het |
| Kdm3b |
G |
A |
18: 34,809,420 |
E655K |
probably damaging |
Het |
| Kifc3 |
A |
G |
8: 95,101,472 |
|
probably null |
Het |
| Kpna2 |
T |
C |
11: 106,992,631 |
S111G |
probably benign |
Het |
| Krt73 |
A |
T |
15: 101,802,016 |
N94K |
probably benign |
Het |
| Lgmn |
G |
T |
12: 102,399,989 |
D247E |
probably damaging |
Het |
| Lilra6 |
C |
T |
7: 3,914,936 |
V70I |
possibly damaging |
Het |
| Lrig3 |
G |
A |
10: 126,013,526 |
|
probably null |
Het |
| Lrrc4 |
T |
C |
6: 28,829,735 |
H627R |
probably benign |
Het |
| Macf1 |
G |
A |
4: 123,450,127 |
|
probably benign |
Het |
| Nat9 |
C |
A |
11: 115,183,408 |
|
probably null |
Het |
| Nutm2 |
A |
G |
13: 50,467,405 |
D2G |
probably benign |
Het |
| Olfr1151 |
A |
G |
2: 87,857,752 |
I192M |
probably benign |
Het |
| Olfr1404 |
A |
T |
1: 173,216,301 |
I217F |
probably benign |
Het |
| Olfr191 |
A |
T |
16: 59,085,675 |
D269E |
probably benign |
Het |
| Parl |
G |
A |
16: 20,287,907 |
P184L |
probably damaging |
Het |
| Pdzd8 |
A |
T |
19: 59,300,379 |
M863K |
probably damaging |
Het |
| Phlda3 |
T |
C |
1: 135,766,821 |
S125P |
probably damaging |
Het |
| Pkd1l3 |
A |
T |
8: 109,650,780 |
R217* |
probably null |
Het |
| Plekhg5 |
T |
C |
4: 152,112,219 |
C695R |
probably damaging |
Het |
| Prg4 |
T |
C |
1: 150,453,547 |
|
probably benign |
Het |
| Prkab1 |
A |
G |
5: 116,021,652 |
|
probably benign |
Het |
| Pyroxd1 |
A |
G |
6: 142,354,630 |
E162G |
possibly damaging |
Het |
| R3hcc1l |
G |
A |
19: 42,582,921 |
|
probably null |
Het |
| Rgs12 |
T |
A |
5: 35,030,498 |
S500T |
probably damaging |
Het |
| Ripor3 |
T |
C |
2: 167,992,598 |
D299G |
probably damaging |
Het |
| Robo4 |
T |
C |
9: 37,402,681 |
L76P |
probably damaging |
Het |
| Sbno1 |
T |
C |
5: 124,376,226 |
Y1302C |
probably damaging |
Het |
| Sec63 |
A |
G |
10: 42,823,908 |
I655V |
possibly damaging |
Het |
| Serpina11 |
T |
A |
12: 103,980,470 |
M389L |
probably benign |
Het |
| Sfswap |
C |
A |
5: 129,554,543 |
P745Q |
possibly damaging |
Het |
| Slc17a3 |
C |
T |
13: 23,855,858 |
S293F |
probably damaging |
Het |
| Slitrk3 |
C |
T |
3: 73,048,577 |
S954N |
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 45,769,829 |
T190A |
probably damaging |
Het |
| Sos2 |
A |
T |
12: 69,617,330 |
I460N |
probably benign |
Het |
| Spink7 |
T |
A |
18: 62,594,352 |
I34L |
probably benign |
Het |
| Srbd1 |
A |
G |
17: 86,057,745 |
S628P |
probably damaging |
Het |
| Srm |
G |
A |
4: 148,593,372 |
G156S |
probably damaging |
Het |
| Sulf2 |
T |
C |
2: 166,085,669 |
|
probably benign |
Het |
| Tmc4 |
T |
A |
7: 3,666,867 |
Y6F |
probably benign |
Het |
| Tmcc2 |
A |
G |
1: 132,360,651 |
F433L |
probably damaging |
Het |
| Tmprss13 |
T |
G |
9: 45,337,100 |
|
probably benign |
Het |
| Tnxb |
T |
C |
17: 34,699,033 |
F2307L |
probably benign |
Het |
| Tsr3 |
A |
G |
17: 25,242,510 |
E274G |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,895,144 |
|
probably benign |
Het |
| Tub |
T |
C |
7: 109,029,341 |
V352A |
possibly damaging |
Het |
| Tubb2a |
A |
G |
13: 34,075,342 |
I155T |
possibly damaging |
Het |
| Ugt2a2 |
T |
C |
5: 87,475,001 |
N36S |
probably damaging |
Het |
| Usp13 |
T |
A |
3: 32,915,664 |
|
probably null |
Het |
| Vmn1r52 |
T |
G |
6: 90,179,611 |
L120R |
possibly damaging |
Het |
| Vmn2r11 |
A |
T |
5: 109,054,102 |
S179T |
probably benign |
Het |
| Vwf |
A |
T |
6: 125,686,510 |
R2805W |
possibly damaging |
Het |
| Wdr7 |
A |
G |
18: 63,904,101 |
T1199A |
probably benign |
Het |
| Zfp286 |
T |
C |
11: 62,780,393 |
T285A |
possibly damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGGCTGGAATTTGAACAACATGC -3'
(R):5'- TGATAGTCCCAAGTCCATGCTCCTC -3'
Sequencing Primer
(F):5'- TTTGAACAACATGCCAGTGATGG -3'
(R):5'- TAGACAGCGgtgtgtgtg -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation