Incidental Mutation 'R7611:Vmn2r6'
ID |
588583 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r6
|
Ensembl Gene |
ENSMUSG00000090581 |
Gene Name |
vomeronasal 2, receptor 6 |
Synonyms |
EG667069, EG620718 |
MMRRC Submission |
045715-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.198)
|
Stock # |
R7611 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
64444916-64472855 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 64472563 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Phenylalanine
at position 53
(V53F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176481]
|
AlphaFold |
H3BK29 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000176481
AA Change: V53F
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000135148 Gene: ENSMUSG00000090581 AA Change: V53F
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 71 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acta2 |
G |
A |
19: 34,229,931 (GRCm39) |
T8I |
probably benign |
Het |
Adcy8 |
C |
T |
15: 64,792,882 (GRCm39) |
G25S |
probably benign |
Het |
Ahnak2 |
G |
T |
12: 112,751,749 (GRCm39) |
D35E |
|
Het |
Birc6 |
T |
C |
17: 74,969,713 (GRCm39) |
M4261T |
probably damaging |
Het |
Caln1 |
T |
G |
5: 130,534,918 (GRCm39) |
F45V |
probably damaging |
Het |
Camta2 |
A |
T |
11: 70,572,372 (GRCm39) |
I313N |
possibly damaging |
Het |
Capns1 |
T |
A |
7: 29,889,539 (GRCm39) |
E220V |
probably damaging |
Het |
Carmil1 |
C |
A |
13: 24,197,315 (GRCm39) |
V1374L |
probably benign |
Het |
Casp2 |
T |
G |
6: 42,250,972 (GRCm39) |
L290R |
possibly damaging |
Het |
Cdkn2b |
C |
A |
4: 89,228,980 (GRCm39) |
V19L |
probably benign |
Het |
Ces1c |
T |
C |
8: 93,851,139 (GRCm39) |
N162D |
probably benign |
Het |
Cfap96 |
A |
G |
8: 46,423,488 (GRCm39) |
Y75H |
probably damaging |
Het |
Chd9 |
T |
C |
8: 91,763,017 (GRCm39) |
S2281P |
probably damaging |
Het |
Chst13 |
T |
C |
6: 90,285,999 (GRCm39) |
D321G |
probably damaging |
Het |
Ckap2l |
G |
T |
2: 129,127,600 (GRCm39) |
P193T |
possibly damaging |
Het |
Clca4b |
T |
A |
3: 144,627,757 (GRCm39) |
T405S |
probably benign |
Het |
Cmah |
T |
C |
13: 24,619,630 (GRCm39) |
V265A |
probably benign |
Het |
Cyp3a11 |
A |
T |
5: 145,797,191 (GRCm39) |
M396K |
probably benign |
Het |
Ddr2 |
A |
T |
1: 169,825,727 (GRCm39) |
M291K |
possibly damaging |
Het |
Ddx43 |
T |
A |
9: 78,309,635 (GRCm39) |
I145N |
probably benign |
Het |
Ephb2 |
T |
A |
4: 136,388,212 (GRCm39) |
|
probably null |
Het |
Fgfr1 |
A |
T |
8: 26,048,221 (GRCm39) |
K106* |
probably null |
Het |
Gpr6 |
A |
G |
10: 40,946,875 (GRCm39) |
F236L |
probably benign |
Het |
Grin2c |
A |
G |
11: 115,143,511 (GRCm39) |
S750P |
probably damaging |
Het |
Hecw2 |
A |
G |
1: 53,952,459 (GRCm39) |
S925P |
probably damaging |
Het |
Hivep3 |
CGG |
CG |
4: 119,955,108 (GRCm39) |
1141 |
probably null |
Het |
Hmg20b |
T |
A |
10: 81,185,432 (GRCm39) |
|
probably benign |
Het |
Kcnk10 |
T |
A |
12: 98,484,899 (GRCm39) |
Y79F |
probably damaging |
Het |
Lrrc30 |
A |
T |
17: 67,939,424 (GRCm39) |
F52Y |
probably damaging |
Het |
Lrriq1 |
T |
C |
10: 103,036,432 (GRCm39) |
K907R |
possibly damaging |
Het |
Mbd3 |
T |
C |
10: 80,231,352 (GRCm39) |
D63G |
probably damaging |
Het |
Mettl21a |
C |
T |
1: 64,654,266 (GRCm39) |
A84T |
probably benign |
Het |
Mmp19 |
A |
G |
10: 128,634,857 (GRCm39) |
D491G |
probably benign |
Het |
Mug1 |
A |
T |
6: 121,852,387 (GRCm39) |
|
probably null |
Het |
Myh1 |
A |
T |
11: 67,101,243 (GRCm39) |
H673L |
possibly damaging |
Het |
Nlrc5 |
T |
C |
8: 95,239,276 (GRCm39) |
|
probably null |
Het |
Nme9 |
T |
A |
9: 99,352,843 (GRCm39) |
S264R |
probably benign |
Het |
Nup153 |
T |
C |
13: 46,840,798 (GRCm39) |
T937A |
probably benign |
Het |
Obsl1 |
T |
C |
1: 75,482,024 (GRCm39) |
E282G |
probably damaging |
Het |
Or1o3 |
A |
G |
17: 37,573,745 (GRCm39) |
V270A |
probably benign |
Het |
Or2w2 |
A |
G |
13: 21,758,488 (GRCm39) |
V46A |
probably benign |
Het |
Or4l15 |
C |
A |
14: 50,198,368 (GRCm39) |
A54S |
probably benign |
Het |
Or5an10 |
T |
A |
19: 12,276,242 (GRCm39) |
M85L |
probably damaging |
Het |
Or5b99 |
T |
A |
19: 12,976,431 (GRCm39) |
I27N |
possibly damaging |
Het |
Or5m5 |
T |
A |
2: 85,814,407 (GRCm39) |
C74* |
probably null |
Het |
Or8k30 |
T |
A |
2: 86,339,397 (GRCm39) |
I198K |
possibly damaging |
Het |
Pcdhga12 |
T |
C |
18: 37,901,478 (GRCm39) |
F770S |
possibly damaging |
Het |
Pfkp |
T |
A |
13: 6,655,119 (GRCm39) |
|
probably null |
Het |
Prr29 |
C |
G |
11: 106,267,158 (GRCm39) |
H58D |
probably damaging |
Het |
Ptprz1 |
T |
A |
6: 23,001,219 (GRCm39) |
M1103K |
probably benign |
Het |
Rigi |
T |
C |
4: 40,225,651 (GRCm39) |
E250G |
probably damaging |
Het |
Rsph4a |
C |
T |
10: 33,781,473 (GRCm39) |
P108S |
probably benign |
Het |
Setd1b |
A |
C |
5: 123,290,657 (GRCm39) |
M875L |
unknown |
Het |
Slc15a2 |
A |
G |
16: 36,576,673 (GRCm39) |
S485P |
probably benign |
Het |
Smoc1 |
A |
G |
12: 81,226,444 (GRCm39) |
D423G |
probably damaging |
Het |
Spast |
T |
A |
17: 74,676,198 (GRCm39) |
V337D |
probably damaging |
Het |
Spesp1 |
T |
C |
9: 62,179,987 (GRCm39) |
K307R |
possibly damaging |
Het |
Sulf1 |
A |
G |
1: 12,906,467 (GRCm39) |
E503G |
probably benign |
Het |
Susd6 |
T |
C |
12: 80,921,341 (GRCm39) |
Y313H |
probably damaging |
Het |
Them4 |
A |
T |
3: 94,238,865 (GRCm39) |
D224V |
possibly damaging |
Het |
Tpsg1 |
G |
T |
17: 25,592,184 (GRCm39) |
G86V |
probably damaging |
Het |
Tspear |
A |
T |
10: 77,717,049 (GRCm39) |
T575S |
probably benign |
Het |
Usp21 |
A |
T |
1: 171,113,142 (GRCm39) |
H211Q |
probably benign |
Het |
Vmn1r189 |
T |
C |
13: 22,286,322 (GRCm39) |
S172G |
probably benign |
Het |
Vmn2r114 |
T |
C |
17: 23,515,944 (GRCm39) |
S516G |
probably damaging |
Het |
Vmn2r28 |
T |
A |
7: 5,484,255 (GRCm39) |
R648S |
probably benign |
Het |
Vmn2r76 |
A |
G |
7: 85,879,388 (GRCm39) |
I304T |
probably benign |
Het |
Vmn2r88 |
A |
C |
14: 51,651,454 (GRCm39) |
Y256S |
|
Het |
Zfhx4 |
A |
T |
3: 5,468,831 (GRCm39) |
K3021N |
probably damaging |
Het |
Zfp647 |
T |
C |
15: 76,795,988 (GRCm39) |
H224R |
probably damaging |
Het |
Zfp865 |
A |
G |
7: 5,034,130 (GRCm39) |
E705G |
probably damaging |
Het |
|
Other mutations in Vmn2r6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01547:Vmn2r6
|
APN |
3 |
64,445,525 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01968:Vmn2r6
|
APN |
3 |
64,463,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02009:Vmn2r6
|
APN |
3 |
64,445,323 (GRCm39) |
missense |
possibly damaging |
0.61 |
IGL02039:Vmn2r6
|
APN |
3 |
64,463,610 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02652:Vmn2r6
|
APN |
3 |
64,463,749 (GRCm39) |
missense |
probably benign |
0.24 |
IGL02737:Vmn2r6
|
APN |
3 |
64,463,911 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL02808:Vmn2r6
|
APN |
3 |
64,463,917 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03066:Vmn2r6
|
APN |
3 |
64,472,574 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03331:Vmn2r6
|
APN |
3 |
64,445,428 (GRCm39) |
missense |
probably damaging |
1.00 |
BB010:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
BB020:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
R0010:Vmn2r6
|
UTSW |
3 |
64,466,966 (GRCm39) |
nonsense |
probably null |
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0208:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0427:Vmn2r6
|
UTSW |
3 |
64,467,008 (GRCm39) |
missense |
probably damaging |
1.00 |
R0466:Vmn2r6
|
UTSW |
3 |
64,463,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R1018:Vmn2r6
|
UTSW |
3 |
64,464,261 (GRCm39) |
missense |
probably benign |
0.00 |
R1104:Vmn2r6
|
UTSW |
3 |
64,445,487 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1186:Vmn2r6
|
UTSW |
3 |
64,472,488 (GRCm39) |
missense |
probably benign |
0.01 |
R1245:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1295:Vmn2r6
|
UTSW |
3 |
64,445,694 (GRCm39) |
missense |
probably damaging |
1.00 |
R1473:Vmn2r6
|
UTSW |
3 |
64,445,579 (GRCm39) |
nonsense |
probably null |
|
R1498:Vmn2r6
|
UTSW |
3 |
64,463,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R1925:Vmn2r6
|
UTSW |
3 |
64,463,698 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2044:Vmn2r6
|
UTSW |
3 |
64,445,262 (GRCm39) |
missense |
probably damaging |
0.96 |
R2069:Vmn2r6
|
UTSW |
3 |
64,463,519 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2253:Vmn2r6
|
UTSW |
3 |
64,467,139 (GRCm39) |
missense |
probably damaging |
1.00 |
R2261:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
R2262:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
R2350:Vmn2r6
|
UTSW |
3 |
64,463,773 (GRCm39) |
missense |
probably benign |
0.01 |
R2680:Vmn2r6
|
UTSW |
3 |
64,445,707 (GRCm39) |
missense |
possibly damaging |
0.91 |
R2846:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
R2860:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
R2861:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
R3766:Vmn2r6
|
UTSW |
3 |
64,463,929 (GRCm39) |
missense |
probably benign |
0.19 |
R3870:Vmn2r6
|
UTSW |
3 |
64,464,042 (GRCm39) |
missense |
probably damaging |
0.96 |
R4018:Vmn2r6
|
UTSW |
3 |
64,463,893 (GRCm39) |
missense |
probably benign |
0.05 |
R4024:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4026:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4227:Vmn2r6
|
UTSW |
3 |
64,445,369 (GRCm39) |
missense |
probably damaging |
0.99 |
R4526:Vmn2r6
|
UTSW |
3 |
64,445,145 (GRCm39) |
missense |
probably benign |
0.32 |
R4570:Vmn2r6
|
UTSW |
3 |
64,467,068 (GRCm39) |
missense |
probably benign |
0.31 |
R4894:Vmn2r6
|
UTSW |
3 |
64,454,829 (GRCm39) |
missense |
probably benign |
|
R4934:Vmn2r6
|
UTSW |
3 |
64,463,766 (GRCm39) |
missense |
probably damaging |
0.99 |
R5057:Vmn2r6
|
UTSW |
3 |
64,445,207 (GRCm39) |
missense |
probably damaging |
1.00 |
R5059:Vmn2r6
|
UTSW |
3 |
64,445,044 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5148:Vmn2r6
|
UTSW |
3 |
64,464,015 (GRCm39) |
missense |
probably damaging |
0.99 |
R5155:Vmn2r6
|
UTSW |
3 |
64,445,935 (GRCm39) |
missense |
probably benign |
0.44 |
R5179:Vmn2r6
|
UTSW |
3 |
64,445,411 (GRCm39) |
missense |
probably benign |
0.00 |
R5256:Vmn2r6
|
UTSW |
3 |
64,464,263 (GRCm39) |
missense |
probably benign |
0.33 |
R5861:Vmn2r6
|
UTSW |
3 |
64,463,454 (GRCm39) |
missense |
probably benign |
0.00 |
R5950:Vmn2r6
|
UTSW |
3 |
64,472,652 (GRCm39) |
missense |
probably benign |
0.05 |
R6081:Vmn2r6
|
UTSW |
3 |
64,463,953 (GRCm39) |
missense |
probably benign |
0.25 |
R6173:Vmn2r6
|
UTSW |
3 |
64,467,176 (GRCm39) |
missense |
probably damaging |
1.00 |
R6190:Vmn2r6
|
UTSW |
3 |
64,445,424 (GRCm39) |
missense |
probably benign |
0.04 |
R6240:Vmn2r6
|
UTSW |
3 |
64,464,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R6433:Vmn2r6
|
UTSW |
3 |
64,454,801 (GRCm39) |
nonsense |
probably null |
|
R6645:Vmn2r6
|
UTSW |
3 |
64,464,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R6791:Vmn2r6
|
UTSW |
3 |
64,445,580 (GRCm39) |
missense |
probably damaging |
1.00 |
R7265:Vmn2r6
|
UTSW |
3 |
64,464,195 (GRCm39) |
missense |
probably benign |
0.00 |
R7503:Vmn2r6
|
UTSW |
3 |
64,447,372 (GRCm39) |
nonsense |
probably null |
|
R7562:Vmn2r6
|
UTSW |
3 |
64,463,941 (GRCm39) |
missense |
probably benign |
0.00 |
R7584:Vmn2r6
|
UTSW |
3 |
64,472,683 (GRCm39) |
missense |
probably benign |
0.07 |
R7759:Vmn2r6
|
UTSW |
3 |
64,463,991 (GRCm39) |
missense |
probably damaging |
1.00 |
R7834:Vmn2r6
|
UTSW |
3 |
64,445,443 (GRCm39) |
missense |
probably damaging |
1.00 |
R7933:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
R7982:Vmn2r6
|
UTSW |
3 |
64,467,241 (GRCm39) |
missense |
probably damaging |
1.00 |
R8024:Vmn2r6
|
UTSW |
3 |
64,467,245 (GRCm39) |
missense |
probably benign |
0.40 |
R8074:Vmn2r6
|
UTSW |
3 |
64,455,064 (GRCm39) |
intron |
probably benign |
|
R8169:Vmn2r6
|
UTSW |
3 |
64,447,310 (GRCm39) |
missense |
probably benign |
0.01 |
R8337:Vmn2r6
|
UTSW |
3 |
64,463,526 (GRCm39) |
nonsense |
probably null |
|
R8736:Vmn2r6
|
UTSW |
3 |
64,467,221 (GRCm39) |
missense |
probably damaging |
1.00 |
R8962:Vmn2r6
|
UTSW |
3 |
64,463,576 (GRCm39) |
missense |
probably damaging |
1.00 |
R9139:Vmn2r6
|
UTSW |
3 |
64,464,277 (GRCm39) |
missense |
probably benign |
0.12 |
R9206:Vmn2r6
|
UTSW |
3 |
64,467,032 (GRCm39) |
missense |
probably damaging |
0.97 |
R9295:Vmn2r6
|
UTSW |
3 |
64,463,484 (GRCm39) |
missense |
probably benign |
0.00 |
R9332:Vmn2r6
|
UTSW |
3 |
64,454,671 (GRCm39) |
missense |
probably benign |
0.01 |
R9616:Vmn2r6
|
UTSW |
3 |
64,445,724 (GRCm39) |
missense |
probably damaging |
1.00 |
R9663:Vmn2r6
|
UTSW |
3 |
64,463,549 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9685:Vmn2r6
|
UTSW |
3 |
64,464,081 (GRCm39) |
missense |
probably benign |
0.19 |
X0020:Vmn2r6
|
UTSW |
3 |
64,445,871 (GRCm39) |
missense |
probably benign |
|
X0066:Vmn2r6
|
UTSW |
3 |
64,454,799 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r6
|
UTSW |
3 |
64,463,746 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- CAGTCTGCAAGCTACCCATTC -3'
(R):5'- CAACATTCCTTCAAGGTGTTTGC -3'
Sequencing Primer
(F):5'- CTTTTCTAGCCACCCAAATTAATGTG -3'
(R):5'- TCCTTCAAGGTGTTTGCTTAAAAGC -3'
|
Posted On |
2019-10-24 |