Incidental Mutation 'R7611:Ces1c'
ID 588604
Institutional Source Beutler Lab
Gene Symbol Ces1c
Ensembl Gene ENSMUSG00000057400
Gene Name carboxylesterase 1C
Synonyms Ces-N, Es-N, Es-1, Ee-1, Es-4, Es1
MMRRC Submission 045715-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7611 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 93825643-93857911 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 93851139 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 162 (N162D)
Ref Sequence ENSEMBL: ENSMUSP00000034189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034189] [ENSMUST00000211843]
AlphaFold P23953
Predicted Effect probably benign
Transcript: ENSMUST00000034189
AA Change: N162D

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000034189
Gene: ENSMUSG00000057400
AA Change: N162D

DomainStartEndE-ValueType
Pfam:COesterase 1 534 4e-167 PFAM
Pfam:Abhydrolase_3 136 235 6.2e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211843
AA Change: N7D

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection against nerve agents such as chlorpyrifos and chlorpyrifos oxon but increased sensitivity to soman coumarin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acta2 G A 19: 34,229,931 (GRCm39) T8I probably benign Het
Adcy8 C T 15: 64,792,882 (GRCm39) G25S probably benign Het
Ahnak2 G T 12: 112,751,749 (GRCm39) D35E Het
Birc6 T C 17: 74,969,713 (GRCm39) M4261T probably damaging Het
Caln1 T G 5: 130,534,918 (GRCm39) F45V probably damaging Het
Camta2 A T 11: 70,572,372 (GRCm39) I313N possibly damaging Het
Capns1 T A 7: 29,889,539 (GRCm39) E220V probably damaging Het
Carmil1 C A 13: 24,197,315 (GRCm39) V1374L probably benign Het
Casp2 T G 6: 42,250,972 (GRCm39) L290R possibly damaging Het
Cdkn2b C A 4: 89,228,980 (GRCm39) V19L probably benign Het
Cfap96 A G 8: 46,423,488 (GRCm39) Y75H probably damaging Het
Chd9 T C 8: 91,763,017 (GRCm39) S2281P probably damaging Het
Chst13 T C 6: 90,285,999 (GRCm39) D321G probably damaging Het
Ckap2l G T 2: 129,127,600 (GRCm39) P193T possibly damaging Het
Clca4b T A 3: 144,627,757 (GRCm39) T405S probably benign Het
Cmah T C 13: 24,619,630 (GRCm39) V265A probably benign Het
Cyp3a11 A T 5: 145,797,191 (GRCm39) M396K probably benign Het
Ddr2 A T 1: 169,825,727 (GRCm39) M291K possibly damaging Het
Ddx43 T A 9: 78,309,635 (GRCm39) I145N probably benign Het
Ephb2 T A 4: 136,388,212 (GRCm39) probably null Het
Fgfr1 A T 8: 26,048,221 (GRCm39) K106* probably null Het
Gpr6 A G 10: 40,946,875 (GRCm39) F236L probably benign Het
Grin2c A G 11: 115,143,511 (GRCm39) S750P probably damaging Het
Hecw2 A G 1: 53,952,459 (GRCm39) S925P probably damaging Het
Hivep3 CGG CG 4: 119,955,108 (GRCm39) 1141 probably null Het
Hmg20b T A 10: 81,185,432 (GRCm39) probably benign Het
Kcnk10 T A 12: 98,484,899 (GRCm39) Y79F probably damaging Het
Lrrc30 A T 17: 67,939,424 (GRCm39) F52Y probably damaging Het
Lrriq1 T C 10: 103,036,432 (GRCm39) K907R possibly damaging Het
Mbd3 T C 10: 80,231,352 (GRCm39) D63G probably damaging Het
Mettl21a C T 1: 64,654,266 (GRCm39) A84T probably benign Het
Mmp19 A G 10: 128,634,857 (GRCm39) D491G probably benign Het
Mug1 A T 6: 121,852,387 (GRCm39) probably null Het
Myh1 A T 11: 67,101,243 (GRCm39) H673L possibly damaging Het
Nlrc5 T C 8: 95,239,276 (GRCm39) probably null Het
Nme9 T A 9: 99,352,843 (GRCm39) S264R probably benign Het
Nup153 T C 13: 46,840,798 (GRCm39) T937A probably benign Het
Obsl1 T C 1: 75,482,024 (GRCm39) E282G probably damaging Het
Or1o3 A G 17: 37,573,745 (GRCm39) V270A probably benign Het
Or2w2 A G 13: 21,758,488 (GRCm39) V46A probably benign Het
Or4l15 C A 14: 50,198,368 (GRCm39) A54S probably benign Het
Or5an10 T A 19: 12,276,242 (GRCm39) M85L probably damaging Het
Or5b99 T A 19: 12,976,431 (GRCm39) I27N possibly damaging Het
Or5m5 T A 2: 85,814,407 (GRCm39) C74* probably null Het
Or8k30 T A 2: 86,339,397 (GRCm39) I198K possibly damaging Het
Pcdhga12 T C 18: 37,901,478 (GRCm39) F770S possibly damaging Het
Pfkp T A 13: 6,655,119 (GRCm39) probably null Het
Prr29 C G 11: 106,267,158 (GRCm39) H58D probably damaging Het
Ptprz1 T A 6: 23,001,219 (GRCm39) M1103K probably benign Het
Rigi T C 4: 40,225,651 (GRCm39) E250G probably damaging Het
Rsph4a C T 10: 33,781,473 (GRCm39) P108S probably benign Het
Setd1b A C 5: 123,290,657 (GRCm39) M875L unknown Het
Slc15a2 A G 16: 36,576,673 (GRCm39) S485P probably benign Het
Smoc1 A G 12: 81,226,444 (GRCm39) D423G probably damaging Het
Spast T A 17: 74,676,198 (GRCm39) V337D probably damaging Het
Spesp1 T C 9: 62,179,987 (GRCm39) K307R possibly damaging Het
Sulf1 A G 1: 12,906,467 (GRCm39) E503G probably benign Het
Susd6 T C 12: 80,921,341 (GRCm39) Y313H probably damaging Het
Them4 A T 3: 94,238,865 (GRCm39) D224V possibly damaging Het
Tpsg1 G T 17: 25,592,184 (GRCm39) G86V probably damaging Het
Tspear A T 10: 77,717,049 (GRCm39) T575S probably benign Het
Usp21 A T 1: 171,113,142 (GRCm39) H211Q probably benign Het
Vmn1r189 T C 13: 22,286,322 (GRCm39) S172G probably benign Het
Vmn2r114 T C 17: 23,515,944 (GRCm39) S516G probably damaging Het
Vmn2r28 T A 7: 5,484,255 (GRCm39) R648S probably benign Het
Vmn2r6 C A 3: 64,472,563 (GRCm39) V53F probably damaging Het
Vmn2r76 A G 7: 85,879,388 (GRCm39) I304T probably benign Het
Vmn2r88 A C 14: 51,651,454 (GRCm39) Y256S Het
Zfhx4 A T 3: 5,468,831 (GRCm39) K3021N probably damaging Het
Zfp647 T C 15: 76,795,988 (GRCm39) H224R probably damaging Het
Zfp865 A G 7: 5,034,130 (GRCm39) E705G probably damaging Het
Other mutations in Ces1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Ces1c APN 8 93,833,301 (GRCm39) missense probably benign 0.02
IGL00558:Ces1c APN 8 93,825,899 (GRCm39) missense probably benign 0.03
IGL00787:Ces1c APN 8 93,846,994 (GRCm39) missense possibly damaging 0.90
IGL00851:Ces1c APN 8 93,849,745 (GRCm39) missense probably benign 0.00
IGL01598:Ces1c APN 8 93,845,041 (GRCm39) missense probably benign
IGL02616:Ces1c APN 8 93,833,243 (GRCm39) missense probably benign 0.01
IGL03087:Ces1c APN 8 93,845,042 (GRCm39) missense probably benign
IGL03203:Ces1c APN 8 93,851,216 (GRCm39) missense probably damaging 1.00
R0119:Ces1c UTSW 8 93,834,238 (GRCm39) missense probably benign 0.00
R0119:Ces1c UTSW 8 93,833,345 (GRCm39) unclassified probably benign
R0255:Ces1c UTSW 8 93,854,152 (GRCm39) missense probably benign
R0759:Ces1c UTSW 8 93,857,492 (GRCm39) nonsense probably null
R1499:Ces1c UTSW 8 93,854,233 (GRCm39) missense probably benign 0.01
R1926:Ces1c UTSW 8 93,854,232 (GRCm39) missense possibly damaging 0.69
R2087:Ces1c UTSW 8 93,834,230 (GRCm39) missense probably benign 0.00
R2142:Ces1c UTSW 8 93,857,468 (GRCm39) missense probably benign
R2442:Ces1c UTSW 8 93,849,840 (GRCm39) missense probably damaging 1.00
R2971:Ces1c UTSW 8 93,830,821 (GRCm39) missense probably benign 0.01
R3079:Ces1c UTSW 8 93,846,975 (GRCm39) missense probably damaging 1.00
R3080:Ces1c UTSW 8 93,846,975 (GRCm39) missense probably damaging 1.00
R3609:Ces1c UTSW 8 93,846,960 (GRCm39) missense probably damaging 1.00
R4131:Ces1c UTSW 8 93,827,312 (GRCm39) missense probably damaging 1.00
R4633:Ces1c UTSW 8 93,845,014 (GRCm39) missense probably benign 0.00
R4988:Ces1c UTSW 8 93,827,336 (GRCm39) missense probably damaging 1.00
R5081:Ces1c UTSW 8 93,854,197 (GRCm39) missense probably damaging 1.00
R5497:Ces1c UTSW 8 93,857,343 (GRCm39) missense possibly damaging 0.91
R5586:Ces1c UTSW 8 93,854,227 (GRCm39) missense probably benign 0.00
R7013:Ces1c UTSW 8 93,857,392 (GRCm39) missense probably damaging 1.00
R7137:Ces1c UTSW 8 93,857,470 (GRCm39) missense probably benign 0.02
R7882:Ces1c UTSW 8 93,833,231 (GRCm39) missense probably benign
R8280:Ces1c UTSW 8 93,825,809 (GRCm39) missense possibly damaging 0.53
R8705:Ces1c UTSW 8 93,857,518 (GRCm39) missense probably benign
R8752:Ces1c UTSW 8 93,846,964 (GRCm39) missense probably damaging 1.00
R8896:Ces1c UTSW 8 93,833,254 (GRCm39) missense probably benign
R9470:Ces1c UTSW 8 93,830,746 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GGTCTTTTACACAAACATGAGTCTTCC -3'
(R):5'- CAGTTTGCAACCTTCCTGGG -3'

Sequencing Primer
(F):5'- CAAACATGAGTCTTCCAAAACTTTC -3'
(R):5'- TGCAACCTTCCTGGGAACTG -3'
Posted On 2019-10-24