|Institutional Source||Beutler Lab|
|Gene Name||NLR family, CARD domain containing 5|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7611 (G1)|
|Chromosomal Location||94434356-94527272 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 94512648 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000138322 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000053085] [ENSMUST00000211816]|
|PDB Structure||The solution NMR structure of the NLRC5 caspase recruitment domain (CARD) [SOLUTION NMR]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cytokine production induced by virus and bacteria infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nlrc5||
(F):5'- AAGCTCTTAGAGGGACCTTCTGTC -3'
(R):5'- ACAGTTGTGGGACCAGCATC -3'
(F):5'- GGACCTTCTGTCATGGTGACC -3'
(R):5'- AGGTTTGGCTTCCATAGACACAC -3'