Incidental Mutation 'R7615:Brwd1'
| ID |
588889 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
G1-403-16, repro5, D530019K20Rik, 5330419I02Rik, Wdr9 |
| MMRRC Submission |
045683-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7615 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
95992092-96082428 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 96033839 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 942
(F942L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023631
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023631
AA Change: F942L
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
AA Change: F942L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099502
AA Change: F942L
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
AA Change: F942L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1415 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (101/101) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931406B18Rik |
T |
C |
7: 43,497,849 (GRCm38) |
I320V |
possibly damaging |
Het |
| Adat2 |
A |
G |
10: 13,553,276 (GRCm38) |
K4R |
probably benign |
Het |
| Adgb |
G |
A |
10: 10,436,010 (GRCm38) |
L226F |
probably damaging |
Het |
| Adgrb3 |
C |
T |
1: 25,098,897 (GRCm38) |
V1192I |
probably damaging |
Het |
| Ahsa2 |
T |
A |
11: 23,496,750 (GRCm38) |
N71I |
possibly damaging |
Het |
| Amigo2 |
T |
G |
15: 97,245,342 (GRCm38) |
T400P |
probably damaging |
Het |
| Ankhd1 |
A |
T |
18: 36,656,773 (GRCm38) |
Q466L |
|
Het |
| Auh |
T |
C |
13: 52,919,013 (GRCm38) |
I111V |
probably benign |
Het |
| C1qtnf7 |
A |
G |
5: 43,616,144 (GRCm38) |
N262D |
probably damaging |
Het |
| Cdh9 |
T |
A |
15: 16,856,230 (GRCm38) |
S785R |
probably damaging |
Het |
| Celsr3 |
A |
G |
9: 108,837,652 (GRCm38) |
T2046A |
possibly damaging |
Het |
| Cep170b |
T |
C |
12: 112,744,665 (GRCm38) |
V1493A |
probably damaging |
Het |
| Cep290 |
C |
T |
10: 100,492,681 (GRCm38) |
R111W |
probably benign |
Het |
| Chd2 |
T |
A |
7: 73,441,642 (GRCm38) |
H1617L |
probably damaging |
Het |
| Clnk |
T |
C |
5: 38,706,698 (GRCm38) |
D404G |
probably damaging |
Het |
| Col18a1 |
C |
T |
10: 77,067,005 (GRCm38) |
G795D |
probably damaging |
Het |
| Csf3r |
T |
A |
4: 126,037,656 (GRCm38) |
Y477* |
probably null |
Het |
| Ddx58 |
T |
A |
4: 40,229,653 (GRCm38) |
I89F |
possibly damaging |
Het |
| Dnah17 |
T |
A |
11: 118,110,547 (GRCm38) |
K857* |
probably null |
Het |
| Dnah2 |
T |
G |
11: 69,435,304 (GRCm38) |
I3674L |
probably damaging |
Het |
| Dnah6 |
A |
C |
6: 73,095,206 (GRCm38) |
I2431S |
possibly damaging |
Het |
| Eml6 |
T |
A |
11: 29,802,501 (GRCm38) |
I971F |
possibly damaging |
Het |
| Fam135b |
A |
T |
15: 71,463,323 (GRCm38) |
I674N |
probably damaging |
Het |
| Fancc |
T |
A |
13: 63,317,558 (GRCm38) |
|
probably null |
Het |
| Gabrb2 |
A |
C |
11: 42,626,742 (GRCm38) |
K464Q |
probably benign |
Het |
| Gbp4 |
T |
A |
5: 105,122,982 (GRCm38) |
D261V |
possibly damaging |
Het |
| Gdf3 |
A |
G |
6: 122,606,916 (GRCm38) |
V164A |
probably benign |
Het |
| Gm19410 |
A |
G |
8: 35,796,359 (GRCm38) |
D978G |
probably damaging |
Het |
| Gm20730 |
C |
T |
6: 43,081,774 (GRCm38) |
G35R |
probably null |
Het |
| Gm9733 |
A |
G |
3: 15,320,485 (GRCm38) |
V119A |
probably damaging |
Het |
| Grin2b |
G |
A |
6: 135,923,364 (GRCm38) |
T173I |
probably damaging |
Het |
| Gtf3c3 |
A |
T |
1: 54,423,572 (GRCm38) |
V344E |
possibly damaging |
Het |
| Hsd3b5 |
A |
G |
3: 98,630,104 (GRCm38) |
I32T |
probably damaging |
Het |
| Ido1 |
G |
C |
8: 24,593,188 (GRCm38) |
L74V |
probably damaging |
Het |
| Igkv1-88 |
T |
A |
6: 68,862,373 (GRCm38) |
D85V |
probably damaging |
Het |
| Il22ra1 |
A |
G |
4: 135,737,459 (GRCm38) |
I159V |
probably benign |
Het |
| Iqgap1 |
A |
G |
7: 80,751,346 (GRCm38) |
V531A |
probably benign |
Het |
| Iqgap1 |
A |
T |
7: 80,730,100 (GRCm38) |
F1175Y |
probably damaging |
Het |
| Itga1 |
T |
A |
13: 114,996,922 (GRCm38) |
Q484L |
probably null |
Het |
| Itga11 |
A |
T |
9: 62,744,018 (GRCm38) |
E281V |
probably benign |
Het |
| Kpna3 |
T |
C |
14: 61,372,962 (GRCm38) |
N343S |
possibly damaging |
Het |
| Larp1b |
A |
G |
3: 41,035,816 (GRCm38) |
N133S |
probably benign |
Het |
| Larp1b |
A |
G |
3: 41,033,534 (GRCm38) |
K64E |
possibly damaging |
Het |
| Lctl |
T |
A |
9: 64,122,110 (GRCm38) |
L161H |
probably damaging |
Het |
| Mlip |
A |
G |
9: 77,230,483 (GRCm38) |
S381P |
probably damaging |
Het |
| Mroh9 |
A |
G |
1: 163,046,032 (GRCm38) |
I518T |
probably benign |
Het |
| Mst1r |
A |
G |
9: 107,920,012 (GRCm38) |
Q1360R |
probably benign |
Het |
| Muc5b |
T |
A |
7: 141,864,892 (GRCm38) |
C3858* |
probably null |
Het |
| Naip1 |
A |
T |
13: 100,425,776 (GRCm38) |
H960Q |
probably benign |
Het |
| Narfl |
C |
T |
17: 25,782,129 (GRCm38) |
P452S |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,884,503 (GRCm38) |
S1321T |
probably benign |
Het |
| Nid2 |
C |
A |
14: 19,802,530 (GRCm38) |
T1102K |
probably damaging |
Het |
| Nsmaf |
C |
T |
4: 6,408,563 (GRCm38) |
V739M |
probably damaging |
Het |
| Olfr1019 |
T |
A |
2: 85,841,657 (GRCm38) |
M45L |
probably benign |
Het |
| Olfr1167 |
T |
C |
2: 88,149,518 (GRCm38) |
Q167R |
probably benign |
Het |
| Olfr1464-ps1 |
A |
G |
19: 13,282,590 (GRCm38) |
I156T |
probably damaging |
Het |
| Olfr727 |
T |
G |
14: 50,126,989 (GRCm38) |
S137R |
probably benign |
Het |
| Olfr97 |
T |
G |
17: 37,231,450 (GRCm38) |
K307Q |
probably benign |
Het |
| Osbpl9 |
G |
A |
4: 109,086,339 (GRCm38) |
P159S |
probably damaging |
Het |
| Parpbp |
A |
G |
10: 88,093,637 (GRCm38) |
S450P |
probably damaging |
Het |
| Pdgfrb |
A |
G |
18: 61,064,046 (GRCm38) |
T185A |
probably benign |
Het |
| Pkd1 |
T |
C |
17: 24,593,502 (GRCm38) |
V3803A |
probably damaging |
Het |
| Plau |
A |
T |
14: 20,839,466 (GRCm38) |
K200* |
probably null |
Het |
| Plce1 |
A |
T |
19: 38,524,665 (GRCm38) |
Q136L |
probably benign |
Het |
| Plekhd1 |
C |
T |
12: 80,722,445 (GRCm38) |
T493I |
probably benign |
Het |
| Pofut1 |
T |
C |
2: 153,259,418 (GRCm38) |
S31P |
unknown |
Het |
| Prlr |
T |
A |
15: 10,325,924 (GRCm38) |
I243N |
probably damaging |
Het |
| Ptgis |
A |
G |
2: 167,223,988 (GRCm38) |
L174P |
probably damaging |
Het |
| Ralgapb |
T |
A |
2: 158,450,270 (GRCm38) |
I792K |
probably damaging |
Het |
| Retreg3 |
C |
T |
11: 101,102,980 (GRCm38) |
S136N |
probably damaging |
Het |
| Rnf213 |
C |
T |
11: 119,467,297 (GRCm38) |
T4291M |
|
Het |
| Rtn1 |
A |
G |
12: 72,304,143 (GRCm38) |
Y431H |
probably damaging |
Het |
| Rwdd3 |
A |
G |
3: 121,171,604 (GRCm38) |
|
probably benign |
Het |
| Scyl3 |
A |
T |
1: 163,950,338 (GRCm38) |
|
probably null |
Het |
| Sh2b2 |
G |
T |
5: 136,219,657 (GRCm38) |
Q510K |
probably damaging |
Het |
| Sh2b3 |
G |
A |
5: 121,818,700 (GRCm38) |
P333S |
probably benign |
Het |
| Slc27a6 |
A |
T |
18: 58,609,183 (GRCm38) |
N490Y |
probably damaging |
Het |
| Slc45a1 |
C |
T |
4: 150,638,545 (GRCm38) |
R294Q |
probably benign |
Het |
| Sorl1 |
A |
C |
9: 41,977,582 (GRCm38) |
I1974S |
possibly damaging |
Het |
| Specc1l |
C |
A |
10: 75,263,286 (GRCm38) |
N857K |
probably benign |
Het |
| Speg |
T |
C |
1: 75,429,242 (GRCm38) |
L3030P |
probably damaging |
Het |
| Spsb1 |
A |
C |
4: 149,906,900 (GRCm38) |
D70E |
probably benign |
Het |
| Srsf11 |
A |
G |
3: 158,016,425 (GRCm38) |
S270P |
unknown |
Het |
| Ssr3 |
A |
C |
3: 65,387,792 (GRCm38) |
V100G |
probably damaging |
Het |
| Synpo |
G |
A |
18: 60,604,475 (GRCm38) |
T133I |
probably damaging |
Het |
| Tas2r120 |
T |
G |
6: 132,657,810 (GRCm38) |
V285G |
probably benign |
Het |
| Tenm4 |
T |
A |
7: 96,845,926 (GRCm38) |
V1187D |
probably damaging |
Het |
| Tmed8 |
C |
A |
12: 87,181,388 (GRCm38) |
|
probably null |
Het |
| Tmem51 |
G |
A |
4: 142,037,564 (GRCm38) |
T61M |
probably damaging |
Het |
| Tonsl |
A |
T |
15: 76,630,607 (GRCm38) |
D1132E |
probably benign |
Het |
| Tor1aip1 |
C |
T |
1: 156,007,584 (GRCm38) |
V358I |
possibly damaging |
Het |
| Txlna |
A |
T |
4: 129,630,319 (GRCm38) |
M415K |
probably damaging |
Het |
| Tyms |
T |
A |
5: 30,073,560 (GRCm38) |
|
probably benign |
Het |
| Uggt2 |
G |
T |
14: 119,089,269 (GRCm38) |
L177I |
probably benign |
Het |
| Uqcrh |
T |
C |
4: 116,069,879 (GRCm38) |
H74R |
probably benign |
Het |
| Wnk1 |
A |
T |
6: 119,932,738 (GRCm38) |
S33T |
probably benign |
Het |
| Zfp553 |
T |
A |
7: 127,236,016 (GRCm38) |
C248S |
probably damaging |
Het |
| Zfp574 |
G |
A |
7: 25,080,576 (GRCm38) |
C341Y |
possibly damaging |
Het |
| Zfp729b |
T |
C |
13: 67,591,498 (GRCm38) |
T883A |
possibly damaging |
Het |
| Zfp738 |
T |
A |
13: 67,670,203 (GRCm38) |
K556N |
probably damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
96,017,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
96,043,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
96,016,173 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
96,047,379 (GRCm38) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
96,047,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
96,046,466 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
96,013,829 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
96,019,456 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
96,002,823 (GRCm38) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
96,052,571 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
96,057,466 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
96,017,677 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
96,011,850 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
96,021,258 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
96,017,677 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
96,037,900 (GRCm38) |
missense |
probably benign |
0.26 |
|
IGL03328:Brwd1
|
APN |
16 |
96,002,725 (GRCm38) |
missense |
probably damaging |
0.99 |
|
bromide
|
UTSW |
16 |
96,064,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
96,017,604 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
96,035,959 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
96,033,843 (GRCm38) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
96,041,274 (GRCm38) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
96,002,671 (GRCm38) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
96,059,652 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
96,059,652 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
96,021,256 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
96,047,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
96,037,964 (GRCm38) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
96,035,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
96,043,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
96,068,584 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
96,031,548 (GRCm38) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
96,003,234 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
96,041,370 (GRCm38) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
96,036,034 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
96,066,151 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
96,028,291 (GRCm38) |
splice site |
probably null |
|
|
R1624:Brwd1
|
UTSW |
16 |
96,008,144 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R1636:Brwd1
|
UTSW |
16 |
96,059,641 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
96,021,237 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
96,021,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
96,046,465 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
96,066,100 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
96,066,574 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
96,044,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
96,046,372 (GRCm38) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
96,023,496 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
96,017,604 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
96,017,604 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
96,017,604 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
96,047,359 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
96,003,318 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
96,053,972 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
96,002,793 (GRCm38) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
96,002,209 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
96,002,557 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
96,016,150 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
96,033,843 (GRCm38) |
nonsense |
probably null |
|
|
R5782:Brwd1
|
UTSW |
16 |
96,043,043 (GRCm38) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
96,019,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
96,064,758 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
96,058,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
96,064,787 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
96,002,956 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
96,013,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
96,007,941 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
96,002,307 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,993,962 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
96,068,572 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
96,041,274 (GRCm38) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
96,009,530 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7131:Brwd1
|
UTSW |
16 |
96,066,498 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7208:Brwd1
|
UTSW |
16 |
96,035,959 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
96,066,119 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7483:Brwd1
|
UTSW |
16 |
96,056,173 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7621:Brwd1
|
UTSW |
16 |
96,064,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
96,041,343 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
96,046,401 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
96,027,368 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
96,019,449 (GRCm38) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
96,002,734 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
96,016,209 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
96,047,430 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
96,058,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
96,028,202 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
96,023,410 (GRCm38) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
96,068,525 (GRCm38) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
96,047,114 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
96,064,930 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
96,037,954 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
96,002,816 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
96,002,493 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
96,053,980 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
96,044,503 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9673:Brwd1
|
UTSW |
16 |
96,011,896 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,993,815 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
96,023,828 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
96,044,491 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
96,011,923 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGCTTCATGACCCTGACG -3'
(R):5'- TGATTGTAGAAGCTGCAGGG -3'
Sequencing Primer
(F):5'- CGGAAGTACATCACCTGCAAAGG -3'
(R):5'- GATTGGATCCAGATGCATTTAAAATC -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation