Incidental Mutation 'R7621:Or8c15'
ID 589149
Institutional Source Beutler Lab
Gene Symbol Or8c15
Ensembl Gene ENSMUSG00000093901
Gene Name olfactory receptor family 8 subfamily C member 15
Synonyms GA_x6K02T2PVTD-31889215-31890153, Olfr893, MOR170-11
MMRRC Submission 045688-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R7621 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38120348-38121289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38120447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 31 (F31L)
Ref Sequence ENSEMBL: ENSMUSP00000148719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093867] [ENSMUST00000211975]
AlphaFold K7N678
Predicted Effect probably benign
Transcript: ENSMUST00000093867
AA Change: F33L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000091390
Gene: ENSMUSG00000093901
AA Change: F33L

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.2e-45 PFAM
Pfam:7tm_1 43 292 8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211975
AA Change: F31L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000212815
Meta Mutation Damage Score 0.3059 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T A 11: 110,051,359 (GRCm39) K112N probably benign Het
Brwd1 A G 16: 95,866,087 (GRCm39) S232P probably damaging Het
Calm5 A T 13: 3,904,629 (GRCm39) M108L possibly damaging Het
Ces1g A T 8: 94,055,094 (GRCm39) V201D probably damaging Het
Cltc C A 11: 86,598,312 (GRCm39) V1017L probably benign Het
Cpt1c C T 7: 44,616,516 (GRCm39) R245Q probably damaging Het
Csrnp1 C A 9: 119,806,158 (GRCm39) A39S probably benign Het
Elf1 A G 14: 79,808,322 (GRCm39) D258G possibly damaging Het
Entrep1 A C 19: 23,972,168 (GRCm39) S179A possibly damaging Het
Glipr1l1 A T 10: 111,896,300 (GRCm39) D29V probably benign Het
Gm4340 T C 10: 104,031,820 (GRCm39) V188A probably benign Het
Gsdma2 T C 11: 98,540,375 (GRCm39) M98T probably benign Het
Hars1 A T 18: 36,903,476 (GRCm39) D315E probably benign Het
Hsph1 A C 5: 149,555,540 (GRCm39) Y89D probably damaging Het
Ighv11-2 T A 12: 114,012,008 (GRCm39) D69V probably benign Het
Kirrel1 C T 3: 86,995,528 (GRCm39) G438D possibly damaging Het
Krt6a G T 15: 101,600,187 (GRCm39) T355K possibly damaging Het
Lce1m T C 3: 92,925,177 (GRCm39) probably null Het
Lmbrd1 A T 1: 24,767,625 (GRCm39) probably null Het
Lmtk3 A G 7: 45,442,841 (GRCm39) E508G probably damaging Het
Lrrc2 G A 9: 110,809,899 (GRCm39) V312I probably benign Het
Lyn A T 4: 3,789,834 (GRCm39) K477* probably null Het
Nfe2l2 T C 2: 75,509,757 (GRCm39) D21G probably damaging Het
Or14c45 G A 7: 86,176,280 (GRCm39) C105Y probably benign Het
Or4f14d T C 2: 111,960,926 (GRCm39) T77A probably benign Het
Or55b3 G A 7: 102,126,472 (GRCm39) R202C possibly damaging Het
Pgap6 C A 17: 26,336,865 (GRCm39) P261Q probably benign Het
Pkm T A 9: 59,585,441 (GRCm39) C474* probably null Het
Prr36 T A 8: 4,263,150 (GRCm39) I839F unknown Het
Qtrt2 A G 16: 43,689,303 (GRCm39) probably null Het
Ripk4 A T 16: 97,547,125 (GRCm39) V379E probably damaging Het
Rreb1 C A 13: 38,133,042 (GRCm39) P304Q Het
Saxo2 A T 7: 82,297,625 (GRCm39) C5S possibly damaging Het
Scart2 G A 7: 139,876,742 (GRCm39) G711D probably damaging Het
Sema5a C A 15: 32,609,378 (GRCm39) T428N possibly damaging Het
Setd5 C A 6: 113,121,010 (GRCm39) P1073Q possibly damaging Het
Sh2d5 T G 4: 137,984,150 (GRCm39) C173G probably benign Het
Slc4a10 T G 2: 62,080,823 (GRCm39) V350G probably damaging Het
Slco1a6 A G 6: 142,106,743 (GRCm39) C15R probably damaging Het
Smg7 A T 1: 152,717,295 (GRCm39) F940Y possibly damaging Het
Spata17 T A 1: 186,854,833 (GRCm39) probably null Het
Specc1 A G 11: 62,019,210 (GRCm39) N603S possibly damaging Het
Tbc1d1 A G 5: 64,421,673 (GRCm39) D355G probably damaging Het
Thbs2 T C 17: 14,894,426 (GRCm39) D807G probably benign Het
Usp53 T C 3: 122,754,934 (GRCm39) T174A probably benign Het
Vmn2r52 A G 7: 9,907,274 (GRCm39) Y151H probably benign Het
Wdr12 G A 1: 60,136,748 (GRCm39) probably benign Het
Other mutations in Or8c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Or8c15 APN 9 38,120,534 (GRCm39) missense probably damaging 1.00
IGL00914:Or8c15 APN 9 38,121,095 (GRCm39) splice site probably null
IGL01563:Or8c15 APN 9 38,120,997 (GRCm39) missense probably damaging 1.00
IGL01696:Or8c15 APN 9 38,120,345 (GRCm39) unclassified probably benign
IGL02064:Or8c15 APN 9 38,120,874 (GRCm39) missense probably damaging 1.00
IGL02605:Or8c15 APN 9 38,120,532 (GRCm39) missense probably damaging 0.99
R0415:Or8c15 UTSW 9 38,121,269 (GRCm39) missense probably benign
R0463:Or8c15 UTSW 9 38,120,360 (GRCm39) missense probably benign 0.00
R0843:Or8c15 UTSW 9 38,120,579 (GRCm39) missense possibly damaging 0.81
R1441:Or8c15 UTSW 9 38,120,777 (GRCm39) missense probably damaging 1.00
R1939:Or8c15 UTSW 9 38,120,725 (GRCm39) nonsense probably null
R2512:Or8c15 UTSW 9 38,120,670 (GRCm39) missense probably damaging 1.00
R4890:Or8c15 UTSW 9 38,120,586 (GRCm39) missense probably benign 0.00
R5439:Or8c15 UTSW 9 38,121,050 (GRCm39) missense probably benign 0.00
R6918:Or8c15 UTSW 9 38,120,948 (GRCm39) missense possibly damaging 0.95
R7715:Or8c15 UTSW 9 38,120,775 (GRCm39) missense probably benign 0.30
R7940:Or8c15 UTSW 9 38,120,496 (GRCm39) missense probably benign 0.00
R8710:Or8c15 UTSW 9 38,121,066 (GRCm39) missense possibly damaging 0.60
R8712:Or8c15 UTSW 9 38,121,099 (GRCm39) missense probably benign 0.39
R8882:Or8c15 UTSW 9 38,120,461 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACAATTGAATGCCATGCAGC -3'
(R):5'- TAGCTGAGTCATGCATCCTGTATAAG -3'

Sequencing Primer
(F):5'- GCAGCATATTCTCAAAATACTGTGC -3'
(R):5'- CATGCATCCTGTATAAGATATGATGC -3'
Posted On 2019-10-24