|Institutional Source||Beutler Lab|
|Gene Name||CDC42 binding protein kinase beta|
|Essential gene?||Possibly essential (E-score: 0.649)|
|Stock #||R7622 (G1)|
|Chromosomal Location||111292976-111377718 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to G at 111294772 bp (GRCm38)|
|Amino Acid Change||Glutamic Acid to Alanine at position 201 (E201A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000152591 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041965] [ENSMUST00000220657]|
AA Change: E201A
|Coding Region Coverage||
|Validation Efficiency||98% (55/56)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdc42bpb||
(F):5'- ACCTGGCTCAACTCTAAGGG -3'
(R):5'- CAAAGGTGTCCTTGTCTGTAGG -3'
(F):5'- TGGCTCAACTCTAAGGGAAATC -3'
(R):5'- AGCCTGGAGTGCCTGTG -3'