Incidental Mutation 'R7623:Ccnb2'
ID 589263
Institutional Source Beutler Lab
Gene Symbol Ccnb2
Ensembl Gene ENSMUSG00000032218
Gene Name cyclin B2
Synonyms CycB2
MMRRC Submission 045718-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.574) question?
Stock # R7623 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 70314974-70328829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70326170 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 58 (V58A)
Ref Sequence ENSEMBL: ENSMUSP00000034742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034742]
AlphaFold P30276
Predicted Effect probably benign
Transcript: ENSMUST00000034742
AA Change: V58A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034742
Gene: ENSMUSG00000032218
AA Change: V58A

DomainStartEndE-ValueType
CYCLIN 171 255 8.58e-28 SMART
Cyclin_C 264 382 9.83e-34 SMART
CYCLIN 268 349 2.73e-21 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510009E07Rik G T 16: 21,513,092 (GRCm39) L22M probably damaging Het
Abca9 T C 11: 109,998,384 (GRCm39) N1468S probably benign Het
Abcc5 C T 16: 20,163,446 (GRCm39) D1264N possibly damaging Het
Abhd10 A G 16: 45,553,099 (GRCm39) probably benign Het
Acadvl G T 11: 69,901,569 (GRCm39) A570E probably damaging Het
Adgrb3 T A 1: 25,586,629 (GRCm39) S355C probably damaging Het
Adgrv1 A G 13: 81,570,344 (GRCm39) V4953A possibly damaging Het
Ano2 T A 6: 125,992,536 (GRCm39) Y836* probably null Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Ccdc8 T A 7: 16,730,537 (GRCm39) D675E possibly damaging Het
Cdcp3 T A 7: 130,879,295 (GRCm39) probably null Het
Cdh24 A T 14: 54,875,547 (GRCm39) Y296N probably damaging Het
Cfap46 T C 7: 139,198,266 (GRCm39) E2054G unknown Het
Cnot1 A T 8: 96,454,276 (GRCm39) F2067I probably damaging Het
Csmd3 A G 15: 47,813,334 (GRCm39) F329S Het
Dact3 C A 7: 16,619,840 (GRCm39) T445K unknown Het
Dph6 C A 2: 114,485,379 (GRCm39) probably benign Het
Dst T A 1: 34,209,517 (GRCm39) C1195S probably damaging Het
Eeig1 A G 2: 32,456,346 (GRCm39) D336G possibly damaging Het
Fat3 T A 9: 15,899,620 (GRCm39) N3138Y probably damaging Het
Fbxw25 T C 9: 109,483,651 (GRCm39) N187S Het
Fuca1 A G 4: 135,660,405 (GRCm39) I308V probably benign Het
Galnt5 A G 2: 57,907,222 (GRCm39) R562G probably damaging Het
Gas8 G T 8: 124,249,718 (GRCm39) R44S probably damaging Het
Gja5 T C 3: 96,958,071 (GRCm39) S43P possibly damaging Het
Gm14403 A G 2: 177,200,405 (GRCm39) D117G probably benign Het
Gmpr2 G A 14: 55,910,491 (GRCm39) V58M probably damaging Het
Gtpbp6 T A 5: 110,252,950 (GRCm39) I301F probably damaging Het
H2bc22 T A 13: 21,971,762 (GRCm39) D26E probably benign Het
Hdhd5 T C 6: 120,498,212 (GRCm39) Y129C probably damaging Het
Hemgn A G 4: 46,396,504 (GRCm39) M244T probably benign Het
Hoxa1 T G 6: 52,135,238 (GRCm39) probably null Het
Iglc1 T A 16: 18,880,551 (GRCm39) H90L Het
Lamb2 C T 9: 108,366,423 (GRCm39) S1545F possibly damaging Het
Mc4r T C 18: 66,992,580 (GRCm39) T178A probably benign Het
Mcam T A 9: 44,050,955 (GRCm39) S346T probably benign Het
Mis18bp1 A G 12: 65,195,626 (GRCm39) S713P probably benign Het
Mybl2 A G 2: 162,914,752 (GRCm39) Y290C probably damaging Het
Or4k44 T C 2: 111,368,281 (GRCm39) M118V probably damaging Het
Or7e168 A T 9: 19,720,225 (GRCm39) I204F possibly damaging Het
Pak6 A G 2: 118,525,068 (GRCm39) T565A probably damaging Het
Pde5a A G 3: 122,568,250 (GRCm39) T284A probably benign Het
Pkd1l2 A T 8: 117,756,384 (GRCm39) F1616Y probably damaging Het
Pp2d1 T C 17: 53,822,907 (GRCm39) E53G probably benign Het
Ppp3cc A C 14: 70,478,394 (GRCm39) S269R probably benign Het
Ptprb A C 10: 116,205,214 (GRCm39) D1856A possibly damaging Het
Rgs22 A T 15: 36,040,856 (GRCm39) V1001E probably benign Het
Rnf8 T A 17: 29,847,980 (GRCm39) V344E probably benign Het
Rpn1 T C 6: 88,061,550 (GRCm39) L13P possibly damaging Het
Rsbn1 A T 3: 103,822,326 (GRCm39) H187L probably benign Het
Sdr16c6 T A 4: 4,058,801 (GRCm39) I262F not run Het
Sec22a A G 16: 35,149,894 (GRCm39) F211L probably benign Het
Slc16a4 G A 3: 107,205,297 (GRCm39) A42T possibly damaging Het
Smap1 T A 1: 23,887,376 (GRCm39) Q386L probably benign Het
Sos1 A T 17: 80,787,323 (GRCm39) F10L probably benign Het
Sptbn2 A G 19: 4,776,196 (GRCm39) T202A probably damaging Het
Stab1 C A 14: 30,862,578 (GRCm39) V2282L probably benign Het
Tex55 C T 16: 38,648,453 (GRCm39) D219N possibly damaging Het
Tmprss11f C T 5: 86,672,019 (GRCm39) G391D probably damaging Het
Tnfaip2 A G 12: 111,412,072 (GRCm39) S158G probably damaging Het
Trav6d-5 A G 14: 53,032,843 (GRCm39) T31A probably benign Het
Tst G A 15: 78,289,903 (GRCm39) A44V probably damaging Het
Vmn1r210 A T 13: 23,011,405 (GRCm39) F294I probably benign Het
Vwc2 T C 11: 11,066,415 (GRCm39) F168L probably damaging Het
Wdr25 G A 12: 108,958,819 (GRCm39) G344S possibly damaging Het
Zfp605 A G 5: 110,275,386 (GRCm39) Y168C probably benign Het
Zfp790 T A 7: 29,525,130 (GRCm39) Y49* probably null Het
Zfp93 T C 7: 23,975,794 (GRCm39) F593S probably damaging Het
Zfr C T 15: 12,160,614 (GRCm39) T729I possibly damaging Het
Other mutations in Ccnb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Ccnb2 APN 9 70,326,189 (GRCm39) missense probably damaging 0.96
IGL01474:Ccnb2 APN 9 70,326,305 (GRCm39) missense probably benign
IGL03097:Ccnb2 APN 9 70,316,678 (GRCm39) splice site probably benign
IGL03298:Ccnb2 APN 9 70,326,156 (GRCm39) missense probably benign
R0042:Ccnb2 UTSW 9 70,326,335 (GRCm39) missense probably benign
R0042:Ccnb2 UTSW 9 70,326,335 (GRCm39) missense probably benign
R1585:Ccnb2 UTSW 9 70,317,559 (GRCm39) splice site probably null
R1756:Ccnb2 UTSW 9 70,318,070 (GRCm39) missense probably benign 0.41
R2046:Ccnb2 UTSW 9 70,316,629 (GRCm39) missense probably benign 0.11
R6045:Ccnb2 UTSW 9 70,326,375 (GRCm39) missense probably benign
R7202:Ccnb2 UTSW 9 70,318,128 (GRCm39) missense probably damaging 1.00
R8515:Ccnb2 UTSW 9 70,320,382 (GRCm39) critical splice donor site probably null
R9072:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9073:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9235:Ccnb2 UTSW 9 70,318,163 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GAATTGAGGCATCACCAAGTTG -3'
(R):5'- CAAGAGCCATGTGACTATCCG -3'

Sequencing Primer
(F):5'- AACTTCAGTTACAGGGGATCTGATGC -3'
(R):5'- ACTATCCGGCGGGCAGTTTTAG -3'
Posted On 2019-10-24