Incidental Mutation 'R7625:Mindy4'
ID 589381
Institutional Source Beutler Lab
Gene Symbol Mindy4
Ensembl Gene ENSMUSG00000038022
Gene Name MINDY lysine 48 deubiquitinase 4
Synonyms Fam188b, C330043M08Rik, LOC384387
MMRRC Submission 045719-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R7625 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 55180368-55297207 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 55253598 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 489 (I489T)
Ref Sequence ENSEMBL: ENSMUSP00000061221 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053094] [ENSMUST00000204842]
AlphaFold Q3UQI9
Predicted Effect possibly damaging
Transcript: ENSMUST00000053094
AA Change: I489T

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000061221
Gene: ENSMUSG00000038022
AA Change: I489T

DomainStartEndE-ValueType
low complexity region 154 166 N/A INTRINSIC
low complexity region 224 240 N/A INTRINSIC
low complexity region 265 277 N/A INTRINSIC
DUF4205 403 739 1.47e-187 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000204842
AA Change: I489T

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000145151
Gene: ENSMUSG00000038022
AA Change: I489T

DomainStartEndE-ValueType
low complexity region 154 166 N/A INTRINSIC
low complexity region 224 240 N/A INTRINSIC
low complexity region 265 277 N/A INTRINSIC
DUF4205 403 591 6.19e-10 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 T A 8: 111,773,587 (GRCm39) V506E probably damaging Het
Acaa2 G T 18: 74,937,213 (GRCm39) V366F possibly damaging Het
Ago1 G A 4: 126,337,022 (GRCm39) R532C probably benign Het
Ank2 T G 3: 126,846,449 (GRCm39) D182A probably damaging Het
Anxa4 T C 6: 86,714,801 (GRCm39) D302G probably damaging Het
Apoa4 A T 9: 46,154,410 (GRCm39) E337V probably damaging Het
Atf1 A G 15: 100,152,158 (GRCm39) probably null Het
Atp8b3 A C 10: 80,355,980 (GRCm39) V1244G probably benign Het
Cactin CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG 10: 81,157,152 (GRCm39) probably benign Het
Camk2a G A 18: 61,085,412 (GRCm39) V132M probably damaging Het
Cdc40 A T 10: 40,724,048 (GRCm39) Y247N probably benign Het
Chd8 G A 14: 52,474,534 (GRCm39) P166S probably benign Het
Chl1 T A 6: 103,706,086 (GRCm39) S1140R probably damaging Het
Clstn3 G T 6: 124,414,377 (GRCm39) S783* probably null Het
Col6a1 A G 10: 76,549,760 (GRCm39) S562P unknown Het
Cpb2 G A 14: 75,509,989 (GRCm39) V250M possibly damaging Het
Cyp2c38 T A 19: 39,451,368 (GRCm39) Q44L possibly damaging Het
Dgat1 T C 15: 76,387,395 (GRCm39) M325V possibly damaging Het
Dnah11 T A 12: 118,160,377 (GRCm39) M118L probably benign Het
Dpy19l3 T A 7: 35,452,106 (GRCm39) I13L probably benign Het
Enkd1 A G 8: 106,431,265 (GRCm39) probably null Het
Fam241b A G 10: 61,970,479 (GRCm39) probably benign Het
Fhit T A 14: 9,870,177 (GRCm38) probably null Het
Gp6 T C 7: 4,373,173 (GRCm39) E250G probably benign Het
Hmgb1 T C 5: 148,987,150 (GRCm39) E84G probably benign Het
Hscb T A 5: 110,977,012 (GRCm39) I227F probably damaging Het
Hspg2 T A 4: 137,292,249 (GRCm39) L4047Q probably damaging Het
Hsph1 A G 5: 149,541,901 (GRCm39) L775P probably benign Het
Hydin A T 8: 111,268,476 (GRCm39) S2947C probably benign Het
Intu T C 3: 40,652,029 (GRCm39) S829P probably benign Het
Kcnn3 C A 3: 89,516,977 (GRCm39) T462K probably damaging Het
Kndc1 G A 7: 139,517,930 (GRCm39) C1622Y possibly damaging Het
Lifr T C 15: 7,198,723 (GRCm39) Y318H probably damaging Het
Mier2 A G 10: 79,378,543 (GRCm39) S332P probably damaging Het
Mmp8 A T 9: 7,566,218 (GRCm39) Q358L probably benign Het
Ms4a4a T A 19: 11,367,728 (GRCm39) probably null Het
Nav1 G C 1: 135,395,483 (GRCm39) S962C probably damaging Het
Nfe2l1 G A 11: 96,710,271 (GRCm39) R653C probably damaging Het
Nherf4 A T 9: 44,161,594 (GRCm39) I95N probably damaging Het
Nod2 A T 8: 89,391,906 (GRCm39) I738F probably damaging Het
Nrf1 G A 6: 30,116,230 (GRCm39) V301I probably benign Het
Oog1 T C 12: 87,655,082 (GRCm39) F410S probably benign Het
Or52a33 A G 7: 103,289,165 (GRCm39) Y61H probably damaging Het
Or6k4 G A 1: 173,964,733 (GRCm39) C141Y probably benign Het
Pcdhga8 G A 18: 37,859,954 (GRCm39) V337I probably benign Het
Pelp1 G T 11: 70,286,260 (GRCm39) N572K probably benign Het
Pikfyve T C 1: 65,307,036 (GRCm39) V1808A possibly damaging Het
Pirt A C 11: 66,816,769 (GRCm39) S27R probably damaging Het
Pramel20 A T 4: 143,298,821 (GRCm39) I255L probably benign Het
Rgs17 A T 10: 5,791,488 (GRCm39) D96E probably benign Het
Senp1 A G 15: 97,964,679 (GRCm39) F206L probably benign Het
Sh3rf1 T A 8: 61,825,756 (GRCm39) S584T probably benign Het
Tex44 A T 1: 86,354,459 (GRCm39) K123* probably null Het
Tpst2 C A 5: 112,455,887 (GRCm39) T142K probably damaging Het
Ttc28 G A 5: 111,433,085 (GRCm39) G2040R possibly damaging Het
Uggt2 T A 14: 119,263,905 (GRCm39) I1042F probably damaging Het
Vmn2r91 T C 17: 18,325,693 (GRCm39) S104P probably damaging Het
Wdfy3 T C 5: 102,003,252 (GRCm39) probably null Het
Zeb2 G A 2: 44,892,584 (GRCm39) A223V probably damaging Het
Zfp1002 T C 2: 150,096,520 (GRCm39) D303G probably benign Het
Zfp566 A G 7: 29,777,930 (GRCm39) S84P probably benign Het
Zfp994 T A 17: 22,420,736 (GRCm39) H71L possibly damaging Het
Other mutations in Mindy4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Mindy4 APN 6 55,261,727 (GRCm39) splice site probably benign
IGL01483:Mindy4 APN 6 55,193,670 (GRCm39) missense probably damaging 1.00
IGL01721:Mindy4 APN 6 55,200,984 (GRCm39) missense probably damaging 1.00
IGL01965:Mindy4 APN 6 55,237,517 (GRCm39) splice site probably benign
IGL02214:Mindy4 APN 6 55,193,636 (GRCm39) missense possibly damaging 0.88
IGL03058:Mindy4 APN 6 55,285,183 (GRCm39) missense probably damaging 1.00
IGL03077:Mindy4 APN 6 55,286,315 (GRCm39) missense probably damaging 1.00
IGL03296:Mindy4 APN 6 55,274,738 (GRCm39) critical splice donor site probably null
R0383:Mindy4 UTSW 6 55,253,619 (GRCm39) missense probably benign 0.00
R0384:Mindy4 UTSW 6 55,193,669 (GRCm39) missense probably damaging 1.00
R0636:Mindy4 UTSW 6 55,253,570 (GRCm39) missense possibly damaging 0.73
R0848:Mindy4 UTSW 6 55,295,271 (GRCm39) nonsense probably null
R1171:Mindy4 UTSW 6 55,232,601 (GRCm39) missense possibly damaging 0.75
R1210:Mindy4 UTSW 6 55,261,798 (GRCm39) missense possibly damaging 0.92
R1341:Mindy4 UTSW 6 55,232,601 (GRCm39) missense probably benign 0.00
R2030:Mindy4 UTSW 6 55,188,247 (GRCm39) missense probably damaging 1.00
R2127:Mindy4 UTSW 6 55,195,250 (GRCm39) missense probably benign 0.05
R2237:Mindy4 UTSW 6 55,278,055 (GRCm39) missense probably damaging 1.00
R2238:Mindy4 UTSW 6 55,278,055 (GRCm39) missense probably damaging 1.00
R2250:Mindy4 UTSW 6 55,277,934 (GRCm39) missense probably damaging 0.99
R2571:Mindy4 UTSW 6 55,261,770 (GRCm39) missense probably damaging 1.00
R2846:Mindy4 UTSW 6 55,255,085 (GRCm39) missense probably damaging 1.00
R3001:Mindy4 UTSW 6 55,195,349 (GRCm39) missense probably benign 0.21
R3002:Mindy4 UTSW 6 55,195,349 (GRCm39) missense probably benign 0.21
R3498:Mindy4 UTSW 6 55,193,510 (GRCm39) missense probably benign 0.01
R4167:Mindy4 UTSW 6 55,201,331 (GRCm39) missense possibly damaging 0.93
R4767:Mindy4 UTSW 6 55,237,550 (GRCm39) missense probably damaging 0.98
R4812:Mindy4 UTSW 6 55,256,088 (GRCm39) missense possibly damaging 0.64
R5109:Mindy4 UTSW 6 55,193,730 (GRCm39) splice site probably null
R5203:Mindy4 UTSW 6 55,232,646 (GRCm39) missense probably benign 0.00
R5221:Mindy4 UTSW 6 55,201,092 (GRCm39) missense probably benign
R5628:Mindy4 UTSW 6 55,237,579 (GRCm39) missense probably damaging 0.98
R6265:Mindy4 UTSW 6 55,278,049 (GRCm39) missense probably damaging 0.99
R6596:Mindy4 UTSW 6 55,201,001 (GRCm39) missense probably damaging 0.99
R7084:Mindy4 UTSW 6 55,255,220 (GRCm39) missense probably benign
R7350:Mindy4 UTSW 6 55,278,010 (GRCm39) missense probably damaging 0.97
R7535:Mindy4 UTSW 6 55,274,738 (GRCm39) critical splice donor site probably null
R8052:Mindy4 UTSW 6 55,277,977 (GRCm39) missense probably damaging 0.99
R8727:Mindy4 UTSW 6 55,256,055 (GRCm39) unclassified probably benign
R8884:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8886:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8890:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8892:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8893:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8894:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8896:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8932:Mindy4 UTSW 6 55,201,115 (GRCm39) missense probably benign
R9018:Mindy4 UTSW 6 55,278,072 (GRCm39) missense possibly damaging 0.91
R9045:Mindy4 UTSW 6 55,295,283 (GRCm39) missense probably benign 0.16
R9185:Mindy4 UTSW 6 55,295,261 (GRCm39) missense possibly damaging 0.88
X0065:Mindy4 UTSW 6 55,239,801 (GRCm39) missense probably damaging 0.99
Z1177:Mindy4 UTSW 6 55,201,326 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- TGTGATAGCATCCTTCAGGCC -3'
(R):5'- ACATGAGCCTGGAGTTTGG -3'

Sequencing Primer
(F):5'- ACCTGGCTCCTGGTCAC -3'
(R):5'- CATGAGCCTGGAGTTTGGAAATC -3'
Posted On 2019-10-24