Incidental Mutation 'R7626:Or2t46'
ID 589458
Institutional Source Beutler Lab
Gene Symbol Or2t46
Ensembl Gene ENSMUSG00000060765
Gene Name olfactory receptor family 2 subfamily T member 46
Synonyms MOR275-11_p, Olfr325, GA_x6K02T2NKPP-844642-843680, MOR275-5
MMRRC Submission 045690-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R7626 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 58471663-58472703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 58471999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 110 (T110P)
Ref Sequence ENSEMBL: ENSMUSP00000145386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169428] [ENSMUST00000203418]
AlphaFold Q5NCD2
Predicted Effect probably damaging
Transcript: ENSMUST00000169428
AA Change: T110P

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131257
Gene: ENSMUSG00000060765
AA Change: T110P

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 2.3e-46 PFAM
Pfam:7TM_GPCR_Srsx 39 290 1.4e-6 PFAM
Pfam:7tm_1 45 294 1.6e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203418
AA Change: T110P

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000145386
Gene: ENSMUSG00000060765
AA Change: T110P

DomainStartEndE-ValueType
Pfam:7tm_4 35 130 7.6e-14 PFAM
Pfam:7TM_GPCR_Srsx 36 130 1.1e-4 PFAM
Pfam:7tm_1 45 130 2.6e-16 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acta2 G A 19: 34,229,931 (GRCm39) T8I probably benign Het
Alox5 T C 6: 116,390,756 (GRCm39) D465G possibly damaging Het
Arhgef16 T A 4: 154,367,339 (GRCm39) K355N possibly damaging Het
Camkk2 T A 5: 122,902,363 (GRCm39) probably benign Het
Ccdc171 C T 4: 83,499,012 (GRCm39) Q237* probably null Het
Ces2b T C 8: 105,564,017 (GRCm39) Y464H possibly damaging Het
Cntfr A G 4: 41,662,013 (GRCm39) F243S possibly damaging Het
Crip3 A T 17: 46,740,791 (GRCm39) R65S probably benign Het
Dcn A G 10: 97,319,340 (GRCm39) Y39C possibly damaging Het
Degs2 T C 12: 108,658,332 (GRCm39) S216G possibly damaging Het
Dmxl1 A G 18: 50,035,861 (GRCm39) I2295V probably benign Het
Dnah2 A G 11: 69,389,511 (GRCm39) S794P probably damaging Het
Eri1 A C 8: 35,941,554 (GRCm39) Y264* probably null Het
Etl4 T C 2: 20,718,189 (GRCm39) L179P probably damaging Het
F5 T G 1: 164,014,481 (GRCm39) M584R possibly damaging Het
Fam98c G T 7: 28,852,248 (GRCm39) R104S probably damaging Het
Flad1 A T 3: 89,310,718 (GRCm39) I443N probably benign Het
Hbp1 T C 12: 31,993,899 (GRCm39) E43G probably benign Het
Hivep3 CGG CG 4: 119,955,108 (GRCm39) 1141 probably null Het
Kcnj3 T A 2: 55,484,833 (GRCm39) C310* probably null Het
Lct T C 1: 128,212,932 (GRCm39) Y1907C probably damaging Het
Loxhd1 T C 18: 77,518,882 (GRCm39) V1896A possibly damaging Het
Lrfn4 C A 19: 4,663,679 (GRCm39) R285L probably damaging Het
Ltb4r2 T A 14: 56,000,338 (GRCm39) S320T probably damaging Het
Mmd G T 11: 90,148,378 (GRCm39) R20L probably damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Nbas T C 12: 13,608,661 (GRCm39) S2146P probably benign Het
Nop14 A G 5: 34,809,135 (GRCm39) F319L probably damaging Het
Numa1 C A 7: 101,648,630 (GRCm39) T787K probably benign Het
Or10q12 T G 19: 13,745,709 (GRCm39) M1R probably null Het
Or6c208 T G 10: 129,223,726 (GRCm39) C75G possibly damaging Het
Patj T C 4: 98,435,224 (GRCm39) V2A probably benign Het
Pisd T C 5: 32,898,032 (GRCm39) H52R probably benign Het
Plekhg6 A T 6: 125,340,631 (GRCm39) D576E probably benign Het
Plekhn1 T A 4: 156,310,110 (GRCm39) H68L probably benign Het
Ppp1r37 T A 7: 19,295,778 (GRCm39) I60F probably damaging Het
Ppp2r1b C T 9: 50,789,476 (GRCm39) T513M possibly damaging Het
Pramel32 A T 4: 88,548,279 (GRCm39) I42N probably damaging Het
Rhobtb2 C A 14: 70,034,386 (GRCm39) A280S probably damaging Het
Rnf40 A G 7: 127,189,047 (GRCm39) D140G probably benign Het
Rxfp1 A G 3: 79,555,397 (GRCm39) L653P probably damaging Het
Satb1 A T 17: 52,074,995 (GRCm39) D500E probably benign Het
Slc15a1 A T 14: 121,713,377 (GRCm39) D383E probably benign Het
Smarcad1 C A 6: 65,073,033 (GRCm39) S604R possibly damaging Het
St7 A G 6: 17,934,216 (GRCm39) T533A probably damaging Het
Sv2c T A 13: 96,122,451 (GRCm39) T442S probably benign Het
Tbx2 A G 11: 85,731,622 (GRCm39) T640A probably benign Het
Tenm4 T A 7: 96,542,221 (GRCm39) N1948K probably damaging Het
Tll1 T C 8: 64,551,268 (GRCm39) probably null Het
Tmem135 A T 7: 88,805,718 (GRCm39) probably null Het
Tonsl A T 15: 76,518,136 (GRCm39) L582Q probably null Het
Unc13c T A 9: 73,641,799 (GRCm39) K1231N probably damaging Het
Vmn2r101 T A 17: 19,832,192 (GRCm39) Y729* probably null Het
Zcchc2 A G 1: 105,928,742 (GRCm39) T334A possibly damaging Het
Zfp655 T C 5: 145,173,917 (GRCm39) L136P probably damaging Het
Zfp729a A T 13: 67,768,437 (GRCm39) C597* probably null Het
Other mutations in Or2t46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Or2t46 APN 11 58,472,636 (GRCm39) missense probably benign
IGL01922:Or2t46 APN 11 58,471,899 (GRCm39) missense probably benign 0.01
IGL02440:Or2t46 APN 11 58,472,035 (GRCm39) missense probably damaging 1.00
IGL02456:Or2t46 APN 11 58,472,024 (GRCm39) missense possibly damaging 0.48
IGL03088:Or2t46 APN 11 58,472,653 (GRCm39) utr 3 prime probably benign
IGL03328:Or2t46 APN 11 58,472,539 (GRCm39) missense probably damaging 1.00
R0604:Or2t46 UTSW 11 58,472,174 (GRCm39) missense probably damaging 0.99
R1698:Or2t46 UTSW 11 58,472,077 (GRCm39) missense probably damaging 1.00
R2473:Or2t46 UTSW 11 58,472,401 (GRCm39) missense probably damaging 1.00
R2888:Or2t46 UTSW 11 58,471,988 (GRCm39) missense possibly damaging 0.96
R4133:Or2t46 UTSW 11 58,471,901 (GRCm39) missense probably damaging 0.97
R4710:Or2t46 UTSW 11 58,472,548 (GRCm39) missense probably damaging 1.00
R4715:Or2t46 UTSW 11 58,472,255 (GRCm39) missense probably damaging 1.00
R4898:Or2t46 UTSW 11 58,472,546 (GRCm39) missense probably damaging 1.00
R4939:Or2t46 UTSW 11 58,472,037 (GRCm39) missense probably damaging 1.00
R4977:Or2t46 UTSW 11 58,472,455 (GRCm39) missense possibly damaging 0.57
R5389:Or2t46 UTSW 11 58,471,825 (GRCm39) missense possibly damaging 0.78
R5393:Or2t46 UTSW 11 58,471,825 (GRCm39) missense possibly damaging 0.78
R6137:Or2t46 UTSW 11 58,471,894 (GRCm39) missense probably benign
R6302:Or2t46 UTSW 11 58,472,464 (GRCm39) missense probably benign
R6655:Or2t46 UTSW 11 58,472,036 (GRCm39) missense probably damaging 1.00
R6927:Or2t46 UTSW 11 58,472,491 (GRCm39) missense possibly damaging 0.81
R7451:Or2t46 UTSW 11 58,472,516 (GRCm39) missense probably damaging 1.00
R7494:Or2t46 UTSW 11 58,472,038 (GRCm39) missense probably damaging 0.97
R7724:Or2t46 UTSW 11 58,472,208 (GRCm39) missense probably benign 0.01
R7874:Or2t46 UTSW 11 58,472,573 (GRCm39) missense possibly damaging 0.93
R8217:Or2t46 UTSW 11 58,471,792 (GRCm39) missense probably benign 0.00
R8252:Or2t46 UTSW 11 58,471,958 (GRCm39) missense probably damaging 1.00
R8992:Or2t46 UTSW 11 58,471,738 (GRCm39) missense probably benign 0.00
R9376:Or2t46 UTSW 11 58,472,636 (GRCm39) missense probably benign
R9439:Or2t46 UTSW 11 58,472,104 (GRCm39) missense probably benign 0.38
Z1177:Or2t46 UTSW 11 58,472,137 (GRCm39) missense probably damaging 1.00
Z1186:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1186:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1187:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1188:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1189:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1190:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1191:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1192:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGTACTCTCTGACACCCAC -3'
(R):5'- TTTGTCACAGCAGGAACCTC -3'

Sequencing Primer
(F):5'- GTACTCTCTGACACCCACCTTCAC -3'
(R):5'- AAGTGATGGATCTCCCGGGATC -3'
Posted On 2019-10-24