Mutagenetix > Incidental Mutations

Incidental Mutation 'R7626:Vmn2r101'

589471

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r101

Ensembl Gene

ENSMUSG00000094892

Gene Name

vomeronasal 2, receptor 101

Synonyms

EG627576

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.100) question?

Stock #

R7626 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19577231-19612317 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 19611930 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 729 (Y729*)

Ref Sequence

ENSEMBL: ENSMUSP00000131583 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171914]

Predicted Effect

probably null
Transcript: ENSMUST00000171914
AA Change: Y729*

SMART Domains

Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: Y729*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	466	1.6e-36	PFAM
Pfam:NCD3G	509	562	6.4e-22	PFAM
Pfam:7tm_3	595	830	1.4e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acta2	G	A	19: 34,252,531	T8I	probably benign	Het
Alox5	T	C	6: 116,413,795	D465G	possibly damaging	Het
Arhgef16	T	A	4: 154,282,882	K355N	possibly damaging	Het
C87499	A	T	4: 88,630,042	I42N	probably damaging	Het
Camkk2	T	A	5: 122,764,300		probably benign	Het
Ccdc171	C	T	4: 83,580,775	Q237*	probably null	Het
Ces2b	T	C	8: 104,837,385	Y464H	possibly damaging	Het
Cntfr	A	G	4: 41,662,013	F243S	possibly damaging	Het
Crip3	A	T	17: 46,429,865	R65S	probably benign	Het
Dcn	A	G	10: 97,483,478	Y39C	possibly damaging	Het
Degs2	T	C	12: 108,692,073	S216G	possibly damaging	Het
Dmxl1	A	G	18: 49,902,794	I2295V	probably benign	Het
Dnah2	A	G	11: 69,498,685	S794P	probably damaging	Het
Eri1	A	C	8: 35,474,400	Y264*	probably null	Het
Etl4	T	C	2: 20,713,378	L179P	probably damaging	Het
F5	T	G	1: 164,186,912	M584R	possibly damaging	Het
Fam98c	G	T	7: 29,152,823	R104S	probably damaging	Het
Flad1	A	T	3: 89,403,411	I443N	probably benign	Het
Hbp1	T	C	12: 31,943,900	E43G	probably benign	Het
Hivep3	CGG	CG	4: 120,097,911		probably null	Het
Kcnj3	T	A	2: 55,594,821	C310*	probably null	Het
Lct	T	C	1: 128,285,195	Y1907C	probably damaging	Het
Loxhd1	T	C	18: 77,431,186	V1896A	possibly damaging	Het
Lrfn4	C	A	19: 4,613,651	R285L	probably damaging	Het
Ltb4r2	T	A	14: 55,762,881	S320T	probably damaging	Het
Mmd	G	T	11: 90,257,552	R20L	probably damaging	Het
Mmp1a	TG	TGG	9: 7,465,083		probably null	Het
Nbas	T	C	12: 13,558,660	S2146P	probably benign	Het
Nop14	A	G	5: 34,651,791	F319L	probably damaging	Het
Numa1	C	A	7: 101,999,423	T787K	probably benign	Het
Olfr1495	T	G	19: 13,768,345	M1R	probably null	Het
Olfr325	A	C	11: 58,581,173	T110P	probably damaging	Het
Olfr784	T	G	10: 129,387,857	C75G	possibly damaging	Het
Patj	T	C	4: 98,546,987	V2A	probably benign	Het
Pisd	T	C	5: 32,740,688	H52R	probably benign	Het
Plekhg6	A	T	6: 125,363,668	D576E	probably benign	Het
Plekhn1	T	A	4: 156,225,653	H68L	probably benign	Het
Ppp1r37	T	A	7: 19,561,853	I60F	probably damaging	Het
Ppp2r1b	C	T	9: 50,878,176	T513M	possibly damaging	Het
Rhobtb2	C	A	14: 69,796,937	A280S	probably damaging	Het
Rnf40	A	G	7: 127,589,875	D140G	probably benign	Het
Rxfp1	A	G	3: 79,648,090	L653P	probably damaging	Het
Satb1	A	T	17: 51,767,967	D500E	probably benign	Het
Slc15a1	A	T	14: 121,475,965	D383E	probably benign	Het
Smarcad1	C	A	6: 65,096,049	S604R	possibly damaging	Het
St7	A	G	6: 17,934,217	T533A	probably damaging	Het
Sv2c	T	A	13: 95,985,943	T442S	probably benign	Het
Tbx2	A	G	11: 85,840,796	T640A	probably benign	Het
Tenm4	T	A	7: 96,893,014	N1948K	probably damaging	Het
Tonsl	A	T	15: 76,633,936	L582Q	probably null	Het
Unc13c	T	A	9: 73,734,517	K1231N	probably damaging	Het
Zcchc2	A	G	1: 106,001,012	T334A	possibly damaging	Het
Zfp655	T	C	5: 145,237,107	L136P	probably damaging	Het
Zfp729a	A	T	13: 67,620,318	C597*	probably null	Het

Other mutations in Vmn2r101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01121:Vmn2r101	APN	17	19589674	missense	probably damaging	0.99
IGL02125:Vmn2r101	APN	17	19589701	missense	possibly damaging	0.95
IGL02300:Vmn2r101	APN	17	19611937	missense	probably damaging	1.00
IGL02682:Vmn2r101	APN	17	19612245	missense	possibly damaging	0.82
IGL02825:Vmn2r101	APN	17	19589870	missense	probably benign	0.00
IGL02862:Vmn2r101	APN	17	19611605	missense	probably damaging	1.00
IGL02943:Vmn2r101	APN	17	19611404	missense	probably damaging	0.99
R0371:Vmn2r101	UTSW	17	19590132	missense	probably benign	0.07
R0462:Vmn2r101	UTSW	17	19590169	missense	probably benign	0.04
R0492:Vmn2r101	UTSW	17	19588983	missense	probably damaging	1.00
R0654:Vmn2r101	UTSW	17	19590111	missense	probably benign	0.01
R1120:Vmn2r101	UTSW	17	19577461	splice site	probably benign
R1323:Vmn2r101	UTSW	17	19612051	missense	probably damaging	1.00
R1323:Vmn2r101	UTSW	17	19612051	missense	probably damaging	1.00
R1676:Vmn2r101	UTSW	17	19611922	missense	probably benign	0.00
R2023:Vmn2r101	UTSW	17	19590106	nonsense	probably null
R2149:Vmn2r101	UTSW	17	19588963	missense	probably benign	0.00
R2350:Vmn2r101	UTSW	17	19589783	missense	probably benign	0.01
R2760:Vmn2r101	UTSW	17	19589639	missense	probably benign	0.14
R3085:Vmn2r101	UTSW	17	19588815	splice site	probably null
R3086:Vmn2r101	UTSW	17	19588815	splice site	probably null
R3719:Vmn2r101	UTSW	17	19589549	missense	possibly damaging	0.50
R3771:Vmn2r101	UTSW	17	19589657	missense	probably benign
R3773:Vmn2r101	UTSW	17	19589657	missense	probably benign
R4225:Vmn2r101	UTSW	17	19611689	missense	probably damaging	1.00
R4248:Vmn2r101	UTSW	17	19589114	missense	probably damaging	1.00
R4290:Vmn2r101	UTSW	17	19612041	missense	probably damaging	1.00
R4291:Vmn2r101	UTSW	17	19612041	missense	probably damaging	1.00
R4293:Vmn2r101	UTSW	17	19612041	missense	probably damaging	1.00
R4307:Vmn2r101	UTSW	17	19590161	missense	probably damaging	1.00
R4721:Vmn2r101	UTSW	17	19612025	missense	probably damaging	0.99
R4829:Vmn2r101	UTSW	17	19611967	missense	probably benign	0.03
R5022:Vmn2r101	UTSW	17	19611387	critical splice acceptor site	probably null
R5110:Vmn2r101	UTSW	17	19611635	missense	possibly damaging	0.92
R5244:Vmn2r101	UTSW	17	19611526	missense	probably damaging	1.00
R5397:Vmn2r101	UTSW	17	19588842	missense	probably damaging	1.00
R5875:Vmn2r101	UTSW	17	19588830	missense	probably damaging	0.99
R5944:Vmn2r101	UTSW	17	19589507	missense	probably benign	0.00
R6216:Vmn2r101	UTSW	17	19591005	missense	probably benign	0.00
R6334:Vmn2r101	UTSW	17	19589850	missense	possibly damaging	0.83
R6512:Vmn2r101	UTSW	17	19588884	missense	probably damaging	1.00
R6607:Vmn2r101	UTSW	17	19612034	missense	probably damaging	1.00
R6965:Vmn2r101	UTSW	17	19591022	missense	probably benign	0.00
R7101:Vmn2r101	UTSW	17	19589088	missense	probably null	0.14
R7183:Vmn2r101	UTSW	17	19612178	missense	probably damaging	1.00
R7344:Vmn2r101	UTSW	17	19611797	missense	probably benign	0.38
R7375:Vmn2r101	UTSW	17	19611390	missense	probably damaging	1.00
R7574:Vmn2r101	UTSW	17	19611637	missense	possibly damaging	0.91
R7575:Vmn2r101	UTSW	17	19611392	missense	probably benign	0.01
R7715:Vmn2r101	UTSW	17	19611915	missense	probably damaging	1.00
R7730:Vmn2r101	UTSW	17	19611688	missense	possibly damaging	0.81
Z1088:Vmn2r101	UTSW	17	19588975	missense	possibly damaging	0.78

Predicted Primers

PCR Primer
(F):5'- TGCTACTGTGTTGGCCAAAG -3'
(R):5'- TCCCTTTAGTGCTGTGGAAG -3'

Sequencing Primer
(F):5'- GCTACTGTGTTGGCCAAAGCTATTAC -3'
(R):5'- GTGAGCCAGACACAGAAGAACAC -3'

Posted On

2019-10-24