Incidental Mutation 'R0055:Mcm10'
ID 58950
Institutional Source Beutler Lab
Gene Symbol Mcm10
Ensembl Gene ENSMUSG00000026669
Gene Name minichromosome maintenance 10 replication initiation factor
Synonyms C330019M07Rik, 2410041F14Rik
MMRRC Submission 038349-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0055 (G1)
Quality Score 160
Status Validated
Chromosome 2
Chromosomal Location 4995535-5017602 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 4996218 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 882 (N882D)
Ref Sequence ENSEMBL: ENSMUSP00000100050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027980] [ENSMUST00000102985]
AlphaFold Q0VBD2
Predicted Effect probably damaging
Transcript: ENSMUST00000027980
AA Change: N882D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027980
Gene: ENSMUSG00000026669
AA Change: N882D

DomainStartEndE-ValueType
coiled coil region 102 138 N/A INTRINSIC
low complexity region 218 228 N/A INTRINSIC
Pfam:zf-primase 398 443 2e-21 PFAM
low complexity region 480 493 N/A INTRINSIC
Mcm10 538 883 2.27e-184 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000102985
AA Change: N882D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100050
Gene: ENSMUSG00000026669
AA Change: N882D

DomainStartEndE-ValueType
coiled coil region 102 138 N/A INTRINSIC
low complexity region 218 228 N/A INTRINSIC
Pfam:zf-primase 398 443 3.7e-21 PFAM
low complexity region 480 493 N/A INTRINSIC
Mcm10 538 883 2.27e-184 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125349
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139882
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150091
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151533
Meta Mutation Damage Score 0.6049 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced embryonic cell proliferation and early embryonic letahlity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,547,057 (GRCm39) probably benign Het
Atp6v1h A T 1: 5,154,677 (GRCm39) T2S probably benign Het
Bcl11b G A 12: 107,932,036 (GRCm39) P179S probably benign Het
Cacna1a C T 8: 85,306,687 (GRCm39) probably benign Het
Ccdc146 C T 5: 21,502,004 (GRCm39) probably null Het
Ccdc61 T C 7: 18,626,461 (GRCm39) D128G probably damaging Het
Cd55 A G 1: 130,387,313 (GRCm39) probably benign Het
Cdk7 C A 13: 100,855,812 (GRCm39) E99* probably null Het
Cfap96 A T 8: 46,421,198 (GRCm39) S108R probably damaging Het
Cox8a A T 19: 7,194,874 (GRCm39) S2T probably damaging Het
Cracdl A C 1: 37,663,337 (GRCm39) S854A probably benign Het
Dennd5a A G 7: 109,498,998 (GRCm39) I955T possibly damaging Het
Dop1a A C 9: 86,394,705 (GRCm39) E602A probably benign Het
Ephx4 T C 5: 107,560,944 (GRCm39) L32S probably damaging Het
Fbxo21 T A 5: 118,138,555 (GRCm39) D493E probably benign Het
Frmd4b A T 6: 97,300,610 (GRCm39) probably benign Het
Fzd1 A T 5: 4,806,037 (GRCm39) M515K possibly damaging Het
Gli2 A G 1: 118,818,138 (GRCm39) probably benign Het
Gm12887 T A 4: 121,473,666 (GRCm39) K61N probably damaging Het
Grin2a A T 16: 9,487,671 (GRCm39) V409D probably damaging Het
Grin2b T C 6: 135,900,201 (GRCm39) I227V probably benign Het
Helz2 T G 2: 180,870,614 (GRCm39) D2879A possibly damaging Het
Itpr2 T C 6: 146,224,631 (GRCm39) N1453S probably benign Het
Itpr3 C A 17: 27,317,296 (GRCm39) S817Y probably damaging Het
Lin7c T A 2: 109,726,798 (GRCm39) probably benign Het
Ly75 T C 2: 60,152,262 (GRCm39) E1097G probably benign Het
Mettl13 A T 1: 162,373,750 (GRCm39) L167Q probably damaging Het
Morn2 A T 17: 80,602,942 (GRCm39) M1L probably benign Het
Mybph G T 1: 134,121,590 (GRCm39) V88L probably damaging Het
Nefm T A 14: 68,358,648 (GRCm39) probably benign Het
Nf1 A G 11: 79,362,377 (GRCm39) E1497G probably damaging Het
Or2j3 T C 17: 38,615,702 (GRCm39) S217G possibly damaging Het
Or4k37 T A 2: 111,158,870 (GRCm39) Y35* probably null Het
Or51ah3 A G 7: 103,210,244 (GRCm39) K187E probably damaging Het
Or52e18 T A 7: 104,609,703 (GRCm39) T79S possibly damaging Het
Phf8-ps A T 17: 33,285,696 (GRCm39) W369R probably damaging Het
Plcd3 C G 11: 102,968,411 (GRCm39) W382S probably damaging Het
Plxna1 T A 6: 89,306,721 (GRCm39) I1370F possibly damaging Het
Qng1 T C 13: 58,531,980 (GRCm39) D192G probably damaging Het
Rarb G A 14: 16,509,066 (GRCm38) R106C probably damaging Het
Rps6ka5 G A 12: 100,644,839 (GRCm39) T37I probably damaging Het
Runx1 G T 16: 92,441,029 (GRCm39) probably benign Het
Scube1 A G 15: 83,518,937 (GRCm39) V301A probably damaging Het
Sema3a A T 5: 13,450,004 (GRCm39) N27I possibly damaging Het
Slc15a3 G T 19: 10,820,406 (GRCm39) E8* probably null Het
Slc22a5 T C 11: 53,782,032 (GRCm39) S112G probably benign Het
Slc25a45 T C 19: 5,930,495 (GRCm39) F3L probably damaging Het
Slc4a4 A C 5: 89,304,195 (GRCm39) H502P possibly damaging Het
Slfn10-ps A G 11: 82,921,126 (GRCm39) noncoding transcript Het
Slit2 C A 5: 48,439,068 (GRCm39) C1077* probably null Het
Spn A G 7: 126,735,494 (GRCm39) F82L possibly damaging Het
Tbccd1 A G 16: 22,660,655 (GRCm39) W54R probably damaging Het
Ucp1 G T 8: 84,017,233 (GRCm39) E8* probably null Het
Unc80 A T 1: 66,545,782 (GRCm39) probably benign Het
Vsnl1 A T 12: 11,436,987 (GRCm39) probably null Het
Zdhhc11 C T 13: 74,130,805 (GRCm39) Q295* probably null Het
Zfp457 T A 13: 67,442,098 (GRCm39) H63L probably damaging Het
Other mutations in Mcm10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01529:Mcm10 APN 2 5,013,439 (GRCm39) missense probably benign 0.00
IGL02028:Mcm10 APN 2 5,013,511 (GRCm39) missense possibly damaging 0.95
IGL02672:Mcm10 APN 2 5,006,092 (GRCm39) missense probably benign 0.00
IGL03352:Mcm10 APN 2 4,999,407 (GRCm39) missense probably damaging 1.00
R0055:Mcm10 UTSW 2 4,996,218 (GRCm39) missense probably damaging 1.00
R0320:Mcm10 UTSW 2 5,008,897 (GRCm39) missense probably benign
R0379:Mcm10 UTSW 2 5,013,434 (GRCm39) missense probably benign 0.05
R0385:Mcm10 UTSW 2 5,008,965 (GRCm39) missense possibly damaging 0.82
R0519:Mcm10 UTSW 2 5,013,356 (GRCm39) missense probably benign
R1537:Mcm10 UTSW 2 5,003,591 (GRCm39) missense possibly damaging 0.77
R1597:Mcm10 UTSW 2 5,003,563 (GRCm39) missense probably damaging 1.00
R1727:Mcm10 UTSW 2 5,011,336 (GRCm39) missense probably benign 0.10
R1758:Mcm10 UTSW 2 5,008,861 (GRCm39) missense probably damaging 1.00
R1997:Mcm10 UTSW 2 4,998,571 (GRCm39) missense probably damaging 1.00
R3618:Mcm10 UTSW 2 5,001,913 (GRCm39) critical splice donor site probably null
R4005:Mcm10 UTSW 2 5,005,814 (GRCm39) missense probably damaging 1.00
R4870:Mcm10 UTSW 2 5,008,970 (GRCm39) missense probably damaging 1.00
R5302:Mcm10 UTSW 2 5,012,181 (GRCm39) missense probably benign 0.12
R5488:Mcm10 UTSW 2 4,996,929 (GRCm39) missense probably damaging 1.00
R6921:Mcm10 UTSW 2 5,005,746 (GRCm39) missense probably benign 0.00
R7259:Mcm10 UTSW 2 5,011,328 (GRCm39) missense probably benign 0.02
R7353:Mcm10 UTSW 2 5,011,920 (GRCm39) missense possibly damaging 0.54
R7489:Mcm10 UTSW 2 5,006,112 (GRCm39) missense probably damaging 1.00
R7744:Mcm10 UTSW 2 4,996,253 (GRCm39) missense probably damaging 1.00
R7903:Mcm10 UTSW 2 5,000,613 (GRCm39) missense probably benign 0.00
R9021:Mcm10 UTSW 2 4,997,782 (GRCm39) missense probably benign 0.03
R9072:Mcm10 UTSW 2 5,013,414 (GRCm39) missense possibly damaging 0.63
R9073:Mcm10 UTSW 2 5,013,414 (GRCm39) missense possibly damaging 0.63
R9135:Mcm10 UTSW 2 5,011,372 (GRCm39) missense probably benign 0.01
X0020:Mcm10 UTSW 2 5,011,959 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCAAATATGGTGTCAGGCCAGC -3'
(R):5'- AAAGATCCCTGGGTCCTCCTGTTC -3'

Sequencing Primer
(F):5'- TCAGGCCAGCACATGGAG -3'
(R):5'- ccacaagtcccaccacc -3'
Posted On 2013-07-11