Incidental Mutation 'R7627:Glp2r'
ID 589506
Institutional Source Beutler Lab
Gene Symbol Glp2r
Ensembl Gene ENSMUSG00000049928
Gene Name glucagon-like peptide 2 receptor
Synonyms GLP-2, 9530092J08Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7627 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 67554877-67661979 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 67637589 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Isoleucine at position 30 (L30I)
Ref Sequence ENSEMBL: ENSMUSP00000021289 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021289] [ENSMUST00000051765]
AlphaFold Q5IXF8
Predicted Effect unknown
Transcript: ENSMUST00000021289
AA Change: L30I
SMART Domains Protein: ENSMUSP00000021289
Gene: ENSMUSG00000049928
AA Change: L30I

DomainStartEndE-ValueType
Pfam:7tm_2 17 225 4.8e-54 PFAM
Predicted Effect silent
Transcript: ENSMUST00000051765
SMART Domains Protein: ENSMUSP00000061560
Gene: ENSMUSG00000049928

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:HRM 53 122 3.4e-16 PFAM
Pfam:7tm_2 137 394 1.5e-79 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230112D13Rik T A 14: 34,234,055 (GRCm39) I79L unknown Het
Acta2 G A 19: 34,229,931 (GRCm39) T8I probably benign Het
Acvrl1 G A 15: 101,033,747 (GRCm39) R143Q probably benign Het
Adam22 A G 5: 8,417,933 (GRCm39) S8P probably benign Het
Ankrd11 A G 8: 123,617,690 (GRCm39) I2054T possibly damaging Het
Cactin CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG 10: 81,157,152 (GRCm39) probably benign Het
Cad T A 5: 31,217,508 (GRCm39) L354Q probably damaging Het
Ccdc15 A T 9: 37,253,698 (GRCm39) C184S unknown Het
Ccl8 A G 11: 82,006,865 (GRCm39) D26G probably benign Het
Ccsap T C 8: 124,569,097 (GRCm39) Y248C probably damaging Het
Col5a1 T G 2: 27,840,665 (GRCm39) Y271* probably null Het
Dnmt3b A G 2: 153,519,500 (GRCm39) N695S probably benign Het
Dync1li2 A G 8: 105,156,140 (GRCm39) C234R probably benign Het
Dync2h1 A T 9: 7,101,111 (GRCm39) D2758E probably benign Het
Eif2ak3 A T 6: 70,869,919 (GRCm39) T869S probably benign Het
Foxn4 G T 5: 114,398,495 (GRCm39) P175H possibly damaging Het
Gbp5 T G 3: 142,206,319 (GRCm39) M1R probably null Het
Gls A T 1: 52,205,425 (GRCm39) D639E probably benign Het
Gm5145 G T 17: 20,790,654 (GRCm39) E11* probably null Het
Gm9772 T A 17: 22,226,160 (GRCm39) K41N probably damaging Het
Gnat3 A T 5: 18,204,746 (GRCm39) D133V Het
Gse1 C A 8: 121,299,516 (GRCm39) P849T unknown Het
H2ac15 C A 13: 21,937,916 (GRCm39) V28L probably benign Het
Hoxb9 A G 11: 96,165,521 (GRCm39) T197A probably damaging Het
Krt39 A G 11: 99,405,575 (GRCm39) S442P possibly damaging Het
Leng9 A G 7: 4,151,617 (GRCm39) L353P probably damaging Het
Mamdc2 A T 19: 23,288,355 (GRCm39) M561K probably damaging Het
Mamdc4 A G 2: 25,458,225 (GRCm39) V395A probably damaging Het
Mrpl32 G A 13: 14,787,498 (GRCm39) R36C probably benign Het
Or6b2b A T 1: 92,419,107 (GRCm39) Y123* probably null Het
Or7e168 A G 9: 19,719,947 (GRCm39) D111G probably damaging Het
Papss1 T A 3: 131,290,873 (GRCm39) D205E probably benign Het
Pdlim2 T C 14: 70,408,924 (GRCm39) D151G probably benign Het
Pdxp T C 15: 78,798,339 (GRCm39) V57A probably damaging Het
Plec T A 15: 76,061,594 (GRCm39) E2781V probably damaging Het
Prr7 GCGCCGCCGCACGCGCACCCGCACCCACACCATCACGCACTGCCGCACCCACCGCCGCCGCAC GCGCCGCCGCAC 13: 55,620,147 (GRCm39) probably benign Het
Rnf32 G A 5: 29,402,948 (GRCm39) probably benign Het
Ryr2 A G 13: 11,776,213 (GRCm39) V1108A possibly damaging Het
Slc4a8 A G 15: 100,686,104 (GRCm39) H276R probably benign Het
Slco1a7 C T 6: 141,690,271 (GRCm39) V161I probably damaging Het
Spta1 T A 1: 174,032,944 (GRCm39) D1000E probably damaging Het
Sva C A 6: 42,019,598 (GRCm39) Q153K unknown Het
Tmprss11d T C 5: 86,457,365 (GRCm39) Y236C possibly damaging Het
Zfp160 T C 17: 21,247,270 (GRCm39) S607P probably damaging Het
Zfp82 C A 7: 29,756,147 (GRCm39) G312W probably damaging Het
Other mutations in Glp2r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Glp2r APN 11 67,600,470 (GRCm39) missense probably benign
IGL02244:Glp2r APN 11 67,612,817 (GRCm39) missense probably damaging 1.00
IGL02484:Glp2r APN 11 67,630,992 (GRCm39) missense possibly damaging 0.90
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0195:Glp2r UTSW 11 67,600,534 (GRCm39) missense probably damaging 0.99
R1612:Glp2r UTSW 11 67,633,033 (GRCm39) missense possibly damaging 0.46
R1699:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
R1944:Glp2r UTSW 11 67,637,618 (GRCm39) missense probably benign 0.01
R3971:Glp2r UTSW 11 67,637,641 (GRCm39) missense possibly damaging 0.65
R4417:Glp2r UTSW 11 67,555,342 (GRCm39) intron probably benign
R4681:Glp2r UTSW 11 67,621,453 (GRCm39) splice site probably null
R4914:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4918:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4938:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4940:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4941:Glp2r UTSW 11 67,637,529 (GRCm39) splice site probably null
R4963:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4966:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R5023:Glp2r UTSW 11 67,631,858 (GRCm39) missense possibly damaging 0.82
R5121:Glp2r UTSW 11 67,612,926 (GRCm39) splice site probably null
R5313:Glp2r UTSW 11 67,648,357 (GRCm39) missense probably damaging 0.96
R5705:Glp2r UTSW 11 67,600,565 (GRCm39) missense probably benign 0.30
R5790:Glp2r UTSW 11 67,655,625 (GRCm39) missense probably damaging 1.00
R6074:Glp2r UTSW 11 67,637,640 (GRCm39) missense unknown
R6595:Glp2r UTSW 11 67,655,603 (GRCm39) missense probably benign 0.10
R6910:Glp2r UTSW 11 67,621,497 (GRCm39) missense probably benign 0.28
R7511:Glp2r UTSW 11 67,648,417 (GRCm39) missense probably damaging 0.98
R7681:Glp2r UTSW 11 67,600,505 (GRCm39) missense probably benign 0.45
R7779:Glp2r UTSW 11 67,600,609 (GRCm39) nonsense probably null
R8743:Glp2r UTSW 11 67,612,901 (GRCm39) missense probably damaging 0.98
R8841:Glp2r UTSW 11 67,653,555 (GRCm39) missense probably damaging 1.00
R9093:Glp2r UTSW 11 67,621,459 (GRCm39) nonsense probably null
R9380:Glp2r UTSW 11 67,637,572 (GRCm39) missense possibly damaging 0.67
R9576:Glp2r UTSW 11 67,655,622 (GRCm39) missense probably benign 0.01
R9733:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
Z1186:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1186:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1186:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1186:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1186:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1187:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1187:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1188:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1188:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1188:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1189:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1189:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1190:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1190:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1190:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1190:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1191:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1191:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1192:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTCAAGAATCTCAAGCTTCCTGC -3'
(R):5'- GCTGCCTATTTGGGTATCAACG -3'

Sequencing Primer
(F):5'- TGCTCTGAAGATCCATGACATC -3'
(R):5'- AGGTCTAAAGACAGGCTGGG -3'
Posted On 2019-10-24