Incidental Mutation 'R7627:Zfp160'
ID |
589521 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp160
|
Ensembl Gene |
ENSMUSG00000067942 |
Gene Name |
zinc finger protein 160 |
Synonyms |
6720480D16Rik, 6720480D16Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7627 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
21229203-21249119 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 21247270 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 607
(S607P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000086191
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088811]
[ENSMUST00000231482]
[ENSMUST00000232320]
[ENSMUST00000232354]
[ENSMUST00000232473]
[ENSMUST00000232663]
|
AlphaFold |
E9Q459 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000088811
AA Change: S607P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000086191 Gene: ENSMUSG00000067942 AA Change: S607P
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.91e-29 |
SMART |
low complexity region
|
100 |
110 |
N/A |
INTRINSIC |
ZnF_C2H2
|
146 |
168 |
1.69e-3 |
SMART |
ZnF_C2H2
|
174 |
196 |
2.91e-2 |
SMART |
ZnF_C2H2
|
202 |
224 |
1.4e-4 |
SMART |
ZnF_C2H2
|
230 |
252 |
3.89e-3 |
SMART |
ZnF_C2H2
|
258 |
280 |
1.72e-4 |
SMART |
ZnF_C2H2
|
286 |
308 |
4.94e-5 |
SMART |
ZnF_C2H2
|
314 |
336 |
2.12e-4 |
SMART |
ZnF_C2H2
|
342 |
364 |
1.12e-3 |
SMART |
ZnF_C2H2
|
370 |
392 |
1.2e-3 |
SMART |
ZnF_C2H2
|
398 |
420 |
6.42e-4 |
SMART |
ZnF_C2H2
|
426 |
448 |
9.08e-4 |
SMART |
ZnF_C2H2
|
454 |
476 |
1.84e-4 |
SMART |
ZnF_C2H2
|
482 |
504 |
1.5e-4 |
SMART |
ZnF_C2H2
|
510 |
532 |
3.44e-4 |
SMART |
ZnF_C2H2
|
538 |
560 |
1.12e-3 |
SMART |
ZnF_C2H2
|
566 |
588 |
2.27e-4 |
SMART |
ZnF_C2H2
|
594 |
616 |
1.04e-3 |
SMART |
ZnF_C2H2
|
622 |
644 |
1.13e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000231482
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000232320
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000232354
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000232473
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000232663
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 45 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9230112D13Rik |
T |
A |
14: 34,234,055 (GRCm39) |
I79L |
unknown |
Het |
Acta2 |
G |
A |
19: 34,229,931 (GRCm39) |
T8I |
probably benign |
Het |
Acvrl1 |
G |
A |
15: 101,033,747 (GRCm39) |
R143Q |
probably benign |
Het |
Adam22 |
A |
G |
5: 8,417,933 (GRCm39) |
S8P |
probably benign |
Het |
Ankrd11 |
A |
G |
8: 123,617,690 (GRCm39) |
I2054T |
possibly damaging |
Het |
Cactin |
CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG |
CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG |
10: 81,157,152 (GRCm39) |
|
probably benign |
Het |
Cad |
T |
A |
5: 31,217,508 (GRCm39) |
L354Q |
probably damaging |
Het |
Ccdc15 |
A |
T |
9: 37,253,698 (GRCm39) |
C184S |
unknown |
Het |
Ccl8 |
A |
G |
11: 82,006,865 (GRCm39) |
D26G |
probably benign |
Het |
Ccsap |
T |
C |
8: 124,569,097 (GRCm39) |
Y248C |
probably damaging |
Het |
Col5a1 |
T |
G |
2: 27,840,665 (GRCm39) |
Y271* |
probably null |
Het |
Dnmt3b |
A |
G |
2: 153,519,500 (GRCm39) |
N695S |
probably benign |
Het |
Dync1li2 |
A |
G |
8: 105,156,140 (GRCm39) |
C234R |
probably benign |
Het |
Dync2h1 |
A |
T |
9: 7,101,111 (GRCm39) |
D2758E |
probably benign |
Het |
Eif2ak3 |
A |
T |
6: 70,869,919 (GRCm39) |
T869S |
probably benign |
Het |
Foxn4 |
G |
T |
5: 114,398,495 (GRCm39) |
P175H |
possibly damaging |
Het |
Gbp5 |
T |
G |
3: 142,206,319 (GRCm39) |
M1R |
probably null |
Het |
Glp2r |
G |
T |
11: 67,637,589 (GRCm39) |
L30I |
unknown |
Het |
Gls |
A |
T |
1: 52,205,425 (GRCm39) |
D639E |
probably benign |
Het |
Gm5145 |
G |
T |
17: 20,790,654 (GRCm39) |
E11* |
probably null |
Het |
Gm9772 |
T |
A |
17: 22,226,160 (GRCm39) |
K41N |
probably damaging |
Het |
Gnat3 |
A |
T |
5: 18,204,746 (GRCm39) |
D133V |
|
Het |
Gse1 |
C |
A |
8: 121,299,516 (GRCm39) |
P849T |
unknown |
Het |
H2ac15 |
C |
A |
13: 21,937,916 (GRCm39) |
V28L |
probably benign |
Het |
Hoxb9 |
A |
G |
11: 96,165,521 (GRCm39) |
T197A |
probably damaging |
Het |
Krt39 |
A |
G |
11: 99,405,575 (GRCm39) |
S442P |
possibly damaging |
Het |
Leng9 |
A |
G |
7: 4,151,617 (GRCm39) |
L353P |
probably damaging |
Het |
Mamdc2 |
A |
T |
19: 23,288,355 (GRCm39) |
M561K |
probably damaging |
Het |
Mamdc4 |
A |
G |
2: 25,458,225 (GRCm39) |
V395A |
probably damaging |
Het |
Mrpl32 |
G |
A |
13: 14,787,498 (GRCm39) |
R36C |
probably benign |
Het |
Or6b2b |
A |
T |
1: 92,419,107 (GRCm39) |
Y123* |
probably null |
Het |
Or7e168 |
A |
G |
9: 19,719,947 (GRCm39) |
D111G |
probably damaging |
Het |
Papss1 |
T |
A |
3: 131,290,873 (GRCm39) |
D205E |
probably benign |
Het |
Pdlim2 |
T |
C |
14: 70,408,924 (GRCm39) |
D151G |
probably benign |
Het |
Pdxp |
T |
C |
15: 78,798,339 (GRCm39) |
V57A |
probably damaging |
Het |
Plec |
T |
A |
15: 76,061,594 (GRCm39) |
E2781V |
probably damaging |
Het |
Prr7 |
GCGCCGCCGCACGCGCACCCGCACCCACACCATCACGCACTGCCGCACCCACCGCCGCCGCAC |
GCGCCGCCGCAC |
13: 55,620,147 (GRCm39) |
|
probably benign |
Het |
Rnf32 |
G |
A |
5: 29,402,948 (GRCm39) |
|
probably benign |
Het |
Ryr2 |
A |
G |
13: 11,776,213 (GRCm39) |
V1108A |
possibly damaging |
Het |
Slc4a8 |
A |
G |
15: 100,686,104 (GRCm39) |
H276R |
probably benign |
Het |
Slco1a7 |
C |
T |
6: 141,690,271 (GRCm39) |
V161I |
probably damaging |
Het |
Spta1 |
T |
A |
1: 174,032,944 (GRCm39) |
D1000E |
probably damaging |
Het |
Sva |
C |
A |
6: 42,019,598 (GRCm39) |
Q153K |
unknown |
Het |
Tmprss11d |
T |
C |
5: 86,457,365 (GRCm39) |
Y236C |
possibly damaging |
Het |
Zfp82 |
C |
A |
7: 29,756,147 (GRCm39) |
G312W |
probably damaging |
Het |
|
Other mutations in Zfp160 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00714:Zfp160
|
APN |
17 |
21,246,964 (GRCm39) |
missense |
probably benign |
|
IGL01019:Zfp160
|
APN |
17 |
21,241,088 (GRCm39) |
missense |
possibly damaging |
0.68 |
IGL02430:Zfp160
|
APN |
17 |
21,245,792 (GRCm39) |
missense |
possibly damaging |
0.76 |
R0412:Zfp160
|
UTSW |
17 |
21,247,139 (GRCm39) |
missense |
probably damaging |
0.97 |
R0600:Zfp160
|
UTSW |
17 |
21,247,268 (GRCm39) |
missense |
probably benign |
0.00 |
R2146:Zfp160
|
UTSW |
17 |
21,247,244 (GRCm39) |
missense |
probably benign |
0.13 |
R2157:Zfp160
|
UTSW |
17 |
21,241,090 (GRCm39) |
missense |
probably benign |
0.23 |
R2411:Zfp160
|
UTSW |
17 |
21,246,007 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2904:Zfp160
|
UTSW |
17 |
21,245,911 (GRCm39) |
missense |
probably benign |
0.00 |
R4249:Zfp160
|
UTSW |
17 |
21,246,000 (GRCm39) |
missense |
probably benign |
0.11 |
R4896:Zfp160
|
UTSW |
17 |
21,240,343 (GRCm39) |
missense |
probably benign |
0.00 |
R5106:Zfp160
|
UTSW |
17 |
21,247,023 (GRCm39) |
missense |
probably damaging |
0.99 |
R5342:Zfp160
|
UTSW |
17 |
21,240,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5352:Zfp160
|
UTSW |
17 |
21,247,114 (GRCm39) |
missense |
probably benign |
0.02 |
R6193:Zfp160
|
UTSW |
17 |
21,247,124 (GRCm39) |
missense |
probably benign |
0.24 |
R6230:Zfp160
|
UTSW |
17 |
21,246,707 (GRCm39) |
missense |
probably benign |
0.38 |
R6753:Zfp160
|
UTSW |
17 |
21,240,996 (GRCm39) |
missense |
probably benign |
0.02 |
R6928:Zfp160
|
UTSW |
17 |
21,261,724 (GRCm39) |
missense |
probably benign |
0.04 |
R7040:Zfp160
|
UTSW |
17 |
21,246,794 (GRCm39) |
missense |
probably damaging |
1.00 |
R7255:Zfp160
|
UTSW |
17 |
21,245,749 (GRCm39) |
missense |
probably benign |
0.18 |
R7497:Zfp160
|
UTSW |
17 |
21,246,455 (GRCm39) |
missense |
probably benign |
0.08 |
R7510:Zfp160
|
UTSW |
17 |
21,246,655 (GRCm39) |
missense |
probably benign |
0.00 |
R7540:Zfp160
|
UTSW |
17 |
21,245,922 (GRCm39) |
nonsense |
probably null |
|
R8169:Zfp160
|
UTSW |
17 |
21,247,298 (GRCm39) |
missense |
probably damaging |
0.97 |
R8240:Zfp160
|
UTSW |
17 |
21,246,350 (GRCm39) |
missense |
probably damaging |
0.99 |
R8330:Zfp160
|
UTSW |
17 |
21,246,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R8367:Zfp160
|
UTSW |
17 |
21,245,804 (GRCm39) |
missense |
probably benign |
0.22 |
R8802:Zfp160
|
UTSW |
17 |
21,246,867 (GRCm39) |
missense |
probably damaging |
1.00 |
R9183:Zfp160
|
UTSW |
17 |
21,240,354 (GRCm39) |
missense |
possibly damaging |
0.84 |
R9556:Zfp160
|
UTSW |
17 |
21,247,031 (GRCm39) |
missense |
probably benign |
0.03 |
R9695:Zfp160
|
UTSW |
17 |
21,245,746 (GRCm39) |
missense |
possibly damaging |
0.53 |
Z1177:Zfp160
|
UTSW |
17 |
21,247,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTACTCAAGTTTGACTACTCATCAG -3'
(R):5'- AACTCATGATGGGTGTTTATCGTC -3'
Sequencing Primer
(F):5'- AGTTTGACTACTCATCAGGCAATCC -3'
(R):5'- ATTCCTGGATATTATGCAAGAAGTG -3'
|
Posted On |
2019-10-24 |