Incidental Mutation 'R7629:Ankrd28'
ID 589564
Institutional Source Beutler Lab
Gene Symbol Ankrd28
Ensembl Gene ENSMUSG00000014496
Gene Name ankyrin repeat domain 28
Synonyms E430019N21Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.284) question?
Stock # R7629 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 31420725-31552608 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 31437221 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 615 (V615I)
Ref Sequence ENSEMBL: ENSMUSP00000014640 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014640] [ENSMUST00000227089] [ENSMUST00000227863]
AlphaFold Q505D1
Predicted Effect probably benign
Transcript: ENSMUST00000014640
AA Change: V615I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000014640
Gene: ENSMUSG00000014496
AA Change: V615I

DomainStartEndE-ValueType
ANK 7 36 5.69e2 SMART
ANK 40 69 2.45e-4 SMART
ANK 73 102 1.59e-3 SMART
ANK 106 135 1.09e-1 SMART
ANK 139 168 1.58e-7 SMART
ANK 172 201 4.97e-5 SMART
ANK 205 234 1.01e-5 SMART
ANK 238 267 2.74e-7 SMART
ANK 271 301 4.13e-2 SMART
ANK 305 334 3.8e-1 SMART
ANK 338 367 3.06e-5 SMART
ANK 371 400 1.44e-1 SMART
ANK 404 433 6.76e-7 SMART
ANK 437 466 1.73e-4 SMART
ANK 470 500 7.83e-3 SMART
ANK 504 534 2.99e1 SMART
ANK 549 578 1.34e-1 SMART
ANK 582 611 3.76e-5 SMART
ANK 616 645 4.13e-2 SMART
ANK 652 681 1.24e-5 SMART
ANK 685 714 4.5e-3 SMART
ANK 718 747 1.93e-2 SMART
ANK 755 784 2.85e-5 SMART
ANK 787 818 2.15e0 SMART
ANK 822 851 2.16e-5 SMART
ANK 855 885 4.5e-3 SMART
ANK 889 918 6.61e-1 SMART
ANK 925 954 3.85e-2 SMART
low complexity region 982 995 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000227089
AA Change: V461I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227863
AA Change: V645I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061N02Rik G A 16: 88,504,293 (GRCm39) T168I probably benign Het
Abtb2 T A 2: 103,513,838 (GRCm39) probably null Het
Ankrd10 A T 8: 11,665,769 (GRCm39) V277E probably benign Het
Aqr G A 2: 113,945,074 (GRCm39) P1079L probably damaging Het
Brox G A 1: 183,074,068 (GRCm39) A60V probably damaging Het
Copg1 T C 6: 87,871,151 (GRCm39) V289A possibly damaging Het
Cplane1 C T 15: 8,256,551 (GRCm39) Q2004* probably null Het
Dido1 T C 2: 180,303,266 (GRCm39) N1546S probably benign Het
Dlg5 G A 14: 24,295,280 (GRCm39) P80L probably damaging Het
Dmxl1 T A 18: 49,992,337 (GRCm39) I361N probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fhod3 T A 18: 24,887,374 (GRCm39) D88E probably benign Het
Flywch1 A G 17: 23,974,744 (GRCm39) M632T probably benign Het
Henmt1 A G 3: 108,865,913 (GRCm39) T213A probably benign Het
Itga9 T C 9: 118,527,514 (GRCm39) V555A probably benign Het
Katnip T C 7: 125,394,422 (GRCm39) L192P probably damaging Het
Kif13b C T 14: 65,016,784 (GRCm39) R1317* probably null Het
Kndc1 A T 7: 139,475,176 (GRCm39) E25V probably damaging Het
Lingo2 T A 4: 35,708,675 (GRCm39) D435V possibly damaging Het
Lrrc14b T A 13: 74,509,283 (GRCm39) M375L probably benign Het
Lrrtm2 T C 18: 35,347,310 (GRCm39) probably null Het
Mgat4c G A 10: 102,224,931 (GRCm39) V382I probably benign Het
Muc16 T C 9: 18,478,081 (GRCm39) T7075A possibly damaging Het
Myo5b T A 18: 74,760,325 (GRCm39) probably null Het
Neb T C 2: 52,163,973 (GRCm39) D1995G possibly damaging Het
Nudt9 T C 5: 104,198,560 (GRCm39) V75A possibly damaging Het
Or4k35 C T 2: 111,100,221 (GRCm39) V164I probably benign Het
Paf1 T C 7: 28,094,493 (GRCm39) Y35H probably damaging Het
Pals2 T C 6: 50,173,603 (GRCm39) I489T probably benign Het
Panx3 T A 9: 37,572,740 (GRCm39) Q270L possibly damaging Het
Pde6h G T 6: 136,936,317 (GRCm39) R20L possibly damaging Het
Pdxk A G 10: 78,280,840 (GRCm39) I200T probably benign Het
Ppara A T 15: 85,682,392 (GRCm39) M363L probably damaging Het
Prmt8 A T 6: 127,666,846 (GRCm39) L376* probably null Het
Serpina1a G C 12: 103,820,067 (GRCm39) T393R probably damaging Het
Sfxn1 C T 13: 54,247,041 (GRCm39) R178C probably damaging Het
Sirpb1c A T 3: 15,902,559 (GRCm39) W7R possibly damaging Het
Skint5 T C 4: 113,799,857 (GRCm39) Y104C probably damaging Het
Slamf6 A T 1: 171,764,191 (GRCm39) T195S probably damaging Het
Slc2a6 T C 2: 26,914,214 (GRCm39) D301G probably benign Het
Stab2 A T 10: 86,719,646 (GRCm39) probably null Het
Tctn3 C G 19: 40,599,780 (GRCm39) D141H probably damaging Het
Tnik A G 3: 28,715,877 (GRCm39) N1164D probably damaging Het
Tpcn1 C T 5: 120,676,002 (GRCm39) V711I probably benign Het
Trim11 G A 11: 58,869,160 (GRCm39) G32D probably damaging Het
Usp32 TTTGGTTG TTTG 11: 84,910,681 (GRCm39) probably null Het
Vmn1r72 T C 7: 11,403,711 (GRCm39) I246V probably benign Het
Zfp362 G T 4: 128,679,848 (GRCm39) R273S probably damaging Het
Zfp715 T C 7: 42,951,100 (GRCm39) D66G possibly damaging Het
Zftraf1 C T 15: 76,532,386 (GRCm39) D241N probably benign Het
Other mutations in Ankrd28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00769:Ankrd28 APN 14 31,465,322 (GRCm39) missense possibly damaging 0.94
IGL01335:Ankrd28 APN 14 31,423,981 (GRCm39) missense probably damaging 0.99
IGL01564:Ankrd28 APN 14 31,477,724 (GRCm39) missense probably damaging 1.00
IGL01624:Ankrd28 APN 14 31,432,814 (GRCm39) missense probably benign 0.00
IGL01987:Ankrd28 APN 14 31,500,931 (GRCm39) missense probably damaging 1.00
IGL02100:Ankrd28 APN 14 31,449,582 (GRCm39) unclassified probably benign
IGL02307:Ankrd28 APN 14 31,455,665 (GRCm39) missense probably damaging 1.00
IGL02656:Ankrd28 APN 14 31,424,197 (GRCm39) missense possibly damaging 0.94
IGL03069:Ankrd28 APN 14 31,477,743 (GRCm39) nonsense probably null
G1citation:Ankrd28 UTSW 14 31,458,797 (GRCm39) critical splice acceptor site probably null
R0038:Ankrd28 UTSW 14 31,429,992 (GRCm39) missense probably damaging 0.99
R0038:Ankrd28 UTSW 14 31,429,992 (GRCm39) missense probably damaging 0.99
R0124:Ankrd28 UTSW 14 31,449,698 (GRCm39) missense probably damaging 1.00
R0347:Ankrd28 UTSW 14 31,423,979 (GRCm39) makesense probably null
R0452:Ankrd28 UTSW 14 31,470,695 (GRCm39) missense probably damaging 1.00
R0685:Ankrd28 UTSW 14 31,465,407 (GRCm39) unclassified probably benign
R0751:Ankrd28 UTSW 14 31,486,225 (GRCm39) missense probably damaging 1.00
R1349:Ankrd28 UTSW 14 31,467,218 (GRCm39) missense probably benign 0.05
R1372:Ankrd28 UTSW 14 31,467,218 (GRCm39) missense probably benign 0.05
R1695:Ankrd28 UTSW 14 31,429,201 (GRCm39) missense probably damaging 1.00
R1888:Ankrd28 UTSW 14 31,453,982 (GRCm39) splice site probably benign
R1938:Ankrd28 UTSW 14 31,427,233 (GRCm39) missense possibly damaging 0.74
R2001:Ankrd28 UTSW 14 31,467,293 (GRCm39) missense possibly damaging 0.94
R2162:Ankrd28 UTSW 14 31,430,719 (GRCm39) missense probably damaging 1.00
R2352:Ankrd28 UTSW 14 31,432,904 (GRCm39) missense probably benign 0.05
R2357:Ankrd28 UTSW 14 31,486,251 (GRCm39) nonsense probably null
R3545:Ankrd28 UTSW 14 31,437,217 (GRCm39) missense probably benign 0.13
R3548:Ankrd28 UTSW 14 31,437,217 (GRCm39) missense probably benign 0.13
R3710:Ankrd28 UTSW 14 31,470,808 (GRCm39) splice site probably benign
R4282:Ankrd28 UTSW 14 31,467,182 (GRCm39) missense possibly damaging 0.74
R4501:Ankrd28 UTSW 14 31,428,753 (GRCm39) missense probably damaging 0.97
R4513:Ankrd28 UTSW 14 31,465,242 (GRCm39) missense probably damaging 1.00
R4658:Ankrd28 UTSW 14 31,432,825 (GRCm39) missense probably damaging 1.00
R4731:Ankrd28 UTSW 14 31,477,698 (GRCm39) missense probably benign 0.43
R4732:Ankrd28 UTSW 14 31,477,698 (GRCm39) missense probably benign 0.43
R4733:Ankrd28 UTSW 14 31,477,698 (GRCm39) missense probably benign 0.43
R4776:Ankrd28 UTSW 14 31,454,011 (GRCm39) missense probably damaging 1.00
R4801:Ankrd28 UTSW 14 31,458,787 (GRCm39) missense probably damaging 1.00
R4802:Ankrd28 UTSW 14 31,458,787 (GRCm39) missense probably damaging 1.00
R5279:Ankrd28 UTSW 14 31,456,963 (GRCm39) missense probably damaging 0.99
R5633:Ankrd28 UTSW 14 31,457,022 (GRCm39) missense probably damaging 1.00
R5809:Ankrd28 UTSW 14 31,465,311 (GRCm39) missense probably benign 0.19
R5959:Ankrd28 UTSW 14 31,451,879 (GRCm39) missense probably benign 0.16
R6228:Ankrd28 UTSW 14 31,429,177 (GRCm39) missense probably damaging 1.00
R6358:Ankrd28 UTSW 14 31,432,821 (GRCm39) missense probably damaging 1.00
R6533:Ankrd28 UTSW 14 31,454,041 (GRCm39) missense possibly damaging 0.49
R6598:Ankrd28 UTSW 14 31,430,896 (GRCm39) missense probably damaging 1.00
R6822:Ankrd28 UTSW 14 31,458,797 (GRCm39) critical splice acceptor site probably null
R7352:Ankrd28 UTSW 14 31,429,998 (GRCm39) missense probably damaging 1.00
R7396:Ankrd28 UTSW 14 31,424,159 (GRCm39) missense probably benign 0.00
R7462:Ankrd28 UTSW 14 31,500,886 (GRCm39) missense probably benign 0.40
R7517:Ankrd28 UTSW 14 31,437,331 (GRCm39) missense possibly damaging 0.65
R7783:Ankrd28 UTSW 14 31,428,770 (GRCm39) missense probably damaging 0.99
R7981:Ankrd28 UTSW 14 31,424,114 (GRCm39) missense probably benign 0.08
R8401:Ankrd28 UTSW 14 31,467,251 (GRCm39) missense probably damaging 1.00
R8483:Ankrd28 UTSW 14 31,457,048 (GRCm39) splice site probably null
R8752:Ankrd28 UTSW 14 31,477,699 (GRCm39) start gained probably benign
R8946:Ankrd28 UTSW 14 31,430,083 (GRCm39) missense probably damaging 1.00
R8963:Ankrd28 UTSW 14 31,477,698 (GRCm39) missense probably benign 0.06
R9064:Ankrd28 UTSW 14 31,454,005 (GRCm39) missense probably damaging 1.00
R9181:Ankrd28 UTSW 14 31,470,627 (GRCm39) missense probably damaging 1.00
R9231:Ankrd28 UTSW 14 31,429,234 (GRCm39) missense possibly damaging 0.91
RF010:Ankrd28 UTSW 14 31,500,943 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAGTCCTTGCAGAAGTTAACATTC -3'
(R):5'- TCATGGTCACCATCAAGCC -3'

Sequencing Primer
(F):5'- CCTCTATTAGGGCTAACAGATGG -3'
(R):5'- CATCAAGCCCTGGAAGTGTTG -3'
Posted On 2019-10-24