Incidental Mutation 'R7629:Kif13b'
ID 589565
Institutional Source Beutler Lab
Gene Symbol Kif13b
Ensembl Gene ENSMUSG00000060012
Gene Name kinesin family member 13B
Synonyms N-3 kinesin, C130021D12Rik, 5330429L19Rik, GAKIN
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7629 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 64647265-64809617 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 64779335 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 1317 (R1317*)
Ref Sequence ENSEMBL: ENSMUSP00000098041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100473] [ENSMUST00000224503]
AlphaFold A0A286YCV9
Predicted Effect probably null
Transcript: ENSMUST00000100473
AA Change: R1317*
SMART Domains Protein: ENSMUSP00000098041
Gene: ENSMUSG00000060012
AA Change: R1317*

DomainStartEndE-ValueType
KISc 3 361 1.4e-182 SMART
FHA 470 520 6.86e-1 SMART
low complexity region 546 560 N/A INTRINSIC
coiled coil region 617 646 N/A INTRINSIC
coiled coil region 669 701 N/A INTRINSIC
Pfam:KIF1B 756 802 4.1e-20 PFAM
Pfam:DUF3694 1003 1279 1.4e-37 PFAM
low complexity region 1514 1526 N/A INTRINSIC
low complexity region 1532 1548 N/A INTRINSIC
low complexity region 1574 1589 N/A INTRINSIC
low complexity region 1617 1630 N/A INTRINSIC
CAP_GLY 1719 1784 1.54e-29 SMART
low complexity region 1814 1826 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000224503
AA Change: R1317*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit increased circulating cholesterol and factor VIII levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061N02Rik G A 16: 88,707,405 (GRCm38) T168I probably benign Het
2410089E03Rik C T 15: 8,227,067 (GRCm38) Q2004* probably null Het
Abtb2 T A 2: 103,683,493 (GRCm38) probably null Het
Ankrd10 A T 8: 11,615,769 (GRCm38) V277E probably benign Het
Ankrd28 C T 14: 31,715,264 (GRCm38) V615I probably benign Het
Aqr G A 2: 114,114,593 (GRCm38) P1079L probably damaging Het
Brox G A 1: 183,292,504 (GRCm38) A60V probably damaging Het
Copg1 T C 6: 87,894,169 (GRCm38) V289A possibly damaging Het
Cyhr1 C T 15: 76,648,186 (GRCm38) D241N probably benign Het
D430042O09Rik T C 7: 125,795,250 (GRCm38) L192P probably damaging Het
Dido1 T C 2: 180,661,473 (GRCm38) N1546S probably benign Het
Dlg5 G A 14: 24,245,212 (GRCm38) P80L probably damaging Het
Dmxl1 T A 18: 49,859,270 (GRCm38) I361N probably damaging Het
Fan1 T A 7: 64,372,486 (GRCm38) N340Y probably damaging Het
Fhod3 T A 18: 24,754,317 (GRCm38) D88E probably benign Het
Flywch1 A G 17: 23,755,770 (GRCm38) M632T probably benign Het
Henmt1 A G 3: 108,958,597 (GRCm38) T213A probably benign Het
Itga9 T C 9: 118,698,446 (GRCm38) V555A probably benign Het
Kndc1 A T 7: 139,895,260 (GRCm38) E25V probably damaging Het
Lingo2 T A 4: 35,708,675 (GRCm38) D435V possibly damaging Het
Lrrc14b T A 13: 74,361,164 (GRCm38) M375L probably benign Het
Lrrtm2 T C 18: 35,214,257 (GRCm38) probably null Het
Mgat4c G A 10: 102,389,070 (GRCm38) V382I probably benign Het
Mpp6 T C 6: 50,196,623 (GRCm38) I489T probably benign Het
Muc16 T C 9: 18,566,785 (GRCm38) T7075A possibly damaging Het
Myo5b T A 18: 74,627,254 (GRCm38) probably null Het
Neb T C 2: 52,273,961 (GRCm38) D1995G possibly damaging Het
Nudt9 T C 5: 104,050,694 (GRCm38) V75A possibly damaging Het
Olfr1277 C T 2: 111,269,876 (GRCm38) V164I probably benign Het
Paf1 T C 7: 28,395,068 (GRCm38) Y35H probably damaging Het
Panx3 T A 9: 37,661,444 (GRCm38) Q270L possibly damaging Het
Pde6h G T 6: 136,959,319 (GRCm38) R20L possibly damaging Het
Pdxk A G 10: 78,445,006 (GRCm38) I200T probably benign Het
Ppara A T 15: 85,798,191 (GRCm38) M363L probably damaging Het
Prmt8 A T 6: 127,689,883 (GRCm38) L376* probably null Het
Serpina1a G C 12: 103,853,808 (GRCm38) T393R probably damaging Het
Sfxn1 C T 13: 54,093,022 (GRCm38) R178C probably damaging Het
Sirpb1c A T 3: 15,848,395 (GRCm38) W7R possibly damaging Het
Skint5 T C 4: 113,942,660 (GRCm38) Y104C probably damaging Het
Slamf6 A T 1: 171,936,624 (GRCm38) T195S probably damaging Het
Slc2a6 T C 2: 27,024,202 (GRCm38) D301G probably benign Het
Stab2 A T 10: 86,883,782 (GRCm38) probably null Het
Tctn3 C G 19: 40,611,336 (GRCm38) D141H probably damaging Het
Tnik A G 3: 28,661,728 (GRCm38) N1164D probably damaging Het
Tpcn1 C T 5: 120,537,937 (GRCm38) V711I probably benign Het
Trim11 G A 11: 58,978,334 (GRCm38) G32D probably damaging Het
Usp32 TTTGGTTG TTTG 11: 85,019,855 (GRCm38) probably null Het
Vmn1r72 T C 7: 11,669,784 (GRCm38) I246V probably benign Het
Zfp362 G T 4: 128,786,055 (GRCm38) R273S probably damaging Het
Zfp715 T C 7: 43,301,676 (GRCm38) D66G possibly damaging Het
Other mutations in Kif13b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Kif13b APN 14 64,669,693 (GRCm38) missense possibly damaging 0.81
IGL00485:Kif13b APN 14 64,765,073 (GRCm38) missense possibly damaging 0.88
IGL00495:Kif13b APN 14 64,714,113 (GRCm38) missense probably benign 0.07
IGL00556:Kif13b APN 14 64,744,888 (GRCm38) missense probably damaging 1.00
IGL00571:Kif13b APN 14 64,746,417 (GRCm38) missense probably damaging 0.99
IGL00590:Kif13b APN 14 64,779,462 (GRCm38) missense probably damaging 1.00
IGL01650:Kif13b APN 14 64,765,145 (GRCm38) missense probably benign 0.00
IGL01730:Kif13b APN 14 64,750,361 (GRCm38) critical splice donor site probably null
IGL01908:Kif13b APN 14 64,757,558 (GRCm38) missense probably damaging 1.00
IGL02388:Kif13b APN 14 64,800,358 (GRCm38) missense probably damaging 1.00
IGL02573:Kif13b APN 14 64,803,431 (GRCm38) missense probably damaging 1.00
IGL02661:Kif13b APN 14 64,767,691 (GRCm38) missense probably benign 0.06
IGL02794:Kif13b APN 14 64,803,440 (GRCm38) missense probably benign 0.00
IGL02959:Kif13b APN 14 64,767,717 (GRCm38) missense probably damaging 1.00
IGL02979:Kif13b APN 14 64,789,697 (GRCm38) missense probably damaging 0.96
IGL03114:Kif13b APN 14 64,788,448 (GRCm38) missense probably benign 0.00
R0024:Kif13b UTSW 14 64,750,273 (GRCm38) missense probably benign 0.30
R0330:Kif13b UTSW 14 64,803,220 (GRCm38) missense probably benign
R0376:Kif13b UTSW 14 64,757,404 (GRCm38) splice site probably benign
R0571:Kif13b UTSW 14 64,751,528 (GRCm38) missense probably damaging 1.00
R0718:Kif13b UTSW 14 64,751,662 (GRCm38) splice site probably benign
R1144:Kif13b UTSW 14 64,714,117 (GRCm38) missense probably benign 0.01
R1183:Kif13b UTSW 14 64,782,377 (GRCm38) missense probably benign 0.00
R1264:Kif13b UTSW 14 64,776,232 (GRCm38) splice site probably benign
R1497:Kif13b UTSW 14 64,736,266 (GRCm38) missense probably damaging 0.99
R1579:Kif13b UTSW 14 64,782,341 (GRCm38) critical splice acceptor site probably null
R1624:Kif13b UTSW 14 64,738,619 (GRCm38) missense probably damaging 0.99
R1706:Kif13b UTSW 14 64,760,666 (GRCm38) splice site probably benign
R2176:Kif13b UTSW 14 64,669,671 (GRCm38) missense probably benign 0.01
R3727:Kif13b UTSW 14 64,765,748 (GRCm38) splice site probably benign
R3785:Kif13b UTSW 14 64,800,400 (GRCm38) missense probably benign 0.00
R3786:Kif13b UTSW 14 64,800,400 (GRCm38) missense probably benign 0.00
R4088:Kif13b UTSW 14 64,767,455 (GRCm38) critical splice donor site probably null
R4279:Kif13b UTSW 14 64,779,356 (GRCm38) missense probably damaging 1.00
R4559:Kif13b UTSW 14 64,806,132 (GRCm38) missense probably damaging 0.98
R4689:Kif13b UTSW 14 64,773,064 (GRCm38) missense probably damaging 1.00
R4692:Kif13b UTSW 14 64,803,575 (GRCm38) missense probably benign 0.05
R4878:Kif13b UTSW 14 64,806,154 (GRCm38) missense probably benign 0.00
R4971:Kif13b UTSW 14 64,757,562 (GRCm38) missense possibly damaging 0.90
R5037:Kif13b UTSW 14 64,758,589 (GRCm38) nonsense probably null
R5119:Kif13b UTSW 14 64,757,453 (GRCm38) missense probably benign 0.01
R5167:Kif13b UTSW 14 64,772,935 (GRCm38) missense probably damaging 1.00
R5408:Kif13b UTSW 14 64,779,689 (GRCm38) critical splice acceptor site probably null
R5437:Kif13b UTSW 14 64,806,114 (GRCm38) missense probably damaging 0.99
R5756:Kif13b UTSW 14 64,736,305 (GRCm38) missense probably damaging 1.00
R5838:Kif13b UTSW 14 64,737,555 (GRCm38) missense probably damaging 1.00
R5891:Kif13b UTSW 14 64,788,405 (GRCm38) splice site probably null
R6120:Kif13b UTSW 14 64,751,558 (GRCm38) missense probably damaging 1.00
R6150:Kif13b UTSW 14 64,751,639 (GRCm38) missense probably damaging 0.99
R6165:Kif13b UTSW 14 64,742,311 (GRCm38) missense probably damaging 1.00
R6187:Kif13b UTSW 14 64,736,215 (GRCm38) missense probably damaging 1.00
R6229:Kif13b UTSW 14 64,738,567 (GRCm38) missense probably damaging 1.00
R6267:Kif13b UTSW 14 64,738,634 (GRCm38) missense probably damaging 1.00
R6347:Kif13b UTSW 14 64,767,619 (GRCm38) missense probably benign 0.26
R6479:Kif13b UTSW 14 64,751,525 (GRCm38) missense probably benign 0.08
R6512:Kif13b UTSW 14 64,744,874 (GRCm38) critical splice acceptor site probably null
R6851:Kif13b UTSW 14 64,773,065 (GRCm38) missense probably damaging 1.00
R7131:Kif13b UTSW 14 64,773,068 (GRCm38) missense probably damaging 1.00
R7217:Kif13b UTSW 14 64,773,068 (GRCm38) missense probably damaging 1.00
R7398:Kif13b UTSW 14 64,757,523 (GRCm38) missense probably null 0.02
R7427:Kif13b UTSW 14 64,788,460 (GRCm38) missense probably benign
R7428:Kif13b UTSW 14 64,788,460 (GRCm38) missense probably benign
R7573:Kif13b UTSW 14 64,803,658 (GRCm38) missense probably benign 0.00
R7683:Kif13b UTSW 14 64,757,507 (GRCm38) missense probably benign 0.24
R7835:Kif13b UTSW 14 64,767,452 (GRCm38) missense probably benign 0.00
R7895:Kif13b UTSW 14 64,736,149 (GRCm38) missense probably damaging 1.00
R8285:Kif13b UTSW 14 64,782,376 (GRCm38) missense probably benign 0.03
R8374:Kif13b UTSW 14 64,788,435 (GRCm38) missense probably damaging 0.97
R8467:Kif13b UTSW 14 64,758,705 (GRCm38) missense probably damaging 0.96
R8804:Kif13b UTSW 14 64,750,342 (GRCm38) missense probably damaging 0.99
R8859:Kif13b UTSW 14 64,742,433 (GRCm38) missense probably benign 0.04
R8891:Kif13b UTSW 14 64,744,877 (GRCm38) missense probably damaging 1.00
R9236:Kif13b UTSW 14 64,744,934 (GRCm38) missense probably benign 0.22
R9446:Kif13b UTSW 14 64,747,021 (GRCm38) missense probably damaging 1.00
R9589:Kif13b UTSW 14 64,776,310 (GRCm38) missense possibly damaging 0.82
Z1176:Kif13b UTSW 14 64,803,344 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCATGTATCAGTGTGCTTGAGC -3'
(R):5'- TATAGAGGCCAGATGGGAGTCC -3'

Sequencing Primer
(F):5'- AGCATGTGTGTTTACATCTGTAATG -3'
(R):5'- TCCACCACAGCGCTGTTG -3'
Posted On 2019-10-24