Incidental Mutation 'R7631:Lrrc74a'
ID 589657
Institutional Source Beutler Lab
Gene Symbol Lrrc74a
Ensembl Gene ENSMUSG00000059114
Gene Name leucine rich repeat containing 74A
Synonyms Gm6772, Lrrc74
MMRRC Submission 045692-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R7631 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 86781143-86810571 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86795884 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 286 (N286Y)
Ref Sequence ENSEMBL: ENSMUSP00000152661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095527] [ENSMUST00000222180] [ENSMUST00000223308]
AlphaFold A0A1Y7VMD6
Predicted Effect probably damaging
Transcript: ENSMUST00000095527
AA Change: N286Y

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000093183
Gene: ENSMUSG00000059114
AA Change: N286Y

DomainStartEndE-ValueType
Blast:LRR 87 116 9e-7 BLAST
LRR 117 144 4.17e-3 SMART
LRR 145 172 3.16e-3 SMART
LRR 174 201 1.92e-2 SMART
LRR 202 229 3.07e-1 SMART
LRR 230 257 1.03e-2 SMART
LRR 258 285 1.64e-1 SMART
LRR 286 313 2.03e0 SMART
LRR 314 341 1.11e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000222180
Predicted Effect probably benign
Transcript: ENSMUST00000223197
Predicted Effect probably damaging
Transcript: ENSMUST00000223308
AA Change: N286Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.3758 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 87% (46/53)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl3 T A 6: 34,834,606 (GRCm39) L930H possibly damaging Het
Albfm1 T C 5: 90,727,531 (GRCm39) L383S probably damaging Het
Alcam C T 16: 52,109,276 (GRCm39) probably null Het
Ankrd31 A G 13: 97,015,462 (GRCm39) H1577R probably benign Het
Arfgef1 T C 1: 10,302,694 (GRCm39) N9S probably benign Het
Cpne9 T C 6: 113,279,079 (GRCm39) V491A possibly damaging Het
Cyb5d1 A T 11: 69,285,865 (GRCm39) L57Q possibly damaging Het
Cyp7a1 T A 4: 6,272,763 (GRCm39) Q150L possibly damaging Het
D430041D05Rik A C 2: 103,979,363 (GRCm39) Y1336* probably null Het
Dcaf7 T C 11: 105,944,579 (GRCm39) V254A probably benign Het
Dchs1 T C 7: 105,408,445 (GRCm39) T1796A probably benign Het
Defa27 T A 8: 21,805,657 (GRCm39) D32E probably benign Het
Eno2 T C 6: 124,744,019 (GRCm39) E96G probably benign Het
Fbxw19 T A 9: 109,311,069 (GRCm39) Y380F probably damaging Het
Fer1l4 A T 2: 155,890,195 (GRCm39) N243K probably damaging Het
Fndc7 G A 3: 108,776,568 (GRCm39) A491V probably damaging Het
Gm14305 A G 2: 176,410,790 (GRCm39) Q15R probably benign Het
Gpr155 T C 2: 73,213,291 (GRCm39) probably benign Het
Grm5 A G 7: 87,624,513 (GRCm39) H360R probably damaging Het
Ifi203 G A 1: 173,754,688 (GRCm39) T681I unknown Het
Klc2 A G 19: 5,158,647 (GRCm39) S616P probably benign Het
Lifr A G 15: 7,214,258 (GRCm39) Y704C probably damaging Het
Lingo4 A C 3: 94,306,767 (GRCm39) D15A possibly damaging Het
Mcm8 A G 2: 132,669,963 (GRCm39) T374A not run Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Naa25 A G 5: 121,576,791 (GRCm39) T847A possibly damaging Het
Nrxn2 T A 19: 6,531,825 (GRCm39) M763K possibly damaging Het
Onecut2 T A 18: 64,474,046 (GRCm39) M180K possibly damaging Het
Or1p4-ps1 A C 11: 74,208,357 (GRCm39) T169P unknown Het
Or2r3 T A 6: 42,448,870 (GRCm39) M81L probably benign Het
Or5m11 A T 2: 85,782,218 (GRCm39) E270D probably benign Het
Or8c13 A T 9: 38,092,002 (GRCm39) V39E probably damaging Het
Otx1 G A 11: 21,949,458 (GRCm39) Q7* probably null Het
Pabpc4 T G 4: 123,182,763 (GRCm39) D133E probably damaging Het
Pcsk5 A T 19: 17,542,144 (GRCm39) C816S probably damaging Het
Pgm2 A G 5: 64,265,522 (GRCm39) T408A possibly damaging Het
Polr2m G C 9: 71,390,757 (GRCm39) Y148* probably null Het
Reln T C 5: 22,176,933 (GRCm39) N1911S probably damaging Het
Scaf4 T C 16: 90,026,445 (GRCm39) D1124G unknown Het
Scgb1b19 C T 7: 32,986,784 (GRCm39) T18I probably damaging Het
Septin12 T A 16: 4,814,320 (GRCm39) I50F probably damaging Het
Slc25a20 T A 9: 108,539,491 (GRCm39) M22K probably benign Het
Sltm C G 9: 70,493,955 (GRCm39) P802R possibly damaging Het
Smchd1 A G 17: 71,705,684 (GRCm39) F972L probably benign Het
Spem1 T C 11: 69,712,409 (GRCm39) Y85C probably benign Het
Strip1 C T 3: 107,524,247 (GRCm39) V557I possibly damaging Het
Tcirg1 G T 19: 3,947,160 (GRCm39) Q634K probably damaging Het
Tma7 T A 9: 108,911,507 (GRCm39) probably benign Het
Tmem204 A G 17: 25,299,414 (GRCm39) L35P probably damaging Het
Trpc6 A G 9: 8,626,702 (GRCm39) T351A probably benign Het
Tubb2a A G 13: 34,259,227 (GRCm39) S188P probably damaging Het
Ubr5 C A 15: 38,029,751 (GRCm39) L485F Het
Vmn1r71 A T 7: 10,482,378 (GRCm39) S103R probably damaging Het
Vmn2r40 C T 7: 8,911,119 (GRCm39) D725N Het
Zfp473 T C 7: 44,383,128 (GRCm39) R402G possibly damaging Het
Zfp82 A T 7: 29,755,851 (GRCm39) S410R probably damaging Het
Other mutations in Lrrc74a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Lrrc74a APN 12 86,801,204 (GRCm39) missense probably damaging 1.00
IGL01380:Lrrc74a APN 12 86,808,496 (GRCm39) missense possibly damaging 0.62
IGL01715:Lrrc74a APN 12 86,801,189 (GRCm39) missense probably benign 0.05
IGL01832:Lrrc74a APN 12 86,808,488 (GRCm39) missense probably benign 0.00
IGL01953:Lrrc74a APN 12 86,788,494 (GRCm39) missense probably damaging 1.00
IGL02218:Lrrc74a APN 12 86,795,822 (GRCm39) missense probably benign 0.15
IGL02637:Lrrc74a APN 12 86,788,521 (GRCm39) nonsense probably null
IGL03397:Lrrc74a APN 12 86,805,312 (GRCm39) missense probably benign 0.39
R0201:Lrrc74a UTSW 12 86,808,547 (GRCm39) splice site probably benign
R0360:Lrrc74a UTSW 12 86,784,569 (GRCm39) missense probably damaging 1.00
R0403:Lrrc74a UTSW 12 86,787,753 (GRCm39) missense probably damaging 1.00
R0729:Lrrc74a UTSW 12 86,792,353 (GRCm39) nonsense probably null
R1675:Lrrc74a UTSW 12 86,787,800 (GRCm39) missense probably damaging 1.00
R1774:Lrrc74a UTSW 12 86,795,827 (GRCm39) missense probably damaging 1.00
R1818:Lrrc74a UTSW 12 86,784,484 (GRCm39) missense probably damaging 1.00
R4688:Lrrc74a UTSW 12 86,784,472 (GRCm39) nonsense probably null
R6023:Lrrc74a UTSW 12 86,805,380 (GRCm39) missense probably damaging 1.00
R6190:Lrrc74a UTSW 12 86,783,263 (GRCm39) missense probably benign 0.01
R6226:Lrrc74a UTSW 12 86,795,231 (GRCm39) missense possibly damaging 0.87
R6247:Lrrc74a UTSW 12 86,805,330 (GRCm39) missense probably damaging 1.00
R7275:Lrrc74a UTSW 12 86,787,753 (GRCm39) missense probably damaging 1.00
R7857:Lrrc74a UTSW 12 86,788,485 (GRCm39) missense probably benign 0.00
R8172:Lrrc74a UTSW 12 86,788,530 (GRCm39) missense probably damaging 1.00
R8715:Lrrc74a UTSW 12 86,805,239 (GRCm39) missense probably damaging 1.00
R8717:Lrrc74a UTSW 12 86,783,253 (GRCm39) missense probably damaging 0.99
R9080:Lrrc74a UTSW 12 86,795,908 (GRCm39) missense possibly damaging 0.87
R9612:Lrrc74a UTSW 12 86,805,345 (GRCm39) missense possibly damaging 0.84
X0024:Lrrc74a UTSW 12 86,795,819 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAGATAAGGGTTAGCATTTAGGTC -3'
(R):5'- ACACGCTCATGGGCACATAG -3'

Sequencing Primer
(F):5'- AAGGGTTAGCATTTAGGTCAGTTAG -3'
(R):5'- CTCATGGGCACATAGGCAGATAC -3'
Posted On 2019-10-24