Mutagenetix > Incidental Mutation

Incidental Mutation 'R0055:Olfr670'

58969

Institutional Source

Beutler Lab

Gene Symbol

Olfr670

Ensembl Gene

ENSMUSG00000044705

Gene Name

olfactory receptor 670

Synonyms

MOR32-8, GA_x6K02T2PBJ9-7589577-7588639

MMRRC Submission

038349-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R0055 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

104957114-104962620 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 104960496 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 79 (T79S)

Ref Sequence

ENSEMBL: ENSMUSP00000151138 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050482] [ENSMUST00000214216]

AlphaFold

Q7TRP3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000050482
AA Change: T79S

PolyPhen 2 Score 0.457 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000060289
Gene: ENSMUSG00000044705
AA Change: T79S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	311	3.7e-121	PFAM
Pfam:7TM_GPCR_Srsx	37	211	4.5e-7	PFAM
Pfam:7tm_1	43	293	3.9e-17	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000214216
AA Change: T79S

PolyPhen 2 Score 0.457 (Sensitivity: 0.89; Specificity: 0.90)

Meta Mutation Damage Score

0.3204

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.6%
20x: 95.6%

Validation Efficiency

98% (59/60)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700029J07Rik	A	T	8: 45,968,161	S108R	probably damaging	Het
2010300C02Rik	A	C	1: 37,624,256	S854A	probably benign	Het
2210016F16Rik	T	C	13: 58,384,166	D192G	probably damaging	Het
4921501E09Rik	A	T	17: 33,066,722	W369R	probably damaging	Het
A2ml1	T	C	6: 128,570,094		probably benign	Het
Atp6v1h	A	T	1: 5,084,454	T2S	probably benign	Het
Bcl11b	G	A	12: 107,965,777	P179S	probably benign	Het
Cacna1a	C	T	8: 84,580,058		probably benign	Het
Ccdc146	C	T	5: 21,297,006		probably null	Het
Ccdc61	T	C	7: 18,892,536	D128G	probably damaging	Het
Cd55	A	G	1: 130,459,576		probably benign	Het
Cdk7	C	A	13: 100,719,304	E99*	probably null	Het
Cox8a	A	T	19: 7,217,509	S2T	probably damaging	Het
Dennd5a	A	G	7: 109,899,791	I955T	possibly damaging	Het
Dopey1	A	C	9: 86,512,652	E602A	probably benign	Het
Ephx4	T	C	5: 107,413,078	L32S	probably damaging	Het
Fbxo21	T	A	5: 118,000,490	D493E	probably benign	Het
Frmd4b	A	T	6: 97,323,649		probably benign	Het
Fzd1	A	T	5: 4,756,037	M515K	possibly damaging	Het
Gli2	A	G	1: 118,890,408		probably benign	Het
Gm12887	T	A	4: 121,616,469	K61N	probably damaging	Het
Grin2a	A	T	16: 9,669,807	V409D	probably damaging	Het
Grin2b	T	C	6: 135,923,203	I227V	probably benign	Het
Helz2	T	G	2: 181,228,821	D2879A	possibly damaging	Het
Itpr2	T	C	6: 146,323,133	N1453S	probably benign	Het
Itpr3	C	A	17: 27,098,322	S817Y	probably damaging	Het
Lin7c	T	A	2: 109,896,453		probably benign	Het
Ly75	T	C	2: 60,321,918	E1097G	probably benign	Het
Mcm10	T	C	2: 4,991,407	N882D	probably damaging	Het
Mettl13	A	T	1: 162,546,181	L167Q	probably damaging	Het
Morn2	A	T	17: 80,295,513	M1L	probably benign	Het
Mybph	G	T	1: 134,193,852	V88L	probably damaging	Het
Nefm	T	A	14: 68,121,199		probably benign	Het
Nf1	A	G	11: 79,471,551	E1497G	probably damaging	Het
Olfr1281	T	A	2: 111,328,525	Y35*	probably null	Het
Olfr137	T	C	17: 38,304,811	S217G	possibly damaging	Het
Olfr615	A	G	7: 103,561,037	K187E	probably damaging	Het
Plcd3	C	G	11: 103,077,585	W382S	probably damaging	Het
Plxna1	T	A	6: 89,329,739	I1370F	possibly damaging	Het
Rarb	G	A	14: 16,509,066	R106C	probably damaging	Het
Rps6ka5	G	A	12: 100,678,580	T37I	probably damaging	Het
Runx1	G	T	16: 92,644,141		probably benign	Het
Scube1	A	G	15: 83,634,736	V301A	probably damaging	Het
Sema3a	A	T	5: 13,400,037	N27I	possibly damaging	Het
Slc15a3	G	T	19: 10,843,042	E8*	probably null	Het
Slc22a5	T	C	11: 53,891,206	S112G	probably benign	Het
Slc25a45	T	C	19: 5,880,467	F3L	probably damaging	Het
Slc4a4	A	C	5: 89,156,336	H502P	possibly damaging	Het
Slfn10-ps	A	G	11: 83,030,300		noncoding transcript	Het
Slit2	C	A	5: 48,281,726	C1077*	probably null	Het
Spn	A	G	7: 127,136,322	F82L	possibly damaging	Het
Tbccd1	A	G	16: 22,841,905	W54R	probably damaging	Het
Ucp1	G	T	8: 83,290,604	E8*	probably null	Het
Unc80	A	T	1: 66,506,623		probably benign	Het
Vsnl1	A	T	12: 11,386,986		probably null	Het
Zdhhc11	C	T	13: 73,982,686	Q295*	probably null	Het
Zfp457	T	A	13: 67,294,034	H63L	probably damaging	Het

Other mutations in Olfr670

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00978:Olfr670	APN	7	104960716	missense	probably damaging	0.96
IGL01100:Olfr670	APN	7	104959995	missense	probably benign	0.07
IGL01351:Olfr670	APN	7	104960739	start gained	probably benign
IGL01478:Olfr670	APN	7	104960348	missense	probably damaging	0.97
IGL01835:Olfr670	APN	7	104960462	missense	probably benign	0.01
IGL02326:Olfr670	APN	7	104960646	missense	probably benign	0.12
IGL02434:Olfr670	APN	7	104960072	missense	probably benign	0.05
IGL02434:Olfr670	APN	7	104960074	nonsense	probably null
IGL02968:Olfr670	APN	7	104960244	missense	possibly damaging	0.90
R0055:Olfr670	UTSW	7	104960496	missense	possibly damaging	0.46
R0345:Olfr670	UTSW	7	104960181	missense	probably damaging	1.00
R0401:Olfr670	UTSW	7	104959943	missense	probably damaging	1.00
R0646:Olfr670	UTSW	7	104959811	missense	probably benign	0.02
R1493:Olfr670	UTSW	7	104960502	missense	probably damaging	0.97
R1532:Olfr670	UTSW	7	104960265	missense	probably benign
R1557:Olfr670	UTSW	7	104960540	missense	probably damaging	0.99
R4072:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4074:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4075:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4076:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4229:Olfr670	UTSW	7	104960594	missense	probably benign	0.18
R4230:Olfr670	UTSW	7	104960594	missense	probably benign	0.18
R5374:Olfr670	UTSW	7	104959996	missense	probably damaging	1.00
R6006:Olfr670	UTSW	7	104960663	missense	probably damaging	0.99
R6891:Olfr670	UTSW	7	104959985	missense	probably damaging	1.00
R7465:Olfr670	UTSW	7	104959917	missense	probably benign	0.23
R8105:Olfr670	UTSW	7	104960422	missense	probably benign	0.15
R8117:Olfr670	UTSW	7	104960149	missense	probably damaging	1.00
R8356:Olfr670	UTSW	7	104960727	missense	probably benign	0.00
R8510:Olfr670	UTSW	7	104960114	nonsense	probably null
R9145:Olfr670	UTSW	7	104959997	missense	probably damaging	1.00
R9168:Olfr670	UTSW	7	104959794	makesense	probably null
R9234:Olfr670	UTSW	7	104960444	missense	probably damaging	1.00
R9706:Olfr670	UTSW	7	104959988	missense	probably damaging	0.99
R9789:Olfr670	UTSW	7	104960450	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- GTGAGAATCTGACTGTACCGCAGAG -3'
(R):5'- AGTTCAAATGGAACTGAATTCCACCCC -3'

Sequencing Primer
(F):5'- CTGACTGTACCGCAGAGGATTG -3'
(R):5'- GAACTGAATTCCACCCCTCTTTTTTC -3'

Posted On

2013-07-11