Incidental Mutation 'R7632:Or5b119'
ID 589729
Institutional Source Beutler Lab
Gene Symbol Or5b119
Ensembl Gene ENSMUSG00000096708
Gene Name olfactory receptor family 5 subfamily B member 119
Synonyms GA_x6K02T2RE5P-3812807-3811863, MOR202-36, Olfr1475
MMRRC Submission 045720-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7632 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13456616-13457560 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13456795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 256 (M256V)
Ref Sequence ENSEMBL: ENSMUSP00000079616 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080801]
AlphaFold Q8VEV6
Predicted Effect possibly damaging
Transcript: ENSMUST00000080801
AA Change: M256V

PolyPhen 2 Score 0.786 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000079616
Gene: ENSMUSG00000096708
AA Change: M256V

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 4.2e-52 PFAM
Pfam:7TM_GPCR_Srsx 33 303 4.7e-9 PFAM
Pfam:7tm_1 39 288 1.6e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 95% (63/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap2a2 A G 7: 141,211,236 (GRCm39) D924G probably benign Het
Armh1 C A 4: 117,070,938 (GRCm39) A396S probably benign Het
Atrnl1 A G 19: 57,618,738 (GRCm39) D152G probably damaging Het
B3gnt8 A G 7: 25,327,860 (GRCm39) I97V possibly damaging Het
Bach1 A G 16: 87,517,031 (GRCm39) D524G probably benign Het
Caprin2 T C 6: 148,784,954 (GRCm39) S107G probably damaging Het
Ccnb1 A G 13: 100,918,209 (GRCm39) I207T probably benign Het
Cdh11 T C 8: 103,400,515 (GRCm39) D151G probably damaging Het
Cdh9 A G 15: 16,851,115 (GRCm39) probably null Het
Cep83 A T 10: 94,586,502 (GRCm39) R433W probably damaging Het
Cspg4b C A 13: 113,457,420 (GRCm39) S1155R Het
D3Ertd751e A G 3: 41,708,163 (GRCm39) E100G probably benign Het
Dchs2 C T 3: 83,255,357 (GRCm39) A2351V probably benign Het
Dhx40 T C 11: 86,690,263 (GRCm39) T253A probably benign Het
Dqx1 A G 6: 83,036,680 (GRCm39) D228G probably benign Het
Dync1h1 T C 12: 110,627,327 (GRCm39) M4002T probably benign Het
Flcn C T 11: 59,686,625 (GRCm39) W376* probably null Het
Flnc A T 6: 29,446,984 (GRCm39) Y1037F probably damaging Het
Fut11 T A 14: 20,745,096 (GRCm39) V9E probably benign Het
Fv1 T A 4: 147,954,392 (GRCm39) N319K possibly damaging Het
Ghrhr G T 6: 55,361,727 (GRCm39) G298V probably benign Het
Gm5800 T A 14: 51,953,905 (GRCm39) probably null Het
Grin2b A G 6: 135,709,553 (GRCm39) M1331T probably benign Het
Hyou1 A G 9: 44,292,433 (GRCm39) probably null Het
Igkv1-117 C A 6: 68,098,792 (GRCm39) Q114K probably damaging Het
Igkv4-68 A G 6: 69,282,048 (GRCm39) V41A possibly damaging Het
Inpp4b A G 8: 82,772,968 (GRCm39) N754S probably damaging Het
Isl2 G A 9: 55,448,440 (GRCm39) probably null Het
Kat2a G A 11: 100,599,422 (GRCm39) Q523* probably null Het
Lypd3 T C 7: 24,337,865 (GRCm39) F77S possibly damaging Het
Map4k2 T C 19: 6,394,084 (GRCm39) L297P probably benign Het
Naca T C 10: 127,876,375 (GRCm39) V469A unknown Het
Notch3 C T 17: 32,377,480 (GRCm39) V199I probably benign Het
Or4k44 T C 2: 111,368,521 (GRCm39) I38V possibly damaging Het
Pabpc1 TGTACCTGTTGCATGGTA TGTA 15: 36,598,212 (GRCm39) probably null Het
Pcdhb8 A T 18: 37,488,648 (GRCm39) I109L probably benign Het
Pde2a A G 7: 101,133,801 (GRCm39) D104G possibly damaging Het
Phip A G 9: 82,785,243 (GRCm39) V824A probably benign Het
Plekhg4 T C 8: 106,106,782 (GRCm39) Y853H probably damaging Het
Plod1 T C 4: 148,011,481 (GRCm39) K248R probably damaging Het
Plxnd1 A T 6: 115,953,600 (GRCm39) Y656N probably benign Het
Pogz G A 3: 94,763,517 (GRCm39) probably null Het
Ppp1r3e T A 14: 55,114,526 (GRCm39) S79C probably damaging Het
Pprc1 T A 19: 46,060,721 (GRCm39) D1595E probably damaging Het
Ptprq A G 10: 107,547,783 (GRCm39) V205A probably benign Het
Rad51ap2 T C 12: 11,507,116 (GRCm39) V346A possibly damaging Het
Rgs12 T A 5: 35,122,934 (GRCm39) L239H probably damaging Het
Rrp8 T C 7: 105,385,727 (GRCm39) probably benign Het
Rsf1 GGCG GGCGACCGCCGCG 7: 97,229,113 (GRCm39) probably benign Het
Scaf1 A T 7: 44,656,503 (GRCm39) V792D unknown Het
Scrn2 G T 11: 96,923,968 (GRCm39) R284L possibly damaging Het
Sgsm1 T A 5: 113,423,948 (GRCm39) Q461L possibly damaging Het
Slc18b1 A G 10: 23,702,080 (GRCm39) T434A probably benign Het
Sltm C G 9: 70,493,955 (GRCm39) P802R possibly damaging Het
Smc4 CTA CTATA 3: 68,925,400 (GRCm39) probably benign Het
Snx33 A T 9: 56,833,702 (GRCm39) D122E probably damaging Het
Srebf2 G T 15: 82,069,497 (GRCm39) V680L probably benign Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Tecpr1 C T 5: 144,155,544 (GRCm39) V5M probably benign Het
Tfg A G 16: 56,532,997 (GRCm39) V54A possibly damaging Het
Tmem237 C T 1: 59,156,060 (GRCm39) C30Y probably benign Het
Tmem245 T C 4: 56,916,787 (GRCm39) K444R probably benign Het
Trim25 T G 11: 88,906,602 (GRCm39) L446R probably null Het
Usp37 T C 1: 74,507,533 (GRCm39) T495A probably benign Het
Vmn1r94 T G 7: 19,901,696 (GRCm39) T203P probably damaging Het
Ywhah T A 5: 33,184,010 (GRCm39) M71K probably benign Het
Other mutations in Or5b119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Or5b119 APN 19 13,457,151 (GRCm39) missense possibly damaging 0.81
IGL01604:Or5b119 APN 19 13,456,612 (GRCm39) unclassified probably benign
IGL01656:Or5b119 APN 19 13,457,454 (GRCm39) missense probably benign 0.08
IGL01802:Or5b119 APN 19 13,456,729 (GRCm39) missense probably benign 0.05
IGL01839:Or5b119 APN 19 13,456,804 (GRCm39) missense probably benign
IGL02255:Or5b119 APN 19 13,457,349 (GRCm39) missense probably damaging 1.00
IGL02706:Or5b119 APN 19 13,457,462 (GRCm39) nonsense probably null
IGL02723:Or5b119 APN 19 13,456,699 (GRCm39) missense probably damaging 1.00
IGL03143:Or5b119 APN 19 13,456,835 (GRCm39) missense probably damaging 1.00
IGL03174:Or5b119 APN 19 13,457,433 (GRCm39) missense probably benign 0.10
BB007:Or5b119 UTSW 19 13,457,019 (GRCm39) missense probably damaging 0.99
BB017:Or5b119 UTSW 19 13,457,019 (GRCm39) missense probably damaging 0.99
R0442:Or5b119 UTSW 19 13,457,412 (GRCm39) missense probably damaging 1.00
R0490:Or5b119 UTSW 19 13,456,857 (GRCm39) missense probably damaging 0.98
R0491:Or5b119 UTSW 19 13,456,857 (GRCm39) missense probably damaging 0.98
R1757:Or5b119 UTSW 19 13,456,971 (GRCm39) missense possibly damaging 0.67
R1843:Or5b119 UTSW 19 13,457,295 (GRCm39) missense probably benign 0.00
R1972:Or5b119 UTSW 19 13,457,058 (GRCm39) missense probably benign 0.00
R2137:Or5b119 UTSW 19 13,457,173 (GRCm39) missense probably damaging 1.00
R3150:Or5b119 UTSW 19 13,456,824 (GRCm39) missense probably damaging 1.00
R3858:Or5b119 UTSW 19 13,457,494 (GRCm39) missense possibly damaging 0.86
R3859:Or5b119 UTSW 19 13,457,494 (GRCm39) missense possibly damaging 0.86
R3953:Or5b119 UTSW 19 13,456,806 (GRCm39) missense probably benign 0.43
R4611:Or5b119 UTSW 19 13,457,376 (GRCm39) missense probably damaging 0.96
R4934:Or5b119 UTSW 19 13,456,956 (GRCm39) missense possibly damaging 0.65
R5580:Or5b119 UTSW 19 13,456,791 (GRCm39) missense probably damaging 1.00
R6278:Or5b119 UTSW 19 13,457,119 (GRCm39) missense probably benign
R6444:Or5b119 UTSW 19 13,456,794 (GRCm39) missense possibly damaging 0.95
R6796:Or5b119 UTSW 19 13,457,278 (GRCm39) missense probably damaging 1.00
R6812:Or5b119 UTSW 19 13,456,975 (GRCm39) missense probably benign 0.03
R7608:Or5b119 UTSW 19 13,456,956 (GRCm39) missense possibly damaging 0.65
R7930:Or5b119 UTSW 19 13,457,019 (GRCm39) missense probably damaging 0.99
R8008:Or5b119 UTSW 19 13,457,170 (GRCm39) missense probably benign 0.01
R8416:Or5b119 UTSW 19 13,456,764 (GRCm39) missense possibly damaging 0.95
R8551:Or5b119 UTSW 19 13,457,109 (GRCm39) missense possibly damaging 0.88
R9058:Or5b119 UTSW 19 13,456,956 (GRCm39) missense possibly damaging 0.65
R9719:Or5b119 UTSW 19 13,457,368 (GRCm39) missense probably damaging 1.00
R9756:Or5b119 UTSW 19 13,456,986 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAAAGACTCAGTGTTTCATATGC -3'
(R):5'- ACATGTGTGGGATCTTACAATCC -3'

Sequencing Primer
(F):5'- ACTGTATACTACAGGGTTCA -3'
(R):5'- GAGATTACAGTCCTTATCTTGGGTAC -3'
Posted On 2019-10-24